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Ultrasound assisted multicomponent reactions:A green method for the synthesis of n-substituted 1,8-dioxo-decahydroacridines usingβ-cyclodextrin as a supramolecular reusable catalyst in water

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Chinese Journal of Catalysis 2016年第1期37卷 146-152页

作者： asha v.chate umesh b.rathod jagdish s.kshirsagar pradip a.gaikwad kishor d.mane prav.n.s.mahajan mukesh d.nikam charansingh h.gill 巴巴萨海布·安贝卡马拉特瓦达大学化学系印度奥兰加巴德431004

We demonstrate a superficial method for the synthesis of n-substituted 1,8-dioxo-decahydroacridines using β-cyclodextrin as a supramolecular,biodegradable,and reusable catalyst in aqueous *** reaction product is in excellent yield with moderate to excellent *** mechanistic transformation presumably proceeds via a one-pot,multicomponent cyclization of dimedone in the presence of aromatic aldehydes and aromatic amines/InH,undergoing a tandem Michael addition *** proposed approach in this study provides a highly efficient and environmentally benign route to n-substituted 1,8-dioxo-decahydroacridines.

关键词： Tandem reaction n-Substituted 1,8-dioxo-decahydroacridines β-Cyclodextrin Supramolecular catalysis Water

Subcutaneous implantable defibrillator: State-of-the art 2013

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World Journal of Cardiology 2013年第9期5卷 347-354页

作者： Finn Akerstrm Miguel A Arias Marta Pachón Alberto Puchol Jesús Jiménez-Lópezl Cardiac Arrhythmia and Electrophysiology Unit Department of CardiologyHospital Virgen de la Salud

The subcutaneous implantable cardioverter-defibrillator(S-ICD)has recently been approved for commercial use in Europe,new Zealand and the United *** is comprised of a pulse generator,placed subcutaneously in a left lateral position,and a parasternal subcutaneous lead-electrode with two sensing electrodes separated by a shocking *** an entirely subcutaneous system it avoids important periprocedural and long-term complications associated with transv.n.us implantable cardioverter-defibrillator(Tv-ICD)systems as well as the need for fluoroscopy during implant *** candidates include pediatric patients with congenital heart disease that limits intracavitary lead placements,those with obstructed v.n.us access,chronic indwelling catheters or high infection risk,as well as young patients with electrical heart disease(e.g.,Brugada Syndrome,long QT syndrome,and hypertrophic cardiomyopathy).nevertheless,giv.n.the absence of intracavitary leads,the S-ICD is unable to offer pacing(apart from shortterm post-shock pacing).It is therefore not suitable in patients with an indication for antibradycardia pacing or cardiac resynchronization therapy,or with a history of repetitive monomorphic v.n.ricular tachycardia that would benefit from antitachycardia *** data from initial clinical studies and post-commercialization"real-life"case series,including over 700 patients,have so far been promising and shown that the S-ICD successfully converts induced and spontaneous v.n.ricular tachycardia/v.n.ricular fibrillation episodes with associated complication and inappropriate shock rates similar to that of ***,by using far-field electrograms better tachyarrhythmia discrimination when compared to Tv-ICDs has been *** results from ongoing clinical studies will determine the S-ICD system’s long-term performance,and better define suitable patient profiles.

关键词： Implantable cardioverter-defibrillator Subcutaneous Sudden death v.n.ricular tachycardia v.n.ricular fibrillation

抗氧指数在生胶质量控制和估计硫化胶老化性能中的作用

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世界热带农业信息 1977年第1期 18-20页

作者：马修(n.M.Mathew) 托马斯(E.v.Thomas) 尤承霖印度橡胶研究所印度橡胶研究所

在标准胶生产中,抗氧指数是一项重要的测定项目,各产胶国的标准化机构也都采用了这个项目。但由于以前发表的文献对抗氧指数的看法不一致,所以直到现在还有人没有充分认识这一测定项目的重要意义。因此,本文试图根据印度橡胶研究所进行... 详细信息

