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Unusual presentations of eosinophilic gastroenteritis:Case series and review of literature

World Journal of Gastroenterology 2009年第17期15卷 2156-2161页

作者： Rafiq A Sheikh Thomas P Prindiville R Erick Pecha boris h ruebner Department of Gastroenterology Kaiser Permanente Medical Center 6600 Bruceville Road SacramentoCA 95823 United States Department of Gastroenterology University of California Davis 4150 V Street Sacramento CA95917 United States Department of Gastroenterology Marshall Medical Center 1100 Marshall Way Placerville CA 95667 United States Department of Pathology University of California Davis 4150 V Street Sacramento CA 95917 United States

Eosinophilic gastroenteritis (EG) is an uncommon disease characterized by focal or diffuse eosinophilic infiltration of the gastrointestinal tract, and is usually associated with dyspepsia, diarrhea and peripheral eosinophilia. Diffuse gastrointestinal tract and colonic involvement are uncommon. The endoscopic appearance may vary from normal to mucosal nodularity and ulceration. Gastrointestinal obstruction is unusual and is associated with predominantly muscular disease. We present five unusual cases of EG associated with gastric outlet and duodenal obstruction. Two cases presented with acute pancreatitis and one had a history of pancreatitis. Four cases responded well to medical therapy and one had recurrent gastric outlet obstruction that required surgery. Four out of the five cases had endoscopic and histological evidence of esophagitis and two had colitis. Two patients had ascites. These cases reaffirm that EG is a disorder with protean manifestations and may involve the entire gastrointestinal tract. Gastric outlet and/or small bowel obstruction is an important though uncommon presentation of EG. It may also present as esophagitis, gastritis with polypoid lesions, ulcers or erosions, colitis and pancreatitis and may mimic malignancy.

关键词： Gastroenteritis Eosinophilic Gastrointestinal obstruction Eosinophilic esophagitis Eosinophilic colitis Eosinophilic pancreatitis

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Effect of Selenium on Aflatoxin hepatocarcinogenesis in the Rat

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Biomedical and Environmental Sciences 1990年第1期3卷 65-80页

作者： boris h.ruebner DENNIS P. h. hSIEh Department of Pathology Department of Environmental Toxicology University of California Davis California 95616

The effects of selenium (Na_2SeO_3) on aflatoxin B_1 (AFB_1)-induced hepatic neoplasia were studied in the rat. Putative preneoplastic foci and nodules composed of basophilic, eosinophilic, and clear cells developed early. Basophilic foci were seen first; in the later stages basophilic and eosinophilic nodules predominated. At each stage the AFB_1 + Se groups showed fewer and smaller foci and nodules than the AFB_1 -Se group. The number of foci in the AFB_1 + 3 ppm Se group and their mean area were smaller than those in the 6 ppm Se + AFB_1 group. At the end of the experiment hepatocellular carcinoma (hCC) was found in 11/18 rats (61%) of the AFB_1-Se group. hCC was not found in either of the groups given AFB_1 +Se. We conclude that Se had an inhibitory effect on the initiation and promotion stages of AFB_1-induced preneoplastic foci and nodules. Se also prevented progression of these nodules to hCC even after cessation of AFB_1 administration. The inhibitory effect of Se at 3 ppm was greater than at 6 ppm. The 6 ppm Se group also showed evidence of toxicity. 1990 Academic ***.

关键词： Effect of Selenium on Aflatoxin hepatocarcinogenesis in the Rat

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黄曲霉毒素B1诱发大鼠肝癌及硒防癌机理的研究

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中华预防医学杂志 1989年第5期23卷 289-292页

作者：王洛权雷道年吴炳辅朱昌仁杜敏捷 boris ruebner 北京医科大学北京天坛医院病理科美国加州大学戴维斯分校医学院病理系

本文用黄曲霉毒素B1诱发大鼠肝癌,同时给予亚硒酸钠,观察肝细胞的癌变过程及硒的作用。发现硒具有明显的防癌作用,未给硒组肝癌发生率为61%,给硒组未发现癌变。硒的防癌作用在早期主要表现为抑制增生灶的形成,在晚期为抑制增生灶的癌变。

关键词：黄曲霉毒素B1 硒肝癌大鼠

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