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Hardware-in-loop adaptive neural control for a tiltable V-tail morphing aircraft

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Defence Technology（防务技术） 2023年第4期22卷 197-211页

作者： Fu-xiang Qiao Jing-ping Shi xiao-bo Qu Yong-xi lyu School of Automation Northwestern Polytechnical UniversityXi'an710129China Shaanxi Province Key Laboratory of Flight Control and Simulation Technology Xi'an710129China

This paper proposes an adaptive neural control(ANC)method for the coupled nonlinear model of a novel type of embedded surface morphing aircraft which has a tiltable V-tail.A nonlinear model with sixdegrees-of-freedom is *** first-order sliding mode differentiator(FSMD)is applied to the control scheme to avoid the problem of“differential explosion”.Radial basis function neural networks are introduced to estimate the uncertainty and external disturbance of the model,and an ANC controller is proposed based on this design *** stability of the proposed ANC controller is proved using Lyapunov theory,and the tracking error of the closed-loop system is semi-globally uniformly *** effectiveness and robustness of the proposed method are verified by numerical simulations and hardware-in-the-loop(HIL)simulations.

关键词： Morphing aircraft Back-stepping control Adaptive control Neural networks Radial basis function

Gut-brain axis as a bridge in obesity and depression:Mechanistic exploration and therapeutic prospects

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World Journal of Psychiatry 2025年第1期15卷 12-20页

作者： Rui-Ying Fang xiao-Rui Pan Xin-Xing Zeng Zheng-Zheng Li bo-Fan Chen Hai-Min Zeng Jie Peng The Second Clinical Medical College The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina

A recent study by Wang et al,published in the World Journal of Psychiatry,provided preventative and therapeutic strategies for the comorbidity of obesity and *** gut-brain axis,which acts as a two-way communication system between the gastrointestinal tract and the central nervous system,plays a pivotal role in the pathogenesis of these *** suggests that metabolic byproducts,such as short-chain fatty acids,lipopolysaccharide and bile acids,which are generated by the gut microbiota,along with neurotransmitters and inflammatory mediators within the gut-brain axis,modulate the host's metabolic processes,neuronal regulation,and immune responses through diverse *** interaction between obesity and depression via the gut-brain axis involves disruptions in the gut microbiota balance,inflammatory immune responses,and alterations in the neuroendocrine *** the gut-brain axis,for example,through a ketogenic diet,the use of probiotics,and the supplementation of antioxidants,offers new remedial approaches for obesity and *** research that explores the mechanisms of the gut-brain axis is needed to provide more evidence for clinical treatment.

关键词： Gut-brain axis Obesity Depression Gut microbiota Mechanism

Study of the standard model with weak decays of charmed hadrons at BESⅢ

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National Science Review 2021年第11期8卷 39-53页

作者： Hai-bo Li xiao-Rui lyu Institute of High Energy Physics Chinese Academy of Sciences University of Chinese Academy of Sciences

A comprehensive review of weak decays of charmed hadrons(D0/+,Ds~+ and Λc~+) based on analyses of the threshold data from e~+e~-annihilation in the BESⅢ experiment is *** experimental challenges and successes in understanding decays of the charmed hadrons are *** calibrations of quantum chromodynamics and tests of the standard model are provided by measurements of purely leptonic and semi-leptonic decays of charmed hadrons,and lepton universality is probed in purely leptonic decays of charmed mesons to three generations of *** correlations in threshold data samples provide access to strong phases in the neutral D meson decays and probe the decay dynamics of the charmed Λ*** physics studies with near-threshold production of charmed particle pairs are unique to BESⅢ,and provide many important opportunities and challenges.

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Natural products as potent inhibitors of hypoxia-inducible factor-1α in cancer therapy

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Chinese Journal of Natural Medicines 2020年第9期18卷 696-703页

作者： ZHONG Jin-Cheng LI xiao-bo lyu Wen-Yu YE Wen-Cai ZHANG Dong-Mei College of Pharmacy Jinan UniversinyGuangzhou 510632.China Guangdong Province Key Laboratory of Pharmacodynamic Constituents 0f Traditional Chinese Medicine and New Drugs Research Jinan UniversityGuangzhou 510632China

Hypoxia is a prominent feature of tumors. Hypoxia-inducible factor-1α(HIF-1α), a major subunit of HIF-1, is overexpressed in hypoxic tumor tissues and activates the transcription of many oncogenes. Accumulating evidence has demonstrated that HIF-1α promotes tumor angiogenesis, metastasis, metabolism, and immune evasion. Natural products are an important source of antitumor drugs and numerous studies have highlighted the crucial role of these agents in modulating HIF-1α. The present review describes the role of HIF-1α in tumor progression, summarizes natural products used as HIF-1α inhibitors, and discusses the potential of developing natural products as HIF-1α inhibitors for the treatment of cancer.

