检索结果-南通市图书馆

Emerging Contaminants 2024年第3期10卷 329-335页

作者： Yao Cheng Yihan Hu Keman Yu boning zeng College of Life Science and Technology Jinan UniversityGuangzhou 510632China Department of Cardiology The First Affiliated HospitalJinan UniversityGuangzhou 510632China Clinical Medicine Research Institute The First Affiliated HospitalJinan UniversityGuangzhou 510632China Department of Pharmacy The Second Clinical Medical CollegeJinan University(Shenzhen People's Hospital)Shenzhen518020China Integrated Chinese and Western Medicine Postdoctoral Research Station Jinan UniversityGuangzhou 510632China

Per-and polyfluoroalkyl substances(PFASs)constitute a broad group of fluorinated organic chemicals that are widely used in consumer products and industrial applications due to their excellent physicochemical *** that people spend a significant portion of their time in office environments,our understanding of the environmental presence and human exposure to these chemicals is *** this study,we conducted a targeted analysis of 24 PFASs in office indoor *** SPFAS concentrations ranged from 51.6 to 219 ng/g with mean(±SE)and median concentrations of 114(±5.75)and 107 ng/g,*** oxide dimer acid(HFPO-DA)was the most abundant emerging PFAS detected in the dust,with mean and median concentrations of 40.5(±1.62)and 40.4 ng/g,respectively,comprising 34.2%of the SPFAS ***,HFPO-DA exhibited a positive correlation with perfluorooctane sulfonate(PFOS)(r:0.427,p<0.01),suggesting a potential common source for these two *** findings underscore the significant contribution of emerging PFASs to total PFAS concentrations and raise concerns about their chronic toxicity and potential health risks to humans in office indoor environments.

关键词： office properties. propylene

TPOL triggers apoptosis with mitochondrial injury through activating a ROS-dependent p53/p21/p27/Rb/Bax/Cyto C/caspase-mediated signaling

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国病理生理杂志 2024年第8期40卷 1488-1496页

作者： CHENG Zongwei zeng boning XING Feiyue Department of Immunobiology Institute of Tissue Transplantation and ImmunologyJinan UniversityGuangzhou 510632China

AIM:To explore the influence of ethyl(2,4,6-trimethylbenzoyl)phenylphosphinate(TPOL)on cell apoptosis and its potential ***:HEK293T cells sensitive to TPOL were treated with different concentrations of TPOL with or without exposure to light radiation,before treatment with various inhibitors,N-acetyl-Lcysteine(NAC),pifithrin-αand *** viability was measured by CCK-8 *** V/propidium iodide staining was used to count the number of apoptotic ***-DA staining was used to detect reactive oxygen species(ROS)levels,and JC-1 staining was used to assess mitochondrial membrane potential by flow *** expression of apoptosis-related proteins and cell cycle-regulated molecules was measured by Western ***:TPOL enhanced the apoptosis of HEK293T cells in a dose-dependent manner(P<0.05),with a decrease in Bcl-2 and increases in Bax and cytochrome C(Cyto C),followed by up-regulation of activated caspase-9 and caspase-3,and the cleavage of PARP(P<0.05).The TPOL-enhanced cleavage of caspase-3 and PARP was rescued by Z-DVED-FMK(P<0.01).TPOL also led to a rapid increase in ROS,a reduction in mitochondrial membrane potential,and the release of Cyto C(P<0.01),all of which could be reversed by the ROS scavenger ***,the TPOL-caused alterations in p21,p27,Rb,and CDK2 were also recovered by the p53 inhibitor pifithrin-α(P<0.05).The TPOL-induced changes in Bax,Bcl-2,cleaved caspase-9,activated caspase-3,and cleaved PARP were subsequently rescued by pretreatment with pifithrin-α(P<0.05).CONCLUSION:TPOL can induce cellular apoptosis with ROS-mediated mitochondrial membrane damage through the activation of a ROS-dependent p53/p21/p27/Rb/Bax/Cyto C/caspase-mediated signal axis.

