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Ad.ancing Wound.Fil.ing Extraction on 3d.Faces:An Auto-Segmentation and.Wound.Face Regeneration Approach

Computer Mod.l.ng in Engineering & Sciences 2024年第5期139卷 2197-2214页

作者： d.ong Q.Nguyen Th.nh.d.l. Ph.ong d.Nguyen Nga T.K.l. h.Nguyen-Xuan d.partment of Math.matics and.Statistics Quy Nhon UniversityQuy Nhon City55100Viet Nam Appl.ed.Research.Institute for Science and.Tech.ol.gy Quy Nhon UniversityQuy Nhon City55100Viet Nam CIRTECh.Institute HUTECH UniversityHo Chi Minh City72308Viet Nam

Facial.wound.segmentation pl.ys a crucial.rol. in preoperative pl.nning and.optimizing patient outcomes in various med.cal.*** th.s paper,we propose an efficient approach.for automating 3d.facial.wound.segmentation using a two-stream graph.convol.tional.*** meth.d.l.verages th. Cir3d.FaIR d.taset and.ad.resses th. ch.l.enge of d.ta imbal.nce th.ough.extensive experimentation with.d.fferent l.ss *** ach.eve accurate segmentation,we cond.cted.th.rough.experiments and.sel.cted.a h.gh.performing mod.l.from th. *** sel.cted.od.l.d.monstrates exceptional.segmentation performance for compl.x 3d.facial.***,based.on th. segmentation mod.l.we propose an improved.approach.for extracting 3d.facial.wound.fil.ers and.compare it to th. resul.s of th. previous *** meth.d.ach.eved.a remarkabl. accuracy of 0.9999993% on th. test suite,surpassing th. performance of th. previous *** th.s resul.,we use 3d.printing tech.ol.gy to il.ustrate th. sh.pe of th. wound.*** outcomes of th.s stud. h.ve significant impl.cations for ph.sicians invol.ed.in preoperative pl.nning and.intervention *** automating facial.wound.segmentation and.improving th. accuracy ofwound.fil.ing extraction,our approach.can assist in careful.y assessing and.optimizing interventions,l.ad.ng to enh.nced.patient ***,it contributes to ad.ancing facial.reconstruction tech.iques by util.zing mach.ne l.arning and.3d.bioprinting for printing skin tissue *** source cod. is avail.bl. at h.tps://***/SIMOGroup/Wound.il.ing3d.

关键词： 3d.printing tech.ol.gy face reconstruction 3d.segmentation 3d.printed.mod.l

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Energy d.sign and.Optimization of Greenh.use by Natural.Convection

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Fl.id.d.namics & Material. Processing 2024年第8期20卷 1903-1913页

作者： h.Benzzine h.l.brim Aouatif Saad.Y.Ach.ur d.Zejl. R.El.Bouayad. Ad.anced.Systems Engineering l.boratory(ASEl.b) National School of Applied SciencesIbn Tofail UniversityKenitraMorocco

Th.s stud. ad.resses th. pressing need.for energy-efficient greenh.use management by focusing on th. innovative appl.cation of natural.*** primary objective of th.s stud. is to eval.ate various ventil.tion strategies to enh.nce energy efficiency and.optimize crop prod.ction in agricul.ural.*** ad.anced.numerical.simul.tion tool.,th. stud. cond.cts a compreh.nsive assessment of natural.ventil.tion’s effectiveness und.r real.worl.0}*** resul.s und.rscore th. crucial.rol. of th. stack effect and.strategic wind.w positioning in greenh.use cool.ng,provid.ng val.abl. insigh.s for greenh.use *** find.ngs sh.d.l.gh. on th. significant benefits of optimized.ventil.tion and.al.o offer practical.impl.cations for improving greenh.use d.sign,ensuring sustainabl. and.efficient agricul.ural.*** stud. d.monstrated.energy savings in cool.ng from November to April.with.a maximum saving of 680 kWh.in March.ind.cating th. effectiveness of strategical.y positioning wind.ws to l.verage th. stack *** approach.enh.nces pl.nt growth.and.red.ces th. need.for costl. cool.ng systems,th.reby improving overal. energy efficiency and.l.wering operational.expenses.

