检索结果-南通市图书馆

Comparative Study of 3D-Printed Porous Titanium Alloy with Rod Designs of Three Different Geometric Structures for Orthopaedic Implantation

引用

Acta Metallurgica Sinica(English Letters) 2024年第1期37卷 54-66页

作者： Jiaxin Li Haozhang Zhong bojun cao Zhaoyang Ran Jia Tan Liang Deng Yongqiang Hao Jinglong Yan Department of Orthopedics The Second Affiliated Hospital of Harbin Medical UniversityHarbin150001China Shanghai Engineering Research Center of Innovative Orthopaedic Instruments and Personalized Medicine Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200011China Institute of Materials Modification and Modeling Shanghai Jiao Tong UniversityShanghai200240China

Porous titanium alloy is currently widely used in clinical treatment of orthopaedic diseases for its lower elastic modulus and ability to integrate with bone tissue.At the micro-level,cells can respond to different geometries,and at the macro-level,the geometric design of implants will also affect the biological function of cells.In this study,three kinds of porous scaffolds with square,triangular and circle rod shapes were designed and 3D printed.This study observed the proliferation and differentiation of MC3T3-E1 cells during surface culture of the three types of scaffolds.It also evaluated the characteristics of the three scaffolds by means of compression tests and scanning electron microscopy to provide a reference for the design of porous titanium alloy implants for clinical applications.The trends of cell proliferation and gene expression between the three types of scaffolds were observed after treatment with two inhibitors.The results show that the square rod porous scaffolds have the best proliferative and osteogenic activities,and these findings may be due to differences in piezo-type mechanosensitive ion channel component 1(Piezo1)and Yes-associated protein(YAP)expression caused by the macro-geometric topography.

关键词： Porous titanium scaffolds Geometric morphology Cell proliferation Structural design

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Accelerated fracture healing by osteogenic Ti45Nb implants through the PI3K–Akt signaling pathway

引用

Bio-Design and Manufacturing 2023年第6期6卷 718-734页

作者： Jia Tan Jiaxin Li Zhaoyang Ran Junxiang Wu Dinghao Luo bojun cao Liang Deng Xiaoping Li Wenbo Jiang Kai Xie Lei Wang Yongqiang Hao Shanghai Key Laboratory of Orthopaedic Implants Department of Orthopaedic SurgeryShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Department of Orthopedics The Second Affiliated Hospital of Harbin Medical UniversityHarbin 150001China Clinical and Translational Research Center for 3D Printing Technology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Ningxia Orient Ta Ind Co. Ltd.Shizuishan 753000China

The key to managing fracture is to achieve stable internal fixation,and currently,biologically and mechanically appropriate internal fixation devices are urgently needed.With excellent biocompatibility and corrosion resistance,titanium–niobium alloys have the potential to become a new generation of internal fixation materials for fractures.However,the role and mechanism of titanium–niobium alloys on promoting fracture healing are still undefined.Therefore,in this study,we systematically evaluated the bone-enabling properties of Ti45Nb via in vivo and in vitro experiments.In vitro,we found that Ti45Nb has an excellent ability to promote MC3T3-E1 cell adhesion and proliferation without obvious cytotoxicity.Alkaline phosphatase(ALP)activity and alizarin red staining and semiquantitative analysis showed that Ti45Nb enhanced the osteogenic differentiation of MC3T3-E1 cells compared to the Ti6Al4V control.In the polymerase chain reaction experiment,the expression of osteogenic genes in the Ti45Nb group,such as ALP,osteopontin(OPN),osteocalcin(OCN),type 1 collagen(Col-1)and runt-related transcription factor-2(Runx2),was significantly higher than that in the control group.Meanwhile,in the western blot experiment,the expression of osteogenic-related proteins in the Ti45Nb group was significantly increased,and the expression of PI3K–Akt-related proteins was also higher,which indicated that Ti45Nb might promote fracture healing by activating the PI3K–Akt signaling pathway.In vivo,we found that Ti45Nb implants accelerated fracture healing compared to Ti6Al4V,and the biosafety of Ti45Nb was confirmed by histological evaluation.Furthermore,immunohistochemical staining confirmed that Ti45Nb may promote osteogenesis by upregulating the PI3K/Akt signaling pathway.Our study demonstrated that Ti45Nb exerts an excellent ability to promote fracture healing as well as enhance osteoblast differentiation by activating the PI3K/Akt signaling pathway,and its good biosafety has been confirmed,which indicates its clinical translation potent