关键词： ethyl(2,4,6-trimethylbenzoyl)phenylphosphinate reactive oxygen species mitochondria apoptosis

基于“两性一度”的医学免疫学与微生物学整合实验教学体系建设与实践

在线全文

学校读者我要写书评

暂无评论

中医教育 2024年第5期43卷 118-122页

作者：杨明锐马伯宁曾郁敏贾翎彭桂英郝钰吴珺北京中医药大学生命科学学院北京102488

医学免疫学与微生物学是联系基础医学和临床医学的重要课程,依照新医科教育背景下课程“两性一度”建设标准,推进实验课程的建设和改革是影响医学生培养质量的重要环节。在传统教学方式下,学生常面临知识脱节、挑战度不足、思维和能力... 详细信息

医学免疫学与微生物学是联系基础医学和临床医学的重要课程,依照新医科教育背景下课程“两性一度”建设标准,推进实验课程的建设和改革是影响医学生培养质量的重要环节。在传统教学方式下,学生常面临知识脱节、挑战度不足、思维和能力欠缺等问题,导致理论联系实际及处理复杂问题的能力较差,教学效果不尽如人意。通过采取一系列创新举措,包括革新教学理念、整合教学内容、改革教学方法、完善教学资源及设定新的教学评价体系,成功构建了医学免疫学与微生物学整合实验教学体系,并在中医学专业教学中进行了实践。该教学体系以解决临床及科研问题为切入点,以基本知识和技术为支撑,引导学生自主设计实验、完成任务、讨论分析,并将项目成果化。改革有效解决了教学中的痛点问题,高质量实现了既定教学目标,显著提升了教学效果,受到学生一致好评。

关键词：两性一度医学免疫学与微生物学整合性实验教学体系构建

Perovskite light-emitting/detecting bifunctional fibres for wearable LiFi communication

在线全文

学校读者我要写书评

暂无评论

Light(Science & Applications) 2020年第1期9卷 441-449页

作者： Qingsong Shan Changting Wei Yan Jiang Jizhong Song Yousheng Zou Leimeng Xu Tao Fang Tiantian Wang Yuhui Dong Jiaxin Liu boning Han Fengjuan Zhang Jiawei Chen Yongjin Wang Haibo zeng MIIT Key Laboratory of Advanced Display Materials and Devices Institute of Optoelectronics&NanomaterialsSchool of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China Peter Grünberg Research Center Laboratory of Broadband Wireless Communication and Sensor Network TechnologyMinistry of EducationNanjing University of Posts and TelecommunicationsNanjing 210003China

Light fidelity(LiFi),which is emerging as a compelling technology paradigm shifting the common means of highcapacity wireless communication technologies,requires wearable and full-duplex compact design because of its great significance in smart wearables as well as the‘Internet of Things’.However,the construction of the key component of wearable full-duplex LiFi,light-emitting/detecting bifunctional fibres,is still challenging because of the conflicting process between carrier separation and recombination,as well as the highly dynamic film-forming ***,we demonstrate light-emitting/detecting bifunctional fibres enabled by perovskite QDs with hybrid *** hybrid perovskite inks endow fibres with super-smooth QD ***,combined with the small exciton binding energy and high carrier mobility of perovskite QDs,enables successful integration of electroluminescence and photodetection into *** bifunctional fibres possess the narrowest electroluminescence full width at half maximum of ~19 nm and,more importantly,the capability for simultaneously transmitting and receiving *** successful fabrication of narrow emission full-duplex LiFi fibres paves the way for the fabrication and integration of low crosstalk interoperable smart wearables.

关键词： process perovskite functional

钙钛矿量子点光伏与荧光聚光电池:现状与挑战

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

无机材料学报 2022年第2期37卷 117-128页

作者：张枫娟韩博宁曾海波河南大学特种功能材料重点实验室开封475004 南京理工大学材料科学与工程学院新型显示材料与器件工信部重点实验室南京210094 天津理工大学材料科学与工程学院天津市光电显示材料与器件重点实验室天津300384

太阳热辐射能储量丰富且无污染,是未来最具竞争力的清洁能源之一。近年来,卤化物钙钛矿量子点以其优异的光电特性以及量子限域效应、可溶液加工等独特优势被广泛应用于太阳能电池和荧光型聚光太阳能电池,应用前景广阔,但在未来的商业化... 详细信息

太阳热辐射能储量丰富且无污染,是未来最具竞争力的清洁能源之一。近年来,卤化物钙钛矿量子点以其优异的光电特性以及量子限域效应、可溶液加工等独特优势被广泛应用于太阳能电池和荧光型聚光太阳能电池,应用前景广阔,但在未来的商业化应用中仍然面临诸多挑战。本文结合钙钛矿量子点太阳能电池领域的国内外研究进展,重点归纳了提升电池性能的优化策略,并探讨了钙钛矿量子点在荧光聚光电池中的应用,最后阐述了该领域当前面临的挑战,并对其发展趋势进行了展望,旨在为未来光伏技术的设计和开发提供一些思路,推进其研究进程。

关键词：钙钛矿量子点太阳能电池荧光太阳能聚光器荧光型聚光太阳能电池综述

Machine Learning Modeling of Protein-intrinsic Features Predicts Tractability of Targeted Protein Degradation

