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Protective effects of a polymethoxy flavonoids-rich Citrus aurantium peel extract on liver fibrosis induced by bile duct ligation in mice

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Asian Pacific Journal of Tropical Medicine 2016年第12期9卷 1135-1141页

作者： Seol-Wa Lim Dong-Ryung Lee bong-Keun choi Hong-Suk Kim Seung Hwan Yang Joo-Won Suh kyung Soo Kim Graduate School of Biomedicine & Health Sciences Catholic University Nutra Pharm Tech Interdisciplinary Program of Biomodulation Myongji University Department of Biotechnology Chonnam National University Center for Nutraceutical and Pharmaceutical Materials Myongji University

Objective: To evaluate the possible protective effect of Citrus aurantium peel extract(CAE) against apoptosis in cholestatic liver fibrosis induced by bile duct ligation in mice. Methods: Male ICR mice were divided to 5 groups: 1) Control group(Sham-operated mice), 2) Cholestatic liver injury group induced by bile duct ligation(BDL), 3) BDL mice treated with silymarin(200 mg/kg) for 4 weeks, 4) BDL mice treated with 50 mg/kg CAE for 4 weeks, 5) BDL mice treated with 200 mg/kg CAE for 4 weeks. Mice were sacrificed and liver fibrosis was evaluated by serum and hepatic tissue biochemistry tests and liver histopathological examination. Effects of CAE on inflammation and apoptosis gene regulation were investigated through real-time PCR. CAE effect on lipid metabolism related signaling was determined by western blot analysis. Results: In BDL mice, administration of CAE for 4 weeks markedly attenuated liver fibrosis based on histopathological alteration. Serum and hepatic tissue biochemistry results revealed that CAE(50 and 200 mg/kg) decreased the levels of alanine transaminase, aspartate transaminase, gamma glutamyl transferase, total bilirubin, nitric oxide, and thiobarbituric acid reactive substances. Real-time PCR and western blot analysis showed that CAE regulated inflammation, apoptosis, and lipid metabolism factors increased by BDL. Interleukin family, tumor necrosis factor α, and related apoptosis factors m RNA levels were increased by BDL treatment. However, these increases were suppressed by CAE administration. In addition, CAE effectively increased phosphorylation of AMPactivated protein kinase, nuclear factor E2-related factor 2, and related cytoprotective proteins. Conclusions: CAE can efficiently regulate BDL-induced liver injury with antioxidant, antiinflammatory, and antiapoptotic activities.

关键词： Liver injury Bile duct ligation Cholestasis Citrus aurantium peel extract Hepatic fibrosis

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Effects of Annealing and Removal of the Water-Soluble Fraction of Dry-Milled Rice Flour on the Texture of Cooked Rice Noodles

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Food and Nutrition Sciences 2017年第10期8卷 889-900页

作者： Soo Young choi bong kyung Koh Department of Food and Nutrition Keimyung University Dalsuh Gu Dae Gu Korea

Rice noodles were prepared using dry-milled rice flours, which were treated by annealing and removing the water-soluble fraction to improve the quality of noodles without using chemical additives. The combined treatment (TC) with annealing and water-soluble fraction removal decreased the cooking losses for Goamibyeo but not for Chenmaai and Milyang260, which had soft kernels and contained less damaged starch than the hard kernel rice after milling. TC significantly reduced the hardness and adhesiveness of cooked noodles, and increased the cohesiveness according to the texture profile analysis. A sensory evaluation detected an increase in mouth feel firmness and elasticity of cooked TC noodles. These results indicate that annealing at room temperature for 3 h followed by the removal of the water-soluble fraction is effective for reducing the cooking losses and improving the textural properties of noodles made from rice flour with high starch damage.

