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云南省泸水市非洲猪瘟疫情流行病学调查

中国动物检疫 2019年第6期36卷 9-11,35页

作者：赵云玲张文东赵柏林王传彬陈继明中国动物卫生与流行病学中心山东青岛266032 云南省动物疫病预防控制中心云南昆明650201 中国动物疫病预防控制中心北京100125

2019年2月,云南省怒江傈僳族自治州泸水市发生非洲猪瘟疫情。农业农村部和云南省农业农村厅联合督导组对此起疫情进行了流行病学调查和扩散风险分析。调查分析显示:泔水喂猪引发此起疫情的可能性最大,当地再次发生非洲猪瘟疫情的风险较... 详细信息

2019年2月,云南省怒江傈僳族自治州泸水市发生非洲猪瘟疫情。农业农村部和云南省农业农村厅联合督导组对此起疫情进行了流行病学调查和扩散风险分析。调查分析显示:泔水喂猪引发此起疫情的可能性最大,当地再次发生非洲猪瘟疫情的风险较高,但疫情扩散到疫点之外和野猪的风险较小。督导组由此提出,明确各相关部门防疫责任,继续加大疫情监测和排查力度,加大对餐厨剩余物和猪肉销售点废弃碎肉的监管,禁止泔水喂猪,进一步提升猪场的猪病防控能力。此起疫情对非洲猪瘟防控具有指导意义,对边远贫困地区扶贫攻坚工作和边境动物卫生安全有一定的警示作用。

关键词：非洲猪瘟流行病学调查暴发风险

Enhanced autophagic clearance of amyloid-βvia histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo

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Neural Regeneration Research 2025年第9期20卷 2633-2644页

作者： Zhimin Long Chuanhua Ge Yueyang zhao Yuanjie Liu Qinghua Zeng Qing Tang Zhifang Dong Guiqiong He Institute of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Physiology Chongqing Medical UniversityChongqingChina Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqingChina Ministry of Education Key Laboratory of Child Development and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina National Clinical Research Center for Child Health and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque ***,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's *** acetylation/deacetylation plays a central role in lysosomal ***,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's *** rthermore,we found that treatment with valproic acid markedly enhanced *** clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's *** findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.

关键词： Alzheimer's disease amyloid-β APP/PS1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPase

猪圆环病毒3型感染的流行情况与检测方法研究进展

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畜牧与兽医 2019年第1期51卷 114-117页

作者：刘颖昳周智关婕葳原霖侯伯赵柏林王传彬杨林中国动物疫病预防控制中心北京100260

猪圆环病毒3型(porcine circovirus 3,PCV3)是猪群中流行的一种新型猪圆环病毒。2016—2017年,世界范围陆续报道在猪群中发现PCV3,包括美国、中国、美国、韩国、巴西、波兰和意大利等。PCV3感染多见于具有皮炎肾病综合征(PDNS)和繁殖障... 详细信息

猪圆环病毒3型(porcine circovirus 3,PCV3)是猪群中流行的一种新型猪圆环病毒。2016—2017年,世界范围陆续报道在猪群中发现PCV3,包括美国、中国、美国、韩国、巴西、波兰和意大利等。PCV3感染多见于具有皮炎肾病综合征(PDNS)和繁殖障碍症状的猪群,目前病毒尚未分离成功。本文综述了已报道的PCV3在世界范围内的流行情况,介绍了当前研究的PCV3分子和血清学诊断方法。

关键词：猪圆环病毒3型(PCV3) 流行检测

Salsolinol as an RNA m~6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy

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Neural Regeneration Research 2025年第3期20卷 887-899页

作者： Jianan Wang Yuanyuan Ran Zihan Li Tianyuan zhao Fangfang Zhang Juan Wang Zongjian Liu Xuechai Chen Beijing International Science and Technology Cooperation Base for Antiviral Drugs College of Chemistry and LifeBeijing University of TechnologyBeijingChina Department of Rehabilitation Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

Salsolinol(1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,Sal)is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,an environmental toxin that causes Parkinson's ***,the mechanism by which Sal mediates dopaminergic neuronal death remains *** this study,we found that Sal significantly enhanced the global level of N~6-methyladenosine(m~6A)RNA methylation in PC12 cells,mainly by inducing the downregulation of the expression of m~6A demethylases fat mass and obesity-associated protein(FTO)and alk B homolog 5(ALKBH5).RNA sequencing analysis showed that Sal downregulated the Hippo signaling *** m~6A reader YTH domain-containing family protein 2(YTHDF2)promoted the degradation of m~6A-containing Yes-associated protein 1(YAP1)mRNA,which is a downstream key effector in the Hippo signaling ***,downregulation of YAP1 promoted autophagy,indicating that the mutual regulation between YAP1 and autophagy can lead to *** findings reveal the role of Sal on m~6A RNA methylation and suggest that Sal may act as an RNA methylation inducer mediating dopaminergic neuronal death through YAP1 and *** results provide greater insights into the neurotoxic effects of catechol isoquinolines compared with other studies and may be a reference for assessing the involvement of RNA methylation in the pathogenesis of Parkinson's disease.

