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Survey of current practices in the management of cervical cancer by Moroccan radiotherapists

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Radiation Medicine and Protection 2024年第2期5卷 124-130页

作者： bouchra Amaoui Slimane Semghouli Hanane el Kacemi Issam Lalya Nadia Benchekroune Fatima Safini Sanae Abbaoui Biotechnology and Medicine(BioMed)Laboratory Faculty of Medicine and PharmacyIbn Zohr UniversityAgadirMorocco Souss Massa University Hospital Center AgadirMorocco Higher Institute of Nursing Professions and Health Techniques AgadirMorocco Mohammed-V University RabatMorocco National Institute of Oncology(INO) RabatMorocco Mohammed-V Military Instruction Hospital RabatMorocco Hassan II University CasablancaMorocco Mohammed VI Oncology Center-Casablanca University Hospital CasablancaMorocco Regional Oncology Center AgadirMorocco

Objective:To assess the applicability degree of the international guidelines by Moroccan radiotherapists,in order to improve the management of cervical cancer(CC),since CC is the second most common cancer for women in ***:This cross-sectional study was carried out using a questionnaire sent online to Moroccan *** questionnaire covered participants'characteristics,initial assessment and treatment preparation,techniques and indications for radiotherapy and brachytherapy,dose and indications,as well as on the protocol adopted in the intermediate stages and the location of adjuvant treatments and assessments'***:74 radiotherapists out of 300 have responded to the *** 27.0%of practitioners reported discussing patient records systematically in a multidisciplinary consultation meeting(MCM).For the initial assessment,77.0%requested pelvic magnetic resonance imaging(MRI).It is significantly less requested in regional oncology centers(ROCs)than in university hospital centers(UHCs)or the private sector(Pelvic MRI(82.2%)while PET/CT was recommended by only less than 10%.Conclusions:The findings obtained show that our radiotherapists generally comply with international guidelines for the cervical cancer ***,they should still enhance their practices for the first staging evaluation,the use of systematic MCMs,the doses and treatment techniques used,and

关键词： Radiotherapy Brachytherapy Cervical cancer Morocco

Physicians’knowledge about radiation protection of patients during prescription of CT scan procedures in Morocco

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Radiation Medicine and Protection 2023年第1期4卷 54-59页

作者： bouchra Amaoui Fatima Safini Laila Lahlou Mohamed el Fahssi Sanae Abbaoui Slimane Semghouli Faculty of Medicine&Pharmacy University Ibn ZohrAgadirMorocco Regional Center of Oncology AgadirMorocco Higher Institute of Nursing Professions and Health Techniques AgadirMorocco

Objective:To evaluate the knowledge and practices of Moroccan physicians in terms of radioprotection of patients when prescribing computed tomography(CT)***:This is a cross-sectional study in which a questionnaire with 23 multiple-choice questions was sent to prescribers of CT examinations such as radiotherapists(RMs),other medical specialists(OMSs),general practitioners(GPs)and residents/interns(R/Is).The first eight questions asked about the demographics of the participants,while the remaining questions asked about knowledge of ionizing radiation examinations,doses received,relative risks,and patient radiation safety ***:A total of 223 physicians participated in this *** therapists,considered as the reference group,had a better knowledge of irradiating and non-irradiating imaging compared to the other groups(P=0.003).Thus,67%of the reference group declared to take into account the number of scans performed by the patient during the last year,unlike the other groups(P=0.002).Furthermore,the knowledge of the different groups about the risks related to exposure to ionizing radiation was globally low(2%)(P=0.73).Regardless of their specialties and seniority,only 12%of the participants informed the patient at the time of prescription about the risks of ***,only 21%of the participants declared having had training in radiation protection,with no significant differences between the subgroups(P=0.832).Conclusions:The results obtained are similar to those reported in previous *** show that Moroccan prescribers have a low level of knowledge of the risks associated with CT *** on patient radiation protection should be included in the initial curriculum of interns and the continuing professional development of physicians should be reinforced.

