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伴有ROBO3突变的水平注视麻痹和进行性脊柱侧凸的神经学特征

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世界核心医学期刊文摘（眼科学分册） 2005年第9期1卷 7-8页

作者： bosley t.m. Salih m.A.m. Jen J.C. 杜兆江 King Khaled Eye Specialist Hospital PO Box 7191 Riyadh 11462 Saudi Arabia Dr.

Objective: to review the neurologic, neuroradiologic, and electrophysiologic features of autosomal recessive horizontal gaze palsy and progressive scoliosis (HGPPS), a syndrome caused by mutation of the ROBO3 gene on chromosome 11 and associated with defective decussation of certain brainst.m.neuronal syst.m.. methods: the authors examined 11 individuals with HGPPS from five genotyped families with HGPPS. Eight individuals had brain mRI, and six had electrophysiologic studies. Results: Horizontal gaze palsy was fully penetrant, present at birth, and total or almost total in all affected individuals. Convergence, ocular alignment, congenital nystagmus, and vertical smooth pursuit defects were variable between individuals. All patients developed progressive scoliosis during early childhood. All appropriately studied patients had hypoplasia of the pons and cerebellar peduncles with both anterior and posterior midline clefts of the pons and medulla and electrophysiologic evidence of ipsilateral corticospinal and dorsal column-medial lemniscus tract innervation. Heterozygotes were unaffected. Conclusions: the major clinical characteristics of horizontal gaze palsy and progressive scoliosiswere congenital horizontal gaze palsy and progressive scoliosis with some variability in both ocular motility and degree of scoliosis. the syndrome also includes a distinctive brainst.m.malformation and defective crossing of some brainst.m.neuronal pathways.

关键词：水平注视麻痹 ROBO3 性脊柱侧凸神经学先天性眼球震颤内侧丘系后正中裂电生理检查常染色体隐性发育缺陷

非动脉性前部缺血性视神经病变患者白细胞内相对性线粒体DNA含量增多

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世界核心医学期刊文摘(眼科学分册) 2006年第12期 27-27页

作者： Abu-Amero K.K. bosley t.m. 邢咏新 mitochondrial Research Laboratory Department of Genetics King Faisal Specialist Hospital and Research Center (MBC

Aim: to investigate possible changes in relative mitochondrial DNA (mtDNA) content in patients with non-arteritic anterior ischaemic optic neuropathy (NAION). methods: 19 patients withNAIONwere compared to 32 controls matched for age, sex distribution, and ethnicity. DNA was extracted from leucocytes and competitive multiplex polymerase chain reaction was carried out with two primer pairs (one pair for mtDNA ND1 gene and the other pair for βactin nuclear gene) in the presence of a fluorescent dye. Results: the mean relative mtDNA content in controls (0.93 (SD 0.11); 95%CI 0.89 to 0.97) was signifi cantly less than in NAION patients (2.40 (1.05); 95%CI 1.90 to 2.91; p tive mtDNA content was negatively correlated with Snellen visual acuity (Spearman's rho; r=-0.37; p=0.022). Conclusion: Increased relative mtDNA content in NAION patients may imply a response to oxidative stress, possibly in part because of mitochondrial respiratory chain defects. Significantly more non-synonymous mtDNA nucleotide changes, significantly increased relative mtDNA content, and a significant association between relative mtDNA content and visual acuity all imply that.m.tochondrial abnormalities may be a risk factor for NAION.

关键词：前部缺血性视神经病变动脉性相对性白细胞白血球线粒体粒线体患者 DNA

非动脉炎性缺血性视神经病变的线粒体DNA核苷酸改变

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世界核心医学期刊文摘(眼科学分册) 2005年第3期 12-12页

作者： bosley t.m.,Abu Amero K.K. ,Ozand P.t. ,杨建刚 King Khaled Eye Speci alist Hospital PO Box 7191 Riyadh 11462 Saudi Arabia Dr

the authors sequenced the entire mitochondrial DNA coding region in a group of 19 patients with non arteritic anterior ischemic optic neuropathy (NAION) and in 100 controls. Synonymous and nonsynonymous nucleotide chan ges were more common in NAION patients (P twelve of these (11 novel) were potentially pathologic, nine of which altered moderately or highly conserv ed amino acids in the functional domain of the affected protein. mitochondrial m alfunction may be a risk factor for NAION.