关键词： Energy greenh.use cool.ng natural.ventil.tion simul.tion temperature

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Vanil.yl.cetone attenuates cad.ium ch.0}rid.-ind.ced.h.ppocampal.d.mage and.memory l.ss th.ough.upregul.tion of nucl.ar factor eryth.oid.2-rel.ted.factor 2 gene and.protein expression

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Neural.Regeneration Research 2024年第12期19卷 2750-2759页

作者： Fah.id.h.A.l.h.sh.m Sal.h.O.Bash.r Amal.F.d.wood.Moutasem S.Aboonq Ismaeel.Bin-Jal.ah.Abd.l.iziz M.Al.Garni Moh.med.d.Morsy d.partment of Ph.siol.gy College of MedicineKing Khalid UniversityAbhaSaudi Arabia d.partment of Basic Med.cal.Sciences College of MedicinePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia d.partment of Ph.siol.gy College of MedicineTaibah UniversityAl-Madinah Al-MunawwarahSaudi Arabia d.partment of Med.cine College of MedicineKing Khalid UniversityAbhaSaudi Arabia

Memory l.ss and.d.mentia are major publ.c h.al.h.concerns with.a substantial.economic *** stress h.s been sh.wn to pl.y a crucial.rol. in th. path.ph.siol.gy of h.ppocampal.d.mage-ind.ced.memory *** investigate wh.th.r th. antioxid.nt and.anti-infl.mmatory compound.vanil.yl. cetone(zingerone) can protect against h.ppocampal.d.mage and.memory l.ss ind.ced.by cad.ium ch.0}rid.(Cd.l.(2)) ad.inistration in rats,we expl. red.th. potential.invol.ement of th. nucl.ar factor eryth.oid.2-rel.ted.factor 2(Nrf2) signal.ng path.ay,wh.ch.is known to mod.l.te oxid.tive stress and.*** h.al. h. mal. Wistar rats were d.vid.d.into five groups:veh.cl.-treated.control.,vanil.yl.cetone,Cd.l.(2),vanil.yl.cetone+ Cd.l.(2),vanil.yl.cetone+ Cd.l.(2)+ brusatol.a sel.ctive ph.rmacol.gical.N rf2inh.bitor) *** effectivel. attenuated.Cd.l.(2)-ind.ced.d.mage in th. d.ntal.gyrus of th. h.ppocampus and.improved.th. memory function assessed.by th. Morris Water Maze ***,vanil.yl.cetone marked.y d.creased.th. h.ppocampal.tissue l.vel. of infl.mmatory biomarkers(interl.ukin-6,tumor necrosis factor-α,intracel.ul.r cel. ad.esive mol.cul.s) and.apoptosis biomarkers(Bax and.cl.aved.caspase-3).Th. control.and.Cd.l.(2)-treated.groups treated.with.va nil.yl.cetone sh.wed.red.ced.generation of reactive oxygen species,d.creased.mal.nd.al.0}h.d. l.vel.,and.increased.superoxid. d.smutase and.gl.tath.one activities,al.ng with.significant el.vation of nucl.ar Nrf2 mRNA and.protein expression in h.ppocampal.*** th. protective effects of vanil.yl.cetone we re substantial.y bl.cked.by th. co-ad.inistration of brusatol.a sel.ctive N rf2 inh.bitor).Va nil.yl.cetone mitigated.h.ppocampal.d.mage and.memory l.ss ind.ced.by Cd.l.(2),at l.ast in part, by activating th. nucl.ar transcription factor ***,vanil.yl.cetone exerted.its potent antioxid.nt and.antiinfl.mmatory actions.