关键词： Annealing Cooking Lose Rice Noodle Texture Water Soluble Fraction

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Effect of Oxide Assisted Metal Nanoparticles on Microstructure and Morphology of Gallium oxide Nanowires

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材料科学与工程学报 2007年第6期25卷 886-891页

作者： Kyo-Hong choi Kwon-Koo CHO Gyu-bong CHO Hyo-Jun AHN Ki-Won KIM Yoo-Young KIM School of Nano & Advanced Materials Engineering ERI & i-cube centerGyeongsang National University900 GazwadongJinjuGyeongnam 660-701Korea Dept.of Mechanical Engineering Jinju National UniversityJinjuKorea

Several researches have been reported about the characteristic of β-Ga_2O_3 nanowires which was synthesized on nickel oxide *** indeed,recent researches about synthesis of β-Ga_2O_3 nanowires on oxide-assisted transition metal are limited to nickel or cobalt oxide *** this work,Gallium oxide(β-Ga_2O_3)nanowires were synthesized by a simple thermal evaporation method from gallium powder in the range of 700-1000℃ using the iron,nickel,copper,cobalt and zinc oxide as a catalyst,*** β-Ga_2O_3 nanowires with single crystalline without defects were successfully synthesized at the reaction temperature of 850,900 and 950℃ in all the *** optimum experimental condition in synthesis of nanowires varied with the kind of *** increasing synthesis temperature,the morphology of gallium oxide nanowires changed from nanowires to nanorods,and its diameter *** these results,we could be proposed that the growth mechanism of β-Ga_2O_3 nanowires was changed with synthesis temperature of *** and morphology of Synthesized nanowire was characterized by HR-TEM,FE-SEM,EDX and XRD.

关键词：金属纳米粒子显微结构镓氧化物形态学

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Enzyme-amplified SERS immunoassay with Ag-Au bimetallic SERS hot spots

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Nano Research 2020年第12期13卷 3338-3346页

作者： Xuan-Hung Pham Eunil Hahm Tae Han Kim Hyung-Mo Kim Sang Hun Lee Sang Chul Lee Homan Kang Ho-Young Lee Dae Hong Jeong Hak Soo choi bong-Hyun Jun Department of Bioscience and Biotechnology Konkuk UniversitySeoul143-701Republic of Korea Department of Nuclear Medicine Seoul National University Bundang HospitalSeongnam13620Republic of Korea Gordon Center for Medical Imaging Department of RadiologyMassachusetts General Hospital and Harvard Medical SchoolBostonMA02114USA Department of Chemistry Education Seoul National UniversitySeoul151-742Republic of Korea

Surface-enhanced Raman scattering(SERS)enables rapid detection of single molecules with high ***,quantitative and sensitive SERS analysis has been a challenge due to the lack of reliable SERS-active *** this study,we developed a quantitative SERS-based immunoassay using enzyme-guided Ag growth on Raman labeling compound(RLC)-immobilized gold nanoparticle(Au NP)-assembled silica NPs(SiO2@Au-RLC@Ag).The enzyme amplified Ag+reduction as well as Ag growth on the RLC-immobilized Au NP-assembled silica NPs(SiO2@Au-RLC),which resulted in a significant increase in SERS *** the presence of target antigens such as immunoglobulinG(IgG)or prostate-specific antigen(PSA),Ab1-Antigen-Ab2 immune complex with alkaline phosphatase triggered an enzyme-catalyzed reaction to convert 2-phospho-L-ascorbic acid(2-phospho-L-AA)to ascorbic acid(AA).As produced AA reduced Ag+to Ag,forming an Ag hot spot on the surface of SiO2@Au-RLC,which enhanced the SERS signal of SiO2@Au-RLC@Ag in a solution with a target antigen *** plasmonic immunoassay for IgG detection showed a high linearity of SERS intensity in the range of 0.6 to 9.0 ng/mL with a detection limit(LOD)of 0.09 ng/mL,while an LOD of 0.006 ng/mL was obtained for *** results indicate that the sensitivity of our novel SERS-based immunoassay is higher than that of conventional enzyme-based colorimetric immunoassays.

