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Unraveling the mechanism of action of Shangxia liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-Jie Quan Hao liang Yong-Hong Tang li Jiang Xiong-Ying Ji Feng-Ying Zhang Ping Zhang bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

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MBBS留学生医学影像学全英文教学初探

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昆明医科大学学报 2016年第7期37卷 131-134页

作者：李宗芳陈绍春何波胡娟李俊赵卫昆明医科大学第一附属医院医学影像学教研室云南昆明650032 昆明医科大学基础医学院人体解剖学与组织胚胎学系云南昆明650500 昆明医科大学国际教育学院云南昆明650500

目的探讨如何保障并提高全英文授课MBBS留学生医学影像学教学质量.方法以昆明医科大学2011级和2012级MBBS留学生共144人、医学影像学全英文授课师资13人的教学实践为基础,采用基础数据分析和问卷调查的方法,从生源特点、师资队伍建设、... 详细信息

目的探讨如何保障并提高全英文授课MBBS留学生医学影像学教学质量.方法以昆明医科大学2011级和2012级MBBS留学生共144人、医学影像学全英文授课师资13人的教学实践为基础,采用基础数据分析和问卷调查的方法,从生源特点、师资队伍建设、教学方法等方面进行了调查研究.结果昆明医科大学留学生主要来自印度、孟加拉国、尼泊尔等南亚国,英语发音有别于英美;医学影像学全英文教学师资队伍以中青年骨干教师为主,具有较好的英语和专业基础,但专业英语沟通能力有待加强;大部分留学生认为"启发式教学法"对提高学习兴趣和效率等有积极作用,授课教师认为"启发式教学法"对促进师生交流、提高教师能力等有明显作用.结论 "启发式教学法"能促进教师熟悉生源国的英语发音特点、增强教师专业英语沟通能力、提高MBBS留学生学习兴趣和学习效率,值得进一步完善和推广.

关键词：医学影像学 MBBS 留学生全英文教学

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Optimized Separation of Nine Xanthones by Microemulsion Electrokinetic Chromatography

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Chinese Chemical Letters 2002年第9期13卷 877-880页

作者： Tao bo hu Wei liU Ke An li Chemistry Department Peking UniversityBeijing 100871

A microemulsion electrokinetic chromatography method has been firstly used for the separation of the therapeutically important xanthones from Securidaca inappendiculata. The separation of the nine xanthones was systematically optimized with respect to pH, composition of microemulsion, addition of cyclodextrins, applied voltage and column temperature. Baseline separation was successfully achieved for the nine xanthones, which was also compared with that by micellar electrokinetic chromatography.

关键词： Separation xanthones Securidaca inappendiculata microemulsion electrokinetic chromatography micellar electrokinetic chromatography.

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加热条件下沙蛰组织构造和流变学特性的变化

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水产学报 2010年第10期34卷 1605-1609页

作者：孟飞张朝辉赵雪陈伯虎高昕李八方中国海洋大学食品科学与工程学院

研究鲜活和不同加热时间条件下沙蛰组织构造及流变学特性的变化。组织构造变化采用Van Gieson染色法观察和扫描电镜观察,流变学特性参数通过应力松弛和破断实验进行测定。结果表明,沙蛰样品在加热过程中其重量和体积均呈现显著减小趋势... 详细信息

研究鲜活和不同加热时间条件下沙蛰组织构造及流变学特性的变化。组织构造变化采用Van Gieson染色法观察和扫描电镜观察,流变学特性参数通过应力松弛和破断实验进行测定。结果表明,沙蛰样品在加热过程中其重量和体积均呈现显著减小趋势;流变学特征参数弹性模量E0和破断强度逐渐减少,而松弛时间τ1、粘性模量η却呈现明显增加趋势,而且流变学特征参数与组织结构变化之间具有较好的相关性。这些变化主要是由于加热过程中沙蛰样品的蛋白质发生热变性所引起。与鲜活样品相比,加热样品具有弹性较大、粘结性较大和硬度小的特点。

关键词：沙蛰加热组织构造流变学特性

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Stellar reaction rate of 55Ni（p,γ）56Cu in Type I X-ray bursts

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Nuclear Science and Techniques 2019年第9期30卷 94-102页

作者： Shao-bo Ma li-Yong Zhang Jun hu Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China University of Chinese Academy of Sciences Beijing 100049 China College of Nuclear Science and Technology Beijing Normal University Beijing 100875 China

56Cu is close to the waiting-point nucleus 56Ni and lies on the rapid proton capture（rp） process path in Type I X-ray bursts（XRBs）. In this work, we obtained a revised thermonuclear reaction rate of 55Ni（p,γ）56Cu in the temperature region relevant to XRBs. This rate was recalculated based on the recent experimental level structure in 56Cu, the recently measured proton separation energy of Sp = 579.8（7.1） keV, together with shell-model calculation, and the mirror nuclear structure in 56Co. The associated uncertainties in the rates were estimated by a Monte Carlo method. Our revised rate is significantly different from the recent results, which were partially based on experimental results; in addition, we found that a result in a previous work was incorrect. We recommend our revised rate to be incorporated in the future astrophysical network calculations.

