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Comparison of the patient and partner satisfaction with 700CX and Titan penile prostheses

Asian Journal of Andrology 2017年第3期19卷 321-325页

作者： Javier Romero Otero Cesar Rojas Cruz borja Garcia gomez Joaquim Sarquella Geli lose Medina Polo Eduard Ruiz Castane Alfredo Rodriguez Antolin 12 de Octubre University Hospital Department of Urology Madrid Spain Fundacio Puigvert Department of Andrology Barcelona Spain.

Most widespread three-component penile prosthesis models are 700CXTM and Titan~. Our purpose is to assess patient and partner satisfaction after the first implant. This is a multicenter, retrospective, nonrandomized study in which all patients who met the inclusion criteria between 2009 and 2013 were included. In total, 248 patients agreed to participate. To evaluate patient satisfaction, a validated but modified 11-question questionnaire was completed （EDITS）; and a nonvalidated two-item questionnaire was given to the partner. Statistical analysis used an ordinal logistic regression model. Two hundred and forty-eight patients （194 with 700CXTM vs 54 with Titan） and 207 couples completed the questionnaire （165 with 700CXTM vs 42 with Titan）. Overall satisfaction was high. Both showed great reliability for sexual intercourse and high compliance with prior expectations. Most patients were able to manage the penile prosthesis correctly within 6 months. Postoperative penile shortening led to some dissatisfaction in 42% and 46% of cases （700CX/Titan）. Significant differences were found in three questions of patients＇ questionnaire. There were more patients satisfied with the 700CXTM （P= 0.0001）. No patient with Titan implant took longer than 6 months to optimal management. Only 4% of patients with 700CXTM implant were dissatisfied with the deflation, in contrast to 24% with the Titan （P = 0.0031）. Of the two partners＇ questions, one showed a statistically significant difference （P = 0.0026）. It seems that group 700CX＂ would recommend to re-implant the prosthesis with a greater tendency. The overall satisfaction was very high for both prostheses. The final aspect of the erected and flaccid penis was satisfactory, but both groups showed significant discontent with its final size. Partners＇ overall satisfaction was high.

关键词： erectile dysfunction penile implantation penile prosthesis

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DET1-mediated COP1 regulation avoids HY5 activity over second-site gene targets to tune plant photomorphogenesis

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Molecular Plant 2021年第6期14卷 963-982页

作者： Esther Canibano Clara Bourbousse Marta Garcia-Leon borja garnel. gomez Lea Wolff Camila Garcia-Baudino Rosa Lozano-Duran Fredy Barneche Vicente Rubio Sandra Fonseca Centro Nacional de Biotecnología CNB-CSICMadrid 28049Spain Institut de biologie de l’École normale supérieure(IBENS) École normale supérieureCNRSINSERMUniversitéPSLParis 75005France Shanghai Center for Plant Stress Biology CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 201602China Department of Plant Biochemistry Centre for Plant Molecular Biology(ZMBP)Eberhard Karls University72076 TübingenGermany

DE-ETIOLATED 1(DET1)and CONSTITUTIVE PHOTOMORPHOGENESIS 1(COP1)are two essential repressors of Arabidopsis *** proteins can associate with CULLIN4 to form independent CRL4-based E3 ubiquitin ligases that mediate the degradation of several photomorphogenic transcription factors,including ELONGATED HYPOCOTYL 5(HY5),thereby controlling multiple gene-regulatory *** extensive biochemical and genetic analyses of their multi-subunit complexes,the functional links between DET1 and COP1 have long remained ***,we report that DET1 associates with COP1 in vivo,enhances COP1-HY5 interaction,and promotes COP1 destabilization in a process that dampens HY5 protein *** regulating its accumulation,DET1 avoids HY5 association with hundreds of second-site genomic loci,which are also frequently targeted by the skotomorphogenic transcription factor PHYTOCHROME-INTERACTING FACTOR ***,ectopic HY5 chromatin enrichment favors local gene repression and can trigger fusca-like *** study therefore shows that DET1-mediated regulation of COP1 stability tunes down the HY5 cistrome,avoiding hyper-photomorphogenic responses that might compromise plant viability.

关键词： HY5 DET1 COP1 photomorphogenesis light signaling fusca

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Use of a lyophilized bovine pericardium graft to repair tunical defect in patients with Peyronie＇s disease： experience in a clinical setting

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Asian Journal of Andrology 2017年第3期19卷 316-320页

作者： Javier Romero Otero borja Garcia gomez Jose Medina Polo Carlos Pascual Mateoe Silvia Garcia Barreras Eduard Garcia Cruz Javier de la Riva de la Vifia Alfredo Rodriguez Antolin 12 de Octubre University Hospital Department of Urology Madrid Spain Monteprincipe University Hospital Department of Urology Madrid Spain Clinic Hospital Department of Urology Barcelona Spain

Many different materials are available for grafting during surgery for Peyronie＇s disease （PD）. To study the outcomes associated with the use of a lyophilized bovine pericardium graft （Peri-Guard） to repair tunical defects in patients with PD, descriptive study of 43 patients with disabling penile curvature was performed. Curvature was measured before and after the intervention using a standardized procedure. Surgical technique was plaque excision and grafting of the tunical defect carried out by a single surgeon. A lyophilized bovine pericardium patch was used for grafting. We measured the change in penile curvature and length, the ability to perform successful sexual intercourse without further pharmacological or surgical treatment, and the satisfaction with treatment. Follow-up data were available for a total of 41 patients. Median age was 50 years （IQR 48-52）; mean follow-up time was 14 ± 6 months. Complete penile straightening was achieved in 33 patients （80.5%） and five patients （12.2%） had curvature under 20. Three months after surgery and stretching therapy, mean （s.d.） flaccid penile length increased from 11.2 ± 2.8 cm to 12.1 ± 2.9 cm （P = 0.062）. Seventy-five percentage of patients reported being able to achieve successful intercourse without further treatment. Eighty-five percentage of patients reported to be satisfied with the treatment. There was no evidence of tissue rejection or infection, and only four patients suffered an adverse event. Plaque excision and grafting of the tunical defect with lyophilized bovine pericardium seems to be a safe and effective treatment for patients with PD.

