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三磷酸腺苷对脂多糖诱导内皮祖细胞表达炎症因子的影响及其机制

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中南大学学报（医学版） 2018年第12期43卷 1301-1308页

作者：肖博林陈美芳杨梅肖智林中南大学湘雅医院老年病科国家老年疾病临床医学研究中心长沙410008 兰州大学口腔医学院兰州710000

目的:分析三磷酸腺苷(adenosine triphosphate,ATP)对脂多糖(lipopolysaccharide,LPS)诱导内皮祖细胞(endothelial progenitor cells,EPCs)表达炎症细胞因子的影响,并探讨其机制。方法:采用密度梯度离心法分离人脐血单个核细胞,用RT-PCR检测LPS(1 mg/mL)诱导EPCs表达炎症细胞因子的情况,低浓度的ATP(5μmol/L)对LPS诱导EPCs表达细胞炎症因子的影响,不同浓度(5,50μmol/L)的ATP对EPCs中TLR4,MyD88和CD14 mRNA表达的影响;Western印迹检测LPS(1 mg/mL)对EPCs表达TLR4调节蛋白MyD88和CD14的影响以及信号通路的活化情况,低浓度ATP(1,5μmol/L)对LPS诱导EPCs表达TLR4,MyD88和CD14的影响以及信号通路的活化情况。结果:EPCs高表达TLR4,其配体LPS(1 mg/mL)显著上调IL-1β,MCP-1和ICAM-1的mRNA表达(均P<0.01),并呈时间依赖性上调My D88和CD14蛋白的表达,同时活化ERK和NF-κB信号通路。低浓度ATP抑制LPS诱导的IL-1β,MCP-1和ICAM-1 mRNA的表达(均P<0.05),同时也下调LPS诱导的TLR4,MyD88和CD14蛋白的表达(P<0.01或P<0.05),并抑制LPS诱导的NF-κB信号通路的活化(P<0.05)。结论:ATP在低浓度时通过负性调节TLR4信号通路而抑制LPS诱导的炎症细胞因子在EPCs中的表达。

关键词：三磷酸腺苷内皮祖细胞炎症因子 TLR4信号通路

Four development stages of collective intelligence

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Frontiers of Information Technology & Electronic Engineering 2024年第7期25卷 903-916页

作者： Renbin xiao School of Artificial Intelligence and Automation Huazhong University of Science and TechnologyWuhan 430074China Key Laboratory of Image Information Processing and Intelligent Control Ministry of EducationWuhan 430074China

The new generation of artificial intelligence(AI)research initiated by Chinese scholars conforms to the needs of a new information environment changes,and strives to advance traditional artificial intelligence(AI 1.0)to a new stage of AI *** one of the important components of AI,collective intelligence(CI 1.0),i.e.,swarm intelligence,is developing to the stage of CI 2.0(crowd intelligence).Through in-depth analysis and informative argumentation,it is found that an incompatibility exists between CI 1.0 and CI ***,CI 1.5 is introduced to build a bridge between the above two stages,which is based on biocollaborative behavioral *** 1.5 is the transition from CI 1.0 to CI 2.0,which contributes to the compatibility of the two ***,a new interpretation of the meta-synthesis of wisdom proposed by Qian Xuesen is *** meta-synthesis of wisdom,as an improvement of crowd intelligence,is an advanced stage of bionic intelligence,i.e.,CI *** is pointed out that the dual-wheel drive of large language models and big data with deep uncertainty is an evolutionary path from CI 2.0 to CI 3.0,and some elaboration is *** a result,we propose four development stages(CI 1.0,CI 1.5,CI 2.0,and CI 3.0),which form a complete framework for the development of *** different stages are progressively improved and have good *** to the dominant role of cooperation in the development stages of CI,three types of cooperation in CI are discussed:indirect regulatory cooperation in lower organisms,direct communicative cooperation in higher organisms,and shared intention based collaboration in *** division is the main form of achieving cooperation and,for this reason,this paper investigates the relationship between the complexity of behavior and types of labor ***,based on the overall understanding of the four development stages of CI,the future development direction and research issues of CI are explored.

关键词： Collective intelligence Meta-synthesis of wisdom Incompatibility Labor division Cooperative behavior Collective intelligence emergence Large language model

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钢渣掺量对膏体早期强度及流变特性的影响

材料导报 2021年第3期35卷 3021-3025页

作者：吴凡杨发光肖柏林杨志强高谦北京科技大学金属矿山高效开采与安全教育部重点实验室北京100083 渥太华大学土木工程系渥太华K1N6N5 金川集团股份有限公司金昌737100

为探讨钢渣掺量对膏体早期强度和流变特性的影响效果,设计不同钢渣掺量的膏体早期强度与流变特性实验,使用XRD、TG/DTG和SEM等手段研究胶凝材料的水化产物,利用Zeta电位和pH计分析料浆屈服应力与黏度变化机理。结果表明,钢渣掺量由30%增... 详细信息