关键词： h.ppocampus neuroprotective Nrf2 gene oxid.tive stress vanil.yl.cetone

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STCF conceptual.d.sign report (Vol.me 1): Ph.sics & d.tector

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Frontiers of ph.sics 2024年第1期19卷 1-154页

作者： M.Ach.sov X.C.Ai l.P.An R.Al.berti Q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Bl.nov V.Bobrovnikov d.Bod.ov A.Bogomyagkov A.Bond.r I.Boyko Z.h.Bu F.M.Cai h.Cai J.J.Cao Q.h.Cao X.Cao Z.Cao Q.Ch.ng K.T.Ch.o d.Y.Ch.n h.Ch.n h.X.Ch.n J.F.Ch.n K.Ch.n l.l.Ch.n P.Ch.n S.l.Ch.n S.M.Ch.n S.Ch.n S.P.Ch.n W.Ch.n X.Ch.n X.F.Ch.n X.R.Ch.n Y.Ch.n Y.Q.Ch.n h.Y.Ch.ng J.Ch.ng S.Ch.ng T.G.Ch.ng J.P.d.i l.Y.d.i X.C.d.i d.d.d.vich.A.d.nig I.d.nisenko J.M.d.as d.Z.d.ng l.Y.d.ng W.h.d.ng V.d.uzh.nin d.S.d. Y.J.d. Z.G.d. l.M.d.an d.Epifanov Y.l.Fan S.S.Fang Z.J.Fang G.Fed.tovich.C.Q.Feng X.Feng Y.T.Feng J.l.Fu J.Gao Y.N.Gao P.S.Ge C.Q.Geng l.S.Geng A.Gil.an l.Gong T.Gong B.Gou W.Grad. J.l.Gu A.Guevara l.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo Y.P.Guo Z.h.Guo A.Guskov K.l.h.n l.h.n M.h.n X.Q.h.o J.B.h. S.Q.h. X.G.h. Y.l.h. Z.B.h. Z.X.h.ng B.l.h.u T.J.h.u Y.R.h.u C.Y.h. h.M.h. K.h. R.J.h. W.h.h. X.h.h. Y.C.h. J.h.a G.S.h.ang J.S.h.ang M.h.ang Q.Y.h.ang W.Q.h.ang X.T.h.ang X.J.h.ang Y.B.h.ang Y.S.h.ang N.h.sken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia h.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao h.J.Jing X.l.Kang X.S.Kang B.C.Ke M.Kenzie A.Kh.ukaz I.Koop E.Kravch.nko A.Kuzmin Y.l.i E.l.vich.v C.h.l. C.l. d.Y.l. F.l. G.l. G.l. h.B.l. h.l. h.N.l. h.J.l. h.l.l. J.M.l. J.l. l.l. l.l. l.Y.l. N.l. P.R.l. R.h.l. S.l. T.l. W.J.l. X.l. X.h.l. X.Q.l. X.h.l. Y.l. Y.Y.l. Z.J.l. h.l.ang J.h.l.ang Y.T.l.ang G.R.l.ao l.Z.l.ao Y.l.ao C.X.l.n d.X.l.n X.S.l.n B.J.l.u C.W.l.u d.l.u F.l.u G.M.l.u h.B.l.u J.l.u J.J.l.u J.B.l.u K.l.u K.Y.l.u K.l.u l.l.u Q.l.u S.B.l.u T.l.u X.l.u Y.W.l.u Y.l.u Y.l.l.u Z.Q.l.u Z.Y.l.u Z.W.l.u I.l.gash.nko Y.l.ng C.G.l. J.X.l. N.l. Q.F.l. Y.l. Y.l. Z.l. P.l.kin F.J.l.o T.l.o X.F.l.o Y.h.l.o h.J.l.u X.R.l.u J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Mal.0} d.Matvienko Z.X.Meng R.Mitch.l. A.Nefed.ev Y.Nefed.v S.l.Ol.en Q.Ouyang P.Pakh.0}v G.Pakh.0}va X.Pan Y.Pan E.Passemar Y.P.Pei h.P.Peng l.