关键词： surface-enhanced Raman scattering(SERS)-based immunoassay Au-Ag alloy surface-enhanced Raman scattering silica template immunoglobulin G(IgG)detection

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Monascus pilosus-fermented black soybean inhibits lipid accumulation in adipocytes and in high-fat diet-induced obese mice

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Asian Pacific Journal of Tropical Medicine 2015年第4期8卷 276-282页

作者： Young-Sil Lee bong-Keun choi Hae Jin Lee Dong-Ryung Lee Jinhua Cheng Won-Keun Lee Seung Hwan Yang Joo-Won Suh Center for Nutraceutical and Pharmaceutical Materials Myongji University Interdisciplinary Program of Biomodulation Myongji University Division of Bioscience and Bioinformatics College of Natural ScienceMyongji University

Objective:To explore the anti-obesity effects and the mechanism of action of Monascus pilosus(***)-fermented black soybean(MFBS)extracts(MFBSE)and MFBS powders(MFBSP)in adipocytes and high-fat diet(HFD)-induced obese mice,***:Black soybean was fermented with ***,and the main constituents in MFBS were analyzed by HPLC *** vitro,MFBSE were examined for anti-adipogenic effects using Oil-Red O *** vivo,mice were fed a normal-fat diet(NFD)control,HFD control or HFD containing 1 g/kg MFBSP for 12 weeks,and then body weight gain and tissues weight ***-time PCR and western blot assay were used to determine the mechanism of anti-adipogenic ***:MFBSE inhibited lipid accumulation in 3T3-L1 adipocytes without exerting cell *** treatment in HFD-fed mice significantly decreased the body weight gain compared with the HFD control *** and MFBSP treatment resulted in significantly lower mRNA levels of adipogenesis-related genes,such as peroxisome proliferator-activated receptorγ(PPARγ),fatty acid-binding protein 4(FABP4),and fatty acid synthase(FAS),in adipocytes and in white adipose tissue(WAT)of HFD-induced obese ***:These results suggest that the anti-obesity effects of MFBS are elicited by regulating the expression of adipogenesis-related genes in adipocytes and WAT of HFDinduced obese mice.

关键词： Monascus pilosus Black soybean Adipocytes High-fat diet-induced obese mice Anti-obesity Adipogenesis-related genes

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Low-intensity treadmill exercise and/or bright light promote neurogenesis in adult rat brain

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Neural Regeneration Research 2013年第10期8卷 922-929页

作者： Sung Jin Kwon Jeongsook Park So Yun Park Kwang Seop Song Sun Tae Jung So bong Jung Ik Ryeul Park Wan Sung choi Sun Ok Kwon Department of Physical Education Gyeongsang National University Department of Anatomy and Neurobiology Medical Research Center for Neural DysfunctionInstitute of Health ScienceSchool of MedicineGyeongsang National University Department of Liberal Arts Gyeongnam National University of Science and Technology

The hippocampus is a brain region responsible for learning and memory functions. The purpose of this study was to investigate the effects of low-intensity exercise and bright light exposure on neurogenesis and brain-derived neurotrophic factor expression in adult rat hippocampus. Male Sprague-Dawley rats were randomly assigned to control, exercise, light, or exercise ＋ light groups （n = 9 per group）. The rats in the exercise group were subjected to treadmill exercise （5 days per week, 30 minutes per day, over a 4-week period）, the light group rats were irradiated （5 days per week, 30 minutes per day, 10 000 Ix, over a 4-week period）, the exercise ＋ light group rats were subjected to treadmill exercise in combination with bright light exposure, and the control group rats remained sedentary over a 4-week period. Compared with the control group, there was a significant increase in neurogenesis in the hippocampal dentate gyrus of rats in the exercise, light, and exercise ＋ light groups. Moreover, the expression level of brain-derived neurotrophic factor in the rat hippocampal dentate gyrus was significantly higher in the exercise group and light group than that in the control group. Interestingly, there was no significant difference in brain-derived neurotrophic factor expression between the control group and exercise ＋ light group. These results indicate that low-intensity treadmill exercise （first 5 minutes at a speed of 2 m/min, second 5 minutes at a speed of 5 m/min, and the last 20 minutes at a speed of 8 m/min） or bright-light exposure therapy induces positive biochemical changes in the brain. In view of these findings, we propose that moderate exercise or exposure to sunlight during childhood can be beneficial for neural development.

