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STARD5对胃癌的预后影响及机制研究

中华肿瘤防治杂志 2024年第1期31卷 19-26页

作者：谢蕊西吴歆姝包博文李文诗俞思琦车晓芳中国医科大学附属第一医院肿瘤内科辽宁省肿瘤药物与生物治疗重点实验室沈阳市恶性肿瘤综合治疗临床医学研究中心辽宁沈阳110001

目的采用人类肿瘤基因表达汇编(GEO)及癌症基因组图谱(TCGA)数据分析类固醇敏感性调节蛋白相关脂类转运结构域蛋白5(STARD5)对胃癌预后的影响,通过细胞实验和分子实验验证并探索其相关机制。方法采用GEO胃癌数据集GSE62254及TCGA胃癌数... 详细信息

目的采用人类肿瘤基因表达汇编(GEO)及癌症基因组图谱(TCGA)数据分析类固醇敏感性调节蛋白相关脂类转运结构域蛋白5(STARD5)对胃癌预后的影响,通过细胞实验和分子实验验证并探索其相关机制。方法采用GEO胃癌数据集GSE62254及TCGA胃癌数据集进行单因素和多因素Cox回归分析,筛选STARD家族中的胃癌独立预后因素,并建立基于STARD家族的列线图模型;分析STARD5表达与临床病理特征的关系;使用基因集富集分析(GSEA)预测STARD5影响胃癌预后的相关通路;瞬时沉默STARD5后检测胃癌细胞的迁移、侵袭及黏附能力和胃癌细胞中相关蛋白表达的变化;采用加州大学圣克鲁兹分校(UCSC)gnome browser预测转录因子与靶基因结合位点。生存分析使用Kaplan-Meier和log-rank检验,STARD5与临床病理特征的关系使用χ^(2)检验,组间比较使用Dunnett’s t检验。结果GSE62254及TCGA胃癌数据集均显示STARD5为胃癌的独立保护因素,均P<0.05;纳入STARD5表达与TNM分期所绘制的列线图预测胃癌患者1、3、5年生存率的性能良好,一致性指数及其95%CI为0.701(0.659~0.744);STARD5表达与胃癌肝转移呈负相关,P=0.020。GSEA提示STARD5低表达与Focal adhesion、PI3K/AKT等通路密切相关,均P<0.05。敲减STARD5后,胃癌细胞迁移、侵袭及黏附能力增加,且AKT磷酸化水平升高,Integrinβ1、XBP-1s、ATF4和ATF6α表达上调;经预测XBP-1与ITGB1(Integrinβ1)启动子区域存在6个结合位点。结论STARD5是胃癌的预后保护因素。STARD5在发生肝转移的胃癌患者中表达降低。STARD5下调可通过上调XBP-1来促进Integrinβ1的转录表达并激活PI3K/AKT信号通路,促进胃癌细胞转移。

关键词：胃癌类固醇敏感性调节蛋白相关脂类转运结构域蛋白5 预后转移内质网应激整合素β1

An effective oxygen electrode based on Ir0.6Sn0.4O2 for PEM water electrolyzers

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Journal of Energy Chemistry 2019年第12期28卷 23-28页

作者： Guang Jiang Hongmei Yu Jinkai Hao Jun chi Zhixuan Fan Dewei Yao bowen Qin Zhigang Shao Fuel Cell System and Engineering Laboratory Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina University of chinese Academy of Sciences Beijing 100039China

An effective oxygen evolution electrode with Ir0.6Sn0.4O2 was designed for proton exchange membrane(PEM)water *** anode catalyst layer exhibits a jagged structure with smaller particles and pores,which provide more active sites and mass transportation *** prepared IrSn electrode showed a cell voltage of 1.96 V at 2.0 A cm^-2 with Ir loading as low as 0.294 mg cm^-***,Ir Sn electrode with different anode catalyst loadings was *** IrS n electrode indicates higher mass current and more stable cell voltage than the commercial Ir Black electrode at low loading.

