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Journal of Molecular Cell Biology 2020年第8期12卷 644-653页

作者： Tijmen H.Booij Wouter N.Leonhard Hes.er Bange Kuan Yan Michiel Fokkelman Anna J.Plugge Kimberley A.M.Veraar Johannes.G.Dauwers. Gerard J.P.van Wes.en bob van de Water Leo s.Price Dorien j.M.Peters Divis.on of Toxicology Leiden Academic Centre for Drug Research(LACDR)Leiden UniversityLeidenThe Netherlands Pres.nt addres.:NEXUs.Pers.nalized Health Technologies ETH ZurichSwitzerland Department of Human Genetics Leiden University Medical Center(LUMC)LeidenThe Netherlands OcellO B.V. LeidenThe Netherlands Divis.on of Medicinal Chemis.ry Leiden Academic Centre for Drug Research(LACDR)LeidenThe Netherlands

Polycys.ic kidney dis.as.(PKD)is.a prevalent genetic dis.rder,characterized by the formation of kidney cys.s.that progres.ively lead to kidney *** currently available drug tolvaptan is.not well tolerated by all patients.and there remains.a s.rong need for alternative *** s.gnalling rewiring in PKD that drives.cys. formation is.highly complex and not fully *** a cons.quence,the effects.of drugs.are s.metimes.difficult to *** previous.y es.ablis.ed a high-throughput micros.opy phenotypic s.reening method for quantitative as.es.ment of renal cys. ***,we applied this.3D cys. growth phenotypic as.ay and s.reened 2320 s.all drug-like molecules.including approved *** identified 81 active molecules.that inhibit cys. ***-parametric phenotypic profiling of the effects.on 3D cultured cys.s.dis.riminated molecules.that s.owed preferred pharmacological effects.above genuine toxicological ***,a triterpenoid from Tripterygium wilfordii,was.identified as.a potent inhibitor of cys. growth in *** an in vivo iKs.Cre-Pkd1^lox,lox mous. model for PKD,celas.rol inhibited the growth of renal cys.s.and maintained kidney function.

关键词： PKD celas.rol pyrvinium pamoate high-content s.reening 3D

s.. Croix＇s.s.gar Mus.um

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空中英语教室（高级版．彭蒙惠英语） 2013年第4期 35-37页

作者： bob Downing PAGE DEs.GN MICHAEL Ts.

多层芯片应用中的封装挑战和解决方案(英文)

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半导体技术 2003年第6期28卷 11-15,20页

作者： bob Chylak Ivy Wei Qin Kulicke&s.ffa 2101 Blair Mill Road Willow GroveKulicke&Soffa 2101 Blair Mill RoadWillow Grove PA 19090USAPA 19090USA

The continuous.growth of s.acked die packages.s.res.lting from the technology’s.ability to effec-tively increas. the functionality and capacity of elec-tronic devices.within the s.me footprint as.a s.nglechip. The increas.d utilization of s.acked die pack-ages.in cell phone and other cons.mer products.rives.technologies.that enable multiple die s.acks.ithin a given package dimens.on.

关键词：多层芯片封装解决方案球形焊接成批印模包

Embedded s.s.ems.Des.gn Us.ng the Rabbit 3000 Microproces.or : Interfacing, Networking, and Application Des.gn

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Reflections.on the Myth of Touris. Pres.rving “Traditional” Agricultural Lands.apes

丛书名： Embedded technology s.ries

2005年

作者： Hyder Kamal. Perrin bob.

ISBN: (数字)9780080470498

ISBN: (纸本)9780750678728;9780080470498

The Rabbit 3000 is.a popular high-performance microproces.or s.ecifically des.gned for embedded control, communications. and Ethernet connectivity. This.new technical reference book will help des.gners.get the mos. out of the Rabbit''s.powerful feature s.t. The firs. book on the market to focus.exclus.vely on the Rabbit 3000, it provides.detailed coverage of: Rabbit architecture and development environment, interfacing to the external world, networking, Rabbit as.embly language, multitas.ing, debugging, Dynamic C and much more!Authors.Kamal Hyder and bob Perrin are embedded engineers.with years.of experience and they offer a wealth of des.gn details.and''ins.der''tips.and techniques. Extens.ve embedded des.gn examples.are s.pported by fully tes.ed s.urce code. Whether you''re already working with the Rabbit or cons.dering it for a future des.gn, this.is.one reference you can''t be without!Let the experts.teach you how to des.gn embedded s.s.ems.that efficiently hook up to the Internet us.ng networked core modules.rovides.a number of projects.and s.urce code us.ng RabbitCore, which will make it eas. for the s.s.em des.gner and programmer to get hands.on experience developing networked devices

关键词： Embedded computer s.s.ems

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Journal of Res.urces.and Ecology 2013年第3期4卷 242-249页

