检索结果-南通市图书馆

Quantitative Biology 2021年第3期9卷 229-241页

作者： Wei Dong boqing qiang Huanming Yang BGI-Beijing Beijing 101318China The State Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China BGI-Shenzhen Shenzhen 518083China University of Chinese Academy of Sciences Beijing 100049China

The year 2021 marks the 20th anniversary of the official publication of the first draft of a human genome sequence generated by the Human Genome Project(HGP)consortium[1].The whole world has further acknowledged the ... 详细信息

关键词： Human life humanity

维普期刊数据库

ALTERATION IN ENTEROCYTE GENE EXPRESSION MAY EXPLAIN STRUCTURAL AND FUNCTIONAL CHANGES FOLLOWING GLUTAMINE SUPPLEMENTED PARENTERAL NUTRITION

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Sciences Journal 1999年第2期 49-53页

作者： $$$$ Jiang Zhuming, MD Liu Yuewu, MD, PhD , Ma Yongxian, MD , Bai Manxi,MD, PhD , qiang boqing, PhD  ,Robert Smith, MD Wlley Souba, MD , ScD and Douglas Wilmore, MD Department of Surgery, Peking

ＩＮＴＲＯＤＵＣＴＩＯＮＡｌｔｅｒａｔｉｏｎｓｉｎｉｎｔｅｓｔｉｎａｌｓｔｒｕｃｔｕｒｅａｎｄｆｕｎｃｔｉｏｎｏｃｕｒｆｏｌｏｗｉｎｇｍａｊｏｒｏｐｅｒａｔｉｏｎ，ｒａｄｉｏｔｈｅｒａｐｙａｎｄｌｏｎｇｔｅｒｍｐａｒ...

ＩＮＴＲＯＤＵＣＴＩＯＮＡｌｔｅｒａｔｉｏｎｓｉｎｉｎｔｅｓｔｉｎａｌｓｔｒｕｃｔｕｒｅａｎｄｆｕｎｃｔｉｏｎｏｃｕｒｆｏｌｏｗｉｎｇｍａｊｏｒｏｐｅｒａｔｉｏｎ，ｒａｄｉｏｔｈｅｒａｐｙａｎｄｌｏｎｇｔｅｒｍｐａｒｅｎｔｅｒａｌｎｕｔｒｉｔｉｏｎ（...

关键词：

Association of the polymorphisms in the promoter of MMP genes with the susceptibility to nasopharyngeal carcinoma

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Association of the polymorphisms in the promoter of MMP gene...

Estrogen Receptor Alpha Polymorphisms Associated with Susceptibility to Hepatoceiiular Carcinoma in Hepatitis B Virus Carriers

中国遗传学会功能基因组学研讨会

作者： Gangqiao Zhou, Yun Zhai, Ying Cui, Wei Qiu, Hao Yang, Xiumei Zhang, Xiaojia Dong, Ying, He, Kaitai Yao, Hongxing Zhang, Xiaoyan Yuan, Lianteng Zhi, Xiaoai Zhang, Ling Yu, Yan, Shen, boqing qiang, Fuchu He

Background: Matrix metalloproteinases (MMPs) play important role in cancer initiation and development. Several polymorphisms in the promoter of a number of MMP genes, which can affect the respective MMP production in an allele-specific manner, have been well characterized. We examined whether these functional polymorphisms were related to the risk of nasopharyngeal

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Estrogen Receptor Alpha Polymorphisms Associated with Suscep...

KDM2B能够依赖其招募PRC1.1复合物的功能调控体细胞重编程

中国遗传学会七届二次青年研讨会

作者： YUN ZHAI GANGQIAO ZHOU,GUOHONG DENG,WEIMIN XIE,XIAOJIA DONG,XIUMEI ZHANG,LING YU,HAO YANG,XIAOYAN YUAN,HONGXIN ZHANG,LIANTENG ZHI,ZHIJIAN YAO,YAN SHEN,boqing qiang,and FUCHU HE Department of Genomics & Proteomics,Beijing Institute of Radiation Medicine,Beijing,China Chinese National Human Genome Center at Beijing,Beijing,China Department of Infectious Diseases,Southwest Hospital,Chongqing,China Cancer Institute of Guangxi,Nanning,Guangxi,China Beijing Proteome Research Center,Beijing,China and Institute of Biomedical Sciences,Fudan University,Shanghai,China.

