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Colourimetric redox-polyaniline nanoindicator for in situ vesicular trafficking of intracellular transport

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Nano Research 2015年第4期8卷 1169-1179页

作者： Eun Bi Choi Jihye Choi seo Ryung bae Hyun-Ouk Kim EunjiJang Byunghoon Kang Myeong-Hoon Kim Byeongyoon Kim Jin-Suck Suh Kwangyeol Lee Yong-Min Huh Seungjoo Haam Department of Chemical and Biomolecular Engineering College of Engineering Yonsei University Seou1120-749 Republic of Korea Department of Radiology College of Medicine Yonsei University Seou1120-752 Republic of Korea Department of Chemistry Korea University Seou1136-701 Republic of Korea

Vesicular pH modulates the function of many organelles and plays a pivotal role in cell metabolism processes such as proliferation and apoptosis. Here, we introduce a simple colorimetric redox-polyaniline nanoindicator, which can detect and quantify a broader biogenic pH range with superior sensitivity compared to pre-established trafficking agents employing one-dimensional turn-on of the fluorescence resonance-energy-transfer （FRET） signal. We fabricated polyaniline- based nanoprobes, which exhibited convertible transition states according to the proton levels, as an in situ indicator of vesicular transport pH. Silica-coated Fe304-MnO heterometal nanoparticles were synthesised and utilised as a metal oxidant to polymerise the aniline monomer. Finally, silica-coated polyaniline nanoparticles with adsorbed cyanine dye fluorophores Cy3 and Cy7 （FPSNIcyB and FPSNIcy7） were fabricated as proton-sensitive nanoindicators. Owing to the selective quenching induced by the local pH variations of vesicular transport, FPSNIcy3 and FPSNIcy7 demonstrated excellent intracellular trafficking and provided sensitive optical indication of minute proton levels.

关键词： redox pH intraceUular compartments organic quencher conducting polymer nanoindicator

Omental infarction diagnosed by computed tomography,missed with ultrasonography:A case report

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World Journal of Clinical Cases 2023年第4期11卷 972-978页

作者： Jae Kyoon Hwang Yu Jeong Cho bo Seung Kang Kyueng-Whan Min Young seo Cho Yong Joo Kim Kyung Suk Lee Department of Pediatrics Hanyang University Guri HospitalHanyang University College of MedicineGuri-si 11923Gyeonggi-doSouth Korea Department of Surgery Hanyang University Guri HospitalHanyang University College of MedicineGuri-si 11923Gyeonggi-doSouth Korea Department of Emergency Medicine Hanyang University Guri HospitalHanyang University College of MedicineGuri-si 11923Gyeonggi-doSouth Korea Department of Pathology Hanyang University Guri HospitalHanyang University College of MedicineGuri-si 11923Gyeonggi-doSouth Korea Department of Radiology Hanyang University Guri HospitalHanyang University College of MedicineGuri-si 11923Gyeonggi-doSouth Korea Department of Pediatrics Hanyang University HospitalHanyang University College of MedicineSeoul 04763South Korea

BACKGROUND Omental infarction(OI)is a surgical abdominal disease that is not common in adults and is very rare in *** to various acute abdominal pain diseases including appendicitis,diagnosis was previously achieved by diagnostic laparotomy but more recently,ultrasonography or computed tomography(CT)examination has been *** SUMMARY A 6-year-old healthy boy with no specific medical history visited the emergency room with right lower abdominal *** underwent abdominal ultrasonography by a radiologist to rule out acute *** was discharged with no significant sonographic finding and symptom ***,the symptoms persisted for 2 more days and an outpatient visit was *** outpatient abdominal CT was used to make a diagnosis of *** laparoscopic operation,his symptoms *** In children’s acute abdominal pain,imaging studies should be performed for appendicitis and OI.

关键词： Omental infarction Children Ultrasonography Computed tomography Case report

Comparison of litterfall production in three forest types in Jeju Island, South Korea

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Journal of Forestry Research 2020年第3期31卷 945-952页

作者： Ji Young An Si Ho Han Woo Bin Youn Sang Ick Lee Afroja Rahman Huong Thi Thuy Dao Jeong Min seo Aung Aung Hyung-Soon Choi Hwa Ja Hyun Byung bae Park Department of Natural Resources Kyoto UniversityKyoto 606-8502Japan Department of Environment and Forest Resources Chungnam National UniversityDaejeon 34134Republic of Korea Forest Environment Conservation Division Korea Forest ServiceDaejeon 35208Republic of Korea Forest Conservation Department National Institute of Forest ScienceSeoul 02455Republic of Korea Warm Temperate and Subtropical Forest Research Center National Institute of Forest ScienceSeogwipo 63582Republic of Korea