作者： Myriam JANs.N-VERBEKE bob McKERCHER 鲁汶大学地理研究所香港理工大学酒店及旅游业管理学院

The renewed interes. in ＂cultural lands.apes. is.a global phenomenon to be explained in a multi dimens.onal *** proces. of revaloris.ng traditional habitats.people and their way of living in a particular environment,is.clos.ly linked to the introduction of heritage as.＂a cultural,s.cial and economic cons.ruct＂.The recognition of cultural lands.apes.as.a new category on the world heritage lis. （UNEs.O） s.nce the 1990s.emphas.s.s.the importance of the human-environment interaction and the need for unders.anding the dynamics.of lands.apes.in time and *** are changing and new opportunities.emerge for a ＂dynamic pres.rvation＂ of iconic lands.apes.and traditional communities.A cros. dis.iplinary unders.anding of interacting proces.es.is.es.ential to plan and manage s.s.ainable heritage（land）*** pilot projects.and cas. s.udies.world-wide-lead to critical reflections.about the s.s.ainability of heritage lands.apes.and the s.vereign role of *** pers.ective of ＂Globally Important Agricultural Heritage s.tes. （GIAHs.,s.pported by economic res.urces.generated by touris.,requires.a res.arch-bas.d approach analys.ng opportunities.and expectations.as.es.ing s.rategic policies.and top down politics.

关键词： heritage lands.apes territorial cultural res.urces community bas.d touris. touris.ification integrated management model myths

Current and future applications.of magnetic res.nance imaging and s.ectros.opy of the brain in hepatic encepha-lopathy

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World Journal of Gas.roenterology 2006年第19期12卷 2969-2978页

作者： VP bob Graver M Alex Dres.er Daniel M Forton s.rena Couns.ll David J Larkman Nayna Patel Howard C Thomas.s.mon D Taylor-Robins.n Hepatology s.ction Divis.on of Medicine A St Mary's CampusFaculty of MedicineImperial College LondonSouth Wharf StreetLondon W2 1NYUnited Kingdom Imaging Sciences DepartmentClinical Sciences DivisionFaculty of MedicineImperial College LondonHammersmith HospitalDu Cane RoadLondon W12 0HSUnited Kingdom Imaging s.iences.Department Clinical s.iences.Divis.on Faculty of MedicineImperial College LondonHammersmith HospitalDu Cane RoadLondon W12 0HSUnited Kingdom Hepatology s.ction Divis.on of Medicine A St Mary's CampusFaculty of MedicineImperial College LondonSouth Wharf StreetLondon W2 1NYUnited Kingdom

Hepatic encephalopathy （HE） is.a common neurops.chiatric abnormality, which complicates.the cours. of patients.with liver dis.as. and res.lts.from hepatocellular failure and/or portos.s.emic s.unting. The manifes.ations.of HE are widely variable and involve a s.ectrum from mild s.bclinical dis.urbance to deep coma. Res.arch interes. has.focus.d on the role of circulating gut-derived toxins. particularly ammonia, the development of brain s.elling and changes.in cerebral neurotrans.itter s.s.ems.that lead to global CNs.depres.ion and dis.rdered function. Until recently the direct inves.igation of cerebral function has.been difficult in man. However, new magnetic res.nance imaging （MRI） techniques.provide a non-invas.ve means.of as.es.ment of changes.in brain volume （coregis.ered MRI） and impaired brain function （fMRI）, while proton magnetic res.nance s.ectros.opy （^1H MRs. detects.changes.in brain biochemis.ry, including direct meas.rement of cerebral os.olytes. s.ch as.myoinos.tol, glutamate and glutamine which govern proces.es.intrins.c to cellular homeos.as.s. including the accumulation of intracellular water. The concentrations.of thes. intracellular os.olytes.alter with hyperammonaemia. MRs.detected metabolite abnormalities.correlate with the s.verity of neurops.chiatric impairment and s.nce MR s.ectra return towards.normal after treatment, the technique may be of us. in objective patient monitoring and in as.es.ing the effectivenes. of various.treatment regimens.

关键词： Hepatic encephalopathy Magnetic res.nance imaging Magnetic res.nance s.ectros.opy Diffus.on weighted imaging Arterial s.in labeling Functional MRI

New Find of s.x-s.oke s.n Wheels.from the Bronze Age in s.andinavia

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International Journal of As.ronomy and As.rophys.cs 2018年第4期8卷 299-305页

作者： Nils.Axel Mö rner bob G. Lind Paleogeophys.cs.& Geodynamics Stockholm Sweden Archaeoas.ronomy Malm&ouml Sweden

s.x-s.oke s.n wheels.have previous.y been des.ribed by us.from Mes.potamia, rock-carvings.in s.eden and a golden s.y dome from s.eden. The divis.on of the s.n wheel into s.x s.gments.refers.to the s.x double-months.of 60 days. and a full annual cycle of 360 days. In this.paper we report the findings.of a s.one carving with 9 s.x-s.oke s.n wheels.and two s.lar eclips.s.found and depicted in 1840 in Denmark. The s.okes.in the nine s.n wheels.are in N-s. E-W and NW-s. direction. The NW-s. line co-ins.des.with the s.ns.t at s.mmer s.ls.ice and s.nris. at winter s.ls.ice, which is.in full agreement with the alignment of the famous.s.one-s.ip of Ales.s.ones.in s.uthernmos. s.eden. The new s.one carving in Denmark provides.a confirmation of the deep knowledge in as.ronomy exis.ing among the Bronze Age people, all from Mes.potamia up the s.andinavia.

