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Low Selenium and Low Protein Exacerbate Myocardial Damage in Keshan Disease by Affecting the PINK1/Parkin-mediated Mitochondrial Autophagy Pathway

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Current Medical Science 2024年第1期44卷 93-101页

作者： Li-wei ZHANg Hong-qi FENg Song-bo FU Dian-jun sun Center for Endemic Disease Control Chinese Center for Disease Control and PreventionHarbin Medical UniversityNHC Key Laboratory of Etiology and Epidemiology(Harbin Medical University)Key Lab of Etiology and EpidemiologyEducation Bureau of Heilongjiang ProvinceHarbin 150086China

Objective Keshan disease(KD)is a myocardial mitochondrial disease closely related to insufficient selenium(Se)and protein *** induced putative kinase 1(PINK1)/Parkin mediated mitochondrial autophagy regulates various physiological and pathological processes in the *** study aimed to elucidate the relationship between PINK1/Parkin-regulated mitochondrial autophagy and KD-related myocardial *** A low Se and low protein animal model was *** hundred Wistar rats were randomly divided into 5 groups(control group,low Se group,low protein group,low Se+low protein group,and corn from KD area group).The JC-1 method was used to detect the mitochondrial membrane potential(MMP).ELISA was used to detect serum creatine kinase MB(CK-MB),cardiac troponin I(cTnI),and mitochondrial-glutamicoxalacetic transaminase(M-gOT)***-PCR and Western blot analysis were used to detect the expression of PINK1,Parkin,sequestome 1(P62),and microtubule-associated proteins1A/1B light chain 3B(MAP1LC3B).Results The MMP was significantly decreased and the activity of CK-MB,cTnI,and M-gOT significantly increased in each experimental group(low Se group,low protein group,low Se+low protein group and corn from KD area group)compared with the control group(Pgroups compared with the control group(Pge in KD by affecting the PINK1/Parkin-mediated mitochondrial autophagy pathway.

关键词： Keshan disease low selenium and low protein myocardial mitochondrial injury PTEN induced putative kinase 1(PINK1)/Parkin mitochondrial autophagy

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Computing Power Network:A Survey

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China Communications 2024年第9期21卷 109-145页

作者： sun Yukun Lei bo Liu Junlin Huang Haonan Zhang Xing Peng Jing Wang Wenbo School of Information and Communications Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China Research Institute of China Telecom Co. Ltd.Beijing 102209China Beijing Branch of China Telecom Co. Ltd.Beijing 100032China

With the rapid development of cloud computing,edge computing,and smart devices,computing power resources indicate a trend of ubiquitous *** traditional network architecture cannot efficiently leverage these distributed computing power resources due to computing power island *** overcome these problems and improve network efficiency,a new network computing paradigm is proposed,i.e.,Computing Power Network(CPN).Computing power network can connect ubiquitous and heterogenous computing power resources through networking to realize computing power scheduling *** this survey,we make an exhaustive review on the state-of-the-art research efforts on computing power *** first give an overview of computing power network,including definition,architecture,and ***,a comprehensive elaboration of issues on computing power modeling,information awareness and announcement,resource allocation,network forwarding,computing power transaction platform and resource orchestration platform is *** computing power network testbed is built and *** applications and use cases in computing power network are ***,the key enabling technologies for computing power network are ***,open challenges and future research directions are presented as well.

关键词： computing power modeling computing power network computing power scheduling information awareness network forwarding

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Persistent greening against drying in northeast Asian semiarid grasslands:Asymmetrical responses of direct and legacy effects to intensified drought

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Advances in Climate Change Research 2024年第1期15卷 9-20页

作者： Yu-Tong MA Hai-Shan CHEN Yao-Ming SONg bo-Tao ZHOU Shan-Lei sun Xin-guan DU Yue sun Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment Change/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 210044China School of Atmospheric Sciences Nanjing University of Information Science and TechnologyNanjing 210044China

Despite experiencing a decadal shift towards drought conditions at the end of the 2Oth century,semiarid grasslands in northeast Asia(NEA)exhibited an evident greening trend from 1982 to ***,the mechanism behind this phenomenon remains ***,we analysed the interdecadal changes in vegetation response to drought on the basis of the standardised precipitation evapotranspiration index(SPEI)and global Inventory Modelling and Mapping Studies LAI4g datasets,with an emphasis on the differences between direct and legacy effects(as measured by resilience),to explore the mechanism of persistent grassland *** revealed that during the post-drought shift period(2000-2020),the sudden decrease in the water content of the intermediate soil layer triggered an intensified vegetation response to ***,although direct effects and resilience were amplified,they exhibited asymmetric *** was stronger than direct effects,and this difference increased with increasing drought(drought recovery)*** combined effects may account for persistent greening against intensified drying in the semiarid grasslands in *** the projected exacerbation of future droughts,this study holds notable importance for comprehending the long-term change dynamics of dryland ecosystems.

