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Paeonol attenuates inflammation-mediated neurotoxicity and microglial activation

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Neural Regeneration Research 2013年第18期8卷 1637-1643页

作者： Kyong Nyon Nam Byung-Cheol Woo Sang-Kwan Moon Seong-Uk Park Joo-young Park Jae-Woong Hwang Hyung-Sup Bae Chang-Nam Ko Eunjoo Hwang lee Graduate School of East-West Medical Science Kyung Hee University Department of Cardiovascular & Neurologic Diseases (Stroke Center) Hospital of Oriental Medicine Kyung Hee University

Chronic activation of microglial cells endangers neuronal survival through the release of various proinflammatory and neurotoxic factors. The root of Paeonia lactiflora Pall has been considered useful for the treatment of various disorders in traditional oriental medicine. Paeonol, found in the root of Paeonia lactiflora Pall, has a wide range of pharmacological functions, including anti-oxidative, anti-inflammatory and neuroprotective activities. The objective of this study was to examine the efficacy of paeonol in the repression of inflammation-induced neurotoxicity and microglial cell activation. Organotypic hippocampal slice cultures and primary microglial cells from rat brain were stimulated with bacterial lipopolysaccharide. Paeonol pretreatment was performed for 30 minutes prior to lipopolysaccharide addition. Cell viability and nitrite （the production of nitric oxide）, tumor necrosis factor-alpha and interleukin-lbeta products were measured after lipopolysaccharide treatment. In organotypic hippocampal slice cultures, paeonol blocked lipopolysaccharide-related hippocampal cell death and inhibited the release of nitrite and interleukin-lbeta. Paeonol was effective in inhibiting nitric oxide release from primary microglial cells. It also reduced the lipopolysaccharide-stimulated release of tumor necrosis factor-alpha and intefleukin-1β from microglial cells. Paeonol possesses neuroprotective activity in a model of inflammation-induced neurotoxicity and reduces the release of neurotoxic and proinflammatory factors in activated microglial cells.

关键词： neural regeneration traditional Chinese medicine brain inflammation interleukin-lbeta microglia neurotoxicity neuroprotection nitric oxide organotypic hippocampal slice culture Paeonia lactifloraPall paeonol tumor necrosis factor-alpha neuroregeneration

East Asian VLBI Network observations of active galactic nuclei jets:imaging with KaVA+Tianma+Nanshan

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Research in Astronomy and Astrophysics 2021年第8期21卷 220-234页

作者： Yu-Zhu Cui Kazuhiro Hada Motoki Kino bong-Won Sohn Jongho Park Hyun-Wook Ro Satoko Sawada-Satoh Wu Jiang Lang Cui Mareki Honma Zhi-Qiang Shen Fumie Tazaki Tao An Ilje Cho Guang-Yao Zhao Xiao-Peng Cheng Kotaro Niinuma Kiyoaki Wajima Ying-Kang Zhang Noriyuki Kawaguchi Juan-Carlos Algaba Shoko Koyama Tomoya Hirota Yoshinori Yonekura Nobuyuki Sakai Bo Xia Yong-Bin Jiang Lin-Feng Yu Wei Gou Ju-Yeon Hwang Yong-Chen Jiang Yun-Xia Sun Dong-Kyu Jung Hyo-Ryoung Kim Jeong-Sook Kim Hideyuki Kobayashi Jee-Won lee Jeong-Ae lee Hua Zhang Guang-Hui Li Zhi-Qiang Xu Peng Li Jung-Hwan Oh Se-Jin Oh Chung-Sik Oh Tomoaki Oyama Duk-Gyoo Roh Katsunori-M.Shibata Wen Guo Rong-Bing Zhao Wei-Ye Zhong Jin-Qing Wang Wen-Jun Yang Hao Yan Jae-Hwan Yeom Bin Li Xiao-Fei Li Jian-Ping Yuan Jian Dong Zhong Chen Kazunori Akiyama Keiichi Asada Do-Young Byun Yoshiaki Hagiwara Jeffrey Hodgson Tae-Hyun Jung Kee-Tae Kim Sang-Sung lee Kunwoo Yi Qing-Hui Liu Xiang Liu Ru-Sen Lu Masanori Nakamura Sascha Trippe Na Wang Xue-Zheng Wang Bo Zhang Department of Astronomical Science The Graduate University for Advanced StudiesSOKENDAI2-21-1 OsawaMitakaTokyo 181-8588Japan Mizusawa VLBI Observatory National Astronomical Observatory of Japan2-12 HoshigaokaMizusawaOshuIwate 023-0861Japan Kogakuin University of Technology and Engineering Academic Support Center2665-1 NakanoHachiojiTokyo 192-0015Japan Korea Astronomy and Space Science Institute Yuseong-guDaejeon 34055Korea Department of Astronomy Yonsei University50 Yonsei-roSeodaemun-guSeoul 03722Korea Department of Astronomy and Space Science University of Science and Technology217 Gajeong-roDaejeonKorea Institute of Astronomy and Astrophysics Academia Sinica645 N Aohoku PIHiloHI 96720USA Graduate School of Sciences and Technology for Innovation Yamaguchi UniversityYoshida 1677-1YamaguchiYamaguchi 753-8512Japan Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210008China Institute of Astronomy The University of Tokyo2-21-1 OsawaMitakaTokyo 181-0015Japan Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomia s/nGranada E-18008Spain Department of Physics Faculty of ScienceUniversity of MalayaKuala Lumpur 50603Malaysia Center for Astronomy Ibaraki University2-1-1 BunkyoMitoIbaraki 310-8512Japan Space Light Laboratory 77Yangjaedae-ro 86 roadGangdong-guSeoulKorea Massachusetts Institute of Technology Haystack Observatory 99 Millstone RoadWestfordMA 01886USA National Radio Astronomy Observatory 520 Edgemont RdCharlottesvilleVA 22903USA Toyo University 5-28-20 HakusanBunkyo-kuTokyo 112-8606Japan Department of Physics and Astronomy Seoul National UniversityGwanak-guSeoul 08826Korea Max Planck Institute for Radio Astronomy Auf dem hiigel 69Bonn 53121Germany SNU Astronomy Research Center Seoul National UniversityGwanak-guSeoul 08826Korea