为探讨钢渣掺量对膏体早期强度和流变特性的影响效果,设计不同钢渣掺量的膏体早期强度与流变特性实验,使用XRD、TG/DTG和SEM等手段研究胶凝材料的水化产物,利用Zeta电位和pH计分析料浆屈服应力与黏度变化机理。结果表明,钢渣掺量由30%增至50%时,膏体早期(3 d、7 d、14 d和28 d)强度先增大后减小,钢渣掺量为35%时强度最优,养护28 d的净浆试样质量总损失为23.40%,水化产物更多,结构更致密。随钢渣掺量的增大,试样的屈服应力和黏度一直增大,固体颗粒间引力大和需要外力破坏絮凝结构是料浆屈服应力高的原因,而固体颗粒间的摩擦加剧是造成料浆黏度高的重要原因。

关键词：膏体钢渣掺量早期强度流变特性矿山充填

Decentralized Optimal Control and Stabilization of Interconnected Systems With Asymmetric Information

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 698-707页

作者： Na Wang xiao Liang Hongdan Li xiao Lu the College of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao 266000China the School of Automation and Electrical Engineering Linyi UniversityLinyi 276000China the College of Energy Storage Technology Shandong University of Science and TechnologyQingdao 266000China

The paper addresses the decentralized optimal control and stabilization problems for interconnected systems subject to asymmetric *** with previous work,a closed-loop optimal solution to the control problem and sufficient and necessary conditions for the stabilization problem of the interconnected systems are given for the first *** main challenge lies in three aspects:Firstly,the asymmetric information results in coupling between control and estimation and failure of the separation ***,two extra unknown variables are generated by asymmetric information(different information filtration)when solving forward-backward stochastic difference ***,the existence of additive noise makes the study of mean-square boundedness an *** adopted technique is proving and assuming the linear form of controllers and establishing the equivalence between the two systems with and without additive noise.A dual-motor parallel drive system is presented to demonstrate the validity of the proposed algorithm.

关键词： Asymmetric information decentralized control forwardbackward stochastic difference equations interconnected system stalibization

Bioinspired nanomaterials for wearable sensing and human–machine interfacing

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Nano Research 2024年第2期17卷 445-461页

作者： Vishesh Kashyap Junyi Yin xiao xiao Jun Chen Department of Bioengineering University of CaliforniaLos AngelesLos AngelesCA 90095USA Department of Mechanical and Aerospace Engineering University of CaliforniaLos AngelesLos AngelesCA 90095USA

The inculcation of bioinspiration in sensing and human–machine interface(HMI)technologies can lead to distinctive characteristics such as conformability,low power consumption,high sensitivity,and unique properties like self-healing,self-cleaning,and *** sensing and HMI are fields rife with opportunities for the application of bioinspired nanomaterials,particularly when it comes to wearable sensory systems where biocompatibility is an additional *** review discusses recent development in bioinspired nanomaterials for wearable sensing and HMIs,with a specific focus on state-of-the-art bioinspired capacitive sensors,piezoresistive sensors,piezoelectric sensors,triboelectric sensors,magnetoelastic sensors,and electrochemical *** also present a comprehensive overview of the challenges that have hindered the scientific advancement in academia and commercialization in the industry.

关键词： bioinspired nanomaterials human–machine interface wearable sensors wearable bioelectronics

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基于支持向量机的高光谱遥感影像分类

科技创新与应用 2020年第4期10卷 22-24页

作者：肖博林重庆交通大学土木工程学院

高光谱遥感是将成像技术和光谱技术相结合的多维信息获取技术。自发展以来,已在各个方面都显示出了巨大的研究潜力,成为遥感应用最广泛的领域之一。然而,如何充分利用高光谱遥感数据提供的丰富的地表信息,以及如何在如此大量的信息中提... 详细信息

高光谱遥感是将成像技术和光谱技术相结合的多维信息获取技术。自发展以来,已在各个方面都显示出了巨大的研究潜力,成为遥感应用最广泛的领域之一。然而,如何充分利用高光谱遥感数据提供的丰富的地表信息,以及如何在如此大量的信息中提取有用信息,是摆在研究者面前的一项重要课题。高光谱遥感影像处理的一项重要内容就是地物目标的分类。文章基于支持向量机算法原理,提出了一种应用于高光谱影像的分类机制,并在印度松树(Indian Pines)和帕维亚大学(Pavia University)数据集上进行了验证实验,取得了较高的分类精度。

关键词：高光谱遥感支持向量机分类算法

Investigation of mechanical and electrical characteristics of selfsensing pneumatic torsional actuators

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Science China(Technological Sciences) 2024年第1期67卷 130-142页

