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World Journal of Emergency Medicine 2024年第3期15卷 175-180页

作者： Yedalm Yoo Shin Ahn bora.cha. Won Young Kim Department of Emergency Medicine Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republic of Korea

BACKGROUND:The accelerated diagnostic protocol(ADP)using the Emergency Department Assessment of Chest pain Score(EDACS-ADP),a tool to identify patients at low risk of a major adverse cardiac event(MACE)among patients presenting with chest pain to the emergency department,was developed using a contemporary troponin *** study was performed to validate and compare the performance of the EDACS-ADP incorporating high-sensitivity cardiac troponin I between patients who had a 30-day MACE with and without unstable angina(MACE I and II,respectively).METHODS:A single-center prospective observational study of adult patients presenting with chest pain suggestive of acute coronary syndrome was *** performance of EDACS-ADP in predicting MACE was assessed by calculating the sensitivity and negative predictive ***:Of the 1,304 patients prospectively enrolled,399(30.6%;95%confidence interval[95%CI]:27.7%–33.8%)were considered low-risk using the *** them,the rates of MACE I and II were 1.3%(5/399)and 1.0%(4/399),*** EDACS-ADP showed sensitivities and negative predictive values of 98.8%(95%CI:97.2%–99.6%)and 98.7%(95%CI:97.0%–99.5%)for MACE I and 98.7%(95%CI:96.8%–99.7%)and 99.0%(95%CI:97.4%–99.6%)for MACE II,***:EDACS-ADP could help identify patients as safe for early ***,when unstable angina was added to the outcome,the 30-day MACE rate among the designated lowrisk patients remained above the level acceptable for early discharge without further evaluation.

关键词： Chest pain Major adverse cardiac event Acute coronary syndrome Emergency department

Effects of Initial and Boundary Conditions on Heavy Rainfall Simulation over the Yellow Sea and the Korean Peninsula:Comparison of ECMWF and NCEP Analysis Data Effects and Verification with Dropsonde Observation

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Advances in Atmospheric Sciences 2024年第9期41卷 1787-1803页

作者： Jiwon HWANG Dong-Hyun cha Donghyuck YOON Tae-Young GOO Sueng-Pil JUNG Department of Civil Urban Earth and Environmental Engineering Ulsan National Institute of Science and TechnologyUlsan 44919South Korea Program in Atmospheric and Oceanic Sciences Princeton UniversityPrincetonNew Jersey 08544USA National Institute of Meteorological Sciences NIMSJeju 63568South Korea

This study evaluated the simulation performance of mesoscale convective system(MCS)-induced precipitation,focusing on three selected cases that originated from the Yellow Sea and propagated toward the Korean *** evaluation was conducted for the European Centre for Medium-Range Weather Forecasts(ECMWF)and National Centers for Environmental Prediction(NCEP)analysis data,as well as the simulation result using them as initial and lateral boundary conditions for the Weather Research and Forecasting ***,temperature and humidity profiles from 3D dropsonde observations from the National Center for Meteorological Science of the Korea Meteorological Administration served as validation *** showed that the ECMWF analysis consistently had smaller errors compared to the NCEP analysis,which exhibited a cold and dry bias in the lower levels below 850 *** model,in terms of the precipitation simulations,particularly for high-intensity precipitation over the Yellow Sea,demonstrated higher accuracy when applying ECMWF analysis data as the initial *** advantage also positively influenced the simulation of rainfall events on the Korean Peninsula by reasonably inducing convective-favorable thermodynamic features(i.e.,warm and humid lower-level atmosphere)over the Yellow *** conclusion,this study provides specific information about two global analysis datasets and their impacts on MCS-induced heavy rainfall simulation by employing dropsonde observation ***,it suggests the need to enhance the initial field for MCS-induced heavy rainfall simulation and the applicability of assimilating dropsonde data for this purpose in the future.

关键词： initial conditions dropsonde heavy rainfall forecast global model analysis evaluation

Building a Business and Strategic Intelligence Policy as a Strategy for Promoting Congolese Business Progress and Healthy Economic Development in Eastern DRC

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Intelligent Information Management 2024年第2期16卷 77-103页

作者： Innocent bora Uzima Department of Media and Film Studies Daystar University Nairobi Kenya Department of Applied Communication Université Chrétienne Bilingue du Congo Beni Democratic Republic of the Congo