关键词： ALKBH5 autophagy FTO Hippo pathway m~6A Parkinson's disease RNA methylation salsolinol YAP1 YTHDF2

MXene Hybridized Polymer with Enhanced Electromagnetic Energy Harvest for Sensitized Microwave Actuation and Self‑Powered Motion Sensing

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Nano-Micro Letters 2025年第3期17卷 265-279页

作者： Yu‑Ze Wang Yu‑Chang Wang Ting‑Ting Liu Quan‑Liang zhao Chen‑Sha Li Mao‑Sheng Cao School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China School of Materials Science and Engineering Peking UniversityBeijing 100871People’s Republic of China School of Mechanical and Material Engineering North China University of TechnologyBeijing 100144People’s Republic of China Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People’s Republic of ChinaHeilongjiang UniversityHarbin 150080People’s Republic of China

Polymeric microwave actuators combining tissue-like softness with programmablemicrowave-responsive deformation hold great promise for mobile intelligentdevices and bionic soft robots. However, their application is challenged by restricted electromagneticsensitivity and intricate sensing coupling. In this study, a sensitized polymericmicrowave actuator is fabricated by hybridizing a liquid crystal polymer with Ti3C2Tx(MXene). Compared to the initial counterpart, the hybrid polymer exhibits unique spacechargepolarization and interfacial polarization, resulting in significant improvements of230% in the dielectric loss factor and 830% in the apparent efficiency of electromagneticenergy harvest. The sensitized microwave actuation demonstrates as the shortenedresponse time of nearly 10 s, which is merely 13% of that for the initial shape memory polymer. Moreover, the ultra-low content of MXene (upto 0.15 wt%) benefits for maintaining the actuation potential of the hybrid polymer. An innovative self-powered sensing prototype that combinesdriving and piezoelectric polymers is developed, which generates real-time electric potential feedback (open-circuit potential of ~ 3 mV) duringactuation. The polarization-dominant energy conversion mechanism observed in the MXene-polymer hybrid structure furnishes a new approachfor developing efficient electromagnetic dissipative structures and shows potential for advancing polymeric electromagnetic intelligent devices.

关键词： Microwave absorption Electromagnetic response Energy harvest Self-sensing Soft actuator

Multifunctional Nacre‑Like Nanocomposite Papers for Electromagnetic Interference Shielding via Heterocyclic Aramid/MXene Template‑Assisted In‑Situ Polypyrrole Assembly

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Nano-Micro Letters 2025年第3期17卷 37-54页

作者： Jinhua Xiong Xu zhao Zonglin Liu He Chen Qian Yan Huanxin Lian Yunxiang Chen Qingyu Peng Xiaodong He National Key Laboratory of Science and Technology On Advanced Composites in Special Environments Center for Composite Materials and StructuresHarbin Institute of TechnologyHarbin 150080People’s Republic of China

Robust, ultra-flexible, and multifunctional MXene-basedelectromagnetic interference (EMI) shielding nanocomposite filmsexhibit enormous potential for applications in artificial intelligence,wireless telecommunication, and portable/wearable electronic *** this work, a nacre-inspired multifunctional heterocyclic aramid(HA)/MXene@polypyrrole (PPy) (HMP) nanocomposite paper withlarge-scale, high strength, super toughness, and excellent tolerance tocomplex conditions is fabricated through the strategy of HA/MXenehydrogel template-assisted in-situ assembly of PPy. Benefiting from the"brick-and-mortar" layered structure and the strong hydrogen-bondinginteractions among MXene, HA, and PPy, the paper exhibits remarkable mechanical performances, including high tensile strength (309.7 MPa),outstanding toughness (57.6 MJ m−3), exceptional foldability, and structural stability against ultrasonication. By using the template effect ofHA/MXene to guide the assembly of conductive polymers, the synthesized paper obtains excellent electronic conductivity. More importantly,the highly continuous conductive path enables the nanocomposite paper to achieve a splendid EMI shielding effectiveness (EMI SE) of 54.1 dBat an ultra-thin thickness (25.4 μm) and a high specific EMI SE of 17,204.7 dB cm2g−1. In addition, the papers also have excellent applicationsin electromagnetic protection, electro-/photothermal de-icing, thermal therapy, and fire safety. These findings broaden the ideas for developinghigh-performance and multifunctional MXene-based films with enormous application potential in EMI shielding and thermal management.