The East Asian Very Long Baseline Interferometry(VLBI) Network(EAVN) is a rapidly evolving international VLBI array that is currently promoted under joint efforts among China,Japan and *** aims at forming a joint VLBI Network by combining a large number of radio telescopes distributed over East Asian *** the combination of the Korean VLBI Network(KVN) and the VLBI Exploration of Radio Astrometry(VERA) into Ka VA,further expansion with the joint array in East Asia is actively *** we report the first imaging results(at 22 and 43 GHz) of bright radio sources obtained with Ka VA connected to Tianma 65-m and Nanshan 26-m Radio Telescopes in *** test the EAVN imaging performance for different sources,we observed four active galactic nuclei(AGN) having different brightness and *** a result,we confirmed that the Tianma 65-m Radio Telescope(TMRT) significantly enhances the overall array sensitivity,a factor of 4 improvement in baseline sensitivity and 2 in image dynamic range compared to the case of Ka VA *** addition of the Nanshan 26-m Radio Telescope(NSRT) further doubled the east-west angular *** the resulting high-dynamic-range,high-resolution images with EAVN(Ka VA+TMRT+NSRT),various fine-scale structures in our targets,such as the counter-jet in M87,a kink-like morphology of the 3 C 273 jet and the weak emission in other sources are successfully *** demonstrates the powerful capability of EAVN to study AGN jets and to achieve other science goals in *** expansion of EAVN will further enhance the angular resolution,detection sensitivity and frequency coverage of the network.

关键词： galaxies:active galaxies:jets instrumentation:interferometers radio continuum:galaxies

共面转换液晶显示器中获得对比度高于1:600的新技术

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现代显示 2004年第5期 31-33页

作者： Jae Hyun Kim Joun Ho lee Ji Chul Lim Chang Hoon lee Moo Hyoung Song Ju Yeon Yoon hee Dong Choi Jeom Jae Kim Chang Ho Oh Sang Deog Yeo 李路海 LG菲利普液晶显示电视开发部乐凯胶片厂

薄膜晶体管液晶电视(TFT-LCDTV)因为具有薄、轻、紧凑和可随意放置的特点,已经占据了大部分电视机市场。除了这些物理特性以外,最重要的特性是已具有了良好像质的对比度。为了将对比度提高到1:600以上,对偏振片膜、背光源板、滤色片树... 详细信息

薄膜晶体管液晶电视(TFT-LCDTV)因为具有薄、轻、紧凑和可随意放置的特点,已经占据了大部分电视机市场。除了这些物理特性以外,最重要的特性是已具有了良好像质的对比度。为了将对比度提高到1:600以上,对偏振片膜、背光源板、滤色片树脂、电极锥角和摩擦条件等都进行了研究。优化的背光板组合,光滑的电极锥角和摩擦方法的控制是提高对比度的主要控制因素。应用新开发的滤色片树脂,对获得高对比度最为有效。

关键词：高对比度共面转换液晶显示器薄膜晶体管背光 TFT-LCD 滤色片光板偏振片紧凑

Effect of Eucommia ulmoides on Longitudinal Bone Growth Rate in Rats

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Effect of Eucommia ulmoides on Longitudinal Bone Growth Rate...

