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International Journal of Clinical Medicine 2014年第21期5卷 1392-1399页

作者： Elizabeth Jeya Vardhini Samuel Ramesh K. B. Latha K. V. Lalitha Peter Prashanth bosco emmanuel Department of General Medicine Pondicherry Institute of Medical Sciences Pondicherry India Department of Pediatrics Pondicherry Institute of Medical Sciences Pondicherry India Central Electrochemical Research Institute (CECRI) Karaikudi India

Background: Patients requiring valve replacement at a younger age, for rheumatic heart disease was apparently increasing after the new age practice of contraception. Methods: In 2012, data of patients referred to tertiary care hospital from two cardiology screening camps conducted in the community, were analyzed for the severity of presentation of rheumatic heart disease and associated contraception status by dividing into the three age groups—20 - 35 years, 36 - 50 years, >51 years;~400 patients attended the camps;31 female and 2 male patients were referred to the tertiary care hospital for further evaluation and categorized treatment, including valve replacement surgeries;among the 33 referred patients, belonging to the three age groups, the data were analyzed for [if any] correlation of contraception status with severe rheumatic heart disease. 8 randomly chosen males, of the 3 age groups, from a different community, whose life partners had undergone sterilization, were assessed for their serum testosterone levels. Results: Among 20 - 35 years, 7 female patients with contraception required valve replacement surgeries [p 51 years, 3 female and 2 male patients without contraception received medical treatment only

关键词： Fragmented Germ Cells Reduced Endogenous Androgen Estrogen Deranged Cell Metabolism Defaulted Genomic Repertoire Enhanced Fibrosis

The role of soil in structure response of a building damaged by the 26 December 2018 earthquake in Italy

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第4期15卷 937-953页

作者： Angela Fiamingo Melina bosco Maria Rossella Massimino Department of Civil Engineering and Architecture University of CataniaViale Andrea Doria 695125CataniaItaly

Local soil conditions can significantly modify the seismic motion expected on the soil *** most cases,the indications concerning the influence of the underlying soil provided by the in-force European and Italian Building Codes underestimate the real seismic amplification *** this reason,numerical analyses of the local seismic response(LSR)have been encouraged to estimate the soil filtering *** analyses are generally performed in free-field conditions,ignoring the presence of superstructures and,therefore,the effects of dynamic soil-structure interaction(DSSI).Moreover,many studies on DSSI are characterised by a sophisticated modelling of the structure and an approximate modelling of the soil(using springs and dashpots at the foundation level);while others are characterised by a sophisticated modelling of the soil and an approximate modelling of the structure(considered as a simple linear elastic structure or a single degree of freedom system).This paper presents a set of finite element method(FEM)analyses on a fully-coupled soil-structure system for a reinforced concrete building located in Fleri(Catania,Italy).The building,designed for gravity loads only,was severely damaged during the 26 December 2018 *** soil was modelled considering an equivalent visco-elastic behaviour,while the structure was modelled assuming both the visco-elastic and visco-inelastic *** comparison made between the results of the FEM analyses and the observed damage is valuable.

关键词： Local site response Seismic risk Reinforced concrete frame Fully-coupled soil-structure system Nonlinear dynamic analysis

Quantifying the link between industrialization,urbanization,and economic growth over Kenya

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Frontiers of Architectural Research 2024年第4期13卷 799-808页

作者： bosco Mumo Kyule Xingping Wang School of Architecture Southeast UniversityNanjing 210096China

Industrialization is a key element for economic growth in both developed and undeveloped *** to globalization,the cause-effect between industrialization,economic growth and urbanization are *** study investigates the relationship between economic expansion,urbanization,and industrialization in Kenya using a quantitative *** World Bank economic indicator parameters,it focuses on understanding the complex interrelationships between these *** Autoregression(VAR)modeling is used to analyze the relationships between GDP,urbanization,and industrialization between 1990 and *** Granger causality test is used to determine the causal linkages between GDP,urbanization,and *** show that urbanization is increasing steadily across Kenya,with a high population in central,western,Rift valley,and coastal *** availability of agricultural land influences urbanization,with a significant positive relationship between the three *** Granger causality test shows a unidirectional relationship between GDP,urbanization,and industrialization.A minimum of 20%is considered as the benchmark for urbanization to reduce both GDP and *** and rapid urbanization,accompanied by ecologically unfavorable industrialization schemes,threatens Kenya’s *** study provides insight into the interconnection between the three pillars of the economy and the statistical models developed are useful in forecasting future trends.