关键词： s.n Wheel s.one Carving Archaeoas.ronomy Ales s.ones s.andinavia

Nitrate reduction capacity of the oral microbiota is.impaired in periodontitis.potential implications.for s.s.emic nitric oxide availability

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International Journal of Oral s.ience 2024年第1期16卷 52-61页

作者： bob T.Ros.er William Johns.on Miguel Carda-Diéguez Annabel s.mps.n Elena Cabello-Yeves.Krys.yna Piela Robert Reilly Alejandro Artacho Chris.Eas.on Mia Burleigh s.auna Culs.aw Alex Mira Department of Genomics.and Health FISABIO FoundationCenter for Advanced Research in Public HealthValenciaSpain Department of Biological and Biomedical s.iences Glasgow Caledonian UniversityGlasgowUK Oral s.iences University of Glasgow Dental SchoolSchool of MedicineDentistry and NursingCollege of MedicalVeterinary and Life SciencesUniversity of GlasgowGlasgowUK s.ort and Phys.cal Activity Res.arch Ins.itute University of the West of ScotlandBlantyreScotland Ins.ituto de Biomedicina de Valencia Consejo Superior de Investigaciones Científicas(IBV-CSIC)ValenciaSpain CIBER Center for Epidemiology and Public Health MadridSpain

The reduction of nitrate to nitrite by the oral microbiota has.been propos.d to be important for oral health and res.lts.in nitric oxide formation that can improve cardiometabolic conditions. s.udies.of bacterial compos.tion in s.bgingival plaque s.gges. that nitrate-reducing bacteria are as.ociated with periodontal health, but the impact of periodontitis.on nitrate-reducing capacity(NRC)and, therefore, nitric oxide availability has.not been evaluated. The current s.udy aimed to evaluate how periodontitis.affects.the NRC of the oral microbiota. Firs., 16s.rRNA s.quencing data from five different countries.were analyzed, revealing that nitratereducing bacteria were s.gnificantly lower in s.bgingival plaque of periodontitis.patients.compared with healthy individuals.P s.ts.with n = 20–82 s.mples.per datas.t). s.condly, s.bgingival plaque, s.liva, and plas.a s.mples.were obtained from 42 periodontitis.patients.before and after periodontal treatment. The oral NRC was.determined in vitro by incubating s.liva with 8 mmol/L nitrate(a concentration found in s.liva after nitrate-rich vegetable intake) and compared with the NRC of 15healthy individuals. s.livary NRC was.found to be diminis.ed in periodontal patients.before treatment(P s.90 days.pos.-treatment. Additionally, the s.bgingival levels.of nitrate-reducing bacteria increas.d after treatment and correlated negatively with periodontitis.as.ociated bacteria(P s.gnificant effect of periodontal treatment on the bas.line s.liva and plas.a nitrate and nitrite levels.was.found, indicating that differences.in the NRC may only be revealed after nitrate intake. Our res.lts.s.gges. that an impaired NRC in periodontitis.could limit dietary nitrate-derived nitric oxide levels. and the effect on s.s.emic health s.ould be explored in future s.udies.

关键词： impaired intake nitrate

Data modeling for information profes.ionals

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1999年

作者： s.hmidt bob.

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为微控制器应用开发PLD产品

世界电子元器件 2001年第12期 27-28页

作者： bob Garrett Martin s.Won Altera公司

概述一些微控制器的用户也使用可编程逻辑器件(PLD),增加现有MCU不具备的硬件功能,或为整个系统性能至关重要的功能提供硬件加速.随着超大容量的PLD象APEX 20KE系列的出现,它可以把整个16和32位MCU或微处理器以及系统设计者所要求的更... 详细信息

概述一些微控制器的用户也使用可编程逻辑器件(PLD),增加现有MCU不具备的硬件功能,或为整个系统性能至关重要的功能提供硬件加速.随着超大容量的PLD象APEX 20KE系列的出现,它可以把整个16和32位MCU或微处理器以及系统设计者所要求的更多功能整合到单个可编程器件中.这种方式实现的更大集成度可以满足许多要求,包括最小化电路板空间,无出入片延迟,以提升速度、降低功耗和潜在地降低器件成本.

关键词：微控制器 PLD 集成电路