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Single-arm phase II three-outcome designs with handling of over-running/under-running

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Statistical Theory and Related Fields 2023年第4期7卷 276-286页

作者： Wenchuan Guo Jianan Hui bob zhong Seagen Inc. BothellWAUSA Servier Pharmaceuticals BostonMAUSA Regeneron Pharmaceuticals TarrytownNYUSA

Phase II clinical trials are commonly conducted as pilot studies to evaluate the efficacy and safety of the investigational drug in the targeted patient population with the disease or condition to be treated or *** designing such a trial considering efficacy conclusions,people natu-rally think as follows:if efficacy evidence is very strong,a go decision should be made;if efficacy evidence is very weak,a no-go decision should be made;if the efficacy evidence is neither strong nor weak,no decision can be made(inconclusive).The designs presented in this paper match this natural thinking process with go/no-go/inconclusive *** two-/three-stage designs are developed with three ***,a general approach based on conditional error function is implemented such that new decision boundaries can be calculated to handle mid-course sample size change which results in either‘over-running’or‘under-running’and ensure the control of overall type I error.A free open-source R package tsdf that calculates the proposed two-/three-stage designs is available on CRAN.

关键词： Phase II trials two-stage and three-stage designs go/no-go/inconclusive outcomes asymmetric alpha alpha spending optimal designs over-running and under-running

Physical layer security via maximal ratio combining and relay selection over Rayleigh fading channels

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Science China(Information Sciences) 2016年第6期59卷 167-176页

作者： Bin zhong Minggang WU Tong LI zhongshan ZHANG School of Information and Electrical Engineering Hunan University of Science and Technology Beijing Engineering and Technology Center for Convergence Networks and Ubiquitous Services University of Science and Technology Beijing

In this paper, the impact of both maximal ratio combining(MRC) and relay selection on the physical layer security in wireless communication systems is investigated by analyzing critical issues such as the probability characteristics of the legitimate receiver(bob) and malicious eavesdropper(Eve)’s end-to-end signal-to-noise ratio(SNR), the secrecy outage probability and the average secrecy channel capacity over Rayleigh fading Channel, etc. Unlike the conventional physical layer security schemes, we assume that bob receives its data from both the relay and the source via cooperative relay, provided that MRC is employed at the ***, compared to the conventional MRC methods, the proposed method is capable of achieving a higher spatial diversity order by performing relay selection, as validated by performing the theoretical analysis as well as numerical simulation. Furthermore, the closed-form expressions in terms of secrecy outage probability and average secrecy capacity are all consistent with the numerical results. Finally, the proposed scheme may be substantially affected by a number of parameters such as the number of relays, the SNR of links and the ratio of main-to-eavesdropper ratio(MER) λME.

关键词： average secrecy capacity cooperative communication maximal ratio combining outage probability physical layer security

Three-step three-party quantum secure direct communication

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Science China(Physics,Mechanics & Astronomy) 2018年第9期61卷 26-30页

作者： Shan-Shan Chen Lan Zhou Wei zhong Yu-Bo Sheng Institute of Quantum Information and Technology Nanjing University of Posts and Telecommunications Nanjing 210003 China College of Mathematics & Physics Nanjing University of Posts and Telecommunications Nanfing 210003 China Key Lab of Broadband Vireless Communication and Sensor Network Technology Nanjing University of Posts and Telecommunications Ministry of Education Nanjing 210003 China

We propose a three-party quantum secure direct communication(QSDC) protocol with hyperentanglement in both spatial-mode and polarization degrees of freedom. The secret message can be encoded independently with desired unitary operations in two degrees of freedom. In this protocol, a party can synchronously obtain the other two parties' messages. Compared with previous three-party QSDC protocols, our protocol has several advantages. First, the single photons in our protocol are only required to transmit for three times. This advantage makes this protocol simple and useful. Second, Alice and bob can send different secret messages to Charlie, respectively. Finally, with hyperentanglement, this protocol has a higher information capacity than other protocols.

关键词： quantum communication quantum secure direct communication hyperentanglement

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一氧化氮化学性质的研究进展

有机化学 2006年第9期26卷 1317-1321页

作者：柳忠全尚筱洁罗海清周波吴隆民赣南师范学院有机化学研究所赣州341000 兰州大学应用有机化学国家重点实验室兰州730000

概括了由Louis ***,Ferid Murad和Robert ***三位诺贝尔奖获得者提出的一氧化氮作为血管内皮松弛因子(EDRF)的作用机制及生物学意义;同时也总结了100多年来一氧化氮在化学本质的探讨方面做出的研究成就;归纳了一氧化氮自由基在化学反应... 详细信息

概括了由Louis ***,Ferid Murad和Robert ***三位诺贝尔奖获得者提出的一氧化氮作为血管内皮松弛因子(EDRF)的作用机制及生物学意义;同时也总结了100多年来一氧化氮在化学本质的探讨方面做出的研究成就;归纳了一氧化氮自由基在化学反应过程中的行为本质.

