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Interaction of Hemoglobin with Binuclearcationic Tetranitrosyl Iron Complex with Penicillamine. Cations Binding Sites

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Advances in Biological Chemistry 2015年第3期5卷 169-178页

作者： Lidia Syrtsova Natalia Sanina boris psikha Ildar Tukhvatullin Natal’ja Shkondina Olesia Pokidova Alexander Kotelnikov Institute of Problems of Chemical Physics of the Russian Academy of Sciences Moscow Region Russian Federation

In this paper, the kinetics of the interaction of the nitrosyl iron complex with the ligands penicillamine [Fe2(SC5H11NО2)2(NO)4]SO4·5H2O (I) with deoxyhemoglobin (Hb) was studied. The kinetic modeling method defined the number of binding (I) molecules and equilibrium constant of the coupling reaction of (Biomedicine, Iron-Sulfur Cluster, Ligand Binding, Heme, Nitric Oxide ) with Hb (Ks). At equimolar concentrations of (I) and Hb (2 × 10−5 M), the Hb molecule binds only one (I) with Ks equal to 4.3 × 107 M−1. When increasing the (Biomedicine, Iron-Sulfur Cluster, Ligand Binding, Heme, Nitric Oxide ) concentration, the number of binding sites of Hb increases and Ks decreases. These results are analyzed in accordance with the data on the existence of cations binding sites in Hb.

关键词： Biomedicine Iron-Sulfur Cluster Ligand Binding Heme Nitric Oxide

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Kinetic of Transport of Technogenic Ecotoxicants through Model Membranes

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Journal of Environmental Protection 2010年第4期1卷 410-419页

作者： Elena A. Saratovskikh boris L. psikha 不详

The kinetics of ecotoxicant transport through the membrane was studied. The ecotoxicants studied were pecticides widely used in agriculture: lontrel (clopyralid), sencor (metribuzin), basagran (bentazon), roundup (glyphosate), kusagard (alloxydim sodium), and sethoxydim, as well as lontrel complexes with cobalt and copper. All compounds considered penetrate through the model phosphatidylcholine liposomal membranes. The transfer rate was monitored by fluorescence quenching of ?-ATP inside the liposomes. The mathematical model for the process was proposed, and the mass transfer rates were calculated. The octanol/water partition constants were determined. All the compounds con- sidered were shown to accumulate in the fatty layer. The kinetics of their accumulation was studied, and the rates of accumulation in the nonpolar phase were calculated, which correlate with the complexation constants of the same compounds. Bioaccumulation of the toxicants is caused by the formation of complexes with the fatty phase (lipid part) of the cellular membranes. The toxicants under study transferred into the nonpolar phase with a considerable rate dur- ing the whole observation time, namely, 18 months.

关键词： Ecotoxicant Pesticides Liposomal Membranes Mass Transfer Constants Lipophilicity Bioaccumulation Octanol/Water Partition (Koct/H2O)

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The reaction of the iron thiosulfate-nitrosyl complex with adenosine triphosphoric acid

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Natural Science 2013年第7期5卷 800-810页

作者： Elena A. Saratovskikh boris L. psikha Natalya A. Sanina Institute of Problems of Chemical Physics Russian Academy of Sciences Chernogolovka Russia

Iron tetranitrosyl complex bearing the thiosulfate ligand (TNIC) is an efficient nitrogen monoxide donor (NO). He shows antitumor properties and may be used as an original drug for the therapy of acute coronary syndrome. In this work, the reaction of the TNIC with adenosine triphosphoric acid (ATP) was studied. Formation of the products for the reaction of ATP with TNIC was shown by electronic microscopy. The kinetics of the reaction was controlled by spectrofluorometric method, and the complexation constant was measured. The mechanism of interaction of ATP with TNIC was proposed, and the relevant kinetic model satisfactorily described the experimental data, which permitted to calculate the rate constants for these process stages. NMR, IR, and M?ssbauer studies were used for determination of the reaction product structure. NMR study showed TNIC interaction only with adenine part of ATP. The method of IR spectroscopy identified both the absence NO in the reaction products and the occurrence of new Fe-S and Fe-N bonds. M?ssbauer study showed that iron in the reaction products was presented by two forms: Fe(II) and Fe(III). Thus, the structures for the [ATP-Fe2+S] and [ATP-Fe3+S] complexes were proposed.

关键词： Adenosine Triphosphoric Acid Thiosulfate-Nitrosyl Iron Complex Nitrogen Monoxide Donors Fluorescence Kinetic model Reaction Rate Constants Iron(II) Complexes Iron(III) Complexes

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