关键词： Fracture healing Ti45Nb alloy PI3K–Akt pathway Orthopedic implant

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Kinetic network models to elucidate aggregation dynamics of aggregation-induced emission systems

Aggregate

引用

Aggregate 2024年第1期5卷 1-8页

作者： Zige Liu Michae L.Kalin bojun Liu Siqin cao Xuhui Huang Theoretical Chemistry Institute Department of ChemistryUniversity of Wisconsin-MadisonMadisonWisconsinUSA Biophysics University of Wisconsin-MadisonMadisonWisconsinUSA

Aggregation-induced emission(AIE)is a phenomenon where a molecule that is weakly or non-luminescent in a diluted solution becomes highly emissive when aggregated.AIE luminogens(AIEgens)hold promise in diverse applications like bioimaging,chemical sensing,and optoelectronics.Investigation in AIE luminescence is also critical for understanding aggregation kinetics as the aggregation process is an essential component of AIE emission.Experimental investigation of AIEgen aggregation is challenging due to the fast timescale of the aggregation and the amorphous aggregate structures.Computer simulations such as molecular dynamics(MD)simulation provide a valuable approach to complement experiments with atomic-level knowledge to study the fast dynamics of aggregation processes.However,individual simulations still struggle to systematically elucidate heterogeneous kinetics of the formation of amorphous AIEgen aggregates.Kinetic network models(KNMs),constructed from an ensemble of MD simulations,hold great potential in addressing this challenge.In these models,dynamic processes are modeled as a series ofMarkovian transitions occurring among metastable conformational states at discrete time intervals.In this perspective article,we first review previous studies to characterize the AIEgen aggregation kinetics and their limitations.We then introduce KNMs as a promising approach to elucidate the complex kinetics of aggregations to address these limitations.More importantly,we discuss our perspective on linking the output of KNMs to experimental observations of time-resolved AIE luminescence.We expect that this approach can validate the computational predictions and provide great insights into the aggregation kinetics for AIEgen aggregates.These insights will facilitate the rational design of improved AIEgens in their applications in biology and materials sciences.

关键词： hydrophobic aggregation kinetic network models molecular dynamics simulations

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

论我国侦查权的性质

引用

湖北警官学院学报 2006年第2期19卷 49-53页

作者：曹博俊解放军西安政治学院军事安全保卫系陕西西安710068

对于刑事诉讼中侦查权的性质,我国学术界一直都存在着不同认识。文章通过对司法权和行政权特点的比较分析,认为无论是从法理的角度出发,还是从侦查实践的角度考察,侦查权应当具有行政权和司法权的双重属性。

关键词：侦查侦查权行政权司法权

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

意大利强制性侦查监控制度之特色

引用

辽宁警专学报 2005年第6期7卷 15-17页

作者：曹博俊张国良解放军西安政治学院军事安全保卫系陕西西安710068 济南军区联勤部33分部河南郑州450053

1988年意大利对刑事诉讼法进行了重大修改,修改之后的刑事侦查制度确立了侦查机关采用强制性侦查措施必须遵循适合性、必要性、相称性三个基本原则,建立了严格的司法授权和审查机制以及完善的司法救济程序。意大利这一改革动向对优化我... 详细信息

1988年意大利对刑事诉讼法进行了重大修改,修改之后的刑事侦查制度确立了侦查机关采用强制性侦查措施必须遵循适合性、必要性、相称性三个基本原则,建立了严格的司法授权和审查机制以及完善的司法救济程序。意大利这一改革动向对优化我国的强制性侦查监控制度具有重大的借鉴意义。