The aim of this study was to verify the existence of business and strategic intelligence policies at the level of Congolese companies and at the state level, likely to foster progress and healthy development in the east of the DRC. The study was based on a mixed perspective consisting of objective analysis of quantitative data and interpretative analysis of qualitative data. The results showed that business and strategic intelligence policies have not been established at either company or state level, as this is an area of activity that is not known to the players in companies and public departments, and there are no units or offices in their organizational structures responsible for managing strategic information for competitiveness on the international market. In addition, there is a real need to establish strategic information management units within companies, upstream, and to set up a national strategic information management department or agency to help local companies compete in the marketplace, downstream. This reflects the importance and timeliness of building business and strategic intelligence policies to ensure economic progress and development in the eastern DRC. Business and strategic intelligence provides companies with an appropriate tool for researching, collecting, processing and disseminating information useful for decision-making among stakeholders, in order to cope with a crisis or competitive situation. The study suggests a number of key recommendations based on its findings. To the government, it is recommended to establish the national policy of business and strategic intelligence by setting up a national agency of strategic intelligence in favor of local companies;and to companies to establish business intelligence units in their organizational structures in favor of stakeholders to foster advantageous decision-making in the competitive market and achieve progress. Finally, the study suggests that studies be carried out to fully understand t

关键词： Business and Strategic Intelligence Strategic Information Congolese Companies Public Departments Decision-Making Information Management Business and Strategic Intelligence Policies Progress Healthy Development Mining and Agriculture Sectors International Market Eastern DRC

Intracellular zinc signaling via Kruppel-like transcription factor 6 promotes HuD expression in pancreatic β cell

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Genes & Diseases 2024年第4期11卷 24-27页

作者： Seongho cha Chongtae Kim Myeongwoo Jung Seungyeon Ryu Sukyoung Han Wook Kim Eun Kyung Lee Department of Biochemistry Department of Biomedicine&Health SciencesCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Catholic Institute for Visual Science College of MedicineThe Catholic University of KoreaSeoul 06591South Korea Department of Molecular Science&Technology Ajou UniversitySuwon 16499South Korea

Dysfunction of pancreaticβcells caused by zinc deficiency is related to the pathogenesis of diabetes.1 Impaired zinc homeostasis in diabetes is associated with reduced zinc transporters.2 Down-regulation of HuD,an es... 详细信息

关键词： βcell homeostasis zinc

A perspective review on the biosynthesis of plant-based secondary metabolites and their application as potent drugs

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BIOCELL 2024年第4期48卷 541-557页

作者： JHILAM PRAMANIK AKASH KUMAR SARVESH RUSTAGI MEHAK KATYAL SHEETAL THAKUR JUTISHNA bora SUMIRA MALIK ANchaL TREHAN NAYAN TALUKDAR PETR SLAMA Department of Food Technology ITM UniversityGwaliorIndia Department of Food Technology SRM UniversitySonipatIndia Department of Food Technology Uttaranchal UniversityDehradunIndia Department of Nutrition and Dietetics Manav Rachna International Institute of Research&Studies(MRIIRS)FaridabadIndia University Centre for Research and Development UIBTChandigarh UniversityMohaliIndia Amity institute of Biotechnology Amity UniversityJharkhandRanchiIndia Department of Biotechnology University Center for Research&Development(UCRD)Chandigarh UniversityMohaliPunjabIndia Department of Science Guru Nanak College of Pharmaceutical SciencesDehradunIndia Program of Biotechnology Faculty of ScienceAssam down town UniversityGuwahatiIndia Department of Animal Morphology Physiology and GeneticsMendel University in BrnoBrnoCzech Republic

Many phytochemicals and their derived metabolites produced by plants are extensively employed in commercial goods,pharmaceutical products as well as in the environmental and medicalﬁ***,these secondary metabolites obtained from plants are in low amounts,and it is difﬁcult to synthesize them at the industrial *** these challenges,they may be utilized for a variety of medicinal products that are either available in the market or are being researched and *** metabolites are complex compounds that exhibit ***,under controlled conditions with elicitors,desired secondary metabolites may be produced from plant cell *** review emphasizes the various aspects of secondary metabolites including their types,synthesis,and applications as medicinal *** article aims to promote the use of plant secondary metabolites in the management and treatment of various diseases.

关键词： Secondary metabolites Medicinal plant Synthesis Health benefits

Deep Convolutional Neural Networks for Accurate Classification of Gastrointestinal Tract Syndromes

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Computers, Materials & Continua 2024年第1期78卷 1207-1225页

作者： Zahid Farooq Khan Muhammad Ramzan Mudassar Raza Muhammad Attique Khan Khalid Iqbal Taerang Kim Jae-Hyuk cha Department of Computer Science COMSATS University IslamabadWah CampusWah47040Pakistan Department of Computer Science and Mathematics Lebanese American UniversityBeirut13-5053Lebanon Department of Computer Science HITEC UniversityTaxila47080Pakistan Department of Computer Science COMSATS University IslamabadAttock CampusAttock43600Pakistan Department of Computer Science Hanyang UniversitySeoul04763Korea