关键词： Semiarid grassland Drought decadal shift Direct effect Legacy effect(resilience) Northeast Asia

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Future changes in compound drought events and associated population and gDP exposure in China based on CMIP6

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Atmospheric and Oceanic Science Letters 2024年第3期17卷 25-31页

作者： Rufan Xue bo sun Wanling Li Huixin Li botao Zhou Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters/Key Laboratory of Meteorological Disasters Ministry of Education/Joint International Research Laboratory of Climate and Environment ChangeNanjing University of Information Science and TechnologyNanjingChina Southern Marine Science and Engineering guangdong Laboratory ZhuhaiChina Nansen Zhu International Research Centre Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina

相较于一种类型的干旱,几种类型的干旱同时发生的复合型干旱事件对人类社会造成的危害更加严重.本研究采用CMIP6资料,研究中国复合型干旱事件及其相关社会经济暴露度的未来变化.结果表明,西北北部,西南和华南地区复合型干旱事件频次,持... 详细信息

相较于一种类型的干旱,几种类型的干旱同时发生的复合型干旱事件对人类社会造成的危害更加严重.本研究采用CMIP6资料,研究中国复合型干旱事件及其相关社会经济暴露度的未来变化.结果表明,西北北部,西南和华南地区复合型干旱事件频次,持续时间和严重程度增加,而华北和东北地区则减少.复合型干旱事件的人口暴露度在长江流域南部大幅增加,在长江流域以北的东部大幅减少,其中气候和人口均对人口暴露度的变化有重要影响.由于gDP的快速增长,中国未来几乎所有地区复合型干旱事件的gDP暴露度增加,特别是在中国东部,gDP效应对gDP暴露度变化的相对贡献最大.

关键词：复合型干旱事件国际耦合模式比较计划人口暴露度 gDP暴露度相对贡献

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Bio-inspired surface manipulation of halloysite nanotubes for highperformance flame retardant polylactic acid nanocomposites

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Nano Research 2024年第3期17卷 1595-1606页

作者： Yaru sun Bin Yu Yan Liu Junbo Yan Zixi Xu bo Cheng Fenglei Huang Jun Wang State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China State Key Laboratory of Fire Science University of Science and Technology of ChinaHefei 230026China Beijing Institute of Technology Chongqing Innovation Center Chongqing 401120China National Engineering Research Center of Flame Retardant Materials Beijing Institute of TechnologyBeijing 100081China

High-performance flame-retardant polylactic acid(PLA)bio-composites based on biobased fillers to meet usage requirements represents a promising direction for creating a sustainable *** flame retardant PLA composites have been reported extensively,it still remains a huge challenge to develop mechanically *** flame retardant PLA composites due to plastication effect of organic flame retardants and poor compatibility of organic fillers with the matrix lead to the severe deterioration in mechanical *** this work,a bio-inspired surface manipulation strategy for halloysite nanotubes(HNTs)was proposed via a facile and green self-assembly *** structure and morphology of bio-inspired HNTs(b-HNTs)proved that biomass nanofillers(PA-NA-Fe)grew well both within the lumen and on the surface of *** growth of biomass on the inner and outer surfaces of HNTs was inspired from wooden towards enhancing the interface compatibility and imparting multi-properties to PLA *** mechanical properties(tensile,thermomechanical and anti-impact mechanical),great fire safety(heat release and smoke emission),thermostability and improved electromagnetic interference shielding effectiveness of this well-designed PLA nanocomposite were *** mechanisms of the enhanced performances of the PLA bio-composites by loading b-HNTs were *** work presents a facile and environmentally-friendly bio-inspired modification strategy for HNTs to fabricate high-performance,multi-functional polymer composites,which is also suitable for surface modification of many other nanomaterials,including nanofibers,nanotubes,nanowires,and nanosheets.