在线全文

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2022年第5期20卷 882-898页

作者： Wubing Zhang Shourya S.Roy Burman Jiaye Chen Katherine A.Donovan Yang Cao Chelsea Shu boning Zhang Zexian zeng Shengqing Gu Yi Zhang Dian Li Eric S.Fischer Collin Tokheim X.Shirley Liu Department of Data Science Dana-Farber Cancer InstituteBostonMA 02215USA Department of Biostatistics Harvard T.H.Chan School of Public HealthBostonMA 02115USA Department of Cancer Biology Dana-Farber Cancer InstituteBostonMA 02215USA Department of Biological Chemistry and Molecular Pharmacology Harvard Medical SchoolBostonMA 02115USA Department of Biomedical Informatics Harvard Medical SchoolBostonMA 02115USA Center of Growth Metabolismand AgingKey Laboratory of Bio-resource and Eco-environmentMinistry of EducationCollege of Life SciencesSichuan UniversityChengdu 610064China Research Scholar Initiative Graduate School of Arts and SciencesHarvard UniversityCambridgeMA 02138USA

Targeted protein degradation(TPD)has rapidly emerged as a therapeutic modality to eliminate previously undruggable proteins by repurposing the cell’s endogenous protein degradation ***,the susceptibility of proteins for targeting by TPD approaches,termed“degradability”,is largely ***,we developed a machine learning model,model-free analysis of protein degradability(MAPD),to predict degradability from features intrinsic to protein *** shows accurate performance in predicting kinases that are degradable by TPD compounds[with an area under the precision–recall curve(AUPRC)of 0.759 and an area under the receiver operating characteristic curve(AUROC)of 0.775]and is likely generalizable to independent non-kinase *** found five features with statistical significance to achieve optimal prediction,with ubiquitination potential being the most *** structural modeling,we found that E2-accessible ubiquitination sites,but not lysine residues in general,are particularly associated with kinase ***,we extended MAPD predictions to the entire proteome to find964 disease-causing proteins(including proteins encoded by 278 cancer genes)that may be tractable to TPD drug development.

关键词： Targeted protein degradation Degradability Protein-intrinsic feature Ubiquitination Machine learning

在线全文

学校读者我要写书评

暂无评论

横纹肌样胶质母细胞瘤的临床病理学特征

中华病理学杂志 2015年第11期44卷 772-777页

作者：李扬曾韬李斌罗柏宁李智中山大学附属第一医院病理科广州510080 中山大学附属第一医院影像科广州510080

目的通过分析横纹肌样胶质母细胞瘤的临床病理学特征，探讨其诊断要点，以期提高对该肿瘤的鉴别诊断能力。方法10岁和45岁女性患者，分别因头痛伴肢体抽搐和视力模糊入院，MRI检查分别显示右侧颞枕叶和左小脑占位性病变。2例患者均行手... 详细信息

目的通过分析横纹肌样胶质母细胞瘤的临床病理学特征，探讨其诊断要点，以期提高对该肿瘤的鉴别诊断能力。方法10岁和45岁女性患者，分别因头痛伴肢体抽搐和视力模糊入院，MRI检查分别显示右侧颞枕叶和左小脑占位性病变。2例患者均行手术完整切除肿瘤，常规HE染色和免疫组织化学染色，并行荧光原位杂交法检测1p／19q缺失状况。结果2例肿瘤组织学构象相似，均可见经典胶质母细胞瘤背景中出现体积大、胞质丰富嗜酸性、核大偏位、核仁明显的横纹肌样细胞。免疫组织化学染色显示横纹肌样细胞波形蛋白弥漫强阳性，并灶性表达胶质纤维酸性蛋白（GFAP）、上皮细胞膜抗原（EMA）和细胞角蛋白（CK）。2例均显示INI-1小灶表达缺失，其中1例可检测到1p／19q共同缺失，2例IDH1R132H均阴性。2例患者术后均给予同步放化疗，1例随访16个月无复发，另1例术后9个月脊髓播散死亡。结论横纹肌样胶质母细胞瘤是少见的高侵袭性胶质肿瘤，组织学形态与其他具有“横纹肌样”特征的肿瘤相似，除细致的组织学观察外，联合使用免疫组织化学套餐波形蛋白、GFAP、CK、EMA、平滑肌肌动蛋白和INI-1有助于相似病变的鉴别。

关键词：脑肿瘤胶质母细胞瘤分子诊断技术诊断鉴别

Giant efficiency and color purity enhancement in multicolor inorganic perovskite light-emitting diodes via heating-assisted vacuum deposition