Accurate detection and classification of artifacts within the gastrointestinal(GI)tract frames remain a significant challenge in medical image *** science combined with artificial intelligence is advancing to automate the diagnosis and treatment of numerous *** to this is the development of robust algorithms for image classification and detection,crucial in designing sophisticated systems for diagnosis and *** study makes a small contribution to endoscopic image *** proposed approach involves multiple operations,including extracting deep features from endoscopy images using pre-trained neural networks such as Darknet-53 and ***,feature optimization utilizes the binary dragonfly algorithm(BDA),with the fusion of the obtained feature *** fused feature set is input into the ensemble subspace k nearest neighbors(ESKNN)*** Kvasir-V2 benchmark dataset,and the COMSATS University Islamabad(CUI)Wah private dataset,featuring three classes of endoscopic stomach images were *** assessments considered various feature selection techniques,including genetic algorithm(GA),particle swarm optimization(PSO),salp swarm algorithm(SSA),sine cosine algorithm(SCA),and grey wolf optimizer(GWO).The proposed model excels,achieving an overall classification accuracy of 98.25% on the Kvasir-V2 benchmark and 99.90% on the CUI Wah private *** approach holds promise for developing an automated computer-aided system for classifying GI tract syndromes through endoscopy images.

关键词： Feature fusion Darknet-53 Xception binary dragonfly algorithm ensemble

Human Gait Recognition for Biometrics Application Based on Deep Learning Fusion Assisted Framework

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Computers, Materials & Continua 2024年第1期78卷 357-374页

作者： Ch Avais Hanif Muhammad Ali Mughal Muhammad Attique Khan Nouf Abdullah Almujally Taerang Kim Jae-Hyuk cha Department of Electrical Engineering HITEC UniversityTaxila47080Pakistan Department of Computer Science and Mathematics Lebanese American UniversityBeirutLebanon Department of Computer Science HITEC UniversityTaxila47080Pakistan Department of Information Systems College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Computer Science Hanyang UniversitySeoul04763Korea

The demand for a non-contact biometric approach for candidate identification has grown over the past ten *** on the most important biometric application,human gait analysis is a significant research topic in computer *** have paid a lot of attention to gait recognition,specifically the identification of people based on their walking patterns,due to its potential to correctly identify people far *** recognition systems have been used in a variety of applications,including security,medical examinations,identity management,and access *** systems require a complex combination of technical,operational,and definitional *** employment of gait recognition techniques and technologies has produced a number of beneficial and well-liked *** proposes a novel deep learning-based framework for human gait classification in video *** framework’smain challenge is improving the accuracy of accuracy gait classification under varying conditions,such as carrying a bag and changing *** proposed method’s first step is selecting two pre-trained deep learningmodels and training fromscratch using deep transfer ***,deepmodels have been trained using static hyperparameters;however,the learning rate is calculated using the particle swarmoptimization(PSO)***,the best features are selected from both trained models using the Harris Hawks controlled Sine-Cosine optimization *** algorithm chooses the best features,combined in a novel correlation-based fusion ***,the fused best features are categorized using medium,bi-layer,and tri-layered neural *** the publicly accessible dataset known as the CASIA-B dataset,the experimental process of the suggested technique was carried out,and an improved accuracy of 94.14% was *** achieved accuracy of the proposed method is improved by the recent state-of-the-art techniques that show the significance of this wor

关键词： Gait recognition covariant factors biometric deep learning fusion feature selection

Enhancement of vertical phase separation in sequentially deposited organic photovoltaics through the independent processing of additives

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Journal of Energy Chemistry 2024年第7期94卷 768-777页

作者： Damin Lee changwoo Park Gayoung Ham Young Yong Kim Sung-Nam Kwon Junyeong Lee Sungjin Jo Seok-In Na Hyojung cha Department of Hydrogen and Renewable Energy Kyungpook National UniversityDaegu 41566Republic of Korea Department of Energy Convergence and Climate change Kyungpook National UniversityDaegu 41566Republic of Korea Pohang Accelerator Laboratory(PAL) Pohang University of Science and Technology(POSTECH)PohangGyeongbuk 37673Republic of Korea Department of Flexible and Printable Electronics Jeonbuk National UniversityJeonju-siJeollabuk-do 54896Republic of Korea School of Energy Engineering Kyungpook National UniversityDaegu 41566Republic of Korea

Herein,the impact of the independent control of processing additives on vertical phase separation in sequentially deposited (SD) organic photovoltaics (OPVs) and its subsequent effects on charge carrier kinetics at the electron donor-acceptor interface are *** film morphology exhibits notable variations,significantly depending on the layer to which 1,8-diiodooctane (DIO) was *** incidence wide-angle X-ray scattering analysis reveals distinctly separated donor/acceptor phases and vertical crystallinity details in SD ***-of-flight secondary ion mass spectrometry analysis is employed to obtain component distributions in diverse vertical phase structures of SD films depending on additive *** addition,nanosecond transient absorption spectroscopy shows that DIO control significantly affects the dynamics of separated charges in SD *** SD OPVs,DIO appears to act through distinct mechanisms with minimal restriction,depending on the applied *** study emphasizes the significance of morphological optimization in improving device performance and underscores the importance of independent additive control in the advancement of OPV technology.