在标准胶生产中,抗氧指数是一项重要的测定项目,各产胶国的标准化机构也都采用了这个项目。但由于以前发表的文献对抗氧指数的看法不一致,所以直到现在还有人没有充分认识这一测定项目的重要意义。因此,本文试图根据印度橡胶研究所进行的试验对抗氧指数的一些早期研究工作作一评述。

关键词：抗氧生胶氧指数硫化胶老化性能

Magnetic and Electrical Properties of Gd Doped ni-Cu-Zn-Fe<sub>2</sub>O<sub>4</sub>

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Adv.n.es in Materials Physics and Chemistry 2018年第10期8卷 401-410页

作者： P. v.n.ata Srinivasa Rao T. Anjaneyulu D. v. Krishna Reddy M. Rami Reddy Department of Physics Acharya Nagarjuna University Guntur India Department of Physics S. S. & N. College Guntur India Department of Physics Narasaraopeta Engineering College Guntur India

ni0.5Cu0.25Zn0.25GdxFe2-xO4 (x = 0.0, 0.025, 0.05, 0.075, 0.1) ferrites were synthesized using an oxalic-based precursor method. The TC for all the ni0.5Cu0.25Zn0.25GdxFe2-xO4 (x = 0.0, 0.025, 0.05, 0.075, 0.1) samples was measured by using one of the double coil susceptibility setup. In all the samples it is observed that, at a certain temperature, susceptibility falls to zero indicating the Curie temperature (TC) and ferrimagnetic samples are converted into paramagnetic sample at that temperature. The electrical properties were investigated for these samples. Dielectric properties and ρdc properties were observed to decrease with the increase in the frequency for all the Gd doped ferrite samples.

关键词： ni-Cu-Zn-Gd nanoferrites Magnetic Properties Electrical Properties

Urine exosome mRnA-based test for monitoring kidney allograft rejection:Effects of sample transportation and storage,and interference substances

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World Journal of Methodology 2023年第5期13卷 492-501页

作者： Matt McFaul Chris v.n.ura Sean Ev.n. Halil Dundar Marc J Rumpler Christopher McCloskey Dave Lowe Alexandre v vlassov Department of Research and Development Thermo Fisher ScientificWest HillsCA 91304United States

BACKGROUnD Exosomes are 30-150 nm nanovesicles with sophisticated nucleic acids cargo,actively secreted by all cells within human body,and found in abundance in all body fluids,including *** extracellular vesicles have tremendous potential for next generation diagnostics,theoretically enabling noninvasive assessment of organ and tissue function via liquid biopsy *** Recently,feasibility of an exosomal molecular test was demonstrated for postorgan transplant monitoring:Analysis of urine-derived exosomal mRnA cargo allowed early detection of kidney allograft ***,we further studied urine-derived exosomes and their mRnA content as a highly promising diagnostic *** included stability studies of urine samples and exosomal mRnA upon transportation from the point of collection to a centralized testing facility,short-term storage of urine at different conditions upon receipt till the point molecular assay is performed,and effects of various potentially interfering substances on the downstream quantitative polymerase chain reaction(qPCR)*** The urine specimens were stored at various conditions and pre-processed in different ***,samples were passed through the columns to capture all extracellular vesicles,the vesicles were lysed to release their content and the exosomal RnA was purified on the mini-columns,reverse transcription was performed,next pre-amplification,followed by a qPCR analysis for a panel of RESULTS To ensure exosomal RnA integrity,the harvested urine specimens should be shipped refrigerated,by overnight *** can next be stored at the test site for up to 1 wk at 4°C,and long term should be frozen at-80°*** specimens must be centrifuge at low G-force to deplete cells and debris,to ensure consistent top results in downstream molecular *** commonly used medications(tacrolimus,cyclosporin A,mycophenolic acid,everolimus,sirolimus,ascomycin,teriflunomide)were tested and confirmed that they do n

关键词： Kidney allograft Post-transplant monitoring Liquid biopsy Exosome mRnA Quantitative polymerase chain reaction

Presenilin mutations and their impact on neuronal differentiation in Alzheimer’s disease

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neural Regeneration Research 2022年第1期17卷 31-37页