关键词： PEM water electrolyzer OER electrode Low Ir loading

Changes in Surface Energy Partitioning in china over the Past Three Decades

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Advances in Atmospheric Sciences 2017年第5期34卷 635-649页

作者： Yitian QIAN Pang-chi HSU chi-Han CHENG Key Laboratory of Meteorological Disaster of Ministry of Education/Joint International Research Laboratory of Climate and Environment Change/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of lnformation Science and Technology Nanjing Jiangsu 210044 China Applied Hydrometeorological Research Institute Nanjing University of Information Science and Technology Nanjing Jiangsu 210044 China

Surface energy balance and the partitioning of sensible heat flux(SHF) and latent heat flux(LHF) play key roles in land–atmosphere feedback. However,the lack of long-term observations of surface energy fluxes,not to mention spatially extensive ones,limits our understanding of how the surface energy distribution has responded to a warming climate over recent decades(1979–2009) at the national scale in china. Using four state-of-the-art reanalysis products with long-term surface energy outputs,we identified robust changes in surface energy partitioning,defined by the bowen ratio(BR = SHF/LHF),over different climate regimes in china. Over the past three decades,the net radiation showed an increasing trend over almost the whole of china. The increase in available radiative energy flux,however,was balanced by differential partitioning of surface turbulent fluxes,determined by local hydrological conditions. In semi-arid areas,such as Northeast china,the radiative energy was transferred largely into SHF. A severe deficiency in near-surface and soil moistures led to a significant decreasing trend in LHF. The combined effect of increased SHF and decreased LHF resulted in significant upward trends in the BR and surface warming over Northeast china. In contrast,in the wet monsoon regions,such as southern china,increased downward net radiation favored a rise in LHF rather than in SHF,leading to a significant decreasing trend in the BR. Meanwhile,the increased LHF partly cancelled out the surface warming. The warming trend in southern china was smaller than that in Northeast china. In addition to impacts on heat-related events,the changes in the BR also reflected recent cases of extreme drought in china. Our results indicate that information regarding the BR may be valuable for drought monitoring,especially in regions prone to such conditions.

关键词： surface energy partitioning bowen ratio climate change long-term trend

双重血浆分子吸附系统模式治疗高原慢性肝衰竭患者的效果分析

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临床肝胆病杂志 2024年第1期40卷 110-115页

作者：王博文彭梦佳江历恒方斐王宇亮沈元弟西藏军区总医院重症医学中心拉萨850000 海军特色医学中心急诊科上海200000

目的比较世居高原和移居高原慢性肝衰竭患者接受双重血浆分子吸附系统模式(DPMAS)治疗后的临床特征和病死率。方法选取2016年1月—2021年12月于西藏军区总医院重症监护室接受DPMAS治疗的63例慢性肝衰竭患者。根据患者的旅居史将患者分... 详细信息

目的比较世居高原和移居高原慢性肝衰竭患者接受双重血浆分子吸附系统模式(DPMAS)治疗后的临床特征和病死率。方法选取2016年1月—2021年12月于西藏军区总医院重症监护室接受DPMAS治疗的63例慢性肝衰竭患者。根据患者的旅居史将患者分为世居高原组(n=29)和移居高原组(n=34),对比两组患者的基线资料和接受DPMAS治疗前后的临床特征。符合正态分布的计量资料组间比较采用成组t检验;组内治疗前与治疗后比较应采用配对t检验。非正态分布计量资料组间比较采用Mann-Whitney U检验;组内治疗前后比较应采用Wilcoxon秩和检验。计数资料组间比较采用χ^(2)检验。Kaplan-Meier法绘制生存曲线,死亡风险比较采用Log-rank检验。结果移居高原组汉族比例明显多于世居高原组(χ^(2)=41.729,P<0.001);世居高原组患者最近一次高原连续居住时间明显长于移居高原组(Z=3.364,P<0.001);MELD评分、肝性脑病、肝肾综合征和消化道出血发生率均较世居高原组明显增高(Z=2.318,χ^(2)值分别为6.903、5.154、6.262,P值均<0.05)。DPMAS治疗前后两组患者的PLT、HGB、ALT、AST、Alb、TBil、DBil、LDH、Cr、INR比较差异均有统计学意义(P值均<0.05)。DPMAS治疗前,移居高原组ALT、AST、TBil、DBil、LDH、Cr、BUN和INR均较世居高原组高(P值均<0.05),HGB较世居高原组低(P<0.05);DPMAS治疗后,移居高原组患者PLT和HGB数量下降较世居高原组更为显著(P值均<0.05),但ALT、AST、TBil、DBil、LDH、BUN和INR均仍较世居高原组高(P值均<0.05)。世居高原组和移居高原组患者接受DPMAS治疗后60天病死率分别为52.5%(95%CI:41.7~63.8)和81.3%(95%CI:77.9~85.6)。相比于世居高原组(HR=0.47,95%CI:0.23~0.95),移居高原组患者60天死亡风险(HR=2.14,95%CI:1.06~4.32)明显增加(P=0.039)。结论与世居高原慢性肝衰竭患者相比,移居高原患者的肝功能损伤更重,DPMAS治疗后肝功能改善程度较弱,同时病死率更高。临床医护人员需要加强对移居高原慢性肝衰竭患者的重视,尽可能提高患者生存率。