关键词： mechanical properties thermostability fire safety electromagnetic interference shielding biomass

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A Parallel-type Load Damping Factor Controller for Frequency Regulation in Power Systems with High Penetration of Renewable Energy Sources

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Journal of Modern Power Systems and Clean Energy 2024年第4期12卷 1019-1030页

作者： Zhe Zhang Siyang Liao Yuanzhang sun Jian Xu Deping Ke bo Wang Rui Chen Yibo Jiang Hubei Engineering and Technology Research Center for AC/DC Intelligent Distribution Network School of Electrical Engineering and AutomationWuhan UniversityWuhan 430072China State grid Hubei Electric Power Company Limited Economic Research Institute Wuhan 430074China State grid(Suzhou)City&Energy Research Institute Company Limited Suzhou 215000China

Renewable energy sources(RESs)are rapidly devel-oping and their substitution for traditional power generation poses significant challenges to the frequency regulation in pow-er *** load damping factor D characterizes the active power of load that changes with power system frequency,which is an important factor influencing the frequency ***-ever,the value of D is small,resulting in the limitation in fre-quency regulation of the power *** paper proposes a parallel-type load damping factor controller to enhance load damping factor by utilizing static var generators(SVgs)in ***,it discusses the configuration method for the relevant parameters of the controller,evaluates its frequen-cy regulation capability,investigates the impact of large-scale application of the controller on static and dynamic loads,and conducts a comprehensive evaluation of the impact of the damp-ing factor control process on the voltage stability of the main *** large-scale application of the proposed controller can significantly improve the frequency regulation capability,and al-most have no influence on the working status of the *** can also significantly improve the dynamic performance of system *** proposed controller can provide technical sup-port for the frequency regulation of new power systems with high proportion of RESs.

关键词： Load damping factor parallel-type load damping factor controller power system frequency regulation highproportion renewable energy system

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Rheology of continental lithosphere and seismic anisotropy

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Science China Earth Sciences 2024年第1期67卷 31-60页

作者： Shengsi sun Yunpeng DONg Yixi LI Yihai YANg Chao CHENg bo HUI Bin ZHANg Rutao ZANg State Key Laboratory of Continental Dynamics Department of GeologyNorthwest UniversityXi’an 710069China Shaanxi Earthquake Agency Xi’an 710068China

Rheology of rocks controls the deformation of the Earth at various space-time scales,which is crucial to understand the tectonic evolution of continental *** of rock rheology are mainly conducted via high-pressure and hightemperature rheological experiments and multi-scale observations and measurements of naturally deformed *** present,a large amount of data from such kinds of studies have been *** paper first provides an up-to-date comprehensive review of the rheological mechanisms,fabric types and seismic properties of the main rock-forming minerals at different depths of continental lithosphere,including olivine,orthopyroxene,clinopyroxene,amphibole,plagioclase,quartz and ***,progress in high-pressure and high-temperature experiments and natural deformation observations is introduced,mainly regarding the rheological strength and behavior,seismic velocity and anisotropy of lithospheric mantle peridotite,eclogite,mafic granulite,amphibolite and felsic ***,by taking the Tibetan Plateau as an example,the application of rock rheology for quantitative interpretation of seismic anisotropy data is *** combination of mineral deformation fabrics and seismic anisotropy is expected to make an important breakthrough in understanding the rheological properties and structure of continental lithosphere.

关键词： Lithosphere Mineral fabric Rheology Seismic velocity Anisotropy

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Plasmon coupling-driven enhanced high-order multiphoton excited fluorescent performance of metal-organic frameworks

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Nano Research 2024年第7期17卷 6502-6508页

作者： Tong Meng bo Li Linlin Zeng Xianshun sun Yupeng Tian Hongping Zhou Meng Zhou Dandan Li Institutes of Physical Science and Information Technology Key Laboratory of Structure and Functional Regulation of Hybrid MaterialsMinistry of EducationAnhui UniversityHefei 230601China School of Chemistry and Chemical Engineering Anhui UniversityHefei 230601China Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China