Litterfall, which is influenced by physical and biological factors, is a major pathway for carbon and nutrient cycling in forest ecosystems. The purpose of this study was to investigate monthly litterfall production in three forests in Jeju Island differentiated by forest composition and precipitation: Cheongsu(Quercus glauca as the dominant species;low precipitation), seonheulb(Q. glauca as the dominant species;high precipitation), and seonheulm(Q. glauca and Pinus thunbergii as the dominant species;high precipitation). Litterfall was collected monthly from April to December 2015 and divided into leaf litter, twig, bark, seeds, and unidentified *** patterns of litterfall production varied across stands according to their species composition. However,the amount of leaf litterfall and total litterfall were comparable among stands, ranging from 362 to 375 g m-2 for leaf litter and 524 g m-2 to 580 g m-2 for total *** leaf litter in May was the highest in all stands, while needle litter was the highest in December in *** twig litterfall in July may be attributable to high rainfall with strong winds and storms during the rainy season. Although forest type and climate factor had no influence on litterfall amounts in this study, the pattern of litterfall production was species dependent, suggesting diverse effects on carbon and nutrient cycling in these forests.

关键词： Coniferous forest Evergreen broadleaved forest Gotjawal Leaf litter Precipitation Temperature

Pressure-responsive pH-triggered layer-by-layer coating of paclitaxel-eluting balloon catheters for instant high-dose drug delivery for percutaneous coronary artery intervention

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Nano Research 2024年第10期17卷 9141-9151页

作者： Jeong Yu Lee Shonit Nair Sharma Sung-Yu Hong Young-Guk Ko Yangsoo Jang Minjae Do Michael Christopher Stark Qiwen Peng Benjamin Allen Mossburg bo Chan seo Yuhan Lee Department of Materials Science and Engineering Korea Advanced Institute of Science and TechnologyDaejeon 305-701Republic of Korea Department of Anesthesiology Perioperativeand Pain MedicineCenter for Accelerated Medical Innovation&Center for NanomedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA Department of Biological Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA Cardiovascular Product Evaluation Center Yonsei University College of MedicineSeoul 120-752Republic of Korea Division of Cardiology Department of Internal MedicineSeverance Cardiovascular HospitalYonsei University College of MedicineSeoul 120-752Republic of Korea

Cardiovascular diseases remain the leading cause of mortality worldwide,with percutaneous coronary interventions(PCI)using drug-eluting stents(DES)as the standard treatment for coronary artery *** advancements in DES technology,challenges such as restenosis and stent thrombosis still necessitate further interventions and carry considerable risks,highlighting an urgent need for a novel therapeutic approach with lower restenosis rates and reduced reintervention *** balloons(DEBs)coated with anti-proliferative agents offer a novel method of local drug delivery for reducing restenosis by directly administering drugs to the lesion ***,efficient delivery of drugs within the brief procedural window while minimizing drug loss during maneuvering to the target site remains a ***,we developed a pressure-responsive and pH-triggered,paclitaxel(PTX)coated DEB catheter for rapid and high-dose delivery of paclitaxel to the lesion sites,overcoming the limitations of drug dispersion and inefficiencies associated with conventional *** the charge reversion of albumin around its isoelectric point,paclitaxel-loaded human serum albumin nanoparticles(PTX-HSA-NPs)and heparin were coated using a layer-by-layer deposition method at pH *** exposure to physiological pH(i.e.,7.4),the coating is rapidly released from the balloon *** with a protective shellac coating,the DEB achieved controlled release of high-dose paclitaxel to the arterial tissue in vivo(up to 400μg per gram tissue),exceeding current DEBs in the *** results suggest the pH-responsive,multi-layer coated DEB’s potential for superior procedural outcomes,addressing a critical unmet need in PCI.

关键词： drug-eluting balloon layer-by-layer coating coronary artery disease paclitaxel

Retinoic acid enhances lactoferrin-induced IgA responses by increasing betaglycan expression

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Cellular & Molecular Immunology 2016年第6期13卷 862-870页

作者： Jeong-Min Lee Young-Saeng Jang bo-Ra Jin Sun-Jin Kim Hyeon-Jin Kim bo-Eun Kwon Hyun-Jeong Ko Sung-il Yoon Geun-Shik Lee Woan-Sub Kim Goo-Young seo Pyeung-Hyeun Kim Department of Molecular Bioscience School of Biomedical Science Kangwon National University Chuncheon Republic of Korea Laboratory of Microbiology and Immunology College of Pharmacy Kangwon National University Chuncheon Republic of Korea Department of Systems Immunology College of Biomedical Science Kangwon National University Chuncheon 200-701 Republic of Korea College of Veterinary Medicine Kangwon National University Chuncheon Gangwon 200-701 Republic of Korea Department of Animal Life and Environmental Science College of Agriculture and Life Science Hankyong National University Anseong-si 456-749 Republic of Korea