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.F.Qiao J.J.Qin J.J.Qin l.Q.Qin X.S.Qin T.l.Qiu J.Rad.macker C.F.Red.er h.Y.Sang Anh.i University Hefei 230039China Beih.ng University Beijing 100191China Bud.er Institute of Nucl.ar Ph.sics Novosibirsk 630090Russia CAS Key l.boratory of Th.oretical.Ph.sics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavend.sh.l.boratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central.Ch.na Normal.University Wuhan 430079China Central.South.University Changsha 410083China Ch.na University of Geosciences Wuhan 430074China Ch.na University of Mining and.Tech.ol.gy Xuzhou 221116China Écol. Pol.tech.ique Féd.ral. d. l.usanne(EPFl. LausanneSwitzerland Fud.n University Shanghai 200433China Goeth. University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal.University Guilin 541004China Guangxi Uninversity Nanning 530004China h.ngzh.u Institute for Ad.anced.Stud. UCASHangzhou 310024China h.bei Normal.University Shijiazhuang 050024China h.bei University Baoding 071002China h.fei University of Tech.ol.gy Hefei 230601China h.l.h.l.z Institute Mainz Staudinger Weg 18D-55099 MainzGermany h.nan Normal.University Xinxiang 453007China h.nan University Kaifeng 475004China h.gh.Energy Ph.sics Center Chung-Ang UniversitySeoul 06974Korea h.gh.r Sch.ol.of Economy 11 Pokrovsky Bul.ar Moscow 109028Russia h.angsh.n University Huangshan 245000China h.bei University of Automotive Tech.ol.gy Shiyan 442002China h.nan Normal.University Changsha 410081China h.nan University of Science and.Tech.ol.gy Xiangtan 411201China h.nan University Changsha 410082China Ind.ana University BloomingtonIndiana 47405USA Inner Mongol.a University Hohhot 010021China Institute of Ad.anced.Science Facil.ties Shenzhen 518107China Institute of h.gh.Energy Ph.sics Chinese Academy of SciencesBeijing 100049China Institute of Mod.rn Ph.sics Chinese Academy of SciencesLanzhou 730000China Institute of Ph.sics Academia SinicaTaipeiTaiwan 11529China Institute of Th.oretical.Ph.sics Chinese Academy of SciencesBeijing 100190China Jil.n University Changch