关键词： CT Ionizing radiation Radiation protection X-rays Radiation risks

Qualitative analysis and simulation of a nonlinear integro-differential system modeling tumor-immune cells competition

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International Journal of Biomathematics 2018年第8期11卷 171-190页

作者： bouchra Aylaj Departement de Mathematiques et Informatique Faculte des Sciences Ain Chock Km 8 Route d'El adida B.P. 5366 Maarif 20100 Casablanca 20000 Maro

This paper deals with a qualitative and computational study of a class of integrodifferential model, with a nonlinear growth rate. The model is applied to immunology problems, in particular to the competition between tumors and immune system. Our purpose is to take into account the activity transfer processes bet ween cells. The first part of this paper deals with the modeling, while the second part develops the existence and uniqueness of global solutions to the initial boundary value problem related to the application of the model. Finally, numerical simulations are used to illustrate the results obtained for a dynamic of tumor cells contrasted by the immune system.

关键词： Population dynamics kinetic theory nonlinear semigroup separable equations immune competition quasilinear cauchy problem global solution integrodifferentialequations simulation

Efficiency of combining pomegranate juice with low-doses of cisplatin and taxotere on A549 human lung adenocarcinoma cells

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Asian Pacific Journal of Tropical Biomedicine 2018年第1期8卷 19-24页

作者： Nasser Mohamad Hijazi Akram Sayed Ahmad bouchra Jamal Eddine Zeinab Ibrahim Sajida Rammal Hassan Al Rekaby Abd-el-Ameer Nasser Mouhamad Doctoral School of Science and Technology Research Platform for Environmental Science (PRASE) Lebanese University Université Fédérale de Toulouse Midi-Pyrénées INP-ENSIACET Laboratoire de Chimie Agro-industrielle Al Mustansiriya University College of Science Department of Biology American University of Beirut

Objective: To test the coalescence effect of two chemotherapy drugs at low effective dose(cisplatin and taxotere) combined with pomegranate juice on A549 cancer cells. Methods: Infrared spectroscopy method is a qualitative test that was performed to ensure the existence of the phytochemicals providing the antioxidant activity through the presence of the hydroxyl group(-OH). The viability of A549 cell line and normal MCs was tested using the neutral red uptake, Clonogenic survival, XTT and Cell migration assays. Results: Our results showed that this combination firstly led to a greater decrease in the viability of cells comparing to those treated with chemotherapy drugs alone, and secondly led to a significant reduction in cell migration. Conclusions: These data suggest a synergistic effect between the pomegranate and cisplatin which makes probably this combination a powerful option for treating lung adenocarcinoma and in parallel minimizing the systemic side effects.

关键词： Lung cancer Chemotherapy Cisplatin Taxotere Pomegranate A549 cells

Selecting accurate post-elimination monitoring tools to prevent reemergence of urogenital schistosomiasis in Morocco:a pilot study

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Infectious Diseases of Poverty 2017年第1期6卷 664-672页

作者： Abdelaali Balahbib Fatima Amarir Paul L.A.M.Corstjens Claudia Jde Dood Govert Jvan Dam Amina Hajli Meryem Belhaddad bouchra el Mansouri Abderrahim Sadak Mohamed Rhajaouim el Bachir Adlaoui National Reference Laboratory for Schistosomiasis and Malacology National Institute of HygieneAgdalRabatMorocco Faculty of Science Laboratory of Zoology and General BiologyAgdalRabatMorocco Laboratory of Parasitology and Malacology Institute of Nursing Professions and Health TechniquesCasablancaMorocco Department of Molecular Cell Biology Leiden University Medical CenterLeidenThe Netherlands Department of Parasitology Leiden University Medical CenterLeidenThe Netherlands

