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High-throughput sequencing analysis of differential microRNA expression in the process of blocking the progression of chronic atrophic gastritis to gastric cancer by Xianglian Huazhuo formula(香连化浊方)

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Journal of Traditional Chinese Medicine 2024年第4期44卷 703-712页

作者： GUO Yuxi LI Ze CHENG Nan JIA Xuemei WANG Jie MA Hongyu zhao Runyuan LI bolin XUE Yucong CAI Yanru YANG Qian Department of spleen and stomach diseases First Affiliated Hospital of Hebei University of Traditional Chinese MedicineShijiazhuang 050000China Department of Traditional Chinese Medicine Hebei General HospitalShijiazhuang 050051China Department of Gastroenterology the First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510405China College of Integrative Medicine Hebei University of Chinese MedicineShijiazhuang 050011China

OBJECTIVE:To explore the mechanism of Xianglian Huazhuo formula(香连化浊方,XLHZ)blocking the development of chronic atrophic gastritis(CAG)to gastric cancer(GC)through bioinformatics analysis and in ***:Pathological morphology of gastric mucosa of rats were ***-throughput sequencing was used to analyze the miRNA expression profile of gastric *** miRanda,miRDB and miRWalk databases were used to predict the differential target *** Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis were performed for differential target ***-time quantitative reverse transcription polymerase chain reaction(qRTPCR)was used to verify the differentially expressed miRNAs and target *** blot,EdU,wound healing and flow cytometry were used to observe the effect of XLHZ on epithelial-mesenchymal transition(EMT)markers,proliferation,migration,apoptosis and cell cycle of CAG cells in ***:A total of five differentially expressed miRNAs and four differential target genes were screened in this *** analysis showed that the target genes were enriched in regulation of neuron development,regulation of transcription factor activity and regulation of RNA *** pathways database differences in gene enrichment of target genes in the Wnt signaling pathway,Phospholipase D signaling pathway and mitogen-activated protein kinase signaling *** confirmed that miRNAs and its target genes were consistent with the screening *** vitro,our study revealed that XLHZ could increase the expression of Ecadherin,decrease the expression of transforming growth factorβ1,vimentin andβ-catenin,inhibite the proliferation and migration of CAG cells,cause cell cycle arrest at G0/G1 and G2/M phase,induce the apoptosis of CAG cells,and prevent the progression of CAG to ***:This study provided a new idea for the mechanism of blocking the progression of CAG to GC by XLHZ,which may be related to the expression

关键词： high-throughput nucleotide sequencing gastritis,atrophic stomach neoplasms microRNAs Xianglian Huazhuo formula

Optimization of Temperature Drop Formula for Annular Gathering Pipeline in High Water Cut Oil Region of Central Hebei Province

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Journal of Power and Energy Engineering 2018年第9期6卷 21-26页

作者： Haonan Cai Lining zhao Xuemei Chen Xintong Chen Tong Guan Jinxiu Wang bolin Lv Shuaibin Li Engineering Technology Institute of PetroChina Huabei Oil Field Renqiu China

In order to respond to the national policy of energy saving and consumption reduction, the temperature drop formula of annular pipeline should be established to optimize the water mixing temperature and water mixing flow. The traditional temperature drop formula applies the high water cut actual situation to 13.7%. On the basis of the traditional Schulhof temperature drop formula, the influence of hydraulic friction on the oil flow temperature is calculated by the calculus idea. The heat transfer coefficient of the pipeline under the complex condition is obtained by the inverse algorithm, and the water mixing flow and water temperature are simulated with MATLAB. The function surface diagram of the degree and the back station temperature. The actual error can be reduced to 4.8%, and the return station temperature can be optimized by 7 degrees.

关键词： Circular Water Collecting Oil Hydraulic Friction Inverse Algorithm Saving Energy Cost

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钛白废水处理研究

工业水处理 2012年第6期32卷 63-65页

作者：赵小红梁柏林贺州学院化学与生物工程系广西贺州542899

以造纸白泥和石灰为中和剂,采用两段中和+曝气沉淀工艺处理钛白废水,考察了中和过程中的时间、温度、中和剂投加量及曝气时间对水质的影响。较佳工艺条件为第一阶段投料比m(废水)∶m(造纸白泥)=1 000∶13.6,常温中和15 min,此时废水pH为... 详细信息

以造纸白泥和石灰为中和剂,采用两段中和+曝气沉淀工艺处理钛白废水,考察了中和过程中的时间、温度、中和剂投加量及曝气时间对水质的影响。较佳工艺条件为第一阶段投料比m(废水)∶m(造纸白泥)=1 000∶13.6,常温中和15 min,此时废水pH为5.61,第二阶段m(废水)∶m(石灰)=1 000∶1.4,常温中和5 min,曝气30 min后静置5 min,废水pH为7.25,Fe2+质量分数<0.1%,出水达到《国家污水综合排放标准》GB 8978—2002的二级排放要求。