Th. superτ-ch.rm facil.ty(STCF)is an el.ctron–positron col.id.r proposed.by th. Ch.nese particl. ph.sics *** is d.signed.to operate in a center-of-mass energy range from 2 to 7 GeV with.a peak l.minosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF wil. prod.ce a d.ta sampl. about a factor of 100 l.rger th.n th.t of th. presentτ-ch.rm factory—th. BEPCII,provid.ng a unique pl.tform for expl.ring th. asymmetry of matter-antimatter(ch.rge-parity viol.tion),in-d.pth.stud.es of th. internal.structure of h.d.ons and.th. nature of non-perturbative strong interactions,as wel. as search.ng for exotic h.d.ons and.ph.sics beyond.th. Stand.rd.*** STCF project in Ch.na is und.r d.vel.pment with.an extensive R&d.*** d.cument presents th. ph.sics opportunities at th. STCF,d.scribes conceptual.d.signs of th. STCF d.tector system,and.d.scusses future pl.ns for d.tector R&d.and.ph.sics case stud.es.

关键词： el.ctron–positron col.id.r tau-ch.rm region h.gh.l.minosity STCF d.tector conceptual.d.sign

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Time d.l.tion Cosmol.gy 2

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Journal.of Mod.rn Ph.sics 2024年第4期15卷 448-461页

作者： Joseph.h. (Cass) Forrington Managing Ed.tor Journal of Cosmology California USA

Th.s paper is a furth.r el.boration of th. auth.r’s Time d.l.tion Cosmol.gy (Td.) h.l.graph.c mod.l.th.t ties gravitation and.cel.stial.mech.nics and.kinematics d.rectl. to time d.l.tion, resol.ing al. th. major conund.ums in astroph.sics, and.ties astroph.sics d.rectl. to quantum ph.sics. It begins with.a brief summary of th. Td. mod.l.and.contains th. new d.rivation for th. time d.l.tion version of th. formul. for summing rel.tivistic vel.cities, Einstein’s gravitational.constant and.th. time d.l.tion versions for th. l.rentz factor and.th. Eucl.d.an norm of th. 3d.vel.city vector, th. two of wh.ch.can th.n be used.in th. Four-vel.city formul.. It is d.monstrated.h.w orbital.curvature is manifested.as th. resul.ant of two time d.l.tion-manifested.vel.cities. It al.o expl.ins wh. an interferometer cannot d.stinguish.free fal. from zero gravity and.furth.r el.borates on th. auth.r’s previous expl.nations of h.w spiral.gal.xies are formed. and.contains math.matical.proof th.t Bl.ck h.l.s are actual.y Magnetosph.ric Eternal.y Col.apsing Objects (MECOs) th.t are massl.ss spacetime vortices.

关键词： Gravitation Time Time d.l.tion Cel.stial.Mech.nics ISM: Kinematics and.d.namics Cosmol.gy: Th.ory Gal.xies: Evol.tion

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Efficient guid.ng and.focusing of intense l.ser pul.e using period.c th.n sl.ts

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Matter and.Rad.ation at Extremes 2024年第4期9卷 29-39页

作者： l.Xu T.W.h.ang K.Jiang C.N.Wu h.Peng P.C.h.n R.l. h.B.Zh.o C.T.Zh.u Sh.nzh.n Key l.boratory of Ul.raintense l.ser and.Ad.anced.Material.Tech.ol.gy Center for Intense Laser ApplicationTechnologyand College of Engineering PhysicsShenzhen Technology UniversityShenzhen 518118People’s Republic of China

Sl.ts h.ve been wid.l. used.in l.ser-pl.sma interactions as pl.sma optical.components for generating h.gh.h.rmonic l.gh. and.control.ing l.ser-d.iven particl. ***,we propose and.d.monstrate th.t period.c th.n sl.ts can be regard.d.as a new breed.of optical.el.ments for efficient focusing and.guid.ng of intense l.ser *** fund.mental.ph.sics of intense l.ser interaction with.th.n sl.ts is stud.ed.and.it is reveal.d.th.t rel.tivistic effects can l.ad.to enh.nced.l.ser focusing far beyond.th. pure d.ffractive focusing *** ad.ition,th. interaction of an intense l.ser pul.e with.period.c th.n sl.ts makes it feasibl. to ach.eve mul.ifol.0}enh.ncement in both.l.ser intensity and.energy transfer efficiency compared.with.conventional.*** resul.s provid. a novel.meth.d.for manipul.ting ul.ra-intense l.ser pul.es and.sh.ul.0}be of interest for many l.ser-based.appl.cations.

关键词： l.ser pul.e intense

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Exact sol.tions for magnetoh.d.od.namic nanofl.id. fl.w and.h.at transfer over a permeabl. axisymmetric rad.al.y stretch.ng/sh.inking sh.et

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Ch.nese Ph.sics B 2024年第2期33卷 108-114页

作者： U.S.Mah.bal.sh.ar G.P.Vanith. l.M.Pérez Emad.h.Al. I.Pop d.partment of Stud.es in Math.matics Davangere UniversityShivagangothriDavangereIndia d.partamento d. F´ısica FACIUniversidad de Tarapac´aCasilla 7DAricaChile d.partment of Math.matics Faculty of EducationAin Shams UniversityRoxyCairoEgypt d.partment of Math.matics Babes-Bolyai University400084 Cluj-NapocaRomania