关键词： MXene Remarkable mechanical properties Heterocyclic aramid Electromagnetic interference shielding Polypyrrole Multifunctionality

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H面波导Y结环行器的CAA及CAD

磁性材料及器件 1999年第3期30卷 18-31页

作者：蒋运石方崇孝赵伯琳中国西南应用磁学研究所绵阳621000 电子科技大学成都610054

对具有圆形匹配台阶和圆形铁氧体样品的Ｈ面波导Ｙ结环行器进行了计算机辅助分析（ＣＡＡ）和计算机辅助设计（ＣＡＤ）。ＣＡＡ以全波分析为基础，包括了在实际的Ｈ面波导结中各种可能存在的模式，分析是完备的。ＣＡＤ是通过计算... 详细信息

对具有圆形匹配台阶和圆形铁氧体样品的Ｈ面波导Ｙ结环行器进行了计算机辅助分析（ＣＡＡ）和计算机辅助设计（ＣＡＤ）。ＣＡＡ以全波分析为基础，包括了在实际的Ｈ面波导结中各种可能存在的模式，分析是完备的。ＣＡＤ是通过计算波导结的相对输入阻抗随各设计参数的变化规律进行的。因为设计参数繁多和场型的三维结构，直接计算环行器性能已较困难，对其优化就更为麻烦。本文首先计算无大匹配台阶的中心结阻抗特性，再由此综合出外匹配电路。环行器的最后性能可由中心结结合匹配台阶一起计算验证之。此外，本文模型不仅包括了濎濜波长变换器的大台阶。

关键词： H面波导环行器全波分析 CAA CAD 环行器

Bending Stiffness of Concrete-Filled Steel Tube and Its Influence on Concrete Placement Timing of Composite Beam-String Structure

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Structural Durability & Health Monitoring 2025年第1期19卷 55-75页

作者： Zhenyu Zhang Quan Jin Haitao Zhang zhao Liu Yuyang Wu Longfei Zhang Renzhang Yan CCCC Third Highway Engineering Co. Ltd.Beijing101300China School of Civil Engineering Chongqing Jiaotong UniversityChongqing400074China

When the upper chord beam of the beam-string structure(BSS)is made of concrete-filled steel tube(CFST),its overall stiffness will change greatly with the construction of concrete placement,which will have an impact on the design of the tensioning plans and selection of control measures for the *** order to accurately obtain the bending stiffness of CFST beam and clarify its impact on the mechanical properties of composite BSS during construction,the influence of some factors such as height-width ratio,wall thickness of steel tube,elasticity modulus of concrete,and friction coefficient on the bending stiffness are analyzed parametrically by the numerical simulation technology based on an actual *** calculation formula of the equivalent bending stiffness of CFST is also established through mathematical statistical ***,the equivalent bending stiffness is introduced into the construction and use stages of the composite BSS,respectively,and the mechanical properties such as prestress-tensioning control value,structural deformation,and internal force of key members are comparatively analyzed when adopting two different construction ***,the optimal construction plan of concrete placement first and then prestress-tensioning is proposed.

关键词： Concrete panels freeze-thaw damage compression-shear crack tension-shear crack

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提高GPS拟合高程精度的方法探讨

工程地球物理学报 2016年第6期13卷 804-807页

作者：祁亚科余力张亚杰张柏林赵越河南省煤田地质局一队河南郑州450000

GPS测量技术在现代测绘工作中发挥着不可替代的关键作用,但是GPS测量直接获取的大地高需要转换成正常高才能在工程中应用。目前将大地高转换为正常高主要采用高程拟合的方式进行,如何提高GPS拟合高程的精度是测绘工作者关注的热点。实... 详细信息

GPS测量技术在现代测绘工作中发挥着不可替代的关键作用,但是GPS测量直接获取的大地高需要转换成正常高才能在工程中应用。目前将大地高转换为正常高主要采用高程拟合的方式进行,如何提高GPS拟合高程的精度是测绘工作者关注的热点。实验了几种不同的GPS高程拟合方式,将其结果与水准测量结果相比较,证明了合理选点对于GPS拟合高程的精度影响很大,并得到了分区拟合是一种较好的拟合方式的结论。

关键词： GPS 拟合高程分区拟合