关键词： Economic growth Industrialization Urbanization VAR Granger causality test

European digital archive on soil maps (EuDASM): preserving important soil data for public free access

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International Journal of Digital Earth 2011年第5期4卷 434-443页

作者： Panos Panagos Arwyn Jones Claudio bosco PSSenthil Kumar Joint Research Centre of the European Commission Institute for Environment and SustainabilityIspra(VA)Italy Department of Soil Science&Agricultural Chemistry Faculty of AgricultureAnnamalai UniversityTamil NaduIndia

Historical soil survey paper maps are valuable resources that underpin strategies to support soil protection and promote sustainable land use practices,especially in developing countries where digital soil information is often ***,many of the soil maps,in particular those for developing countries,are held in traditional archives that are not easily accessible to potential ***,many of these documents are over 50 years old and are beginning to *** the need to conserve this information,the Joint Research Centre(JRC)and the ISRIC-World Soil Information foundation have created the European Digital Archive of Soil Maps(EuDASM),through which all archived paper maps of ISRIC has been made accessible to the public through the *** immediate objective is to transfer paper-based soil maps into a digital format with the maximum possible resolution and to ensure their preservation and easy *** than 6,000 maps from 135 countries have been captured and are freely available to users through a user-friendly web-based *** feedback has been very positive,especially from users in Africa,South America and Asia to whom archived soil maps were made available to local users,often for the first ***:http://***/library/maps/country_maps/list_***.

关键词： soil maps digital archive electronic restoration digital earth online catalogue

Neuro-fuzzy and model-based motion control for mobile manipulator among dynamic obstacles

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Science in China(Series F) 2003年第1期46卷 14-30页

作者：魏武 Jean bosco Mbede 黄心汉张毅 Department of Automation Tsinghua University Departement des Genies Industrie Universit de Yaound I Ecole Nationals Superieure Polytechnique Department of Control Science and Engineering Huazhong University of Science and Technology

This paper focuses on autonomous motion control of a nonholonomic platform with a robotic arm, which is called mobile manipulator. It serves in transportation of loads in imperfectly known industrial environments with unknown dynamic obstacles. A union of both procedures is used to solve the general problems of collision-free motion. The problem of collision-free motion for mobile manipulators has been approached from two directions, Planning and Reactive Control. The dynamic path planning can be used to solve the problem of locomotion of mobile platform, and reactive approaches can be employed to solve the motion planning of the arm. The execution can generate the commands for the servo-systems of the robot so as to follow a given nominal trajectory while reacting in real-time to unexpected events. The execution can be designed as an Adaptive Fuzzy Neural Controller. In real world systems, sensor-based motion control becomes essential to deal with model uncertainties and unexpected obstacles.

关键词： autonomous mobile manipulators dynamic obstacle avoidance dynamic path planning model and sensor-based control neuro-fuzzy controller nonholonomic and redundant systems.