关键词：核苷酸线粒体粒线体 DNA

transport.m.chanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 177-192页

作者： m.NAVEED m.ImRAN t.ASGHAR Z.ABBAS Department of mathematics Division of Science and TechnologyUniversity of Education Department of mathematics The Islamia University of Bahawalpur

this paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. the influence of magnetic fields is also inspected in terms of their physical characteristics. to depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate syst.m. the flow problem is formulated as partial differential equations(PDEs)for moment.m. concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAm).the effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and t.m.erature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and t.m.erature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

关键词： hybrid nanofluid oscillating curved stretchable sheet gyrotactic microorganism Cattaneo-Christov heat and mass flux chemical reaction analytical solution O368

the geology, structure and mineralisation of the Oyu tolgoi porphyry copper-gold-molybdenum deposits, mongolia： A review

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Geoscience Frontiers 2016年第3期7卷 375-407页

作者： t.m.(mike) Porter Porter CeoConsultancy Ply Ltd. Linden Park 5065 SA Australia

the Oyu tolgoi cluster of seven porphyry Cu-Au-mo deposits in southern mongolia,define a narrow,linear,12 km long,almost continuously mineralised trend,which contains in excess of 42 mt of Cu and1850 t of Au,and is among the largest high grade porphyry Cu-Au deposits in the *** deposits lie within the Gurvansayhan island-arc terrane,a fault bounded segment of the broader Silurian to Carboniferous Kazakh-mongol arc,located towards the southern margin of the Central Asian Orogenic Belt,a collage of magmatic arcs that were periodically active from the late Neoproterozoic to Permotriassic,extending from the Urals mountains to the Pacific *** at Oyu tolgoi is associated with multiple,overlapping,intrusions of late Devonian（～372 to 370 ma） quart.m.nzodiorite intruding Devonian（or older） juvenile,probably intra-oceanic arc-related,basaltic lavas and lesser volcaniclastic rocks,unconformably overlain by late Devonian（～370 ma） basaltic to dacitic pyroclastic and volcano sedimentary *** quartz-monzodiorite intrusions range from earlymineral porphyritic dykes,to larger,linear,syn-,late- and post.m.neral dykes and *** was deposited within syn-mineral quartz-monzodiorites,but is dominantly hosted by augite basalts and to a lesser degree by overlying dacitic pyroclastic *** ore deposition,an allochthonous plate of older Devonian（or pre-Devonian） rocks was overthrust and a post-ore biotite granodiorite intruded at～365 *** is characterised by varying,telescoped stages of intrusion and *** A-type quartz veined dykes were followed by Cu-Au mineralisation associated with potassic alteration,mainly K-feldspar in quartz-monzodiorite and biotite-magnetite in basaltic *** reflux of cooled,late-magmatic hydrothermal fluid resulted in intense quartz-sericite retrograde alteration in the upper parts of the main syn-mineral intrusions,and an equivalent chlorite-muscovite/illite-hematite assemblage in bas

关键词： tectonic setting Porphyry copper-gold-molybdenum deposit High sulphidation Geology Alteration Structure

Regional tectonics, geology, magma chamber processes and mineralisation of the Jinchuan nickel-copper-PGE deposit, Gansu Province, China： A review

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Geoscience Frontiers 2016年第3期7卷 431-451页

作者： t.m. (mike) Porter Porter GeoConsultancy Pry Ltd. Linden Park 5065 SA Australia

the Jinchuan Ni-Cu-PGE deposit（〉500 mt @1.2%Ni,0.7%Cu,～0.4 g/t PGE）,one of the largest.m.gmatic sulphide deposits in the world,is located within the westernmost terrane of the North China *** is hosted within the 6.5 km long,Neoproterozoic（～0.83 Ga） Jinchuan ultramafic intrusion,emplaced as a sill-like body into a Palaeoproterozoic suite of gneisses,migmatites,marbles and amphibolites,below an active intracratonic *** parental magma was high-mg basalt,generated through melting of subcrustal lithospheric mantle by a mantle plume during the initiation of Rodinia supercontinent *** lower Palaeozoic collision of the exotic Qilian Block with the breakup-related southern margin of the craton accreted a subduction complex,and emplaced voluminous granitic intrusions and foreland basin sequences within the craton,to as far north as *** the Cainozoic,allochthonous lower Palaeozoic rocks were thrust up to 300 km to the northeast over cratonic basement,to within 25 km of the Jinchuan *** Jinchuan ultramafic intrusion was injected into three interconnected sub-chambers,each containing a separate *** essentially comprises an olivine-orthopyroxene-chromite cumulate,with interstitial orthopyroxene,clinopyroxene,plagioclase and phlogopite,and is predominantly composed of lherzolite（～80%）,with an outer rim of olivine pyroxenite and cores of mineralised *** occurs as disseminated and net-textured sulphides,predominantly within the dunite,with lesser,PGE rich lenses,late massive sulphide accumulations,small copper rich pods and limited mineralised diopside skarn in wall rock *** principal ore minerals are pyrrhotite（the dominant sulphide）,pentlandite,chalcopyrite,cubanite,mackinawite and pyrite,with a variety of platinum group minerals and minor *** deposit underwent significant post.m.gmatic tremolite-actinolite,chlorite,serpentine and magnetite *** volume of thejinchuan intrusion accounts for 〈3%