关键词： penile curvature pericardium patch Peyronie's disease surgical treatment

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Role of neutrophil-to-lymphocyte and platelet-tolymphocyte ratios in Peyronie’s disease: a new diagnostic approach to predict the stage of the disease?

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Asian Journal of Andrology 2021年第3期23卷 325-329页

作者： Esther Garda Rojo borja Garda gomez Rocio Santos-Perez de la Blanca Celeste Manfredi Manuel Alonso Isa Jose Medina Polo Alfredo Rodriguez Antolin Javier Romero Otero Department of Urology Research Institute Hospital 12 de Octubre(Imasl2)Madrid 29041Spain Department of Urology University Hospital HM MonteprfncipeMadrid 28668Spain.

Neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)have been associated with multiple entities and several types of *** can be assumed as markers of inflammatory *** objective of this study is to evaluate the NLR and PLR in Peyronie’s disease(PD)and to establish a comparison of its values in the acute and chronic *** recruited patients with PD from March 2018 to March *** patients enrolled underwent medical and sexual history as well as a physical *** values of blood count of each patient were collected both in the acute and chronic *** test was used to compare the acute and chronic stage ***-Wallis test was carried out to evaluate the impact of treatments on the *** identify cutoff values,we used sensibility and specificity tables and receiver operating characteristic(ROC)curves.A total of 120 patients were *** mean age was 55.85(range:18-77)years and the mean penile curvature was 48.43°(range:10°-100°).In the acute stage,the mean NLR was 2.35 and the mean PLR was *** ratios,in the chronic stage,were 1.57 and 100.00,*** significant differences between acute and stable stages for both indices were found(NLR:P<0.0001;PLR:P=0.0202).The optimal cutoff for classification in acute or stable stage was 2 for NLR and 102 for *** to our results,with an ordinary blood count,we could have important indications regarding the disease stage of the patient,and consequently on the most appropriate type of therapy to choose.

关键词： diagnosis inflammation neutrophil-to-lymphocyte ratio Peyronie^disease platelet-to-lymphocyte ratio

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CXCR4+ and SDF-1+ Bone Marrow Cells Are Mobilized into the Blood Stream in Acute Myocardial Infarction and Acute Ischemia

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World Journal of Cardiovascular Diseases 2014年第7期4卷 361-367页

作者： Jose Luis Aceves Rafael Vilchis Maria Antonieta Medina Monserrat borja Silvia Cortes Guillermo Diaz Armando Castro Alexis gomez Jose JParra Martha Alvarado Manuel Lopez Hernandez Virna Poveda Felipe Masso Luis FMontano Division de Cardiocirugia Centro Medico Nacional 20 de Noviembre ISSSTEMexico DFMexico Departamento de Hematologia Centro Medico Nacional 20 de Noviembre ISSSTEMexico DFMexico Laboratorio de Hormonas Centro Medico Nacional 20 de Noviembre ISSSTEMexico DFMexico Departamento de Inmunobiologia Biologia Celular y Tisular Facultad de Medicina UNAMMexico DFMexico

Cell therapy has shown beneficial effects on ventricular function and tissue regeneration in patients with acute and chronic myocardial infarction, although with diverse grades of variability in the results, possibly by proportion, subtype and cell cycle status. Objective: Identify and phenotypically characterize, via CXCR4 and SDF-1 expression, the bone marrow cell subpopulations that are mobilized into the bloodstream in patients with Acute Myocardial Infarction (AMI) and Acute Ischemia (AI) such as acute angina and Chronic Ischemia (CI) such as chronic stable angina, and also determine the cell cycle status of these cells. Method: Patients with AMI and AI were recruited in the ICCU, and patients with CI in the departments of cardiology and cardiovascular surgery. The quantification of cellular subpopulations was made by cytofluorometry with a FACS caliburcyto fluorometry (Becton Dickinson) with specific FITC-labeled anti human monoclonal antibodies against CD34, CD133, CD117, CD48, CXCR4, SDF-1 and Ki67 (Becton Dickinson). Serum concentration of IL-6 and IL-8 were determined by a sequential solid phase chemiluminescent assay performed in a SIEMENS IMMULITE 1000 Analyzer. Statistical analysis was made with the SPSS version 20.0 for Windows. A p value 3/ml) than that in AI (9.2 ± 1.3 × 103/ml) and CI (6.6 ± 1.1 × 103/ml) patients (p p = 0.22 to 0.39), but interestingly in AMI and AI patients, cells were CXCR4+ in almost half of these mobilized cells, although the proportion was significantly higher in AMI patients (46.8% ± 7.1% to 55.7% ± 6.3% vs 23% ± 1.6% to 28.4% ± 2.1%, p = 0.03 to 0.05). A similar behavior was observed with the Ki67 antibody (29.9% ± 2.1% to 36.1% ± 6.3% vs 10% ± 1.2% to 24% ± 1.1%, p = 0.001 to 0.05). Bivariate analysis of the results showed a significant correlation of the cell proportion in AMI but not in AI and CI patients (p = 0.001 to 0.05;0.12 to 0.87 and 0.17 to 0.92 respectively). The amount of myocardial tissue infarcted did not show

关键词： Stem Cells CXCR4:SDF-1 Axis Cardiac Repair Acute and Chronic Ischemia

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