关键词： Sequential deposition Vertical phase separation charge dynamics Organic photovoltaics Nonfullerene acceptors

An Artificial Intelligence-Based Framework for Fruits Disease Recognition Using Deep Learning

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Computer Systems Science & Engineering 2024年第2期48卷 529-554页

作者： Irfan Haider Muhammad Attique Khan Muhammad Nazir Taerang Kim Jae-Hyuk cha Department of Computer Science HITEC UniversityTaxila47080Pakistan Department of Computer Science Hanyang UniversitySeoulKorea

Fruit infections have an impact on both the yield and the quality of the *** a result,an automated recognition system for fruit leaf diseases is *** artificial intelligence(AI)applications,especially in agriculture,deep learning shows promising disease detection and classification *** recent AI-based techniques have a few challenges for fruit disease recognition,such as low-resolution images,small datasets for learning models,and irrelevant feature *** work proposed a new fruit leaf leaf leaf disease recognition framework using deep learning features and improved pathfinder *** fruit types have been employed in this work for the validation process,such as apple,grape,and *** the first step,a noisy dataset is prepared by employing the original images to learn the designed framework *** EfficientNet-B0 deep model is fine-tuned on the next step and trained separately on the original and noisy *** that,features are fused using a serial concatenation approach that is later optimized in the next step using an improved Path Finder Algorithm(PFA).This algorithm aims to select the best features based on the fitness score and ignore redundant *** selected features are finally classified using machine learning classifiers such as Medium Neural Network,Wide Neural Network,and Support Vector *** experimental process was conducted on each fruit dataset separately and obtained an accuracy of 100%,99.7%,99.7%,and 93.4%for apple,grape,Citrus fruit,and citrus plant leaves,respectively.A detailed analysis is conducted and also compared with the recent techniques,and the proposed framework shows improved accuracy.

关键词： Fruit disease contrast enhancement augmentation deep learning fusion feature selection classification

TRAIL and Celastrol Combinational Treatment Suppresses Proliferation, Migration, and Invasion of Human Glioblastoma Cells via Targeting Wnt/β-catenin Signaling Pathway

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Chinese Journal of Integrative Medicine 2024年第4期30卷 322-329页

作者： QIN Jing-jing NIU Meng-da cha Zhe GENG Qing-hua LI Yu-lin REN Chun-guang David P.Molloy YU Hua-rong Research Center of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqing(400016)China Laboratory of Developmental Biology Department of Cell Biology and GeneticsSchool of Basic Medical SciencesChongqing Medical UniversityChongqing(400016)China Department of Biochemistry and Molecular Biology School of Basic Medical SciencesChongqing Medical UniversityChongqing(400016)China

Objective To investigate the mechanistic basis for the anti-proliferation and anti-invasion effect of tumor necrosis factor-related apoptosis-induced ligand(TRAIL)and celastrol combination treatment(TCCT)in glioblastoma *** Cell counting kit-8 was used to detect the effects of different concentrations of celastrol(0-16µmol/L)and TRAIL(0-500 ng/mL)on the cell viability of glioblastoma cells.U87 cells were randomly divided into 4 groups,namely control,TRAIL(TRAIL 100 ng/mL),Cel(celastrol 0.5µmol/L)and TCCT(TRAIL 100 ng/mL+celastrol 0.5µmol/L).Cell proliferation,migration,and invasion were detected by colony formation,wound healing,and Transwell assays,*** reverse transcription polymerase chain reaction and Western blotting were performed to assess the levels of epithelial-mesenchymal transition(EMT)markers(zona occludens,N-cadherin,vimentin,zinc finger E-box-binding homeobox,Slug,and β-catenin).Wnt pathway was activated by lithium chloride(LiCl,20 mol/L)and the mechanism for action of TCCT was *** Celastrol and TRAIL synergistically inhibited the proliferation,migration,invasion,and EMT of U87 cells(Pchanism of action for TCCT as an effective therapy for glioblastoma.

关键词： celastrol Chinese medicine tumor necrosis factor-related apoptosis-induced ligand glioblastoma β-catenin Tripterygium wilfordii