关键词： Rodinia break-up rifting Plume related Deep staging chamber Olivine-orthopyroxene-chromite cumulate Net textured and disseminated sulphides Post.m.gmatic alteration

microstructure of Cu-based Amorphous Composite Coatings on AZ91D magnesium Alloy by Laser Cladding

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Journal of materials Science & technology 2009年第4期25卷 492-498页

作者： Kaijin Huang Changsheng Xie t.m. Yue State Key Laboratory of Advanced Welding Production technology Harbin Institute of Technology Harbin 150001 China State Key Laboratory of materials Processing and Die ＆ mould technology Huazhong University of Scienee and Technology Wuhan 430074 China Department of Industrial and Syst.m. Engineering Hong Kong Polytechnic University Hung Horn Hong Kong China

to improve the sliding wear resistance of AZ91D magnesium alloy, Cu-based amorphous composite coatings made of Cuatti34Zr11Nis and Cu47ti34Zr11Ni8＋20 wt pct SiC powders were fabricated on AZ91D magnesium alloy by laser cladding, respectively. SEm （scanning electron microscopy）, EDS （energy dispersive X-ray spectroscopy）, XRD （X-ray diffraction） and t.m.（transmission electron microscopy） techniques were employed to study the phases of the coatings. the results show that the coatings mainly consist of amorphous phase and different intermetallic compounds. the reason of formation of amorphous phase and the function of SiC particles were explained in details.

关键词： Laser cladding Cu-based amorphous composite coating SiC particle AZ91D magnesium alloy

Fatigue reliability analysis of fixed offshore structures:A first passage problem approach

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第11期7卷 1839-1845页

作者： mADHAVAN PILLAI t.m. VEENA G. Department of Civil Engineering National Institute of Technology Calicut 673601 India

this paper describes a methodology for computation of reliability of members of fixed offshore platform structures, with respect to fatigue. Failure criteria were formulated using fracture mechanics principle. the problem is coined as a “first passage problem”. the method was illustrated through application to a typical plane frame structure. the fatigue reliability degradation curve established can be used for planning in-service inspection of offshore platforms. A very limited parametric study was carried out to obtain insight into the effect of important variables on the fatigue reliability.

关键词： Reliability Fatigue Fracture mechanics Offshore structures

microstructure and Wear Behaviour of Laser-induced thermite Reaction Al_2O_3 Ceramic Coating on AA7075 Aluminum Alloy

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Journal of materials Science & technology 2007年第2期23卷 201-206页

作者： Kaijin HUANG Xin LIN Changsheng XIE t.m. Yue State Key Laboratory of Plastic Forming Simulation and mould technology Huazhong University of Science and Technology Wuhan 430074 China State Key Laboratory of Solidification Processing Northwestern Polytechnic University Xi＇an 710072 China Department of Industrial and Syst.m. Engineering Hong Kong Polytechnic University Hung Hom Hong Kong China

the microstructure and wear behaviour of the thermite reaction coating produced by the hybrid laser claddingremelting on AA7075 aluminum alloy for the syst.m. of Al-CuO-SiO2, Al-Cr2O3-SiO2, Al-Fe2O3-SiO2, and Al-tiO2-SiO2 were studied. the results of the X-ray diffraction （XRD） analysis show that in all the four reaction coatings, α-Al2O3 and γ-Al2O3 phases were present at the top surface, together with various intermetallic phases, the corresponding reduced metal and Al phase in the fusion zone. Under the dry sliding condition, the wear resistance, in terms of weight loss, of the laser-clad specimens was considerably higher than that of the untreated specimen. the predominant wear mechanism of the former specimens was abrasive wear, while for the latter, it was the adhesive wear that prevailed.

关键词： Laser cladding thermite reaction Aluminum alloy Wear