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Liposome-Encapsulated Hemoglobin Vesicle Improves Persistent Anti-arrhythmogenesis through Improving Myocardial Electrical Remodeling and Modulating Cardiac Autonomic Activity in a Hemorrhagic Shock-Induced Rat Heart Model

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Current Medical Science 2023年第2期43卷 232-245页

作者： bonpei takase Yuko Higashimura Haruka Asahina Masayuki Ishihara Hiromi Sakai Department of Intensive Care Medicine National Defense Medical CollegeTokorozawa359-8513Japan Division of Traumatology Research Institute National Defense Medical College Research InstituteTokorozawa359-8513Japan Division of Biomedical Engineering National Defense Medical College Research InstituteTokorozawa359-8513Japan Department of Chemistry School of MedicineNara Medical UniversityNara634-8521Japan

Objective Shock heart syndrome(SHS)is associated with lethal arrhythmias(ventricular tachycardia/ventricular fibrillation,VT/VF).We investigated whether liposome-encapsulated human hemoglobin vesicles(HbVs)has comparable persistent efficacy to washed red blood cells(wRBCs)for improving arrhythmogenesis in the subacute to chronic phase of *** Optical mapping analysis(OMP),electrophysiological study(EPS),and pathological examinations were performed on blood samples from Sprague-Dawley rats following induction of hemorrhagic *** hemorrhagic shock,the rats were immediately resuscitated by transfusing 5%albumin(ALB),HbV,or *** rats survived for 1 *** and EPS were performed on Langendorff-perfused *** arrhythmias and heart rate variability(HRV)were evaluated using awake 24-h telemetry,cardiac function by echocardiography,and pathological examination of *** OMP showed significantly impaired action potential duration dispersion(APDd)in the left ventricle(LV)in the ALB group whereas APDd was substantially preserved in the HbV and wRBCs *** VT/VF was easily provoked by EPS in the ALB *** VT/VF was induced in the HbV and wRBCs ***,spontaneous arrhythmias,and cardiac function were preserved in the HbV and wRBCs *** showed myocardial cell damage and Connexin43 degradation in the ALB group,all of which were attenuated in the HbV and wRBCs *** LV remodeling after hemorrhagic shock caused VT/VF in the presence of impaired *** to wRBCs,HbV persistently prevented VT/VF by inhibiting persistent electrical remodeling,preserving myocardial structures,and ameliorating arrhythmogenic modifying factors in the subacute to chronic phase of hemorrhagic shock-induced SHS.

关键词： artificial oxygen carrier hemorrhage lethal arrhythmia resuscitation heart rate variability

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