关键词：意大利刑事诉讼法强制性侦查监控制度

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

乙烯基含氟硅油改性有机硅防粘涂层的制备与性能研究

引用

工程与试验 2021年第3期61卷 38-40页

作者：窦艳丽黄加明李金良曹博君管东波吉林大学材料科学与工程学院教育部汽车材料重点实验室吉林长春130025 苏州华旃航天电器有限公司江苏苏州215000

以含氢硅油、甲基乙烯基MQ硅树脂、乙烯基硅油以及纳米SiO 2粉末为原料,改变乙烯基氟硅油的含量,在一定条件下得到一种有机硅含氟防粘涂层。研究发现:乙烯基氟硅油的加入,涂层表面的粗糙程度呈先减小后增大的趋势;去离子水和乙二醇与涂... 详细信息

以含氢硅油、甲基乙烯基MQ硅树脂、乙烯基硅油以及纳米SiO 2粉末为原料,改变乙烯基氟硅油的含量,在一定条件下得到一种有机硅含氟防粘涂层。研究发现:乙烯基氟硅油的加入,涂层表面的粗糙程度呈先减小后增大的趋势;去离子水和乙二醇与涂层表面的接触角呈增大的趋势,表面能最低为18.77mJ/m 2,剥离力最小为9.5g/25mm。综上所述,乙烯基氟硅油含量为7wt.%时,涂层的疏水性较好,并具有较低的表面能和剥离力,综合性能最好。

关键词：乙烯基氟硅油含氢硅油防粘涂层

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Outcomes of peripheral blood stem cell transplantation in patients from human leukocyte antigen matched or mismatched unrelated donors

引用

Chinese Medical Journal 2014年第14期127卷 2612-2617页

作者： cao Tingting Li Yanfen Wang Quanshun Li Honghua Bo Jian Zhao Yu Jing Yu Wang Shuhong Zhu Haiyan Dou Liping Jia bojun Gao Chunji Yu Li Huang Wenrong Chinese Peoples Liberat Army Gen Hosp Dept Hematol Beijing 100853 Peoples R China Cangzhou Cent Hosp Dept Hematol Cangzhou 061001 Hebei Peoples R China Chinese Peoples Liberat Army Gen Hosp Dept Hematol Hainan Branch Hainan 572013 Peoples R China

Background AIIogeneic peripheral blood stem cell transplantation from unrelated donors （UR-PBSCT） is an alternative treatment for many hematologic diseases due to lack of human leukocyte antigen （HLA）-identical sibling donors. This study aimed to evaluate the impact of the degree of the HLA match on the clinical efficacy of UR-PBSCT. Methods Patients who underwent UR-PBSCT from September 2003 to September 2012 were retrospectively investigated. They were divided into three groups according to high-resolution molecular typing. SPSS version 17.0 was used to analysis and compare the statistics of engraftment, incidence of GVHD, other complications and survival among the groups. Results One hundred and eleven patients received UR-PBSCT, 60 of them with an HLA matched donor （10/10）, 36 of them with a one locus mismatched donor （9/10）, and 15 of them with a two loci mismatched donor （8/10）. Similar basic characteristics were found in the three groups. No differences were found in engraftment of myeloid cells or platelets in the three groups （P〉0.05）. Two-year cumulative incidence of relapse, overall survival （OS） and disease-free survival （DFS） among those three groups were similar （P〉0.05）. The cumulative incidence of 100-day Ill-IV aGVHD in the HLA matched group and the one HLA locus mismatched group were significantly lower than that in the two HLA loci mismatched group （3.3%, 8.6%, and 26.7%, P=0.009）. The occurrence rate of new pulmonary infections in the HLA matched group was lower than in the two HLA mismatched groups （26.67%, 52.78%, and 41.18%, P=0.035）. The cumulative incidence of 100-day and 2-year transplantation related mortality （TRM） in two HLA loci mismatched group was higher than in the HLA matched group and in the one HLA locus mismatched group, （8.4%, 11.8% and 33.3%, P=0.016） and （12.3%, 18.7% and 47.5%, P=0.002）. Conclusions HLA mismatch will not significantly impact the engraftment or 2-year survival after UR-PBSCT, but two mismatched HLA loci may increase the cumulative incidence of severe aGVHD

关键词： human leukocyte antigen locus allogeneic hematopoietic peripheral blood stem cells transplantation unrelated donor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

