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临床与实验病理学杂志 2011年第12期27卷 1368-1368页

作者： Dujardin F Binh M B bouvier c 孙琦樊祥山南京大学医学院附属鼓楼医院病理科南京210008

低级别骨肉瘤是较为少见的恶性肿瘤,依据肿瘤原发位置与骨皮质的关系可分为两种亚型,即骨旁骨肉瘤和低级别中央型骨肉瘤。两者组织学形态相似,主要由轻到中度异型的梭形细胞和分化良好的网状新生骨小梁结构组成。

关键词：低级别中央型骨肉瘤免疫组化标记骨原发性 cDK4 MDM2 联合应用病变骨性

Histological and molecular classification of gliomas

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中国神经肿瘤杂志 2008年第2期6卷 102-102页

作者： Figarella-Branger D colin c coulibaly B Quilichini B Maues De Paula A Fernandez c bouvier c Service d' anatomie pathologique et de neuropathologie hospital de la TimoneMarseilleFrance EA 3281 labo-ratoire de biopathologie de l' adhésion et de la signalisation facultéde médecineuniversitéde la Méditerranée27boulevard Jean-Moulin13385 Marseille cedex 05France.

Rev Neurol (Paris). 2008 June-July;164(6-7):505-515. Epub 2008 Jun *** are the most frequent tumors of the central nervous system. The WHO classification, based on the presumed cell origin,distinguishes astrocytic,oli... 详细信息

关键词：神经胶质瘤临床分析诊断方法肿瘤

Trends in incidence and management of cancer of the ampulla of Vater

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World Journal of Gastroenterology 2014年第29期20卷 10144-10150页

作者： Florian Rostain Samia Hamza Antoine Drouillard Jean Faivre Anne-Marie bouvier c?me Lepage Registre Bourguignon des cancers Digestifs INSERM U866CHU de DijonFaculté de Médecine21079 Dijon CedexFrance

AIM: To provide trends in incidence, management and survival of cancer of the ampulla of Vater in a well-defined French population.

关键词： cancer of the ampulla of Vater Incidence Survival Treatment Epidemiology

combined evaluation of biomarkers as predictor of maintained remission in crohn's disease

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World Journal of Gastroenterology 2019年第19期25卷 2354-2364页

作者： Elisa Sollelis Régine Minet Quinard Guillaume Bouguen Marion Goutte Félix Goutorbe Damien bouvier Bruno Pereira Gilles Bommelaer Anthony Buisson Inserm 3i HP CHU Clermont-Ferrand Service d’Hépato-Gastro Entérologie Université Clermont Auvergne Inserm U1071 M2i SH USC-INRA 2018 Université Clermont Auvergne Biochemistry laboratory University Hospital G.Montpied cHU Rennes Univ Rennes INSERM CIC1414 Institut NUMECAN (Nutrition Metabolisms and Cancer) Gastroenterology Department Hospital of Bayonne Biostatistics Unit DRCI University Hospital

BAcKGROUND The individual performances and the complementarity of crohn's disease(cD)activity index(cDAI), c-reactive protein(cRP) and faecal calprotectin(Fcal) to monitor patients with cD remain poorly inves-tigated in the era of "tight control"and "treat to target" *** To assess cDAI, cRP and Fcal variation, alone or combined, after 12 wk(W12) of anti-tumor necrosis factor(TNF) therapy to predict corticosteroids-free remission(cFREM = cDAI cRP cal c intensification and no surgery) at *** cD adult patients needing anti-TNF therapy with cDAI > 150 and either cRP >2.9 mg/L or Fcal > 250 μg/g were prospectively *** Among the 40 included patients, 13 patients(32.5%) achieved cFREM at W52. In univariable analysis, cDAI cRP level cal improvement at W12(Fcal cal crease of Fcal or normalization of Fcal(ctive of cFREM at W52. combined endpoint(cDAI cRP ≤ 2.9 mg/L and Fcal improvement) at W12 was the best predictor of cFREM at W52 with positive predictive value = 100.0%(100.0-100.0)and negative predictive value = 87.1%(75.3-98.9). In multivariable analysis, Fcal improvement at W12 [odd ratio(OR) = 45.1(2.96-687.9); P = 0.03] was a better predictor of cFREM at W52 than cDAI cRP cONcLUSION The combined monitoring of cDAI, cRP and Fcal after anti-TNF induction therapy is able to predict favorable outcome within one year in patients with cD.