关键词： neural regeneration neurogenesis neurorehabilitation exercise bright light brain-derivedneurotrophic factor hippocampus childhood grants-supported paper neuroregeneration

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Lanthanide-Activated Fiber Materials for Broadband Optical Amplifiers

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光学学报 2003年第S1期23卷 74-75页

作者： Yong Gyu choi bong Je Park Doo Hee Cho Hong Seok Seo Myung Hyun Lee Kyong Hon Kim Electronics and Telecommunications Research Institute (ETRI) Daejeon Republic of Korea

Some intra-4/-configurational transitions of lanthanide, of which radiative emissions cover in wavelengths the optical communication window of the currently available OH-free silica-based line fibers, are discussed in... 详细信息

关键词： Optical Amplifiers optical communication emission properties

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Generation of induced secretome from adipose-derived stem cells specialized for disease-specific treatment:An experimental mouse model

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World Journal of Stem Cells 2020年第1期12卷 70-86页

作者： Ok-Hee Kim Ha-Eun Hong Haeyeon Seo bong Jun Kwak Ho Joong choi Kee-Hwan Kim Joseph Ahn Sang Chul Lee Say-June Kim Catholic Central Laboratory of Surgery Institute of Biomedical IndustryCollege of Medicinethe Catholic University of KoreaSeoul 06591South Korea Department of Surgery Division of Hepato-biliary Pancreatic SurgerySeoul St.Mary’s HospitalCollege of Medicinethe Catholic University of KoreaSeoul 06591South Korea Department of Surgery Uijeongbu St.Mary's HospitalCollege of Medicinethe Catholic University of KoreaSeoul 11765South Korea Department of Surgery Daejeon St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 34943South Korea

BACKGROUND Recently,the exclusive use of mesenchymal stem cell(MSC)-secreted molecules,named as the secretome,have been evaluated for overcoming the limitations of cell-based therapy while maintaining its *** To improve cell-free therapy by adding disease-specificity through stimulation of MSCs using disease-causing *** We collected the secretory materials(named as inducers)released from AML12 hepatocytes that had been pretreated with thioacetamide(TAA)and generated the TAA-induced secretome(TAA-isecretome)after stimulating adipose-derived stem cells with the *** TAA-isecretome was intravenously administered to mice with TAA-induced hepatic failure and those with partial *** TAA-isecretome infusion showed higher therapeutic potential in terms of(1)restoring disorganized hepatic tissue to normal tissue;(2)inhibiting proinflammatory cytokines(interleukin-6 and tumor necrosis factor-α);and(3)reducing abnormally elevated liver enzymes(aspartate aminotransferase and alanine aminotransferase)compared to the naïve secretome infusion in mice with TAA-induced hepatic ***,the TAA-isecretome showed inferior therapeutic potential for restoring hepatic function in partially hepatectomized *** analysis of TAA-isecretome identified that antioxidant processes were the most predominant enriched biological networks of the proteins exclusively identified in the *** addition,peroxiredoxin-1,a potent antioxidant protein,was found to be one of representative components of TAA-isecretome and played a central role in the protection of TAA-induced hepatic *** Appropriate stimulation of adipose-derived stem cells with TAA led to the production of a secretome enriched with proteins,especially peroxiredoxin-1,with higher antioxidant *** results suggest that appropriate stimulation of MSCs with pathogenic agents can lead to the production of a secretome specialized for protecting agains

