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Risk factors for immediate post-operative fatal recurrence after curative resection of hepatocellular carcinoma

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World Journal of Gastroenterology 2006年第1期12卷 99-104页

作者： bong-wan kim Young-Bae kim Hee-Jung wang Myung-Wook kim Department of Surgery Ajou University School of MedicineWonchon dongYoungtong kuSuwonKyounggi ProvinceSouth Korea Department of Pathology Ajou University School of Medicine.Wonchon dongYoungtong kuSuwonKyounggi ProvinceSouth Korea

AIM： To investigate the clinicopathological risk factors for immediate post-operative fatal recurrence of hepatocellular carcinoma （HCC）, which may have practical implication and contribute to establishing high risk patients for pre- or post-operative preventive measures against HCC recurrence. METHODS： From June 1994 to May 2004, 269 patients who received curative resection for HCC were reviewed. Of these patients, those who demonstrated diffuse intrahepatic or multiple systemic recurrent lesions within 6 mo after surgery were investigated （fatal recurrence group）. The remaining patients were designated as the control group, and the two groups were compared for clinicopathologic risk factors. RESULTS： Among the 269 patients reviewed, 30 patients were enrolled in the fatal recurrence group. Among the latter, 20 patients showed diffuse intrahepatic recurrence type and 10 showed multiple systemic recurrence type. Multivariate analysis between the fatal recurrence group and control group showed that preoperative serum alpha-fetoprotein （AFP） level was greater than 1 000 μg/L （P= 0.02; odds ratio = 2.98）, tumor size greater than 6.5 cm （P= 0.03; OR= 2.98）, and presence of microvascular invasion （P= 0.01; OR=4.89） were the risk factors in the fatal recurrence group. The 48.1% of the patients who had all the three risk factors and the 220 of those who had two risk factors experienced fatal recurrence within 6 mo after surgery. CONCLUSION： Three distinct risk factors for immediate post-operative fatal recurrence of HCC after curative resection are pre-operative serum AFP level 〉 1 000 μg/L,tumor size〉6.5 cm, and microvascular invasion. The high risk patients with two or more risk factors should be the candidates for various adjuvant clinical trials.

关键词： Hepatocellular carcinoma Hepatectomy Early recurrence Risk factors

Risk factor for ischemic-type biliary lesion after ABO-incompatible living donor liver transplantation

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World Journal of Gastroenterology 2016年第30期22卷 6925-6935页

作者： Jun Bae Bang bong-wan kim Young Bae kim Hee-Jung wang Hyun Yeong Lee Joohyun Sim Taegyu kim Kyeong Lok Lee Xu-Guang Hu Wei Mao Department of Liver Transplantation and Hepatobiliary Surgery Ajou University School of Medicine Department of Pathology Ajou University School of Medicine Department of Biostatistics Ajou University School of Medicine

AIM: To evaluate the risk factors for ischemic-type biliary lesion(ITBL) after ABO-incompatible(ABO-I) adult living donor liver transplantation(ALDLT).METHODS: Among 141 ALDLTs performed in our hospital between 2008 and 2014, 27(19%) were ABO-I ALDLT and 114 were ABO-identical/compatible ALDLT. In this study, we extensively analyzed the clinico-pathological data of the 27 ABO-I recipients to determine the risk factors for ITBL after ABO-I ALDLT. All ABO-I ALDLT recipients underwent an identical B-cell depletion protocol with preoperative rituximab, plasma exchange(PE), and operative splenectomy. The median follow-up period after transplantation was 26 mo. The clinical outcomes of the 27 ABO-I ALDLT recipients were compared with those of 114 ABO-identical/compatible ALDLT ***: ITBL occurred in four recipients(14.8%) between 45 and 112 d after ABO-I ALDLT. The overall survival rates were not different between ABO-I ALDLT and ABO-identical/compatible ALDLT(P = 0.303). Among the ABO-I ALDLT recipients, there was no difference between patients with ITBL and those without ITBL in terms of B-cell and T-cell count, serum isoagglutinin titers, number of PEs, operative time and transfusion, use of graft infusion therapy, or number of remnant B-cell follicles and plasma cells in the spleen. However, the perioperative NK cell counts in the blood of patients with ITBL were significantly higher than those in the patients without ITBL(P 150/μL and postoperative NK cell count > 120/μL were associated with greater relative risks(RR) for development of ITBL(RR = 20 and 14.3, respectively, P < 0.05). CONCLUSION: High NK cell counts in a transplant recipient's blood are associated with ITBL after ABO-I ALDLT. Further research is needed to elucidate the molecular mechanism of NK cell involvement in the development of ITBL.