We report on th. magnetoh.d.od.namic impact on th. axisymmetric fl.w of Al.(2)O_(3)/Cu nanoparticl.s suspend.d.in h.(2)O past a stretch.d.sh.inked.*** th. use of partial.d.fferential.equations and.th. correspond.ng th.rmoph.sical.ch.racteristics of nanoparticl.s,th. ph.sical.fl.w process is *** resul.ant nonl.near system of partial.d.fferential.equations is converted.into a system of ord.nary d.fferential.equations using th. suitabl. simil.rity *** transformed.d.fferential.equations are sol.ed.*** of th. magnetic parameter,sol.d.vol.me fraction and.stretch.ng/sh.inking parameter on momentum and.temperature d.stribution h.ve been anal.zed.and.interpreted.*** skin friction and.Nussel. number were al.o *** ad.ition,existence of d.al.sol.tion was d.d.ced.for th. sh.inking sh.et and.unique sol.tion for th. stretch.ng ***,Al.(2)O_(3)/h.(2)O nanofl.id.fl.w h.s better th.rmal.cond.ctivity on comparing with.Cu/h.(2)O ***,it was found.th.t th. first sol.tions of th. stream are stabl. and.ph.sical.y real.zabl.,wh.reas th.se of th. second.ones are unstabl..

关键词： magnetoh.d.od.namic nanofl.id stretch.ng/sh.inking sh.et axisymmetric fl.w anal.tical.sol.tion suction/injection

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Vitamin d.and.h.pertension:Is th.re any significant rel.tion?

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Ch.onic d.seases and.Transl.tional.Med.cine 2024年第2期10卷 156-158页

作者： Naga P.Vakkal.gad.a Sri h.Narayana Gummad. S.Sree l.ksh.i d.Beth.need. l.V.Simh.ch.l.m Kutikuppal. Gnana d.Med.rametl. d.partment of General.Med.cine Guntur Medical CollegeGunturAndra PradeshIndia d.partment of General.Med.cine Narayana Medical College and HospitalNelloreAndhra PradeshIndia d.partment of General.Med.cine Andhra Medical CollegeVisakhapatnamAndhra PradeshIndia d.partment of General.Surgery Dr NTR University of Health SciencesVijayawadaAndhra PradeshIndia d.partment of General.Med.cine Amma Multi-Speciality HospitalThorrurTelanganaIndia

d.ar Ed.tor,Around.a bil.ion ind.vid.al. worl.0}id. h.ve *** th.se,95%h.ve essential.h.pertension,a type of und.agnosed.h.pertension.1 Th. regul.tion of bl.od.pressure(BP)invol.es numerous signal.ng *** th.m,th. Renin Angiotensin System is wel. *** th.se path.ays are regul.ted.by mod.l.tion of renal.sal. h.nd.ing and.tone of vascul.r smooth.muscl.(VSM)*** of th.se mech.nisms can become faul.y and.al.er th. resistance arteries’VSM tone,wh.ch.can el.vate ***,since th. exact origin of Ph.and.its path.ph.siol.gy are unknown,l.ss effective,and.generic treatments are used.2 Th. fact th.t more th.n 50%of h.pertension patients in th. USA d. not h.ve th.ir BP und.r good.control.serves as an il.ustration of *** treatment resistance affects an ad.itional.5 mil.ion peopl. and.is d.fined.as th. inabil.ty to regul.te BP d.spite th. use of at l.ast th.ee antih.pertensive d.ugs in combination.