关键词：肝人工肝功能衰竭高原病

Design and development of radio frequency output window for circular electron–positron collider klystron

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chinese Physics B 2018年第11期27卷 620-625页

作者： Zhijun Lu Shigeki Fukuda Zusheng Zhou Shilun Pei Shengchang Wang Ouzheng Xiao UnNisa Zaib bowen Bai Guoxi Pei Dong Dong Ningchuang Zhou Shaozhe Wang Yunlong chi Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China University of chinese Academy of Sciences Beijing 100049 China Key Laboratory of Particle Acceleration Physics and Technology Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China High Energy Accelerator Research Organization KEK Oho Ibaraki 305-0801 Japan GLVAC Industrial Technology Research Institute of High Power Devices Kunshan 215300 China

This paper presents the first phase of design, analysis, and simulation for the klystron coaxial radio frequency（RF）output window. This study is motivated by 800 kW continuous wave（CW）, 650 MHz klystrons for the future plan of circular electron–positron collider（CEPC） project. The RF window which is used in the klystron output section has a function to separate the klystron from the inner vacuum side to the outside, and high RF power propagates through the window with small power dissipation. Therefore, the window is a key component for the high power klystron. However, it is vulnerable to the high thermal stress and multipacting, so this paper presents the window design and analysis for these problems. The microwave design has been performed by using the computer simulation technology（CST） microwave studio and the return loss of the window has been established to be less than-90 d B. The multipacting simulation of the window has been carried out using MultiPac and CST particles studio. Through the multipacting analysis, it is shown that with thin coating of TiN, the multipacting effect has been suppressed effectively on the ceramic surface. The thermal analysis is carried out using ANSYS code and the temperature of alumina ceramic is lower than 310 K with water *** design result successfully meets the requirement of the CEPC 650 MHz klystron. The manufacturing and high power test plan are also described in this paper.

关键词： klystron coaxial radio frequency window thermal stress multipacting

238例老年耐多药肺结核临床特点及不良治疗结局影响因素分析

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中国热带医学 2024年第3期24卷 276-281页

作者：梁博文鲜馥阳李波罗敬月赵丽萍安军高孟秋李华首都医科大学附属北京胸科医院北京101149

目的分析老年耐多药肺结核临床特点和不良治疗结局的影响因素,为老年耐多药肺结核临床诊治提供参考。方法回顾性收集2008—2023年北京胸科医院初次收治的老年耐多药肺结核患者临床数据,对合并症/并发症、药物不良反应、初治和复治耐药... 详细信息

目的分析老年耐多药肺结核临床特点和不良治疗结局的影响因素,为老年耐多药肺结核临床诊治提供参考。方法回顾性收集2008—2023年北京胸科医院初次收治的老年耐多药肺结核患者临床数据,对合并症/并发症、药物不良反应、初治和复治耐药情况进行统计描述,并对不良治疗结局影响因素进行χ^(2)检验及logistic回归分析。结果共收集老年耐多药肺结核患者238例,其中出现药物不良反应发生152例(占63.9%),复治耐多药184例(占77.3%),广泛耐药结核(XDR-TB)广泛耐药27例(占11.3%),治愈41例,完成治疗6例,治疗失败39例,死亡6例,失访107例,无法评价31例,治疗未结束8例,治疗成功率20.4%(47/230)。治疗不良结局占比79.6%(183/230)。单因素分析显示不同年龄、是否有药物不良反应、患者来源对治疗结局的影响具有统计学意义(P<0.05)。以治疗结局良好和不良为因变量对三因素进行logistic回归分析,结果显示年龄70岁及以上、治疗中出现药物不良反应和外埠病人是不良治疗结局的影响因素[OR(95%CI):2.507(1.027~6.121)、3.253(1.635~6.473)、2.563(1.285~5.111)]。结论老年耐多药肺结核患者合并症/并发症多、药物不良反应发生率高、治疗结局不理想。异地就医、高龄、出现药物不良反应是不良治疗结局的危险因素。

关键词：老年人耐多药结核临床特点治疗结局影响因素

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党参组植物种质资源研究进展

现代中药研究与实践 2024年第2期38卷 90-96页

作者：郑博文杨光陈美兰池秀莲王铁霖程蒙李晓琳李颖胡利峰李娅妮中国中医科学院中药资源中心道地药材品质保障与资源持续利用全国重点实验室山西振东种业科技有限公司

党参是我国传统常用中药材,2023年纳入药食同源物质,市场需求将进一步增加。党参组是党参亚属下级分类单位,包含12种3变种,其中,大多数植物与《中国药典》收载的党参功效相似。通过概述党参组植物资源、药用情况、开发利用现状和中药党... 详细信息