关键词： Nuclear astrophysics Reaction rate X-ray burst

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Sequential Fault Diagnosis Using an Inertial Velocity Differential Evolution Algorithm

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International Journal of Automation and computing 2019年第3期16卷 389-397页

作者： Xiao-Hong Qiu Yu-Ting hu bo li Software School Jiangxi University of Science and TechnologyNanchang 330013China College of Information Engineering Jiangxi University of Science and TechnologyGanzhou 341000China

The optimal test sequence design for fault diagnosis is a challenging NP-complete *** improved differential evolution(DE)algorithm with additional inertial velocity term called inertial velocity differential evolution(IVDE)is proposed to solve the optimal test sequence problem(OTP)in complicated electronic *** proposed IVDE algorithm is constructed based on adaptive differential evolution *** it is used to optimize the test sequence sets with a new individual fitness function including the index of fault isolation rate(FIR)satisfied and generate diagnostic decision tree to decrease the test sets and the test *** simulation results show that IVDE algorithm can cut down the test cost with the satisfied *** with the other algorithms such as particle swarm optimization(PSO)and genetic algorithm(GA),IVDE can get better solution to OTP.

关键词： Differential evolution(DE) evolutionary computation fault isolation rate(FIR) testability fault diagnosis

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Pentafluoroethylation of Arenediazonium Tetrafluoroborates Using On-Site Generated Tetrafluoroethylene

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Chinese Journal of Chemistry 2019年第11期37卷 1131-1136页

作者： bo Xing lingchun li Chuanfa Ni Jinbo hu Key Laboratory of Organofluorine Chemistry Centerfor Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of Sciences345 Ling Ling RoadShanghai 200032China

Background and Originality Content Scheme I Aromatic pentafluoroethylation using TFE and CsF Perfluoroalkylated compounds are of great interest in pharmaceutical,agrochemical and material research and industry.[1]In this context,numerous efforts have been devoted to developing novel methods for the introduction of trifluoromethyl group(CF3)into organic aromatic compounds.[2]However,the similar pentafluoroethylation processes are still underexploited.[3] Currently available aromatic pentafluoroethylation methods mainly rely on transition-metal-mediated cross-coupling of aryl halides131 or aryl-boron compounds,141 and C-H functionalization of arenes.

关键词： compounds. aromatic devoted

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A power fluctuation evaluation method of PV plants based on Rankboost ranking

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Protection and Control of Modern Power Systems 2021年第1期6卷 347-356页

作者： Weiyi Xia Zhouyang Ren hui li bo hu The State Key Laboratory of Power Transmission Equipment&System Security and New Technology School of Electrical EngineeringChongqing UniversityChongqing400044PR China

Fluctuation evaluation is an important task in promoting the accommodation of photovoltaic (PV) power generation. This paper proposes an evaluation method to quantify the power fluctuation of PV plants. This consists of an index system and a ranking method based on the Rankboost algorithm. Eleven indices are devised and included in the index system to fully cover diverse fluctuation features. By handling missing and invalid data effectively, the ranking method fuses multiple indices automatically and provides a systematic and comprehensive comparison of power fluctuation. Simulation results based on power data from six PV plants indicate that the evaluation list obtained by the Rankboost ranking method is better represented and more comprehensive than that derived by the equal weight method.

关键词： Fluctuation evaluation Photovoltaic power Rankboost ranking algorithm

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Wind speed model based on kernel density estimation and its application in reliability assessment of generating systems

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Journal of Modern Power Systems and Clean Energy 2017年第2期5卷 220-227页

作者： bo hu Yudun li Hejun YANG He WANG State Key Laboratory of Power Transmission Equipment&System Security and New Technology Chongqing UniversityChongqingPeople’s Republic of China Electric Power Research Institute of Shandong Electric Power Corporation of SGCC JinanPeople’s Republic of China

An accurate probability distribution model of wind speed is critical to the assessment of reliability contribution of wind energy to power systems. Most of current models are built using the parametric density estimation(PDE) methods, which usually assume that the wind speed are subordinate to a certain known distribution(e.g. Weibull distribution and Normal distribution) and estimate the parameters of models with the historical data. This paper presents a kernel density estimation(KDE) method which is a nonparametric way to estimate the probability density function(PDF) of wind speed. The method is a kind of data-driven approach without making any assumption on the form of the underlying wind speed distribution, and capable of uncovering the statistical information hidden in the historical data. The proposed method is compared with three parametric models using wind data from six *** results indicate that the KDE outperforms the PDE in terms of accuracy and flexibility in describing the longterm wind speed distributions for all sites. A sensitivity analysis with respect to kernel functions is presented and Gauss kernel function is proved to be the best one. Case studies on a standard IEEE reliability test system(IEEERTS) have verified the applicability and effectiveness of the proposed model in evaluating the reliability performance of wind farms.

关键词： Wind speed model Kernel density estimation Reliability evaluation Wind power

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TO DETERMINE THAT ALL THE ROOTS OF A TRANSCENDENTAL POLYNOMIAL HAVE NEGATIVE REAL PARTS

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Chinese Annals of Mathematics,Series B 1997年第3期18卷 373-392页

作者： hu bo Department of Information Shanghai University of Finance and EconomicsShanghai 200433China Department of Matheinatics University of Notre DameIN 46556USA.

A transcendental polynomial which has all its roots lying in the left half plane is called stable. In this paper, the stability of transcendental polynomials which are nearly as general as those discussed by L. S. Pontryagin are investigated through direct analytic *** application of the method presented in this paper, the asymptotic stability of some differential-difference equations is investigated.

关键词： Transcendental polynomial Direct analytic method Asymptotic stability

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