关键词： Liver transplantation ABO-incompatibility Ischemic-type biliary lesion Natural killer cell

Metastatic liver cancer: A rare case

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World Journal of Gastroenterology 2005年第27期11卷 4281-4284页

作者： bong-wan kim Hee-Jung wang In-Ho Jeong Sang-Ick Ahn Myoung-Wook kim Department of Surgery

Hemangioperioltoma is a rare tumor especially when it rises in the peritoneal cavity. We present a case of a 60-year-old woman with an isolated recurrent hemangiopericytoma of the liver. The patient presented with a palpable right upper quadrant abdominal mass, which occurred 7 years after undergoing resection of a malignant hemangiopericytoma arising from the greater omentum. She had not followed up 6 mo after surgery. Various imaging studies showed a single large, well-capsulated liver tumor with central necrosis, accompanied by hypervascularity typical of a vascular tumor. Preoperative laboratory HBsAg and anti-HCV workup were both negative. Under the impression of recurrent malignant hemangiopericytoma, right trisegmentectomy was performed to completely resect the tumor. Pathological examination confirmed the diagnosis of recurrent hemangiopericytoma. Even though the incidence of the hemangiopericytoma is relatively low, malignant hemangiopericytoma has a tendency to recur frequently after a long-term disease-free interval. Also, the recurrent hemangiopericytoma is not easily detected early during follow-up until it becomes symptomatic because there are no specific tumor markers, and because of the diversity with regard to site of recurrence. The authors suggest that Positron Emission Tomogram （PET） may be a useful tool for the detection of recurrent hemangioperioltoma. We describe herein some characteristics and behaviors of malignant hemangiopericytoma, particularly after surgical resection.

关键词： Hemangiopericytoma Greater omentum Hepatic metastasis Follow-up Positron emission tomography

Amylase level in extra hepatic bile duct in adult patients with choledochal cyst plus anomalous pancreatico-biliary ductal union

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World Journal of Gastroenterology 2005年第13期11卷 1965-1970页

作者： In-Ho Jeong Yong-Sik Jung Hong kim bong-wan kim Jung-Woon kim Jeong Hong Hee-Jung wang Myung-Wook kim Byung-Moo Yoo Jin-Hong kim Jae-Ho Han Wook-Hwan kim Department of Surgery Department of Gastroenterology Department of Pathology

AIM: To investigate the relationship between pancreatic amylase in bile duct and the clinico-pathological features in adult patients with choledochal cyst and anomalous pancreatico-biliary ductal union (APBDU).METHODS: From 39 patients who underwent surgery for choledochal cyst between March 1995 and March 2003,we selected 15 adult patients who had some symptoms and were radiologically diagnosed as APBDU, and their clinico-pathological features were subsequently evaluated retrospectively. However, we could not obtain biliary amylase in all the patients because of the surgeon's ***, we measured the amylase level in gall bladder of 10 patients and in common bile duct of 11 ***: Levels of amylase in common bile duct and gall bladder ranged from 11 500 to 212 000 IU/L, and the younger the patients, the higher the biliary amylase level (r= -0.982, P＜0.01). Pathologically, significant correlation was found between the size of choledochal cyst and the grade of inflammation (r= 0.798,P＜0.01). And, significant correlation was found between the level of amylase in gall bladder and the grade of hyperplasia. On the other hand, there was no correlation to the age of symptomatic onset or inflammatory grade (r = 0.743, P＜0.05). Level of lipase was elevated from 6 000 to 159 000 IU/L in bile duct and from 14 400 to 117 000 IU/L in the gall bladder;however, there was no significant correlation with age or clinico-pathological ***: The results support the notion that amylase has a particular role in the onset of symptoms, and suggest that a large amount of biliary amylase induces early onset of symptom, thereby making early diagnosis possible.