关键词： Biomarkers crohn's disease Faecal calprotectin crohn's disease activity index c-reactive protein Tight control Anti-tumor necrosis factor

The Land- Potential Knowledge System (LandPKS): mobile apps and collaboration for optimizing climate change investments

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Ecosystem Health and Sustainability 2016年第3期2卷 31-38页

作者： Jeffrey E.Herrick Adam Beh Edmundo Barrios Ioana bouvier Marina coetzee David Dent Emile Elias Tomislav Hengl Jason W.Karl Hanspeter Liniger John Matuszak Jason cNeff Lilian Wangui Ndungu Michael Obersteiner Keith D.Shepherd Kevin c.Urama Rik van den Bosch Nicholas P.Webb U.S.Department of Agriculture-Agricultural Research Service New Mexico State UniversityJornada Experimental Range MSC 3JERBox 30003Las CrucesNew Mexico 88003-8003 USA World Agroforestry centre United Nations AvenueGigiriP.O.Box 30677Nairobi00100Kenya U.S.Agency for International Development 3014th StreetSW SA-44(Rm 848)WashingtonD.C.20024 USA Namibia University of Science and Technology 13 Storch StreetPrivate Bag 13388WindhoekNamibia Merchants of Light Ltd Forncett EndNorfolkEngland ISRIc-World Soil information Droevendaalsesteeg 36708PB WageningenThe Netherlands center for the development and Environment University of BernHallerstrasse 103012BernSwitzerland U.S.Department of State/OES 2201 C St.NWWashingtonD.C.20520USA Environmental Studies Program University of Colorado at BoulderCampus Box 397BoulderColorado 80309 USA RcMRD SERVIR-Eastern&Southern AfricaP.O.Box 63200618 RuarakaNairobiKenya International Institute for Applied Systems Analysis Schlossplatz 1 A-2361LaxenburgAustria African Development Bank Avenue Jean-Paul II01 BP 1387Abidjan 01Côte d’Ivoire

Massive investments in climate change mitigation and adaptation are projected during coming *** of these investments will seek to modify how land is *** return on both types of investments can be increased through an understanding of land potential:the potential of the land to support primary production and ecosystem services,and its resilience.A Land-Potential Knowledge System(LandPKS)is being developed and implemented to provide individual users with point-based estimates of land potential based on the integration of simple,geo-tagged user inputs with cloud-based information and *** system will rely on mobile phones for knowledge and information exchange,and use cloud computing to integrate,interpret,and access relevant knowledge and information,including local knowledge about land with similar *** system will initially provide management options based on long-term land potential,which depends on climate,to-pography,and relatively static soil properties,such as soil texture,depth,and *** mod-ules will provide more specific management information based on the status of relatively dynamic soil properties such as organic matter and nutrient content,and of *** paper includes a discus-sion of how this system can be used to help distinguish between meteorological and edaphic drought.

关键词： agriculture analytics crowdsourcing expert systems extension knowledge management land evaluation land-use planning mobile apps sustainability sustainable land management

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根据一种新方法估计法国产妇的死亡率

世界核心医学期刊文摘（妇产科学分册） 2005年第4期1卷 61-61页

作者： bouvier-colle M.-H. Deneux c. Szego E. 高雪莲 INSERM Unit'eH.e 149 MaternitéHpital Tenon 4 rue de la Chine 75020 Paris France

Objective. Ten years after implementation of maternal mortality monitoring in France, we established a new estimate of the current maternal mortality ratio (MMR) and revisited maternal death data collection. Material and methods. Linkages were set up between female deaths and childbirths and between female deaths and causes of death. Information provided by confidential inquiries into maternal deaths carried out by the National committee for maternal mortality study was added. The World Health Organization (WHO) definitions were used for maternal death and maternal mortality ratio. The study concerned deaths occurring in 1999. Results were compared with data from 1989. Results. The official data showed 20%fewer maternal deaths than our inquiry. Estimated from our data, the MMR was 9 per 100000 live births in 1999. Direct obstetric causes were more often recorded than indirect causes. Hemorrhage was the leading obstetric cause of maternal death (21%). In comparison with the 1989-90 data, the underestimation of maternal deaths and maternal mortality ratios are improving (from 18 to 9 per 100000). conclusion. These results, obtained while the mean maternal age at childbirth increased regularly, are interpreted as a sign of improvement in care. But the persistence of post partum hemorrhages as the leading cause of maternal death and the high rate of avoidable deaths, disclose important targets for further progress.