Background:After alleged stop of transmission of schistosomiasis and further down the line in post elimination settings,sensitive tools are required to monitor infection status to prevent potential *** Rahala,where transmission cycle of Schistosoma haematobium is interrupted since 2004 but where 30%of snails are still infected by ***,potential human *** infection can’t be *** methods based on egg-counts do not provide the required sensitivity,antibody or antigen assays are envisaged as the most appropriate tools for this type of ***:In this pilot study,the performances of three assays were compared:two commercially available antibody tests(elISA and haemagglutination format)indicating exposure,and an antigen test(lateral flow strip format)demonstrating active *** 37 recruited study participants resided in Rahala(Akka,province Tata,Morocco).Participants had been diagnosed and cured from schistosomiasis in the period between 1983 and *** 2015 these asymptomatic participants provided fresh clinical samples(blood and urine)for analysis with the aforementioned diagnostics ***:No eggs were identified in the urine of the 37 *** haemagglutination test indicated 6 antibody positives whereas the elISA indicated 28 antibody positives,one indecisive and one false *** and haemagglutination results matched for 18 individuals,amongst which 5 out of 6 haemagglutination *** the antigen test(performed on paired serum and urine samples),serum from two participants(cured 21 and 32 years ago)indicated the presence of low levels of the highly specific Schistosoma circulating anodic antigen(CAA),demonstrating low worm level infections(less than 5 pg/ml corresponding to probably single worm pair).One tested also CAA positive with *** indicated the presence of human anti-Schistosoma antibodies in these two CAA positive cases,haemagglutination results were ***:To pre

关键词： Schistosomiasis Transmission stop elimination Monitoring Antibody test Antigen test Circulating Anodic Antigen(CAA) Active infection

添加植物激素对提高破囊壶菌菌株生物量和脂肪酸产量的潜在作用评估

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添加植物激素对提高破囊壶菌菌株生物量和脂肪酸产量的潜在作用评...

作者： el Amouri bouchra 天津大学

学位级别：硕士

近年来,破囊壶菌作为脂肪酸生产的可持续和可再生来源,在世界范围内受到广泛关注。但目前破囊壶菌脂肪酸的生产效率仍然较低,限制了其工业生产。植物激素在信号传导及抗逆反应中发挥着重要作用。在培养基中添加植物激素,可调节微藻的生... 详细信息

近年来,破囊壶菌作为脂肪酸生产的可持续和可再生来源,在世界范围内受到广泛关注。但目前破囊壶菌脂肪酸的生产效率仍然较低,限制了其工业生产。植物激素在信号传导及抗逆反应中发挥着重要作用。在培养基中添加植物激素,可调节微藻的生长及脂肪酸的合成过程,进而有效提高脂肪酸生产效率,但关于植物激素对破囊壶菌影响的研究则很少。本研究首先选取了赤霉素、吲哚乙酸、激动素、脱落酸和水杨酸等五种典型植物激素,测定了它们对两株破囊壶菌Schizochytrium ***#Mn4和Thraustochytriidae ***#SW8在M4和碳源优化培养基中生物量及油脂积累的影响,并对植物激素的浓度及添加时间进行了优化;然后,对氮源种类及浓度进行了优化,确定了适于脂肪酸生产的限氮培养基;最后,分析评价了这些植物激素在限氮条件下对两株破囊壶菌生物量及油脂产量的影响。在0h添加激动素（5 mg/L）和吲哚乙酸（1 mg/L）使PKU#Mn4的生物量分别提高了31%和23%。然而,与对照组相比,脂肪酸的产量增加了32%和30%。吲哚乙酸（1 mg/L）对PKU#Sw8的生物量和脂肪酸产量的影响较其它植物激素显著,分别提高了1.07倍和1.34倍。添加植物激素的效果也显示出时间依赖性。在培养PKU#Mn4的第48 h添加吲哚乙酸（1 mg/L）、在培养PKU#Sw8的24 h添加激动素（0.1 mg/L）,可以产生更高的生物量和脂肪酸产量。事实上,与0 h试验结果相比,在48 h添加吲哚乙酸和24 h添加激动素使PKU#Mn4的生物量和脂肪酸产量分别增加20%和33%,使PKU#Sw8的生物量和脂肪酸产量分别增加51%和34%。为了进一步提高生物量和脂肪酸产量,我们以酵母提取物（0.5-1 g/L）和蛋白胨（0.5-1.5 g/L）为氮源,分析评价了氮优化条件下植物激素的添加效果。结果表明,激动素（4 mg/L）和酵母提取物（1g/L）联合使用可提高PKU#Mn4菌株的生物量和脂肪酸产量,分别比不添加植物激素的M4优化培养基提高31%和30%。同时,酵母抽提物、蛋白胨和激动素（5 mg/L）联合使用可使PKU#Sw8菌株的生物量和脂肪酸产量分别提高29%和27%。本研究表明,添加植物激素是促进破囊壶菌生物量和脂肪酸生产的一个颇有前景的策略。