关键词： Choledochal cyst Anomalous pancreaticobiliary ductal union Amylase Hyperplasia

New-onset diabetes after adult liver transplantation in the Korean Organ Transplantation Registry (KOTRY) study

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Hepatobiliary Surgery and Nutrition 2020年第4期9卷 425-439页

作者： Jong Man kim Shin Hwang Kwang-Woong Lee Jae-Geun Lee Je Ho Ryu bong-wan kim Dong Lak Choi Young Kyoung You Dong-Sik kim Yang Won Nah Koo Jeong Kang Jai Young Cho Geun Hong In Seok Choi Hee Chul Yu Dongho Choi Myoung Soo kim 无 Department of Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoulSouth Korea Department of Surgery Asan Medical CenterCollege of Medicine University of UlsanSouth Korea Department of Surgery Seoul National University College of MedicineSeoulSouth Korea Department of Surgery Yonsei University College of MedicineSeoulSouth Korea Department of Surgery Pusan National University College of MedicineBusanSouth Korea Department of Liver Transplantation and Hepatobiliary Surgery Ajou University School of MedicineSuwonSouth Korea Department of Surgery Catholic University of Daegu College of MedicineDaeguSouth Korea Department of Surgery College of MedicineCatholic University of KoreaSeoulSouth Korea Division of HBP Surgery and Liver Transplantation Department of SurgeryKorea University College of MedicineSeoulSouth Korea Department of Surgery Ulsan University HospitalUniversity of Ulsan College of MedicineUlsanSouth Korea Department of Surgery Keimyung University School of MedicineDaeguSouth Korea Department of Surgery Seoul National University Bundang HospitalSeoul National University College of MedicineSungnamSouth Korea Department of Surgery Ewha Woman’s University School of MedicineSeoulSouth Korea Department of Surgery Konyang University HospitalDaejonSouth Korea Department of Surgery Chonbuk National University School of MedicineJeonjuSouth Korea Department of Surgery Hanyang University College of MedicineSeoulSouth Korea The Korean Organ Transplantation Registry Study Group

Background:New-onset diabetes after transplantation(NODAT)is a serious complication following liver transplantation(LT).The present study aimed to investigate the incidence of and risk factors for NODAT using the Korean Organ Transplantation Registry(KOTRY)***:Patients with history of pediatric transplantation(age≤18 years),re-transplantation,multi-organ transplantation,or pre-existing diabetes mellitus were excluded.A total of 1,919 non-diabetic adult patients who underwent a primary LT between May 2014 and December 2017 were *** factors were identified using Cox regression ***:NODAT occurred in 19.7%(n=377)of adult liver transplant *** analysis showed steroid use,increased age,and high body mass index(BMI)in recipients,and implantation of a left-side liver graft was closely associated with NODAT in adult *** living donor liver transplant(LDLT)patients(n=1,473),open donor hepatectomy in the living donors,steroid use,small for size liver graft(graft to recipient weight ratio≤0.8),increased age,and high BMI in the recipient were predictive factors for *** use of antimetabolite and basiliximab induction reduced the incidence of NODAT in adult LT and in adult ***:Basiliximab induction,early steroid withdrawal,and antimetabolite therapy may prevent NODAT after adult *** BMI or advanced age in liver recipients,open donor hepatectomy in living donors,and small size liver graft can predict the occurrence of NODAT after adult LT or LDLT.