关键词： Adipose-derived stem cells Disease-specificity Mesenchymal stem cells Secretome Peroxiredoxin-1 Thioacetamide Toxic hepatic failure

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An Evaluation of the Machinability of Nitinol SMA Using Combined Process of EP and MR Polishing

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Journal of Iron and Steel Research International 2012年第S2期19卷 629-632页

作者： HA Seok-Jae SHIN bong-Cheol CHO Myeong-Woo LEE Eun-Sang choi Seung-Bok Department of Mechanical Engineering Inha University Samsung Electro-Mechanics

Nitinol,a shape memory alloy(SMA),is manufactured from titanium and *** is employed in various fields for use in devices such as micro sensors,ultra-precision devices and satellite *** is highly recommended as a material in medical stents for insertion into the body because it has excellent organic ***,because they are intended to be inserted into the human body,products such as medical stents require a high-quality *** nitinol has more of the characteristics of titanium than of nickel,one of its drawbacks is that heat generated in nitinol during machining is not discharged smoothly,leading to areas of inner stress which occur when traditional machining methods are *** overcome this difficulty,various non-traditional machining methods,including non-contact machining,have been investigated for use with *** study is focused on the application of an effective fabrication method that combines electrolytic polishing(EP)and MR polishing to improve the surface integrity of nitinol through a series of *** roughness variations of the polished nitinol were investigated by changing the imposed polishing conditions of EP and MR polishing,***,the variations in the surface roughness were observed with polished previously performed via the EP process.

关键词： electrolytic polishing(EP) magnetorheological(MR)fluids Ni-Ti alloy shape memory alloy(SMA) surface roughness

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Inhibition of Proliferation of Prostate Cancer Cell Line DU-145 in vitro and in vivo Using Salvia miltiorrhiza Bunge

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Chinese Journal of Integrative Medicine 2020年第7期26卷 533-538页

作者： Woong Jin Bae Jin bong choi Kang Sup Kim U Syn Ha Sung Hoo Hong Ji Youl Lee Tae-Kon Hwang Sung Yeoun Hwang WANG Zhi-ping Sae Woong Kim Department of Urology The Catholic University of KoreaCollege of MedicineSeoul(06591)Republic of Korea Catholic Integrative Medicine Research Institute College of MedicineThe Catholic University of KoreaSeoul(06591)Republic of Korea Korea Bio-Medical Science Institute Seoul(06106)Republic of Korea Department of Urology Second Hospital of Lanzhou UniversityLanzhou(730030)China

Objective:To investigate the antiproliferative activity of Salvia miltiorrhiza Bunge.(SM)on the castration-resistant prostate cancer(CRPC)cell line DU-145 in vitro and in ***:Prostate cancer cell line(DU-145)and normal prostate cell line(RWPE-1)were treated with SM at different concentrations(3.125,12.5,25 and 50μg/mL)to investigate the antiproliferative *** laddering analysis was performed to investigate the apoptosis of DU-145 *** mechanism was investigated by Western blot analysis of p53,Bcl-2,prostate specific antigen(PSA),and androgen receptor(AR).Six-week-old male BALB/c nude mice were randomly divided into normal control group(n=101)and treated group(n=101)which administered 500 mg/kg SM for 2 *** volumes were ***:Treatment with SM resulted in a dose-dependent decrease in cell number of DU-145 cells in comparison with *** laddering analysis indicated the apoptosis of DU-145 *** with SM increased the expression of p53 and reduced the expression of Bcl-2 *** levels of PSA were considerably reduced in SM-treated group compared to the controls,and a decrease in AR expression was observed when cells were treated with SM in the same pattern as a reduction in *** the tumour xenograft study,SM given once a day for 2 weeks significantly inhibited tumour ***:SM might contribute to the anticancer actions such as induction of apoptosis and inhibition of proliferation of prostate cancer cells.

关键词： apoptosis prostate cancer Salvia miltiorrhiza Bunge Chinese medicine

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