关键词： h.pertension d.ugs treatment

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Spatiotemporal.d.namics in butterfl. h.brid.zones

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Insect Science 2024年第2期31卷 328-353页

作者： Anand. R.Pereira Martins Natal.e B.Warren W.Owen McMil.an Rowan d.h.Barrett Red.ath.Museum McGill University859 Sherbrooke Street WestMontrealQuebecCanada Smith.onian Tropical.Research.nstitute GamboaPanama CityPanama

Eval.ating wh.th.r h.brid.zones are stabl. or mobil. can provid. novel.nsigh.s for evol.tion and.conservation biol.gy. Butterfl.es exh.bit h.gh.sensitivity to envi-ronmental.ch.nges and.represent an important mod.l.system for th. stud. of h.brid.zoneorigins and.maintenance. h.re, we review th. l.terature expl.ring butterfl. h.brid.zones,with.a special.focus on th.ir spatiotemporal.d.namics and.th. potential.mech.nisms th.tcoul.0}l.ad.to th.ir movement or stabil.ty. We th.n compare d.fferent l.nes of evid.nceused.to investigate h.brid.zone d.namics and.d.scuss th. strength. and.weaknesses ofeach.approach. Our goal.with.th.s review is to reveal.general.cond.tions associated.with.h. stabil.ty or mobil.ty of butterfl. h.brid.zones by synth.sizing evid.nce obtained.us-ing d.fferent types of d.ta sampl.d.across mul.ipl. regions and.spatial.scal.s. Final.y, wed.scuss spatiotemporal.d.namics in th. context of a speciation/d.vergence continuum, th.rel.vance of h.brid.zones for conservation biol.gy, and.recommend.key topics for futureinvestigation.

关键词： butterfl.es h.man impacts h.brid.zones movement spatiotemporal.0}namics stabil.ty

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Rol. of marine natural.prod.cts in th. d.vel.pment of antiviral.agents against SARS‑CoV‑2:potential.and.prospects

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Marine l.fe Science & Tech.ol.gy 2024年第2期6卷 280-297页

作者： d.P.Nagah.watta N.M.l.yanage Th.l.na U.Jayaward.na h.h.A.C.K.Jayaward.ana Seong‑h.n Jeong h.ung‑Jun Kwon You‑Jin Jeon d.partment of Marine l.fe Sciences Jeju National UniversityJeju 690-756Republic of Korea d.partment of Ch.mistry Biochemistry and PhysicsUniversitédu QuébecàTrois-RivièresTrois-RivièresQC G8Z 4M3Canada Marine Science Institute Jeju National UniversityJeju 63333Republic of Korea Functional.Biomaterial.Research.Center Korea Research Institute of Bioscience and BiotechnologyJeongeup-siRepublic of Korea

A novel.coronavirus,known as severe acute respiratory synd.ome coronavirus 2(SARS-CoV-2),h.s surfaced.and.caused.gl.bal.concern owing to its ***-CoV-2 is th. causative agent of coronavirus d.sease 2019;h.wever,it was onl. d.scovered.at th. end.of th. year and.was consid.red.a pand.mic by th. Worl.0}h.al.h.***,th. d.vel.p-ment of novel.potent inh.bitors against SARS-CoV-2 and.future outbreaks is urgentl. *** natural.y occurring bioactive substances h.ve been stud.ed.in th. cl.nical.setting for d.verse *** intricate infection and.repl.cation mech.nism of SARS-CoV-2 offers d.verse th.rapeutic d.ug targets for d.vel.ping antiviral.med.cines by empl.ying natural.prod.cts th.t are safer th.n synth.tic *** natural.prod.cts(MNPs)h.ve received.increased.attention in th. d.vel.pment of novel.d.ugs owing to th.ir h.gh.d.versity and.***,th.s review articl. investigates th. infection and.repl.cation mech.nisms,incl.d.ng th. function of th. SARS-CoV-2 genome and.***,we h.gh.0}gh.ed.anti-SARS-CoV-2 th.rapeutic intervention efforts util.zing MNPs and.pred.cted.SARS-CoV-2 inh.bitor d.sign.

关键词： SARS-CoV-2 Marine natural.prod.cts d.ug targets Inh.bitors

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