关键词： Diabetes living donors immunosuppression Asia

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以辅助性肝移植成功治疗血友病1例

以辅助性肝移植成功治疗血友病1例

活体部分肝移植时利用冻藏大动脉片重建流出道

2008年浙江省外科学术年会

作者： Hee-Jung wang bong-wan kim Byong-Ku Bae Department of Surgery and Hematology Ajou University School of Medicine

背景及目的对血友病患者来说,补充凝血因子是控制出血的方法。但是,受到多名供者的感染凝血因子,使得患者对抗病毒感染,肝硬化,肝细胞癌更加脆弱。2007年1月,我们成功的对肝细胞癌合并肝硬化的血友病患者行活体部分肝移植。虽然,没有对...

背景及目的对血友病患者来说,补充凝血因子是控制出血的方法。但是,受到多名供者的感染凝血因子,使得患者对抗病毒感染,肝硬化,肝细胞癌更加脆弱。2007年1月,我们成功的对肝细胞癌合并肝硬化的血友病患者行活体部分肝移植。虽然,没有对无肝硬化及肝细胞癌的血友病患者施行肝移植的报道。可是,我们认为肝移植有可能成为治疗血友病的有效选择。

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活体部分肝移植时利用冻藏大动脉片重建流出道

Aligned Ion Conduction Pathway of Polyrotaxane‑Based Electrolyte with Dispersed Hydrophobic Chains for Solid‑State Lithium–Oxygen Batteries

2008年浙江省外科学术年会

作者： bong-wan kim Byong-Ku Bae Hee-Jung wang Department of Surgery Ajou University School of Medicine

绪论目前,因尸体肝移植供肝不足,而广泛利用肝右叶行活体部分肝移植。在活体部分肝移植时,为了取得适当的肝容积,有必要重建肝中静脉。作者在此介绍利用冻藏大动脉片重建肝右叶流出道的新技术。

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Nano-Micro Letters 2025年第2期17卷 169-186页

作者： Bitgaram kim Myeong‑Chang Sung Gwang‑Hee Lee Byoungjoon Hwang Sojung Seo Ji‑Hun Seo Dong‑wan kim Department of Materials Science and Engineering Korea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea School of Civil Environmental and Architectural EngineeringKorea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea Materials Science and Chemical Engineering Center Institute for Advanced Engineering(IAE)Yongin 17180Republic of Korea

A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety *** study addresses these problems by proposing a modified polyrotaxane(mPR)-based solid polymer electrolyte(SPE)design that simultaneously mitigates solvent-related problems and improves ***-SPE exhibits high ion conductivity(2.8×10^(−3)S cm^(−1)at 25℃)through aligned ion conduction pathways and provides electrode protection ability through hydrophobic chain *** this mPR-SPE into solid-state LOBs resulted in stable potentials over 300 *** situ Raman spectroscopy reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxygen *** situ X-ray diffraction confirm the ability of the SPE to hinder the permeation of oxygen and moisture,as demonstrated by the air permeability *** present study suggests that maintaining a low residual solvent while achieving high ionic conductivity is crucial for restricting the sub-reactions of solid-state LOBs.

关键词： Solid polymer electrolyte Lithium-oxygen batteries Polyrotaxane ion conductivity Hydrophobic chain

Molecules“buckle up”to drive layered hybrid perovskites into single-crystal nanowires in water

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Science China Chemistry 2025年第1期68卷 3-4页

作者： Seokhyoung kim Department of Chemistry Michigan State UniversityEast LansingMI 48824USA

Layered 2D metal halide perovskites(MHPs)are one of the most exciting candidates for next-generation light sources owing to their outstanding optoelectronic *** properties are readily tunable by controlling the halide composition,number of inorganic layers,and the chemistry of organic *** key element that can substantially impact the materials’functionalities is crystal morphology^([1]).

关键词： nanowires perovskite halide