关键词：估计法死亡调查产科原因数据记录产后出血官方统计间接原因保健工作持续增长

选择性经动脉化疗栓塞在耐受性、肿瘤反应及生存期的效果研究

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国际医学放射学杂志 2011年第5期 507-507页

作者： A.bouvier V.Ozenne c.Aubé J.Boursier M.P.Vullierme F.Thouveny 王翠 Département de radiologie CHU Angers4rue Larrey49933 AngersFrance

目的比较选择性和非选择性经动脉化疗栓塞(TAcE)技术在治疗肝细胞癌(Hcc)的疗效,重点探讨临床与肝脏的耐受性、肿瘤反应及病人生存期。方法回顾性收集

关键词：肝细胞癌经动脉化疗栓塞选择性技术耐受性生存期肿瘤反应

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特定人群食管腺癌的发病趋势与治疗

世界核心医学期刊文摘（胃肠病学分册） 2006年第6期2卷 28-28页

作者： Lepage c. bouvier A. -M. Manfredi S. J. Faivre. 王晓君(译) 史敏(校) 不详 Faculte de Medecine BP 87900 21079 Dijon Cedex

Objectives-Little epidemiological data is available concerning esophageal adenocarcinomas in France. The aim of this study was to study epidemiological characteristics and management of esophageal adenocarcinoma in a well-defined population. Methods-Data were collected by the Burgundy Digestive cancer Registry covering a population of 1 052 000, over a 28-year period (1976-2001). Incidence, treatment and stage at diagnosis were noted. Univariate and multivariate analysis of survival was performed. Results-Age standardized incidence rates were 1.60/100,000 in men and 0.15/100,000 in women. The mean increase in incidence rates by 5-year periods were respectively +68.1%(P cancers were located in the lower third of the esophagus. Surgical resection was performed in 32.1%of patients. Among the surgical patients, the tumor was limited to the esophageal wall in 11.4%, lymph node metastases were present in 18.1%and non-resectable distant metastases in 70.5%. There was no improvement of stage at diagnosis over time. Survival rates were 14.4%at 3 years and 9.2%at 5 years. Five-year survival rates varied from 38.4%for cases limited to the esophageal wall to 1.8%for metastatic and non resectable cases. Stage at diagnosis was the only significant prognostic factor in the multivariate analysis. conclusion-Esophageal adenocarcinomas are rare cancers characterized by a sharp rise in incidence over the past years in France. Stage at diagnosis and prognosis are worse than reported in hospital statistics.

关键词：食管腺癌治疗方案特定人群发病趋势 5年存活率消化道癌症淋巴结转移多变量分析诊断分期年发病率

对先天性红细胞生成性卟啉病患儿进行非亲属捐献者匹配骨髓的成功移植

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世界核心医学期刊文摘（儿科学分册） 2005年第7期1卷 27-28页

作者： Dupuis-Girod S. Akkari V. Ged c. 高蕊 Immuno-hematologie Pediat.T. Hpital Debrousse 29 rue Soeur Bouvier 6932 Lyon Cedex 05 France

congenital erythropoietic porphyria (cEP; Günther disease; OMIM 263700) is a rare autosomal recessive disorder caused by a deficiency of uroporphyrinogen III synthase (UROS).The deficiency of this enzyme is associated with lifelong overproduction of series I porphyrins which circulate and are deposited in many tissues, causing light-sensitisation and severe damage to skin beginning in *** and scarring of exposed areas may lead to mutilating *** describe two cases: a 4-year-old boy and his first cousin who were cured of cEP by matched unrelated donor bone marrow *** are alive and disease-free 3 and 2 years post-transplant, *** lesions improved *** correction of the enzyme deficiency was confirmed by measuring erythrocyte UROS activity and urinary porphyrin *** was complete for both *** patients were homoallelic for a novel mutation of the UROS gene, the missense mutation ***: considering the severity of the disease, if HLA-matched sibling donor is not available, haematopoietic stem cell transplantation using amatched unrelated donor should be strongly considered for treating congenital erythropoietic porphyria since this is currently the only known curative therapy.

关键词：捐献者尿卟啉原光过敏酶缺乏血液循环聚合酶嵌合性造血干细胞移植捐赠者错义突变