作者： Mercedes A.Hernández-Sapiéns Edwin E.Reza-Zaldívar Ana L.Márquez-Aguirre Ulises Gómez-Pinedo Jorge Matias-Guiu Ricardo R.Cevallos Juan C.Mateos-Díaz víctor J.Sánchez-González Alejandro A.Canales-Aguirre Unidad de Evaluación Preclínica Unidad de Biotecnología Médica y FarmacéuticaCentro de Investigación y Asistencia en Tecnología y Diseño del Estado de JaliscoGuadalajaraMéxico Instituto de neurociencias IdISSCHospital Clínico San CarlosMadridEspaña Biochemistry and Molecular Genetics Department University of AlabamaBirminghamAlabama Unidad de Biotecnología Industrial Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de JaliscoGuadalajaraMéxico Centro Universitario de los Altos Universidad de GuadalajaraGuadalajaraMéxico

The presenilin genes(PSEn1 and PSEn2)are mainly responsible for causing early-onset familial Alzheimer’s disease,harboring~300 causative mutations,and representing~90%of all mutations associated with a very aggressive disease *** 1 is the catalytic core of theγ-secretase complex that conducts the intramembranous proteolytic excision of multiple transmembrane proteins like the amyloid precursor protein,notch-1,n-and E-cadherin,LRP,Syndecan,Delta,Jagged,CD44,ErbB4,and *** 1 plays an essential role in neural progenitor maintenance,neurogenesis,neurite outgrowth,synaptic function,neuronal function,myelination,and ***,an imbalance caused by mutations in presenilin 1/γ-secretase might cause aberrant signaling,synaptic dysfunction,memory impairment,and increased Aβ42/Aβ40 ratio,contributing to neurodegeneration during the initial stages of Alzheimer’s disease *** review focuses on the neuronal differentiation dysregulation mediated by PSEn1 mutations in Alzheimer’s ***,we emphasize the importance of Alzheimer’s disease-induced pluripotent stem cells models in analyzing PSEn1 mutations implication over the early stages of the Alzheimer’s disease pathogenesis throughout neuronal differentiation impairment.

关键词： familial Alzheimer’s disease familial Alzheimer’s disease-induced pluripotent stem cells models induced pluripotent stem cells neurogenesis neuronal differentiation notch presenilin 1 PSEn1 mutations γ-secretase complex

Feed Signal Influence and Potential Performances of a Compact Radiation Source Based on a Helical Antenna

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Journal of Electromagnetic Analysis and Applications 2015年第7期7卷 199-208页

作者： Laurent Pecastaing Marc Rivaletto Antoine de Ferron Romain Pecquois René vézinet Jean-Christophe Diot Stéphane Tortel Laboratoire SIAME Equipe Génie Electrique Université de Pau et des Pays de l’Adour Hélioparc Pau-Pyrénées Pau France Hi-Pulse 300 rue des arts et métiers Pont-de-Pany France French Alternative Energies and Atomic Energy Commission (CEA) Gramat France

In the class of emerging high power electromagnetic sources, a complete pulsed power source, named MOUnA (French acronym of “Module Oscillant Utilisant une nouvelle Architecture”) has been developed. This device must transmit waveforms with a wide frequency band and a high figure-of-merit. To improve the overall performance of the MOUnA system while maintaining its compact size, two approaches are being explored in the paper: the replacement of the dipole antenna by a helical antenna and its feeding signal influence. Helical antenna is cylindrical shape and relatively compact. It offers relatively good gain factor and directivity. The waveform delivered to the antenna is directly related to the amplitude of the radiated electric field. Therefore, different waveforms (step pulse, Gaussian pulse, bipolar pulse and damped sinusoid) are compared to point out the feed signal influence on the radiated electric field. Switch oscillators appear to be considered as interesting resonant sources for driv.n. an antenna. The novel radiating source consists of a primary power source, a resonant transformer, a coaxial transmission line damped oscillator (also termed as coaxial resonator), and a helical antenna. This high voltage pulsed source is very compact (volume of only 2500 cc without the antenna). Our study aims at designing the antenna (number of turns, size…) and a coaxial damped oscillator directly implemented at the output of the transformer. A CST-based simulation is proposed to predict the performances of this wideband source.