关键词：水处理钛白废水造纸白泥

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科技情报用户画像标签生成与推荐

情报学报 2020年第11期39卷 1214-1222页

作者：赵辉化柏林何鸿魏北京大学信息管理系北京100871

科技管理部门是科技情报的重要用户,如何主动地了解科技管理部门的情报需求,成为大数据时代快速地提供精准情报服务的重要内容,而用户画像的方法为这项工作提供了可能。通过多源数据的采集与分析,为情报用户打标签,用标签来刻画用户特... 详细信息

科技管理部门是科技情报的重要用户,如何主动地了解科技管理部门的情报需求,成为大数据时代快速地提供精准情报服务的重要内容,而用户画像的方法为这项工作提供了可能。通过多源数据的采集与分析,为情报用户打标签,用标签来刻画用户特征与需求,并实施推荐。基于上述目的,本文采用自然语言处理的相关方法生成标签,在文本中抽取出关键词,采用直接抽取、词对匹配、主题词抽取、基于TF-IDF的生成方案、组合词生成方案共五种方法。标签生成后,根据词林表中的词间关系分析标签之间的关联和相似度。然后采用协同过滤、基于常识、标签关联等推荐算法为不同的用户推荐标签,并建立了初步的用户画像。通过研究与实证发现,利用这一套方法能够有效勾勒出科技管理部门的情报需求特征,对于科技情报工作而言,推荐的内容也具备一定的启示性。

关键词：科技情报用户画像标签生成推荐算法

Study on Interference from the Peel to Predict Apple Firmness by Near Infrared Spectroscopy

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Study on Interference from the Peel to Predict Apple Firmnes...

不同分子量醋柴胡多糖对Raw264.7巨噬细胞抗炎免疫活性的影响

作者： bolin Shi Lei zhao Houyin Wang Wen Liu Dazhou Zhu Zhentua Tu Jingyuan Yin School of Communication and Information Engineering Shanghai University Food and Agriculture Standardization Institute China National Institute of Standardization Nation Engineering Research Center for Information Technology in Agriculture College of Food Science and Nutritional Engineering China Agricultural University

The near infrared spectra of apples with peel and peeled were collected by FT-NIR *** order to reduce the influence on the model of apple firmness,the useful wavelengths were selected and the outlier samples were *** analyze the difference between the models with peel and peeled,the calibration and prediction samples were divided for ten times and were used to build the ten different firmness models for both peel and *** the models of peeled apple,the correlation coefficient(r) and the relative standard deviation of prediction(RSDp) were all around 0.84 and12.6%,respectively,indicating that the peeled models were *** the peel model,r and RSDp were 0.74-0.86 and 13.5-17.7%,respectively,suggesting that the stability of the peel model was not very *** f-test for ten groups of RSDp showed that the difference was significant between the peel and peeled models(P < 0.0001).In addition,the results from Magness-Taylor puncture test only represented the firmness of ***,the near infrared diffuse reflectance spectra of peel apples contained the information of pectin substance from both peel and *** pectin substance content was closely related to the apple’s ***,the spectra and reference firmness data were not corresponded and the absorbance spectra of peel became the interference for the near infrared spectra of peel *** was obtained the reason for the prediction ability of peel apple model for the firmness reducing.

关键词： Near Infrared Spectroscopy Apple Peel Firmness Pectin Substance

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中国现代应用药学 2020年第10期37卷 1153-1156页

作者：李苹卢柏林邓时贵赵瑞芝赵亚广州中医药大学第二附属医院广州510006 广州中医药大学中药学院广州510006

目的探讨不同分子量醋柴胡多糖对Raw264.7小鼠巨噬细胞抗炎免疫活性的影响。方法采用截留不同分子量的透析袋将醋柴胡多糖进行不同分子量分离;采用MTT检测不同分子量醋柴胡多糖对Raw264.7小鼠巨噬细胞活力的影响;采用中性红吞噬实验检... 详细信息

目的探讨不同分子量醋柴胡多糖对Raw264.7小鼠巨噬细胞抗炎免疫活性的影响。方法采用截留不同分子量的透析袋将醋柴胡多糖进行不同分子量分离;采用MTT检测不同分子量醋柴胡多糖对Raw264.7小鼠巨噬细胞活力的影响;采用中性红吞噬实验检测多糖对细胞吞噬活性的影响;采用Griess法检测不同分子量醋柴胡多糖对LPS刺激Raw264.7炎症细胞模型NO释放的影响。结果分离得到1 000 kDa 6个不同分子量段的醋柴胡多糖;各分子量段醋柴胡多糖在1.95~31.25μg·mL^-1对巨噬细胞无毒性;除100 kDa醋柴胡多糖活性更显著;各分子量段醋柴胡多糖均能显著抑制LPS刺激Raw264.7炎症细胞NO的释放。结论分子量是影响醋柴胡多糖抗炎免疫活性差异的重要因素。

