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Et.nobot.ny, Pharmacology and Phyt.chemical Invest.gat.ons of t.e Seeds of &lt.i&gt.Pent.clet.ra macrophylla&lt./i&gt.Bent. (Mimosaceae)

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Advances in Biological Chemist.y 2021年第3期11卷 126-141页

作者： Pierre V. k. Sinda Beaudelaire k. Ponou borice t. tsafack.jonas k.hlborn Roland t. t.huenguem Rémy B. t.ponno Jean P. Dzoyem t.ll Opat. Léon A. t.pondjou Research Unit.of Environment.l and Applied Chemist.y Department of Chemistry Faculty of Science University of Dschang Dschang Cameroon Depart.ent.of Chemist.y Johannes Gutenberg University Duesbergweg Mainz Germany Research Unit.of Microbiology and Ant.microbial Subst.nces Department of Biochemistry Faculty of Science University of Dschang Dschang Cameroon

Phyt.chemical invest.gat.on of t.e seeds of Pent.clet.ra macrophylla led t. t.e isolat.on of a mixt.re of t.o new aromat.c monot.rpene glycosides, pent.macrophylloside A (1a) and pent.macrophylloside B (1b), t.get.er ... 详细信息

Phytochemical investigation of the seeds of Pentaclethra macrophylla led to the isolation of a mixture of two new aromatic monoterpene glycosides, pentamacrophylloside A (1a) and pentamacrophylloside B (1b), together with six known secondary metabolites: Comososide (2), secopentaclethroside (3), caffeoylputrescine (4), β-sitosterol-3-O-β-D-glucopyranoside (5), 2-hydroxymethyl-5-(2-hydroxypropant.le="font.family:Verdana;"

关键词： Pent.clet.ra macrophylla Et.nobot.ny Pharmacology Aromat.c Monot.rpenoids Chemophenet.c Significance Ant.microbial Act.vit.

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Prot.ct.ve Effect. of Ext.act., Isolat.d Compounds from &lt.i&gt.Desmodium uncinat.m&lt./i&gt.and Semi-Synt.et.c Isovit.xin Derivat.ves against.Lipid Peroxidat.on of Hepat.cyt.’s Membranes

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Advances in Biological Chemist.y 2018年第6期8卷 101-120页

作者： borice t. tsafack Cyrille L. k. Bomgning jonas k.hlborn Romuald t. Fouedjou Beaudelaire k. Ponou Remy B. t.ponno Agat.e L. Fot.o Luciano Barboni t.ll Opat. t.lesphore B. Nguelefack Léon A. t.pondjou Research Unit.of Applied and Environment.l Chemist.y Department of Chemistry Faculty of Science University of Dschang Dschang Cameroon Research Unit.of Animal Physiology and Phyt.pharmacology Department of Animal Biology Faculty of Science University of Dschang Dschang Cameroon Inst.t.t. of Organic Chemist.y Johannes Gutenberg University Mainz Mainz Germany Depart.ent.of Zoology and Animal Physiology Faculty of Science University of Buea Buea Cameroon School of Science and t.chnology Chemistry Division University of Camerino Camerino Italy

Lipid peroxidat.on plays a pivot.l role in t.e pat.ogenicit. and maint.nance of hepat.t.s. t.us, subst.nces prot.ct.ng hepat.cyt. membranes from lipid peroxidat.on are of great.import.nce in t.e management.of hepat.t.xicit. and hepat.t.s. t.e present.work deals wit. t.e in vit.o hepat.prot.ct.ve act.vit. of t.e met.anol ext.act.of Desmodium uncinat.m, it. sub-fract.ons, t.e major isolat.d compounds and some of t.eir semi-synt.et.c derivat.ves in order t. st.dy st.uct.re act.vit. relat.onships. Using hydrogen peroxide (H2O2)-induced lipid peroxidat.on of hepat.cyt. membranes as a model, t.e hepat.prot.ct.ve-guided phyt.chemical survey of t.e met.anol ext.act.of aerial part. of D. uncinat.m was carried out.by successive column chromat.graphy. One of t.e most.act.ve compounds (Isovit.xin) was chemically t.ansformed t. yield new semi-synt.et.c. t.e ident.ficat.on of isolat.d and semi-synt.et.c compounds was performed using NMR t.chniques, mass spect.omet.y and by comparison of t.eir dat. wit. t.ose report.d in t.e lit.rat.re. t.e n-but.nol fract.on was t.e most.effect.ve (IC50: 22.9 μg/mL) compared t. t.e crude met.anol ext.act.(IC50: 43.6 μg/mL) and ot.er fract.ons. t.e n-but.nol sub-fract.ons FA (cont.ining non-phenolic compounds) and FB (mainly cont.ining phenolic compounds) exhibit.d respect.ve IC50 of 14.36 and 128.2 μg/ml. Purificat.on of FA yielded 3-O-β-D-glucopyranosyl-β-sit.st.rol (1), 3-O-β-D- 2-acet.l-amino-2-deoxyglucopyranoxyloleanoic acid (2), (2S, 3S, 4R, 7R, 8Z)-1-O-β-D-glucopyranosyl-2-[(R)-2'-hydroxyarachidoylamino]-docosan-8-ene-3,4,7-t.iol (4), spiraeamide (5), mannit.l (6), while FB afforded essent.ally t.ree C-glycosylflavonoids namely isovit.xin (7), vit.xin (8) and vicenin-3 (9). Chemical t.ansformat.ons (met.ylat.on, allylat.on and prenylat.on) of isovit.xin afforded five new semi-synt.et.c derivat.ves: 4',5,7-O- t.imet.yli-sovit.xin (10), 4'-O-allylisovit.xin (11), 4',7-O-diallylisovit.xin (12), 4'-O-prenylisovit.xin (13) and 8-C-prenyl-4',7-O

关键词： Desmodium uncinat.m Hepat.prot.ct.ve Act.vit. Lipid Peroxidat.on Hepat.cyt. Membranes C-glycosylflavonoids

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