关键词： Hypoxia-inducible factor-1α Hypoxia Cancer Natural products Anticancer treatment

Characteristics of gully bed scour and siltation between check dams

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Journal of Mountain Science 2023年第1期20卷 49-64页

作者： lyu xiao-bo YOU Yong WANG Zhuang LIU Jin-feng SUN Hao ZHAO Wan-yu Key Laboratory of Mountain Hazards and Earth Surface Process Chinese Academy of SciencesChengdu610041China Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu610041China University of Chinese Academy of Sciences Beijing100049China

Check dams are the most commonly used engineering measure for debris flow control *** scour and siltation characteristics between dams are important factors affecting dam *** this study,classical dimensional analysis of the variables that influence the development of gully bed scour and siltation was carried *** experiments were conducted to examine the influence characteristics of opening width,flume slope,debris flow density,and opening rate on the characteristics of gully bed scour and *** influential characteristics of variables on the dimensionless scour depth,scour length,siltation length,scour volume and siltation volume were *** experiments showed that,with an increase in the relative opening from 1.5 to 2.5,scour depth increased by 7.4%,scour length decreased by 11.2%,siltation length increased by 22.0%,scour volume decreased by 4.7%and siltation volume increased by 22.0%.With an increase in flume gradient from 0.105 to 0.213,scour depth,siltation length and siltation volume increased by 40.0%,65.9%and 65.9%,respectively,and scour length decreased by 20.1%.With an increase in sediment concentration from 0.303 to 0.545,siltation length and siltation volume increased by 15.4%and 15.4%,respectively,and scour depth,scour length and scour volume decreased by 9.6%,9.1%and 17.8%,*** opening rate increased from 0.08 to 0.32,siltation length and siltation volume increased by 33.3%and 33.3%,respectively,and scour depth,scour length and scour volume decreased by 5.4%,13.7%and 18.4%,*** results showed that the flume gradient was the most influential factor on scour depth,scour length,siltation length and siltation volume,and the sediment concentration was the most influential factor on scour ***,according to the experimental data,some empirical formulas predicting scour depth,scour length,siltation length,scour volume and siltation volume were *** error between the computed values accord

关键词： Debris flow Gully bed scour Gully bed siltation Window dam

Ineffectiveness of Skin Tests in Predicting Allergic Reactions Induced by Chinese Herbal Injections

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Chinese Journal of Integrative Medicine 2022年第1期28卷 36-42页

作者： lyu Chun-xiao ZHANG Jun-hua WANG Bao-he ZHANG bo-li LIU Chang-xiao LI Yan-fen HUANG Yu-hong Department of Clinical Pharmacology Second Affiliated Hospital of Tianjin University of Traditional Chinese MedicineTianjin(300250)China Research Institute of Traditional Chinese Medicine Evidence-Based Medicine CentreTianjin University of Traditional Chinese MedicineTianjin(300250)China Tianjin State Key Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin(300250)China State Key Laboratory of Drug Delivery Technology and Pharmacokinetics Tianjin Institute of Pharmaceutical ResearchTianjin(300250)China

Objective:To evaluate whether skin tests are suitable to predict the allergy reactions induced by Chinese herbal injections(CHIs).Methods:The skin tests including skin prick tests(SPT),intradermal tests(IDT)and provocation tests including subcutaneous tests and intravenous tests were administered to 249 healthy subjects and 180 allergic patients for 3 CHIs,including ginkgolide injection,diterpene ginkgolide meglumine injection and Salvianolate lyophilized *** results of the provocation tests were used as the"gold standard"to determine the sensitivity and specificity of the skin ***:The results did not show any significant differences between the healthy and allergy groups in both skin tests and provocation tests(P>0.05).The specificities of SPT and IDT were 0.976 and 0.797,respectively,and the sensitivities of both SPT and IDT were ***:Skin tests are insufficient to predict the likelihood of allergic reactions resulting from CHIs.(ChiCTR-CPC-15006921)

