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NO-cGMP-K channel-dependent anti-nociceptive activities of methanol stem bark extract of Piptadeniastrum africanum(Mimosaceae) on rats

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Asian Pacific Journal of Tropical Biomedicine 2018年第3期8卷 150-159页

作者： Mbiantcha Marius Almas Jabeen Ateufack Gilbert Shabana u.Simjee bomba tatsink.u francis desire Nida Dastagir Laboratory of Animal Physiology and Phytopharmacology Faculty of Science University of Dschang Dr.Panjwani Center for Molecular Medicine and Drug Research International Center for Chemical and Biological Sciences University of Karachi H.E.J.Research Institute of Chemistry International Center for Chemical and Biological Sciences University of Karachi

Objective: To explore anti-hyperalgesic properties of methanol extract of Piptadeniastrum africanum stem bark(PAME) and it possible action mechanism. Methods: PAME was tested on carrageenan ?induced hyperalgesia using plantar test(thermal) and analgesymeter(mechanical) in rats, on prostaglandin E_2(PGE_2) induced mechanical hyperalgesia and vincristine induced neuropathic pain in rat, both with analgesymeter. Modulators of NO/cG MP/K^+ channel pathway and endogenous opioids receptor antagonists and/or agonists were used to determine the possible action mechanism of PAME. Results: PAME significantly decreased carrageenan induced thermal and mechanical hyperalgesia, as well as PGE_2 induced mechanical hyperalgesia. PAME significantly protected the animals against the installation of neuropathic pain. Anti-nociception activity produced by PAME was significantly blocked in animals pre?treated with all the antagonists(naloxone, NW-nitro-L-arginine methyl ester(L-NAME), methylene blue and glibenclamide). Conclusions: Results of this study reveal that, PAME administrate orally, can induce anti-hyperalgesic action against installation of inflammatory pain as well as neuropathic pain. The mechanism underlying PAME antihyperalgesic effect could probably be associated with an activation of opioid receptors and NO/cG MP/K^+ channel pathway.

关键词： Piptadeniastrum africanum Neuropathic pain Inflammatory pain cGMP Nitric oxide

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