Background & Aims:Overexpression of estrogen receptors (ESRs) is implicated in the development of hepatocellular carcinoma (HCC) in both animal models and humans. We examined whether the ESR1 polymorphisms were related to HCC risk among chronic hepatitis B virus (HBV) carriers. Methods: Six ESR1 polymorphisms, which are (TA)n repeat in the promoter, T29C at codon 10 in exon 1, Pvu Ⅱ and Xba Ⅰ site in intron 1, C136474G at codon 325 in exon 4 and A252966G in intron 5, were genotyped in 248 HCC patients and 239 controls. The associations with the susceptibility to HCC were estimated by logistic regression. Allele-specific transcription difference of ESR1 mRNA was performed by real-time quantitative PCR. Results: We observed a statistically significantly increased susceptibility to HCC associated with the homozygous alleles with a high number of TA repeats (assigned as H/H genotype, odds ratio [OR] = 2.66,95% confidence interval [Cl] = 1.44-4.94, P= 0.0018), T29C C/C genotype (OR = 2.31, 95% Cl=1.25-4.26, P= 0.0076) and Pvu Ⅱ C/C genotype (OR = 2.19, 95% Cl = 1.27-3.78, P = 0.0048), compared with the homozygous alleles with a low number of TA repeats (assigned as L/L genotype), T29C T/T and Pvu Ⅱ T/T genotype, respectively. In accordance, the relative mRNA levels of the at-risk C allele of T29C were consistently higher than those of the T allele in heterozygous cells. Conclusions: Our findings suggest that the genetic polymorphism in ESR1 may play a role in mediating susceptibility to HCC in Chinese HBV carriers.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

科学新闻 2018年第4期 144-144页

作者： Zhiwei Zhou Xuejie Yang Jiangping He Jing Liu Fang Wu Shengyong Yu Yuting Liu Runxia Lin He Liu Yuanbin Cui Chunhua Zhou Xiaoshan Wang Jian Wu Shangtao Cao Lin Guo Lihui Lin Tao Wang Xiaozhong Peng boqing qiang Andrew P.Hutchins 裴端卿陈捷凯中国科学院广州生物医药与健康研究院

文章简介PRC1(Polycomb Repressive Complex 1)复合物在发育过程中起着非常重要的作用,很多复合物成分的缺失或者异常都能直接导致胚胎发育的异常。最近的研究发现PRC1包含多种变体,但是其对细胞命运调控的具体机制并不十分清楚。

关键词：复合物 KDM2B PRC1.1 体细胞重编程

基于有限元的门座起重机结构强度分析及应力测试

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

自动化与信息工程 2013年第4期34卷 31-34页

作者：陈敏黄国健吴粤平王强刘柏清王新华广州市特种机电设备检测研究院研发中心广州港股份有限公司新港港务分公司

为保证某港长时期服役的门座起重机工作的安全,运用有限元分析与实测相结合的方法对其金属结构的应力分布进行分析,辅助起重机安全评估工作。根据实际评估需求,选取起重机最危险工作位置时的作业工况进行分析。通过ANSYS有限元计算结果... 详细信息

为保证某港长时期服役的门座起重机工作的安全,运用有限元分析与实测相结合的方法对其金属结构的应力分布进行分析,辅助起重机安全评估工作。根据实际评估需求,选取起重机最危险工作位置时的作业工况进行分析。通过ANSYS有限元计算结果显示:在选择的载荷组合作用下,整机应力分布比较合理,基本小于100 MPa,最大应力值为145 MPa,小于材料的许用应力值,与实际测试的应力数据比较,两者的数据基本吻合,金属结构可安全使用。

关键词：门座起重机有限元 ANSYS 安全评估

维普期刊数据库

在线全文

学校读者我要写书评

暂无评论

甘蔗秸秆综合利用技术研究现状

甘蔗糖业 2023年第5期52卷 42-51页

作者：梁强梁宏卫胡水凤韦淙凯欧阳静韦海勇刘晓燕李毅杰林善海李杨瑞宋修鹏广西农业科学院甘蔗研究所广西南宁530007 广西博庆食品有限公司广西宜州546300 广西来宾东糖集团有限公司广西来宾546100 广西博宣食品有限公司广西武宣545900

甘蔗秸秆包括原料蔗收获之后剩下的枯叶、绿叶及蔗梢,如果不及时处理会对后期蔗田管理产生较大影响。近年来,国家对秸秆野外焚烧进行了严格管控。在新环保形势下,通过一系列新型技术手段对蔗田中残留蔗叶进行无害或资源化处理、变废为宝... 详细信息

甘蔗秸秆包括原料蔗收获之后剩下的枯叶、绿叶及蔗梢,如果不及时处理会对后期蔗田管理产生较大影响。近年来,国家对秸秆野外焚烧进行了严格管控。在新环保形势下,通过一系列新型技术手段对蔗田中残留蔗叶进行无害或资源化处理、变废为宝,是实现甘蔗秸秆综合利用的重要途径。据此,研究者通过查阅相关文献,对目前较为成熟的技术模式进行了整理,归纳总结了一套较为完善的适宜我国国情的秸秆综合利用技术,其中包括低秸秆残留良种、原位粉碎腐熟发酵还田、青储饲料、燃料以及锅炉灰分肥料生产等技术模式,为促进环境友好型的蔗糖业发展提供理论指导。

关键词：甘蔗秸秆新品种腐熟灰分肥料

维普期刊数据库