作者： xiao Wei HU DeAn HU GuoLiang xiao YiHua Key Laboratory of Conveyance and Equipment Ministry of EducationEast China Jiaotong UniversityNanchang 330013China Key Laboratory of Advanced Design and Simulation Techniques for Special Equipment Ministry of EducationHunan UniversityChangsha 410082China

Soft pneumatic actuators are one of the most promising actuation for soft robots,and great achievements have been *** it remains challenging to endow sensing capabilities to pneumatic actuators,especially for the sensing ability originating directly from the actuator ***,a self-sensing pneumatic torsional actuator(SPTA)is designed based on the electromagnetic induction effect and magnetically responsive *** SPTA can generate feedback voltage and current with the deformation,in which the sensing function comes from its inherent *** investigate the mechanical and electrical characteristics,an experimental platform and a finite element model are established,*** find that the torsion angle and output torque increase in nonlinear with the actuating *** maximum torsion angle is 66.35°,which is 84.34%of that for the actuator fabricated by pure *** maximum output torque(24.9 N mm)improves by 23.19%compared with the actuator made by pure *** regards the electrical characteristics,the maximum feedback voltage and current are 2.90μV and 29.50 nA when the SPTA is actuated by a pressure of−40 *** also demonstrate that the relationship between the torsion angle and the magnetic flux change is approximately ***,the number of turns of wires,magnetic powders contents,and magnetic direction on the feedback voltage and current are *** show that the feedback voltage and current can be enhanced by increasing the number of turns and magnetic powders *** envision that the SPTA would be promising for soft robots to realize their accuracy control and intelligentization.

关键词： pneumatic torsional actuators self-sensing feedback voltage finite element modeling soft robots

Surface Polarization Effects on Collapse Transition of Polyelectrolyte Brushes

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Chinese Journal of Polymer Science 2024年第9期42卷 1313-1320,I0006页

作者： xiao-Fei Xu State Key Laboratory of Chemical Engineering and School of Chemical Engineering East China University of Science and TechnologyShanghai200237China

Polyelectrolyte brushes(PEBs)are commonly used to modify surface that have attracted great research *** dielectric permittivity of the grafted surface is typically significantly different from that of solution,which results in surface polarization(SP)effect with a jump of electric *** is thus important to study how SP alters the PEB’s structure and *** this work,the SP effects on PEB structure was studied using a statistical thermodynamic *** free energy functional to describe SP effect was constructed by using the image-charge ***,the electrostatic potential was solved from a modified Poisson-Boltzmann equation taking the ion solvation effect into *** the absence of SP,the thickness of PEB exhibited a continuous collapse transition when decreasing the solvent *** the presence of SP,the collapse became a jump-like *** energy analysis showed that the long-range Coulombic interaction dominated the transition because of the enhanced counterion condensation in the presence of *** theory provides an effective tool to study SP effect on PEBs,and the results explain the underlying physics in PEB collapse transition.

关键词： Surface polarization Polyelectrolyte brush Image charge Ion solvation Polyelectrolyte collapse transition

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阶段回采与顶板支护中深孔一孔两用试验研究

金属矿山 2023年第10期 18-23页

作者：覃凯张鹏飞肖柏林中色非洲矿业有限公司基特韦赞比亚22592 北京科技大学土木与资源工程学院北京100083

针对谦比西铜矿预控顶上向中深孔空场嗣后充填法的采矿工艺,利用Sandvik DS421锚索台车,提出了一种“一孔两用”的预护顶技术方案,可不施工支护巷,直接在凿岩巷施工护顶锚索,安装好锚索后锚索孔作为回采中深孔使用。首先详细介绍了技术... 详细信息

针对谦比西铜矿预控顶上向中深孔空场嗣后充填法的采矿工艺,利用Sandvik DS421锚索台车,提出了一种“一孔两用”的预护顶技术方案,可不施工支护巷,直接在凿岩巷施工护顶锚索,安装好锚索后锚索孔作为回采中深孔使用。首先详细介绍了技术方案的设计思路,然后根据相关手册对扇形中深孔孔网及爆破参数进行计算与验证,最后介绍了该技术方案的现场施工,讨论了“一孔两用”的后续改进方向。结果表明:通过自制锚索套管装置,可实现矿体内自由端锚索的分离回收利用,实现了仅支护末端6.5 m的预期目的;将锚索孔并入扇形中深孔统一孔网参数设计,锚索孔排面与常规中深孔排距0.5 m,锚索孔孔底距为1.6 m;有间隔锚索孔的中深孔孔底距3.2 m,其余中深孔的孔底距为2.2 m,炸药单耗0.45 kg/m^(3);以谦比西铜矿采场参数为例,每个采场可节约采切工程量1672 m^(3)、管缝锚杆330根、金属锚网496 m^(2),减少了锚索使用量221 m、中深孔850 m,具有良好工程效益与应用价值。

关键词：扇形中深孔锚索支护爆破参数一孔两用