Nursing Theory and Its Practices in Two Health Care Facilities of Bujumbura

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Open Journal of Nursing 2021年第9期11卷 757-771页

作者： emmanuel Gasaba bosco Ntiranyibagira Iranyishuye Joseph Thérèse Uwamariya emmanuel Nkurikiye Pierre Hategekimana emmanuel Ndarusanze Edouard Niyongabo Faculty of Health Sciences Hope Africa University Bujumbura Burundi Hope Africa University Bujumbura Burundi Department of Public Health Sciences National Institute of Public Health Bujumbura Burundi

Introduction: Nursing theory provides a systematic explanation and description of nursing phenomena. It is very important during nursing practice in healthcare facilities (HCFs) because it guides nurses on how to collect data, which data to collect, decide how to interpret the data through the perspective of the theorist, how to plan and implement care, how to make a change and how to evaluate the patient’s outcomes. This study aims to illustrate how nursing theory can be applied during the implementation of nursing care in HCFs of Burundi by orienting the nurses to understand its application during practice. Methods: A cross-sectional study design was used to assess the use of nursing theories in healthcare facilities. A purposive sampling method was used also to select 81 nurses working full and part by applying Alain Bouchard’s formula and the questionnaire was used as the data collection instrument. Results: The current study had revealed a poor knowledge among the participants on the use of nursing theory in these two HCFs as for all variables, their average scores were almost 24.1% whilst those who had no notion related to nursing theory reach a percentage of 75.9%. Conclusion: The study findings were slightly poor as for all variables, they scored less than 40%. Therefore, the use of theories to guide their practice was highly recommended to enhance the patients’ outcomes based on the use of scientific-based experts which could result from continuous education.

关键词： Nursing Nursing Theory Nursing Practice Healthcare Facilities (HCFs)

How does innovation's tail risk determine marginal tail risk of a stationary financial time series?

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Science China Mathematics 2004年第3期47卷 321-338页

作者： YU bosco W. T. PANG W. K. Department of Business Studies The Hong Kong Polytechnic University Hong KongDepartment of Applied Mathematics The Hong Kong Polytechnic University Hong Kong

We discuss the relationship between the marginal tail risk probability and the innovation'stail risk probability for some stationary financial time series *** first give the main results on the tail behavior of a class of infinite weighted sums of random variableswith heavy-tailed probabilities. And then, the main results are applied tothree important types of time series models:infinite order moving averages, the simple bilinear time series and the solutions of stochasticdifference equations. The explicit formulas are given to describe how the marginaltail probabilities come from the innovation's tail probabilities for these time *** results can be applied to the tail estimation of time series and are useful for risk analysis in finance.

关键词： risk analysis, infinite weighted sum, moving average, bilinear model, stochastic difference equation, tail probability, vague convergence.

Modeling and Control of Parallel Hybrid Electric Vehicle Using Sea-Lion Optimization

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Intelligent Automation & Soft Computing 2023年第2期35卷 1441-1454页

作者： J.Leon bosco Raj M.Marsaline Beno Department of EEE St.Xavier’s Catholic College of EngineeringChunkankadaiAnna UniversityChennaiIndia St.Xavier’s Catholic College of Engineering ChunkankadaiAnna UniversityChennaiIndia

This paper develops a parallel hybrid electric vehicle(PHEV)propor-tional integral controller with driving *** improve fuel efﬁciency and reduce hazardous emissions in hybrid electric vehicles(HEVs)combine an electric motor(EM),a battery and an internal combustion engine(ICE).The electric motor assists the engine when accelerating,driving longer highways or climbing *** enables the use of a smaller,more efﬁcient *** also makes use of the concept of regenerative braking to maximize energy efﬁ*** a Hybrid Electric Vehicle(HEV),energy dissipated while braking is utilized to charge the *** proportional integral controller was used in this paper to analyze engine,motor performance and the New European Driving Cycle(NEDC)was used in the vehicle driving test using Matlab/*** proportional integral controllers were designed to track the desired vehicle speed and manage the vehi-cle’s energyﬂ*** Sea Lion Optimization(SLnO)methods were created to reduce fuel consumption in a parallel hybrid electric vehicle and the results were obtained for the New European Driving Cycle.