在线全文

学校读者我要写书评

暂无评论

Journal of Semiconductors 2020年第5期41卷 91-98页

作者： boning Han Qingsong Shan Fengjuan Zhang Jizhong Song Haibo zeng School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China MIIT Key Laboratory of Advanced Display Materials and Devices Institute of Optoelectronics&NanomaterialsNanjing 210094China School of Physics and Engineering Zhengzhou UniversityZhengzhou 450052China

Inorganic perovskites(Cs Pb X3(X=I,Br,Cl))have broad prospection in the field of high-definition displaying due to its excellent optoelectronic *** vacuum deposition process possesses advantages and competitiveness in the industrialized ***,the performance of light emitting diodes(LEDs)based on vacuum-deposited is incredibly ***,we proposed a heating-assisted vacuum deposition(HAVD)method to construct inorganic perovskite LEDs(Pe LEDs)with enhanced *** roughness and crystallinity of perovskite film were improved by regulating the heating treatment of *** the perovskite film exhibited largely rise in luminescence,with decreasing defect ***,with the optimized temperature,the green Pe LEDs exhibited 100-fold improvement of external quantum efficiency(EQE)with the luminance of up to 11941 cd/m2,and the full width at half-maximum(FWHM)of the electroluminescence(EL)spectra was decreased from 25 to 17 *** the same time,the red and blue Pe LEDs also exhibited obvious enhancement in EQE and luminance by HAVD method,and both the FWHM of EL spectra dropped below 20 nm,exhibiting excellent high color *** strategy has a huge potential to be a new commonly used method for low-cost fabrication of displays and lighting.

关键词： all-inorganic perovskites light-emitting diodes heating assisted vacuum deposition Cs Pb Br3 color purity

室温合成具有超纯绿光发射的准二维CsPbBr_(3)钙钛矿纳米片

在线全文

学校读者我要写书评

暂无评论

发光学报 2023年第3期44卷 508-517页

作者：沈亚龙韩博宁靳梓诺胡殷茜曾海波宿迁学院材料工程系江苏宿迁223800 南京理工大学材料科学与工程学院江苏南京210094

通过配体辅助溶液相法,在室温下成功合成出一种具有超纯绿光发射的准二维CsPbBr_(3)钙钛矿纳米片。该制备方法可以实现低成本、高质量CsPbBr_(3)纳米片的合成。实验结果表明,合成出的CsPbBr_(3)纳米片荧光发射峰位于526 nm,发射峰半高宽... 详细信息

通过配体辅助溶液相法,在室温下成功合成出一种具有超纯绿光发射的准二维CsPbBr_(3)钙钛矿纳米片。该制备方法可以实现低成本、高质量CsPbBr_(3)纳米片的合成。实验结果表明,合成出的CsPbBr_(3)纳米片荧光发射峰位于526 nm,发射峰半高宽(FWHM)能够达到16 nm,纳米片的荧光量子效率(PLQY)高达87%。将CsPbBr_(3)纳米片应用于背光显示,实现了(0.145,0.793)的绿光坐标,该色坐标覆盖近91%的Rec.2020绿光色域,色域范围优于目前报道的绿色荧光粉材料。此外,基于上述CsPbBr_(3)荧光纳米片,我们还成功构筑出一种白光LED器件,并测得该器件在20 mA驱动电流下的发光效率为39 lm/W。

关键词： CsPbBr_(3)钙钛矿纳米片超纯绿光白光LED

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

太阳活动周与全球大震

地球科学（中国地质大学学报） 2014年第12期39卷 1857-1863页

作者：林云芳林泊宁陈维升白志强郑吉盎曾小苹中国地震局地球物理研究所北京100081 益正科技震磁关系研究课题组北京102218 北京工业大学地震研究所北京100124 益正科技公司洛杉矶CA91731

为研究太阳活动与全球大震的关系,引入一个无量纲的"地震能量函数√G",并分析研究了1681—2011故年间全球M≥7.0大震的能量释放的时间序列.由此发现全球大震在太阳活动周4个阶段的分布和活动度,随震级的强度而异.提出地壳对太阳风暴加... 详细信息

为研究太阳活动与全球大震的关系,引入一个无量纲的"地震能量函数√G",并分析研究了1681—2011故年间全球M≥7.0大震的能量释放的时间序列.由此发现全球大震在太阳活动周4个阶段的分布和活动度,随震级的强度而异.提出地壳对太阳风暴加卸载响应模式,用于解释此现象:通过考察最近331a,得出全球共发生了10个M≥9.0超级巨震的时空分布特征,特别是太阳活动峰年期间没有发生过超级巨震.该研究结果可为判断全球大震提供参考.

关键词：太阳活动周太阳黑子数地震能量函数超级巨震加卸载响应天然地震