关键词： adverse drug reactions allergic reactions Chinese herbal injections skin tests

电刺激诱导miR-741-3p调控Radil促进施万细胞的迁移

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中国组织工程研究 2025年第19期29卷 4038-4043页

作者：刘庆高博杨霄姜宇王培承德医学院附属医院河北省承德市067000 承德医学院河北省承德市067000

背景:越来越多的动物实验和临床研究证实电刺激可以促进周围神经损伤修复,具体的机制尚未完全明确。目的:探讨电刺激诱导miR-741-3p调控Radil对施万细胞迁移的影响。方法:①12只雄性SD大鼠,随机分为电刺激组和对照组,电刺激组在坐骨神... 详细信息

背景:越来越多的动物实验和临床研究证实电刺激可以促进周围神经损伤修复,具体的机制尚未完全明确。目的:探讨电刺激诱导miR-741-3p调控Radil对施万细胞迁移的影响。方法:①12只雄性SD大鼠,随机分为电刺激组和对照组,电刺激组在坐骨神经挤压伤后连续电刺激7 d,对照组在坐骨神经挤压后不做任何处理。术后第7天取损伤处神经,利用荧光原位杂交技术检测两组miR-741-3p的表达差异。②通过miRDB、TargetScan和miRWalk数据库预测miR-741-3p靶基因。③将miR-741-3p模拟物及其对照、miR-741-3p抑制物及其对照、Radil siRNA及其对照、miR-741-3p抑制物+Radil siRNA及miR-741-3p抑制物+siRNA对照对施万细胞进行转染,采用RT-PCR检测转染效率,Transwell小室检测施万细胞的迁移能力。结果与结论:①电刺激组神经残端miR-741-3p荧光强度低于对照组;②数据库预测结果显示有69个基因可能是miR-741-3p靶基因,Radil是预测靶基因之一,主要参与细胞黏附和迁移;③与miR-741-3p抑制物对照组相比,miR-741-3p抑制物组施万细胞迁移数增多(P<0.05);与miR-741-3p模拟物对照组相比,miR-741-3p模拟物组施万细胞迁移数减少(P<0.05);与siRNA对照组相比,Radil siRNA组施万细胞迁移数减少(P<0.05);④与miR-741-3p抑制物对照组相比,miR-741-3p抑制物组Radil的表达水平升高;与miR-741-3p模拟物对照组相比,miR-741-3p模拟物组Radil的表达水平降低;⑤与miR-741-3p抑制物+siRNA对照组相比,miR-741-3p抑制物+Radil siRNA组施万细胞迁移数减少(P<0.05)。结果表明,电刺激通过下调miR-741-3p调控Radi的表达来促进施万细胞迁移。

关键词：施万细胞电刺激 miR-741-3p Radil 细胞迁移神经再生

Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-bo Feng Hai-Hui Jiang Hui-Li Kang Yi Jiang Hua-Wei Zhang xiao-Mei Song Yu-Ze Li Wen-Li Huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

Nanoporous metal organic framework materials for hydrogen storage

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Particuology 2009年第2期7卷 129-140页

作者： bo xiao Qingchun Yuan EaStChem School of Chemistry Purdie Building North Haugh University of St. Andrews Fife St. Andrews KY16 9ST UK Institute of Particle Science and Engineering School of Processing Environmental & Mineral Engineering University of Leeds Houldworth Building Leeds LS2 9JT UK

Hydrogen is expected to play an important role in future transportation as a promising alternative clean energy source to carbon-based fuels. One of the key challenges to commercialize hydrogen energy is to develop appropriate onboard hydrogen storage systems, capable of charging and discharging large quantities of hydrogen with fast enough kinetics to meet commercial requirements. Metal organic framework （MOF） is a new type of inorganic and organic hybrid nanoporous particulate materials. Its diverse networks can enhance hydrogen storage through tuning the structure and property of MOFs. The MOF materials so far developed adsorb hydrogen through weak dispersion interactions, which allow significant quantity of hydrogen to be stored at cryogenic temperatures with fast kinetics. Novel MOFs are being developed to strengthen the interactions between hydrogen and MOFs in order to store hydrogen under ambient conditions. This review surveys the development of such candidate materials, their performance and future research needs.

关键词： Hydrogen storage Metal organic framework Nanoporous particulate materials