关键词：醋柴胡多糖分子量 Raw264.7巨噬细胞抗炎免疫

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黑龙江省国有林区经济差异的空间统计分析

林业经济问题 2016年第3期36卷 203-208页

作者：赵晓光田博林东北林业大学经济管理学院哈尔滨150040

通过将区域经济研究理论与空间统计相结合的研究方式,找到适合黑龙江省国有林区经济发展的新出路。运用Arc GIS及空间计量经济学软件Geo Da提供的空间分析功能对1998年至2014年黑龙江省国有林区经济的动态演变过程进行空间统计分析研究... 详细信息

通过将区域经济研究理论与空间统计相结合的研究方式,找到适合黑龙江省国有林区经济发展的新出路。运用Arc GIS及空间计量经济学软件Geo Da提供的空间分析功能对1998年至2014年黑龙江省国有林区经济的动态演变过程进行空间统计分析研究。利用已经完善的ESDA分析方法即Moran I指数、Moran散点以及LISA显著性水平图,来揭示黑龙江省国有林区经济差异的空间自相关和空间集聚特征。研究表明:黑龙江省国有林区各林业局的经济呈现了正自相关的发展态势,低低类型的经济发展地区分布不集中,数量不多,但是高高类型的经济地区较为稳定并且开始逐步形成了高经济产业集聚区,而且经济带动作用有所显现。基于研究,提出加强重点扶持力度,带动林区整体经济发展;加强重点扶持力度,带动林区整体经济发展;加强重点扶持力度,带动林区整体经济发展等建议。

关键词：区域经济空间统计分析黑龙江国有林区

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花椒麻度感官评价自校准线性标度的建立

中国食品学报 2015年第10期15卷 211-216页

作者：赵镭张璐璐史波林汪厚银支瑞聪中国标准化研究院食品与农业标准化研究所北京102200

麻感标度的建立是对麻味感觉强度进行量化评价的基础。本文在对评价员麻感语义描述差异性分析的基础上,采用自校准的方法,即在不改变评价员使用标度习惯和范围的前提下,通过统计分析统一评价小组的标度范围,最终建立了花椒麻度感官评价... 详细信息

麻感标度的建立是对麻味感觉强度进行量化评价的基础。本文在对评价员麻感语义描述差异性分析的基础上,采用自校准的方法,即在不改变评价员使用标度习惯和范围的前提下,通过统计分析统一评价小组的标度范围,最终建立了花椒麻度感官评价的15-cm标记线性标度。麻感标记值分别为:0.8(微麻),3.1(有点麻),6.4(麻),8.1(较麻),10.3(很麻)和12.5(特麻)。该标度本质上为等比标度,符合y=2.7321ln(x)+4.941。评价员使用该标度的重复性和一致性满足要求。重复性考察指标相对标准偏差值小于20%,一致性考察指标|En|值小于1。建立的麻感标记线性标度对于花椒麻感强度(麻度)的量化评价及开展相关研究具有重要的理论和实践意义。

关键词：感官评价标记线性标度麻感

硫毒化NH_(3)-SCR脱硝催化剂再生方式的构建及机制研究

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环境科学学报 2023年第2期43卷 447-460页

作者：邹博霖赵琦石川陈冰冰大连理工大学化工学院精细化工国家重点实验室大连116024 辽宁师范大学化学化工学院大连116029

以CeTi复合氧化物负载NH_(4)HSO_(4)(模拟SO_(2)毒化催化剂)为研究对象,并向其中掺杂Mo作为改性组分,研究了硫毒化催化剂的再生过程与机制.与热再生相比,冷等离子体在再生毒化后催化剂的过程中显现出独特的优势.通过对再生后催化剂的物... 详细信息

以CeTi复合氧化物负载NH_(4)HSO_(4)(模拟SO_(2)毒化催化剂)为研究对象,并向其中掺杂Mo作为改性组分,研究了硫毒化催化剂的再生过程与机制.与热再生相比,冷等离子体在再生毒化后催化剂的过程中显现出独特的优势.通过对再生后催化剂的物理化学性质表征及优化再生气氛,确认了冷等离子再生催化剂的优点:不仅能够保持催化剂物相结构的稳定,还可促进催化剂表面NH_(4)HSO_(4)的低温分解和硫物种的脱附.虽然冷等离子体再生后的催化剂NH_(3)-SCR反应活性下降,但可通过纯O_(2)气氛中焙烧的方式,实现对催化剂物理化学性质的重构和催化活性的再生.通过此研究,初步建立了催化剂“毒化-再生-重构”的基本构效关系,为硫中毒NH_(3)-SCR脱硝催化剂的再生提供了可行性方案.

关键词：冷等离子体辅助再生 Mo改性CeO_(2)-TiO_(2)催化剂硫中毒催化剂 NH_(3)-SCR