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用于BNCT-SPECT的帕维亚TRIGA MARK Ⅱ反应堆热柱优化设计

强激光与粒子束 2017年第12期29卷 87-93页

作者：龚春慧 Fatemi Starehe Protti Ncolettai Postuma Ina bortolussi slvai 耿长冉汤晓斌 Altieri Sverioa 南京航空航天大学核科学与工程系南京211100 意大利国家核物理研究所帕维亚分部帕维亚27100

针对坐落于意大利帕维亚大学的TRIGA Mark Ⅱ反应堆热柱结构进行优化设计,从而满足面向硼中子俘获治疗(BNCT)的单光子发射计算机断层成像(SPECT)研究要求。为提高计算效率并减小统计误差,对比分析使用SSW/SSR方法与直接使用反应堆为源... 详细信息

针对坐落于意大利帕维亚大学的TRIGA Mark Ⅱ反应堆热柱结构进行优化设计,从而满足面向硼中子俘获治疗(BNCT)的单光子发射计算机断层成像(SPECT)研究要求。为提高计算效率并减小统计误差,对比分析使用SSW/SSR方法与直接使用反应堆为源项时热柱内照射位置处中子能谱,其结果基本一致,从而验证了SSW/SSR方法的可靠性。为在该反应堆开展BNCT中SPECT实验,热柱中子束需准直为笔形束。对比分析四种热柱优化方案下束流口处及探测器处热中子和光子通量:40cm长石墨(射束口5cm×3cm);0.5cm厚硼包裹40cm长石墨(射束口5cm×3cm);30cm长天然锂聚乙烯(射束口直径4cm);30cm长天然锂聚乙烯(20cm长射束口直径5cm,5cm长射束口直径4cm,5cm长射束口直径2cm)。结果显示,射束口处热中子通量分别为1.05×108,2.52×107,6.08×107和5.10×107#/(cm2·s)。综合考虑中子准直效果及光子污染,方案三具有最优性能。为后续进行BNCT-SPECT理论和实验研究提供了基础,从而有效促进BNCT剂量准确评估方法的研究进程。

关键词： TRIGA Mark Ⅱ反应堆硼中子俘获治疗 SSW/SSR MCNP6

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Analysis of influencing factors on the method for determining boron concentration and dose through dual prompt gamma detection

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Nuclear Science and Techniques 2021年第4期32卷 10-19页

作者： Feng Tian Chang-Ran Geng Xiao-Bin Tang Di-Yun Shu Huang-Feng Ye Silva bortolussi Chun-Hui Gong Department of Nuclear Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China Key Laboratory of Nuclear Technology Application and Radiation Protection in Astronautics(Nanjing University of Aeronautics and Astronautics) Ministry of Industry and Information TechnologyNanjing 210016China Unit of Pavia National Institute of Nuclear Physics(INFN)Via A.Bassi 627100 PaviaItaly

A method based on the cross-sectional relationship between^(10)B(n,α)^(7)Li and^(1)H(n,γ)^(2)H was proposed to detect and reconstruct the three-dimensional boron concentration/dose distribution in vivo during boron neutron capture therapy(BNCT).Factors such as the neutron energy,fluence rate,and degree of non-uniform distribution of the boron concentration in a voxel may affect the results of this method.A theoretical analysis of the accuracy of the method using a Monte Carlo simulation shows that the determining error is generally less than 1%under different tumor locations and neutron source *** the voxel size is larger than 0.4 cm,the determining error might be higher for a non-uniformly distributed boron concentration in the voxel because of the changes in the neutron energy and fluence *** conclusion,the proposed method enables an accurate threedimensional boron determination in vivo during BNCT.

关键词： BNCT Boron concentration Prompt gamma Capture cross section

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Strategies for accurate response assessment of radiochromic film using flatbed scanner for beam quality assurance

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Nuclear Science and Techniques 2019年第11期30卷 1-9页

作者： Xu-Dong Zhang Yuan-Hao Liu Xiao-Bin Tang Ming-Chen Hsiao Wei-Lin Chen Chang-Ran Geng Wen-Cheng Shao Chun-Hui Gong Silva bortolussi Di-Yun Shu Department of Nuclear Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China Neuboron Medtech Ltd. Nanjing 211112China Unit of Pavia National Institute of Nuclear Physics INFNVia A.Bassi 627100 PaviaItaly

