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Fecal microbes, short chain fatty acids, and colorectal cancer across racial/ethnic groups

World Journal of Gastroenterology 2015年第9期21卷 2759-2769页

作者： Christina M Hester Venkatakrishna R Jala Morgan GI Langille Shahid Umar K Allen Greiner bodduluri haribabu Department of Family Medicine Research Division University of Kansas Medical CenterKansas CityKS 66160United States University of Kansas Cancer Center University of Kansas Medical Center Kansas CityKS 66160United States James Graham Brown Cancer Center and Department of Microbiology and Immunology University of LouisvilleLouisvilleKY 40202United States Department of Pharmacology Dalhousie UniversityHalifaxNS B3H 4R2Canada Department of Molecular and Integrative Physiology University of Kansas Medical CenterKansas CityKS 66160United States

AIM:To investigate differences in microbes and short chain fatty acid(SCFA) levels in stool samples from Hispanic and non-Hispanic African American,American Indian,and White ***:Stool samples from twenty participants were subjected to analysis for relative levels of viable bacteria and for SCFA ***,the samples were subjected to 16 S r RNA gene pyrosequencing for identification of bacteria present in the *** used a metagenome functional prediction technique to analyze genome copy numbers and estimate the abundance of butyrate kinase in all ***:We found that African Americans had significantly lower levels of acetate,butyrate,and total SCFAs than all other racial/ethnic *** also found that participant microbial profiles differed by racial/ethnic *** Americans had significantly more Firmicutes than Whites,with enriched *** Firmicutes /Bacteroidetes ratio was also significantly higher for African Americans than for Whites(P =0.049).We found Clostridium levels to be significantly and inversely related to total SCFA levels(P =0.019) and we found Bacteroides to be positively associated(P =0.027) and Clostridium to be negatively associated(P =0.012) with levels of *** also identified a correlation between copy number for a butyrate kinase predicted from 16 S r RNA gene abundance and levels of butyrate in ***:The identified differences in gut flora and SCFA levels may relate to colorectal cancer mortality differentials and may be useful as targets for future clinical and behavioral interventions.

关键词： Colorectal cancer Short chain fatty acids Racial/e

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Arylamine N-acetyltransferase 2 genotype-dependent N-acetylation of isoniazid in cryopreserved human hepatocytes

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Acta Pharmaceutica Sinica B 2017年第4期7卷 517-522页

作者： Mark A.Doll Raúl A.Salazar-González Srineil bodduluri David W.Hein Department of Pharmacology and Toxicology and James Graham Brown Cancer Center University of LouisvilleLouisvilleKY 40202USA

Cryopreserved human hepatocytes were used to investigate the role of arylamine Nacetyltransferase 2(NAT2; EC 2.***.1.5) polymorphism on the N-acetylation of isoniazid(INH). NAT2 genotype was determined by Taqman allelic discrimination assay and INH N-acetylation was measured by high performance liquid chromatography. INH N-acetylation rates in vitro exhibited a robust and highly significant(P o0.005) NAT2 phenotype-dependent metabolism. N-acetylation rates in situ were INH concentration-and time-dependent. Following incubation for 24 h with 12.5 or 100 mmol/L INH, acetylINH concentrations varied significantly(P = 0.0023 and P = 0.0002) across cryopreserved human hepatocytes samples from rapid, intermediate, and slow acetylators, respectively. The clear association between NAT2 genotype and phenotype supports use of NAT2 genotype to guide INH dosing strategies in the treatment and prevention of tuberculosis.

关键词：异菸肼 N-Acetyltransferase 2 Acetylation 多型性人的 hepatocytes 遗传型显型

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胸部CT中气道的性别差异:COPD基因队列研究

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国际医学放射学杂志 2023年第1期46卷 112-113页

作者： S.P.Bhatt S.bodduluri A.Nakhmani Y.Kim J.M.Reinhardt E.A.Hoffman 张颖

摘要女性慢性阻塞性肺疾病(COPD)的发病率正快速接近男性,并且女性症状更严重。虽然肺气肿的性别差异已有报道,气道的性别差异尚未见系统研究。目的评估气道是

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