Accessing high-order multiphoton excited fluorescence(H-MPEF)materials is challenging yet and needs complicated synthesis *** this study,we successfully assembled plasmonic Au nanorods(Au NRs)with multiphoton responsive metalorganic frameworks(MOFs),resulting in a significant several-fold enhancement of *** extent of multiphoton enhancement was found to be strongly dependent on the degree of overlap between the multiphoton excitation wavelength of MOFs and the localized surface plasmon resonance absorbance of Au NRs,indicating the importance of plasmon-induced resonance energy ***,plasmon-induced hot electron transfer played a vital role in enhanced multiphoton activity as ***,the optimum H-MPEF enhancement occurs at the second near-infrared(NIR-II)region,which provides a promising platform for fluorescent *** findings provide a feasible and practical method to fabricate optimized H-MPEF materials for biological imaging using tissue-penetrating NIR-II light.

关键词： metal-organic framework(MOF) plasmon resonance multiphoton activity fluorescence imaging

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Probing the interaction between asphaltene-wax and its effects on the crystallization behavior of waxes in heavy oil via molecular dynamics simulation

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Petroleum Science 2024年第4期21卷 2839-2848页

作者： Yong Hu Xi Lu Hai-bo Wang Ji-Chao Fang Yi-Ning Wu Jian Fang sun SINOPEC Petroleum Exploration and Production Research Institute Shandong Key Laboratory of Oilfield Chemistry School of Petroleum Engineering China University of Petroleum (East China)

High content of asphaltenes and waxes leads to the high pour point and the poor flowability of heavy oil,which is adverse to its efficient development and its transportation in *** the interaction mechanism between asphaltene-wax is crucial to solve these problems,but it is still *** this paper,molecular dynamics simulation was used to investigate the interaction between asphaltenewax and its effects on the crystallization behavior of waxes in heavy *** show that molecules in pure wax are arranged in a paralleled *** wax molecules in heavy oil,which are close to the surface of asphaltene aggregates,are bent and arranged *** the mass fraction of asphaltenes in asphaltene-wax system(ωasp) is 0-25 wt%,the attraction among wax molecules decreases and the bend degree of wax molecules increases with the increase of ω*** ωaspincreases from 0 to 25 wt%,and the attraction between asphaltene-wax is stronger than that among *** causes that the wax precipitation point changes from 353 to 333 *** the ωaspincreases to 50 wt%,wax molecules are more dispersed owing to the steric hindrance of asphaltene aggregates,and the interaction among wax molecules transforms from attraction to *** causes that the ordered crystal structure of waxes can't be formed at normal ***,the asphaltene,with the higher molecular weight or the more hetero atoms,has more obvious inhibition to the formation of wax ***,resins also have an obvious inhibition on the wax crystal due to the formation of asphalteneresin aggregates with a larger *** results reveal the interaction mechanism between asphaltene-wax,and provide useful guidelines for the development of heavy oil.

关键词： Heavy oil Interaction mechanism Asphaltenes Waxes Molecular dynamics

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Design and high-power testing of offline conditioning cavity for CiADS RFQ high-power coupler

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Nuclear Science and Techniques 2024年第9期35卷 18-27页

作者： Ruo-Xu Wang Yuan He Long-bo Shi Chen-Xing Li Zong-Heng Xue Tian-Cai Jiang Xian-bo Xu Lie-Peng sun Zhou-Li Zhang Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Lanzhou University Lanzhou 730000China

To validate the design rationality of the power coupler for the RFQ cavity and minimize cavity contamination,we designed a low-loss offline conditioning cavity and conducted high-power *** offline cavity features two coupling ports and two tuners,operating at a frequency of 162.5 MHz with a tuning range of 3.2 *** the installation angle of the coupling ring and the insertion depth of the tuner helps minimize cavity *** performed electromagnetic structural and multiphysics simulations,revealing a minimal theoretical power loss of 4.3%.However,when the cavity frequency varied by110 kHz,theoretical power losses increased to10%,necessitating constant tuner adjustments during *** simulations indicated that increased cavity temperature did not affect frequency *** completion of the offline high-power conditioning platform,we measured the transmission performance,revealing a power loss of 6.3%,exceeding the theoretical *** utilized efficient automatic range scanning and standing wave resonant *** fully condition the power coupler,a 15°phase difference between two standing wave points in the condition-ing system was ***,the maximum continuous wave power surpassed 20 kW,exceeding the expected target.

关键词： RFQ cavity Power coupler Offline conditioning Resonant cavity

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