关键词：一氧化氮自由基杂环

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可调频闪仪的结构及其工作原理

仪器仪表学报 1998年第1期19卷 61-66页

作者：白象忠 Филиппов.Е.Б 燕山大学俄罗斯喀山大学

本文介绍了一种新型的可调频闪仪的结构及其工作原理。利用该仪器可获取振动、高速旋转或作周期运动构件的单一“静止”，或者两个及多个位置的“静止”图象，并可观察构件的运动轨迹。文中给出了测量实例。

关键词：可调频闪仪振动高速旋转构件

雨季前后珠峰地区近地层气象要素、辐射及能量平衡分量变化特征

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高原气象 2007年第6期26卷 1269-1275页

作者：仲雷马耀明苏中波王永杰吕雅琼朱志鵾中国科学院青藏高原研究所 International Institute for Geo-Information Science and Earth Observation Enschede 7500the Netherland

利用架设在珠峰北坡4475 m高度处的一套开路涡动协方差测量系统,对曲宗地区的大气状况进行了连续观测。分析了近地层气象要素、辐射平衡各分量和能量平衡各分量在高原雨季前(5月)、雨季中(7月)和雨季后(11月)的变化特征。通过分析,发现... 详细信息

利用架设在珠峰北坡4475 m高度处的一套开路涡动协方差测量系统,对曲宗地区的大气状况进行了连续观测。分析了近地层气象要素、辐射平衡各分量和能量平衡各分量在高原雨季前(5月)、雨季中(7月)和雨季后(11月)的变化特征。通过分析,发现曲宗地区气温和相对湿度日平均变化均呈单峰单谷型特征,气压则呈双峰双谷型特征,风速日变化为单峰型特征,风速一般在午后突然增大。伴随着雨季的爆发,曲宗地区气温升高,相对湿度增大,气压升高,风速减小。主导风向由东北风转换成西南风。雨季前后,辐射平衡各分量及能量平衡各分量均具有明显的变化趋势。

关键词：珠峰地区雨季气象要素辐射通量能量通量

关于升级改造活禽市场降低禽流感循环传播风险的初步研究

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中国动物检疫 2013年第6期30卷 51-55页

作者： bob Burden 郭福生彭聪 Martin Vincent 贾贝贝王杰钟江国彭南秀王永玲刘拥军联合国粮农组织北京代表处北京100000 广州市动物卫生监督所广东广州510000 中国动物卫生与流行病学中心山东青岛266032

选择广州某活禽批发市场为试点,在对该活禽市场重要环节调查分析基础上,采取对活禽市场生物安全设施升级改造,加强相关人员生物安全知识培训,对禽类尸体和粪便等废弃物加强管理等措施,以降低禽流感病毒在活禽交易市场流通链中持续循环... 详细信息

选择广州某活禽批发市场为试点,在对该活禽市场重要环节调查分析基础上,采取对活禽市场生物安全设施升级改造,加强相关人员生物安全知识培训,对禽类尸体和粪便等废弃物加强管理等措施,以降低禽流感病毒在活禽交易市场流通链中持续循环的风险。

关键词：活禽市场生物安全设施升级改造禽流感病毒

基于多光子纠缠的具有身份认证功能的多方量子安全直接通信

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科学通报 2024年第11期69卷 1491-1500页

作者：刘成杜明明钟伟盛宇波周澜南京邮电大学理学院南京210023 南京邮电大学电子与光学工程学院柔性电子(未来技术)学院南京210023 南京邮电大学量子信息与技术研究所南京210003

多方量子安全直接通信(multi-party quantum secure direct communication,MQSDC)可使多个信息发送方通过量子信道同时向一个信息接收方传递秘密信息,并从理论上保证传递信息的绝对安全性.已有的MQSDC方案均默认所有通信方为合法通信方... 详细信息

多方量子安全直接通信(multi-party quantum secure direct communication,MQSDC)可使多个信息发送方通过量子信道同时向一个信息接收方传递秘密信息,并从理论上保证传递信息的绝对安全性.已有的MQSDC方案均默认所有通信方为合法通信方,这在实际实验条件下难以保证,为窃听者冒充合法通信方窃取信息或扰乱通信提供了可能.本文提出了基于Greenberger-Horne-Zeilinger(GHZ)态的具有身份认证功能的三方量子安全直接通信方案.信息接收方可同时认证两个实际信息发送方的身份,确认身份合法后,再接收其发送的秘密信息,理论上可保证合法通信方身份认证码以及传输信息的安全.本方案使用单光子测量代替GHZ态测量,操作简单且成功率高.本文对方案在实际实验条件下的安全信息容量进行了数值模拟.本方案在未来量子网络领域具有重要的应用.

关键词：多方量子安全直接通信身份认证 Greenberger-Horne-Zeilinger态安全信息容量

A Modest Discussion on The Themes of bob Dylan's Works in the 1960s

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新东方英语（中英文版） 2019年第7期 90-90页

作者： zhong Yaohui Dalian Maritime University

This paper aims at interpreting bob Dylan's deconstruction and criticism of the 1960s American mainstream values through his classic poems and *** respect to the social background of chauvinism and racism in the United States,the paper researches on the anti-war theme and pursuit of equality in his works,which have a positive impact not only on the American society in 1960s,but also on the development of human society today.

关键词： bob Dylan The 1960s American mainstream values Peace Equality