关键词： Hybrid electric vehicle(HEV) proportional integral controller parallel HEV fuel efﬁciency new European driving cycle(NEDC) sea lion optimization(SLnO)

Desmosterol, the main sterol in rabbit semen： distribution among semen subfractions and its role in the in vitro spermatozoa acrosome reaction and motility

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Asian Journal of Andrology 2010年第6期12卷 862-870页

作者： Evangelia Mourvaki Raffaella Cardinali Rita Roberti Alessandro Dal bosco Cesare Castellini Department of Applied Biology Section of Animal Science University of Perugia Perugia 06100 Italy Department of Internal Medicine Section of Biochemistry University of Perugia Perugia 06122 Italy

Sterols are essential components of the cell membrane lipid bilayer that include molecules such as cholesterol and desmosterol, which are significantly found in the spermatozoa of several animal species. However, the presence of desmosterol in rabbit semen has never been investigated. The aims of this study were to characterize the sterol composition of subfractions of ejaculated rabbit semen and evaluate the in vitro effects of sterol on the spermatozoa acrosome reaction and motility. Two sterols, occurring prevalently in the free form （94.3%）, were identified in whole semen collected from 10 fertile New Zealand White rabbits, specifically desmosterol （58.5% of total sterols） and cholesterol （35.9% of total sterols）. Desmosterol was the predominant sterol found in all subfractions of rabbit semen, varying from 56.7% （in the prostatic secretory granules, PSGs） to 63.8% （in the seminal plasma）. Spermatozoa contained an intermediate proportion of desmosterol （59.8%）, which was asymmetrically distributed between the heads （52.0% of the total content of sterols） and the tails （81.8%）. Results showed that both desmosterol and cholesterol can be transferred from the PSGs to the spermatozoa and are equally effective in inhibiting in vitro spermatozoa capacitation at a concentration higher than 1 mg L^-1. In contrast, neither desmosterol nor cholesterol had a significant effect on spermatozoa motility. Thus, it was concluded that, the various fractions of rabbit seminal fluid differ from each other in sterol composition and quantity, probably due to their different functional properties, and these fractions may undergo significant sterol changes depending on the stage of spermatozoa capacitation.

关键词： acrosome reaction cholesterol desmosterol motility prostatic secretory granules rabbit seminal plasma spermatozoa head spermatozoa tail

RNAi mechanisms in Huntington’s disease therapy:siRNA versus shRNA

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Translational Neurodegeneration 2017年第1期6卷 300-309页

作者： Sebastian Aguiar Bram van der Gaag Francesco Albert bosco Cortese Molecular Neuroscience Laboratory Swammerdam Institute for Life Sciences(SILS-CNS)University of AmsterdamAmsterdamNetherlands Fulbright Program US Department of State(IIE)New York CityNYUSA Department of Neurobiology Care Sciences and SocietyKarolinska InstituteStockholmSweden Biogerontology Research Foundation(BGRF) OxfordUK Department of Biomedical and Molecular Sciences Queen’s University School of MedicineQueen’s UniversityKingstonCanada

Huntington’s Disease(HD)is a genetically dominant trinucleotide repeat disorder resulting from CAG repeats within the Huntingtin(HTT)gene exceeding a normal range(>36 CAGs).Symptoms of the disease manifest in middle age and include chorea,dystonia,and cognitive *** latency from diagnosis to death is 20 *** are currently no disease-modifying therapies available to HD *** is a potentially curative therapy for HD.A popular line of research employs siRNA or antisense oligonucleotides(ASO)to knock down mutant Huntingtin mRNA(mHTT).Unfortunately,this modality requires repeated dosing,commonly exhibit off target effects(OTEs),and exert renal and hepatic *** contrast,a single AAV-mediated short-hairpin RNA(shRNA)dose can last years with low *** addition,we highlight research indicating that shRNA elicits fewer OTEs than siRNA when tested *** this promise,shRNA therapy has been held back by difficulties controlling expression(oversaturating cells with toxic levels of RNA construct).In this review,we compare RNAi modalities for HD and propose novel methods of optimizing shRNA expression and on-target fidelity.

关键词： RNAi shRNA siRNA Huntington’s disease Off-target effects Huntingtin Silencing