关键词：破囊壶菌植物激素脂肪酸生产生物量添加时间氮优化

Learning to Support Derivation of Adaptable Products in Software Product Lines

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Journal of Computer and Communications 2020年第4期8卷 114-126页

作者： Anissa Benlarabi Amal Khtira bouchra el Asri IMS Team ADMIR Laboratory Rabat IT Center ENSIAS Mohammed V University Rabat Morocco

Software product line engineering is a large scale development paradigm based on mass production. It consists in building a common platform from which a set of products can be derived. Under the constraints of continuous evolution and costs optimization, the derivation process must be able to answer customers’ requirements and provide adequate products in a short time without defects. However, this purpose cannot be achieved if the customer must wait for the change is implemented in the common platform. In this paper, we describe our work which proposes a framework to manage derivation of adaptable products. An adaptable product is obtained by deriving the most similar product from the common platform and changing it to support the new requirements. The aim of the framework is to give quick response to the customers need while the new requirements are being implemented in the common platform. The framework includes tools for processing natural language requirements, computing the similarity between products on the basis of their requirements, and the product adaptation effort measuring.

关键词： Software Product Lines Requirement Similarity Product Derivation Natural Language Processing Semantic Models

Removal of Methylene Blue from Water Using Hydroxyapatite Submitted to Microwave Irradiation

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Journal of Water Resource and Protection 2016年第3期8卷 358-371页

作者： Khadija Allam Abdeslam el Bouari bouchra Belhorma Lahcen Bih Laboratory of Physical Chemistry of Materials Applied Department of Chemistry Faculty of Sciences Ben M’sik University Hassan II Casablanca Casablanca Morocco National Centre for Energy Nuclear Science and Technology CNESTEN Rabat Morocco Group of Physico-Chemical of the Condensed Matter (PCMC) Faculty of Sciences Meknes University Moulay Ismail Meknès Morocco

This study investigated the power of hydroxyapatite adsorbent prepared by a combined precipitation-microwave method, for removing a cationic dye methylene blue in aqueous media. The used adsorbent was characterized by X-ray diffraction (XRD) and infrared spectroscopy (IR). The adsorption tests were conducted in batch mode. The effect of temperature, the pH of the solution and the mass of the adsorbent on the adsorption were determined. It is found that the adsorption was pH and temperature dependent. The kinetic study showed that the second-order model gives a better description of the kinetics of the adsorption reaction than the first-order model. Analysis of adsorption isotherms using different classical models showed that adsorption may be governed by the isotherms of Langmuir. The thermodynamic parameters were determined from the values of the maximum adsorption capacity and equilibrium constants.

关键词： Microwave Hydroxyapatite Methylene Blue Adsorption Kinetic Isotherms

基于双质量模型的非线性变速海流发电机最优反馈控制

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Journal of Marine Science and Application 2020年第1期19卷 83-95页

作者： Rajae Gaamouche Abdelbari Redouane Imad el harraki bouchra Belhorma Abdennebi el Hasnaoui electromechanics Department Mohammadia School of Engineering10000 RabatMorocco electromechanics Department National Superior School of Mines10000 RabatMorocco National Centre for Energy Sciences and Nuclear Techniques 10000 RabatMorocco

This paper presents a contribution related to the control of nonlinear variable-speed marine current turbine(MCT)without pitch operating below the rated marine current *** that the operation of the MCT can be divided into several operating zones on the basis of the marine current speed,the system control objectives are different for each *** deal with this issue,we develop a new control approach based on a linear quadratic regulator with variable generator *** proposed approach enables the optimization of the rotational speed of the turbine,which maximizes the power extracted by the MCT and minimizes the transient loads on the *** novelty of our study is the use of a real profile of marine current speed from the northern coasts of *** simulation results obtained using MATLAB Simulink indicate the effectiveness and robustness of the proposed control approach on the electrical and mechanical parameters with the variations of marine current speed.

关键词： Marine current turbine Two-mass model Tip speed ratio Linearization Optimal control Linear quadratic regulator(LQR)