Experimental and thermodynamic investigations on MnO-SiO_2-Al_2O_3-MnS system

第十四届全国中药和天然药物学术研讨会

作者： Hyun Soo Kim Hyun Jeong lee Donghun lee Jungbin Song Hocheol Kim Kyung hee University

＜正＞Eucommia ulmoides is one of the popular tonic herbs to treat of back pain and bone fracture and reinforce muscles and bones in the traditional Korean *** study was performed to investigate the effect of *** on longitudinal bone growth ***（30 and 100 mg/kg,p.o.）was orally administered to adolescent female rats twice per

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Baosteel Technical Research 2010年第S1期4卷 23-页

作者： Youn-Bae KANG Dae-hee WOO Ye-Jin KIM Henri GAYE Hae-Geon lee Graduate Institute of Ferrous Technology Pohang University of Science and Technology Pohang790-784Rep.of Korea

MnO-SiO_2-Al_2O_3-MnS oxysulfide system has been investigated by experimental phase diagram and activity measurement coupled with thermodynamic *** equilibria of the MnO-MnS,MnO-SiO_2-MnS, MnO-Al_2O_3-MnS and MnO-SiO_2-Al_2O_3-MnS systems under low oxygen partial pressure have been experimentally investigated for the temperature range of 1 185 to 1 500℃using equilibration and quenching techniques. Equilibrium phases were analyzed by scanning electron microscope,electron probe X-ray microanalysis(EPMA), and differential thermal analysis(DTA ).Phase diagrams were successfully constructed for the systems *** ternary compounds in the MnO-SiO_2-MnS system were *** of MnO and MnS in MnO-SiO_2-Al_2O_3-MnS liquid oxysulfide solution from very low sulfur concentration to high sulfur concentration at solid MnS saturation were investigated employing gas/liquid/Pt - Mn alloy under controlled atmosphere at 1 500℃.As X(SiO_2)/(X(MnO) + X(SiO_2)) increases in liquid oxysulfide solution,activity coefficient of MnO decreases while that of MnS *** X(AlO_(1.5)) increases,the activity coefficient of MnS increases while no remarkable change was observed for the activity coefficient of *** analysis of the thermodynamic properties of the oxysulfide solution as well as phase diagram of the system was also earned out by employing the Modified Quasichemical Model in the quadruplet *** view of inclusion utilization for free - cutting steel,it might have an advantage to decrease the Al_2O_3 content and increase the MnO/SiO_2 ratio.

关键词： MnO-SiO_2-Al_2O_3-MnS oxysulfide phase diagram activity thermodynamics inclusion

IoTFLiP： IoT-based flipped learning platform for medical education

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Digital Communications and Networks 2017年第3期3卷 188-194页

作者： Maqbool Ali Hafiz Syed Muhammad Bilal Muhammad Asif Razzaq Jawad Khan Sungyoung lee Muhammad Idris Mohammad Aazam Taebong Choi Soyeon Caren Han Byeong Ho Kang Department of Computer Science and Engineering Kyung Hee University Yongin 446-701 Republic of Korea IT4BI Universite Libre de Bruxelles Belgium Carleton University Canada Hanwha Systems as Senior Manager Communication PM Team Seongnam 13524 Republic of Korea School of Engineering and ICT Uniuersity of Tasmania Hobart Tasmania 7005 Australia

Case-Based Learning （CBL） has become an effective pedagogy for student-centered learning in medical education, which is founded on persistent patient cases. Flippped learning and Internet of Things （IoTs） concepts have gained significant attention in recent years. Using these concepts in conjunction with CBL can improve learning ability by providing real evolutionary medical eases. It also enables students to build confidence in their decision making, and efficiently enhances teamwork in the learning environment. We propose an IoT-based Flip Learning Platform, called IoTFLiP, where an IoT infrastrneture is exploited to support flipped case-based learning in a cloud environment with state of the art security and privacy measures for personalized medical data. It also provides support for application delivery in private, public, and hybrid approaches. The proposed platform is an extension of our Interactive Case-Based Flipped Learning Tool （ICBFLT）, which has been developed based on current CBL practices. ICBFLT formulates summaries of CBL cases through synergy between students＇ and medical expert knowledge. The low cost and reduced size of sensor device, support of IoTs, and recent flipped learning advancements can enhance medical students＇ academic and practical experiences. In order to demonstrate a working scenario for the proposed IoTFLiP platform, real-time data from IoTs gadgets is collected to generate a real-world case for a medical student using ICBFLT.