深度学习在头影测量中的应用研究进展

引用

口腔疾病防治 2023年第1期31卷 58-62页

作者：曹凌云颜家榕汤博钧赵婷婷花放贺红武汉大学口腔医学院口腔基础医学省部共建国家重点实验室培育基地口腔生物医学教育部重点实验室湖北武汉430079 武汉大学口腔医院口腔正畸一科湖北武汉430079 武汉大学口腔医院循证口腔医学中心湖北武汉430079

头影测量是正畸和正颌外科诊疗过程中普遍采用的关键技术。常规的手工头影测量和半自动头影测量依赖于医师手工定点,存在耗时过长、精确度和稳定性欠佳等问题。深度学习(deep learning,DL)是人工智能(artificial intelligence,AI)领域... 详细信息

头影测量是正畸和正颌外科诊疗过程中普遍采用的关键技术。常规的手工头影测量和半自动头影测量依赖于医师手工定点,存在耗时过长、精确度和稳定性欠佳等问题。深度学习(deep learning,DL)是人工智能(artificial intelligence,AI)领域最热门的技术方法之一,具有强大的图像识别能力。在头影测量领域,目前已有较多研究致力于采用DL实现头影测量的自动化,包括自动定点、自动诊断分析、颈椎成熟度分析、腺样体肥大自动诊断和气道分析。研究显示,DL能有效提高工作效率,其准确率多已达到80%以上,与金标准之间的差异多在临床可接受范围内,具有良好的应用前景。然而,当前此类研究仅限于自动定点的实现,其数据集往往存在数据量不够丰富、数据范围局限等问题。后期研究应进一步扩展研究范围、提升算法的同时注意数据集的丰富程度,并将DL技术与其他AI技术适当结合,从而进一步提高算法的准确性、稳定性和普适性。

关键词：头影测量深度学习人工智能头颅侧位片头颅正位片自动定点自动诊断腺样体肥大气道分析颈椎成熟度分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

新型全聚赛络混纺纱的成纱质量

引用

纺织学报 2016年第8期37卷 26-31页

作者：曹梦龙徐伯俊刘新金朱预坤生态纺织教育部重点实验室(江南大学) 江苏无锡214122

为研究新型全聚赛络混纺纱成纱性能,采用一根5.0 g/10 m精梳棉粗纱与另一根3.4 g/10 m涤纶粗纱在细纱工序进行全聚赛络混纺,纺出4种细度的棉/涤(60/40)新型全聚赛络混纺纱,并与单根混纺粗纱喂入所纺出的纱进行成纱质量对比;运用哈氏切片... 详细信息

为研究新型全聚赛络混纺纱成纱性能,采用一根5.0 g/10 m精梳棉粗纱与另一根3.4 g/10 m涤纶粗纱在细纱工序进行全聚赛络混纺,纺出4种细度的棉/涤(60/40)新型全聚赛络混纺纱,并与单根混纺粗纱喂入所纺出的纱进行成纱质量对比;运用哈氏切片器,切取8种混纺纱线样本,在MOTTC B1型显微镜下观察纤维的分布状况,结合汉密尔顿指数分析方法,得到每种混纺纱内纤维的分布规律及内外转移趋势。结果表明:新型全聚赛络混纺纱的单纱条干CV值、断裂强力明显优于环锭混纺纱,且毛羽少;从单纱截面图得出,新型混纺纱中涤纶向纱芯转移呈现棉包覆涤纶的趋势,而环锭纺混纺纱中涤纶分布比较随机。

关键词：全聚纺赛络纺混纺纱汉密尔顿指数

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于PLC的细纱机电子凸轮设计

引用

上海纺织科技 2013年第6期41卷 16-18页

作者：曹静徐伯俊朱广平江南大学生态纺织教育部重点实验室江苏无锡214122

电子凸轮是数字化细纱机的关键部件之一,也是设计难点所在。首先简单介绍了PLC在纺织机械中的用途,细纱机电子凸轮的概念以及细纱机电子凸轮的设计原理,在此基础上给出部分电子凸轮的设计程序,为细纱机电子卷绕机构的设计奠定了基础。

关键词： PLC 细纱机凸轮编程设计

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：