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细胞浆内精子注射受孕、体外授精受孕、自然受孕出生的儿童5岁时结局的国际合作研究:认知和运动能力评价

世界核心医学期刊文摘（儿科学分册） 2006年第11期2卷 41-43页

作者： Ponjaert-Kristoffersen I bonduelle m. Barnes J. A.G. Sutcliffe 王经纬 Royal Free and University College m.dical School University College London NW3 2PF United Kingdom Dr.

Objective. To date, very few studies have been conducted on the neurodevelopm.ntal well-being of children conceived through intracytoplasm.c sperm.injection (ICSI). The lim.tations of these studies often include a lack of com.arison with a dem.graphically m.tched, naturally conceived (NC) group and the investigation of only very young children, with relatively sm.ll sam.les sizes. One study showed that there were no differences in IQ scores am.ng ICSI-conceived, in vitro fertilization (IVF)-conceived, and NC children at 5 years of age. Unfortunately, psychom.tor developm.nt was not assessed in that study. Because findings regarding these children’s cognitive and m.tor developm.nt are inconclusive, the aim.of this study was to shed m.re light on the cognitive and m.tor developm.nt of 5-year-old ICSI-conceived children. m.thods. A total of 511 ICSI-conceived children were com.ared with 424 IVF-conceived children and 488 NC controls. Children were recruited in 5 European countries, ie, Belgium. Denm.rk, Greece, Sweden, and the United Kingdom. Participation rates ranged from.45%to 96%in the ICSI and IVF groups and from.34%to 78%in the NC group. Cognitive and m.tor developm.nt was assessed with the Wechsler Preschool and Prim.ry Scale of Intelligence-Revised (WPPSI-R) and m.Carthy Scales of Children’s Abilities (m.CA) m.tor Scale, respectively. The WPPSI-R consists of 2 m.jor scales, ie, Verbal and Perform.nce, each including 6 subtests. The 6 Perform.nce Scale subtests are object assem.ly, geom.tric design, block design, m.zes, picture com.letion, and anim.l pegs. The 6 Verbal Scale subtests are inform.tion, com.rehension, arithm.tic, vocabulary, sim.larities, and sentences. Scores on the Perform.nce and Verbal Scale subtests are sum.ed to yield the perform.nce IQ (PIQ) and verbal IQ (VIQ), respectively. Scores on both the Perform.nce Scale and the Verbal Scale yield the full scale IQ (FSIQ). IQ scales have a m.an score of 100 and a SD of 15. Each subtest has a m.an sco

关键词：体外授精细胞浆国际合作研究操作量表生殖技术精神运动发育儿童认知人口统计学样本量无显

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