关键词： Internet of things Cloud environment Flipped learning Case-based learning Medical education

Clinical application of traditional herbal medicine in five countries and regions: Japan;South Korea;China's Mainland;Hong Kong, China;Taiwan, China

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Journal of Traditional Chinese Medical Sciences 2015年第3期2卷 140-149页

作者： Liming Chen Yanling Fu Lin Zhang Sijia Zhao Qing Feng Yihua Cheng Tosha Yanai Daji Xu Mingyu Luo Sang Woo An Woong Seok lee Seong Hoon Cho Byung Wook lee Beijing University of Chinese Medicine Beijing 100029China Dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100029China School of Chinese Medicine Hong Kong Baptist UniversityHong Kong SAR 999077China Chia-Ho Chinese Medicine Clinic Taipei 11271TaiwanROC Korean Institute of Oriental Medicine SeoulRepublic of Korea College of Oriental Medicine Kyung Hee UniversitySeoulRepublic of Korea School of Korean Medicine Pusan National UniversityYangsanRepublic of Korea

Objective:To study the characteristics of the clinical application of traditional herbal medicine in five countries and regions where traditional medicine(TM)is widely used:Japan;South Korea;China's Mainland;Hong Kong,China;Taiwan,*** to analyze,from multiple angles,the variations in the methods of TM used in each countries and ***:Fifty commonly used traditional herbs(TOP50)from classical formulae were selected,and descriptive statistics,correlation analyses,and Friedman test were used to compare methods of clinical application and dosages in the countries and regions of interest based on a retrospective review of randomly-selected medical ***:There were significant differences in sequencing TOP50 among the five countries and regions(P<.01).The adherence to the classical formulae,from strong to weak was Japan;China's Mainland;Taiwan,China;Hong Kong,China;South *** were also significant differences in TOP50 dosing regimens(P<.01).Overall dosages of TOP50 from high to low were:China's Mainland;Hong Kong,China;Taiwan,China;South Korea;***,there were significant differences in the dosage intervals(P<.01),with dosage intervals from maximum to minimum as follows:China's Mainland;Taiwan,China;Hong Kong,China;South Korea;***:The clinical dosages of traditional herbal medicine used in the China's Mainland are relatively large compared with those prescribed in the other four countries and regions,and the range of dosages in China's Mainland is more *** the other hand,clinical dosages of TOP50 are the lowest in Japan,where the dosage range is also the narrowest,supporting the idea that Doctors of Kampo medicine are highly cautious and are likely to adhere strictly to classical formulae,while Hong Kong,China and Taiwan,China are in the *** dosage of TOP50 in South Korea is significantly lower than that used in the China's Mainland;Hong Kong,China and Taiwan,China where the adherence to the classical f

关键词： Traditional herbal medicine Dosage Classical formulae China's Mainland Japan South Korea

Traditional Chinese medicine in psychiatry： the fruit-basket-problem

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Journal of Integrative Medicine 2016年第4期14卷 239-240页

作者： Peggy Bosch Peter de Rover Sujung Yeo Sook-Hyun lee Sabina Lim Maurits van den Noort Donders Center for Cognition Radboud University Nijmegen 6525 HR Nijmegen The Netherlands Psychiatric Research Institute LVR-Klinik Bedburg-Hau 47551 Bedburg-Hau Germany Division of Acupuncture & Meridian WHO Collaborating Center for Traditional Medicine East-West Medical Research Institute and School of Korean Medicine Kyung Hee University Seoul 130-701Korea Karel de Grote Hoge School 2018 Antwerp Belgium Department of Acupuncture & Meridian of Oriental Medicine Sang Ji University Wonju 26339 Korea Brussels Institute for Applied Linguistics Free University of Brussels 1050 Brussels Belgium

Traditional Chinese medicine （TCM） is gaining popularity in the treatment of psychiatric disorders that can be described and treated from either an Eastern or a Western perspective. In Eastern medicine, the disorders are described according to five diagnostic methods that are used in TCM： inspection, auscultation, olfaction, inquiry, and palpation, including tongue and pulse diagnosis.

关键词： medicine Chinese traditional diagnostic methods psychiatry

Effect of the Aerial Part of Glechoma grandis Kuprianova *** Kitagawa on Wound Healing in Scalded Rat

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Effect of the Aerial Part of Glechoma grandis Kuprianova ***...