党参是我国传统常用中药材,2023年纳入药食同源物质,市场需求将进一步增加。党参组是党参亚属下级分类单位,包含12种3变种,其中,大多数植物与《中国药典》收载的党参功效相似。通过概述党参组植物资源、药用情况、开发利用现状和中药党参种质鉴别、栽培、育种等方面的研究进展,提出了党参组研究利用的建议,以期为党参组植物的开发利用提供参考。

关键词：党参组党参种质资源栽培育种

Global methane and nitrous oxide emissions from terrestrial ecosystems due to multiple environmental changes

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Ecosystem Health and Sustainability 2015年第1期1卷 23-43页

作者： Hanqin Tian Guangsheng Chen Chaoqun Lu Xiaofeng Xu Wei Ren bowen Zhang Kamaljit Banger Bo Tao Shufen Pan Mingliang Liu chi Zhang Lori Bruhwiler Steven Wofsy International Center for Climate and Global Change Research School of Forestry and Wildlife SciencesAuburn UniversityAuburnAlabama 36849 USA Environmental Sciences Division Oak Ridge National LaboratoryOak RidgeTennessee 37831 USA Department of Biological Sciences University of Texas at El Paso500 West University AvenueEl PasoTexas 79902 USA Department of Civil and Environmental Engineering Washington State UniversityPullmanWashington 99164 USA Xinjiang Institute of Ecology and Geography Chinese Academy of SciencesUrumqi 830011 China NOAA Earth System Research Laboratory 325 BroadwayBoulderColorado 80305-3337 USA Department of Earth and Planetary Science Harvard University29 Oxford StreetCambridgeMassachusetts 02138 USA

Greenhouse gas(GHG)-induced climate change is among the most pressing sustainability challenges facing humanity today,posing serious risks for ecosystem ***(CH_(4))and nitrous oxide(N_(2)O)are the two most important GHGs after carbon dioxide(CO_(2)),but their regional and global budgets are not well *** this study,we applied a process-based coupled biogeochemical model to concurrently estimate the magnitude and spatial and temporal patterns of CH_(4)and N_(2)O fluxes as driven by multiple environmental changes,including climate variability,rising atmospheric CO_(2),increasing nitrogen deposition,tropospheric ozone pollution,land use change,and nitrogen fertilizer *** estimated CH_(4)and N_(2)O emissions from global land ecosystems during 1981-2010 were 144.39±12.90 Tg C/yr(mean 62 SE;1 Tg=1012 g)and 12.52±0.74 Tg N/yr,*** simulations indicated a significant(P,0.01)annually increasing trend for CH_(4)(0.43±0.06 Tg C/yr)and N_(2)O(0.14±0.02 Tg N/yr)in the study ***_(4)and N_(2)O emissions increased significantly in most climatic zones and continents,especially in the tropical regions and *** most rapid increase in CH_(4)emission was found in natural wetlands and rice fields due to increased rice cultivation area and climate warming.N_(2)O emission increased substantially in all the biome types and the largest increase occurred in upland crops due to increasing air temperature and nitrogen fertilizer ***,the three major GHGs(CH_(4),N_(2)O,and CO_(2))should be simultaneously considered when evaluating if a policy is effective to mitigate climate change.

关键词： coupled biogeochemical cycles global warming potential greenhouse gas methane nitrous oxide terrestrial ecosystem

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面向客机总体设计的涡扇发动机分析模型

南京航空航天大学学报 2016年第3期48卷 382-388页

作者：张帅王宇钟伯文张驰中国商飞北京民用飞机技术研究中心总体论证研究部北京102211 南京航空航天大学飞行器先进设计技术国防重点学科实验室南京210016

建立一种用于估算涡扇发动机特性的工程分析模型,该模型以涡喷发动机推力估算模型与涡扇发动机效率分析方法为基础,引入高涵道比涡扇发动机的循环分析方法进行修正。利用该模型可以获取涡扇发动机的推力和油耗特性,进而考察总体循环参... 详细信息

建立一种用于估算涡扇发动机特性的工程分析模型,该模型以涡喷发动机推力估算模型与涡扇发动机效率分析方法为基础,引入高涵道比涡扇发动机的循环分析方法进行修正。利用该模型可以获取涡扇发动机的推力和油耗特性,进而考察总体循环参数对发动机性能的影响。通过与文献验证数据对比,判定了分析模型的精度。该模型只需要输入少量参数就可以快速完成计算过程,适合于飞机总体设计阶段,可以评估涡扇发动机参数对飞机性能的影响。

关键词：客机总体设计涡扇发动机工程分析模型推力油耗