关键词： Pulse Transformer Helical Antenna Coaxial Damped Oscillator High voltage Peaking Switch Electric Field

The value of the World Conferences on Research Integrity:perspectives from Peru

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Forensic Sciences Research 2021年第3期6卷 347-349页

作者： Mariela Dejovásquez Roxana Lescano Juan Guillermo PérezCarreño Universidad de Lima LimaPeru Asociación Peruana para el empleo y bienestar de animales en investigación y docencia(ASOPEBAID) LimaPeru Universidad del Rosario BogotáColombia

“The World Conferences on Research Integrity(WCRIs),six to date,were initiated at a time when researchers in various countries were at quite different stages in their thinking about research *** the course of the past decade,the global conferences have reflected and documented significant changes in the way research integrity is viewed and supported”[1].

关键词： quite World initiated

Characterization and performance of the Apollon short-focal-area facility following its commissioning at 1 PW level

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Matter and Radiation at Extremes 2021年第6期6卷 12-25页

作者： K.Burdonov A.Fazzini v.Lelasseux J.Albrecht P.Antici Y.Ayoul A.Beluze D.Cav.n.a T.Ceccotti M.Chabanis A.Chaleil S.n.Chen Z.Chen F.Consoli M.Cuciuc X.Davoine J.P.Delaneau E.d’Humieres J.-L.Dubois C.Evrard E.Filippov A.Freneaux P.Forestier-Colleoni L.Gremillet v.Horny L.Lancia L.Lecherbourg n.Lebas A.Leblanc W.Ma L.Martin F.negoita J.-L.Paillard D.Papadopoulos F.Perez S.Pikuz G.Qi F.Quere L.Ranc P.-A.Soderstrom M.Sciscio S.Sun S.vallieres P.Wang W.Yao F.Mathieu P.Audebert J.Fuchs LULI–CnRS CEASorbonne UniversiteEcole PolytechniqueInstitut Polytechnique de ParisF-91128 Palaiseau CedexFrance Sorbonne Universite Observatoire de ParisUniversite PSLCNRSLERMAF-75005 ParisFrance IAP Russian Academy of Sciences603155 Nizhny NovgorodRussia InRS-EMT 1650Boulevard Lionel-BouletVarennesQuebec J3X 1S2Canada Universite Paris-Saclay CEACNRSLIDYL91191Gif-sur-YvetteFrance Universite Paris-Saclay CEALMCE91680 Bruy`eres-le-ChˆatelFrance “Horia Hulubei”national Institute for Physics and nuclear Engineering 30 Reactorului StreetRO-077125 Bucharest-MagureleRomania EnEA Fusion and Technologies for Nuclear Safety DepartmentC.R.FrascatiVia E.Fermi 4500044 FrascatiItaly University of Bordeaux Centre Lasers Intenses et ApplicationsCNRSCEAUMR 5107F-33405 TalenceFrance Joint Institute for High Temperatures RAS125412 MoscowRussia Laboratoire d’Optique Appliquee Ecole Polytechnique–ENSTA–CNRS–Institut Polytechnique de ParisPalaiseauFrance State Key Laboratory of nuclear Physics and Technology School of PhysicsCAPTPeking UniversityBeijing 100871China Laboratoire Charles Fabry Institut d’Optique Graduate SchoolCNRSUniversite Paris-Saclay91127 Palaiseau CedexFrance

We present the results of the first commissioning phase of the short-focal-length area of the Apollon laser facility(located in Saclay,France),which was performed with the first available laser beam(F2),scaled to a nominal power of 1 *** the conditions that were tested,this beam delivered on-target pulses of 10 J average energy and 24 fs *** diagnostics were fielded to assess the performance of the *** on-target focal spot and its spatial stability,the temporal intensity profile prior to the main pulse,and the resulting density gradient formed at the irradiated side of solid targets have been thoroughly characterized,with the goal of helping users design future *** of energetic electrons,ions,and electromagnetic radiation were recorded,showing good laser-to-target coupling efficiency and an overall performance comparable to that of similar international *** will be followed in 2022 by a further commissioning stage at the multipetawatt level.

关键词： performance beam nominal