Radiochromic film is a useful tool for beam quality assurance, but accurate response assessment of the film is still a problem. In this study, the response uncertainties of HDV2 film were investigated using a flatbed scanner from both the scanning settings and interscan variability. Scanning settings are fixed conditions for scanning, including scanning resolution and focus *** this study, multipeak distributions of pixel values were found under some dots-per-inch values, which should be avoided, and the optimal setting of 2000 dpi without this problem was selected. By changing the focus setting, the relative standard deviation of pixel values was reduced by 36–50%. The influence of the interscan variability induced by three factors was investigated, including the outside illumination intensity, film homogeneity, and operating temperature. Scanning the film before and after irradiation at the same position was recommended. Moreover, the suitable operating temperature range for the scanner was found to be 15–24 °C, which results in stable film responses. Regarding the studied factors, correction methods and strategies were proposed, and the accurate response assessment of HDV2 film was realized. Finally, a standard operating procedure for response assessment of films was introduced. It can help other researchers study more scanners, films, and particle types.

关键词： Radiochromic film Response assessment Scanning setting Interscan variability Standard operating procedure

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金钢砂绳索切割硬岩及耐磨岩石的计算机模拟方法

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科教译丛 2000年第2期 2-7页

作者： A.bortolussi R.Ciccu P.Manca G.Massacci 杨满琴不详本溪冶专·高职专资建系采12班

现代采石场广泛使用金钢砂绳索切割技术．以获得整齐的岩块形状及高回采率。工具性能及切割成本取决于多种作业参数(周边速度、返回拉力、喷水速度、岩石外部的绳索夹角．以及切体的几何特征(面积及形状)。再者，切割速度及绳索的生声... 详细信息

现代采石场广泛使用金钢砂绳索切割技术．以获得整齐的岩块形状及高回采率。工具性能及切割成本取决于多种作业参数(周边速度、返回拉力、喷水速度、岩石外部的绳索夹角．以及切体的几何特征(面积及形状)。再者，切割速度及绳索的生声事还会受到金钢砂粒形状及单位长度上致量的影响，当然也与岩性(花岗岩或大理石)有关系。针对上述问题的复杂性．开发出一个计算机程序．并且通过现场及试验室效据的检验．证明切实可行。本文介绍了切割机理模型．并着重描述了其主要特征。然后讨论了在各种条件下计算模拟的结果。该程序适用于额定的最佳传动的标准，并有利于进一步试验研究。

关键词：金钢砂绳索硬岩耐磨岩石计算机模拟切割机理

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Single vs double antiplatelet therapy in acute coronary syndrome: Predictors of bleeding after coronary artery bypass grafting

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World Journal of Cardiology 2015年第9期7卷 571-578页

作者： Vincenzo Tarzia Giacomo bortolussi Edward Buratto Carla Paolini Carlo Dal Lin Giulio Rizzoli Tomaso Bottio Gino Gerosa Division of Cardiac Surgery Department of Cardiac Thoracic and Vascular Sciences University of Padua Medical School Division of Cardiology Department of Cardiac Thoracic and Vascular Sciences University of Padua Medical School

AIM:To investigate the contribution of anti-platelet therapy and derangements of pre-operative classical coagulation and thromboelastometry parameters to major bleeding post-coronary artery bypass grafting(CABG).METHODS:Two groups of CABG patients were studied:Group A,treated with aspirin alone(n=50),and Group B treated with aspirin and clopidogrel(n=50).Both had similar preoperative,clinical,biologic characteristics and operative *** coagulation parameters and rotational thromboelastometry(ROTEM)profiles were determined preoperatively for both groups and the same heparin treatment was *** profiles(INTEM and EXTEM assays)were analyzed,both for traditional parameters,and thrombin generation potential,expressed by area-under-curve(AUC).RESULTS:There was no significant difference betweenrates of major bleeding between patients treated with aspirin alone,compared with those treated with aspirin and clopidogrel(12%vs 16%,P=0.77).In the 14 cases of major bleeding,pre-operative classic coagulation and traditional ROTEM parameters were *** we observed that the AUC in the EXTEM test was significantly lower in bleeders(5030±1115 Ohm*min)than non-bleeders(6568±548Ohm*min)(P<0.0001).CONCLUSION:We observed that patients with a low AUC value were at a significantly higher risk of bleeding compared to patients with higher AUC,regardless of antiplatelet *** suggests that thrombin generation potential,irrespective of the degree of platelet inhibition,correlates with surgical bleeding.

关键词： Platelet inhibitors Thromboelastometry Bleeding Ac

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