Lactoferrin （LF） and retinoic acid （RA） are enriched in colostrum, milk, and mucosal tissues. We recently showed that LF-induced IgA class switching through binding to betaglycan （transforming growth factor-beta receptor III, TpRIII） and activation of canonical TGF-p signaling. We investigated the combined effect of LF and RA on the overall IgA response. An increase in IgA production by LF was further augmented by RA. This combination effect was also evident in Ig germ-line α （GLa） transcription and GLa promoter activity, indicating that LF in cooperation with RA increased IgA isotype switching. We subsequently found that RA enhanced TβRIII expression and that this increase contributed to LF-stimulated IgA production. In addition to the IgA response, LF and RA in combination also enhanced the expression of the gut-homing molecules C-C chemokine receptor 9 （CCR9） and a4β7 on B cells. Finally, peroral administration of LF and RA enhanced the frequency of CCR9＋ IgA＋ plasma cells in the lamina propria. Taken together, these results suggest that LF in cooperation with RA can contribute to the establishment of gut IgA responses.

关键词： gut homing molecule IgA lactoferrin retinoic acid TGF-β receptor

Wavelength calibration and spectral analysis of vacuum ultraviolet spectroscopy in EAST

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Plasma Science and Technology 2024年第8期26卷 37-43页

作者：计华健张洪明吕波 Cheonho bae 何梁林子超尹相辉沈永才戴舒宇 Institute of Plasma Physics Chinese Academy of SciencesHefei 230031People’s Republic of China Science Island Branch Graduate SchoolUniversity of Science and Technology of ChinaHefei 230031People’s Republic of China College of Electrical Engineering University of South ChinaHengyang 421001People’s Republic of China School of Physics and Materials Engineering Hefei Normal UniversityHefei 230601People’s Republic of China School of Physics Dalian University of TechnologyDalian 116024People’s Republic of China

A vacuum ultraviolet(VUV)spectroscopy with a focal length of 1 m has been engineered specifically for observing edge impurity emissions in Experimental Advanced Superconducting Tokamak(EAST).In this study,wavelength calibration for the VUV spectroscopy is achieved utilizing a zinc *** grating angle and charge-coupled device(CCD)position are carefully calibrated for different wavelength *** wavelength calibration of the VUV spectroscopy is crucial for improving the accuracy of impurity spectral data,and is required to identify more impurity spectral lines for impurity transport *** spectra of EAST plasmas have also been obtained in the wavelength range of 50–300 nm with relatively high spectral *** is found that the impurity emissions in the edge region are still dominated by low-Z impurities,such as carbon,oxygen,and nitrogen,albeit with the application of fulltungsten divertors on the EAST tokamak.

关键词： vacuum ultraviolet spectroscopy wavelength calibration impurity spectra

Hydrogen-enriched water eliminates fine particles from the lungs and blood by enhancing phagocytic activity

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The Journal of Biomedical Research 2017年第6期31卷 503-511页

作者： Jieun Choi Eun Suk An Young-Hwan Ban Da Woom seo Tae-Su Kim Sung-Pyo Lee You Lin Ehn-Kyoung Choi Yun-bae Kim College of Veterinary Medicine and Veterinary Medical Center Chungbuk National UniversityCheongffuChungbukRepublic of Korea Anydoctor Healthcare Co. Ltd.CheonanChungnamRepublic of Korea Hotan Dichen Medicine Biotechnology Co.Ltd Hotan Xinjiang China

Particulate matters（PM） are one of the major body burdens leading to diseases. We investigated the capacities of a hydrogen-enriched water（HW） eliminating carbon nanoparticles（CNP） and carbon microparticles（CMP） from the lungs and blood, respectively. In CNP-elimination test, rats were orally administered with purified water（PW） or HW（10 or 30 mL/kg/day） for 10 weeks. At the time point of 4 weeks, the rats were challenged with intratracheal instillation of CNP（4 mg）. CNP accumulated in the airways and alveoli, and induced inflammatory lesions. Such pneumoconiosis was markedly improved by feeding HW, while PW was ineffective. CNP-induced pneumoconiosis caused systemic hematological alterations, decreasing major inflammatory cells, but markedly increasing eosinophils,indicative of an allergic reaction, which were attenuated by treatment with HW. Such PM-eliminating and antiallergic effects of HW reduced body burden as confirmed from the facilitated recovery of body and lung weights. In CMP-clearance test, mice were orally administered with PW or HW for 7 days, and intravenously injected with CMP（300 mg/kg）. CMP was rapidly eliminated from the blood in HW-fed mice. Indeed, the phagocytic indices increased to 3.5 and 6.7 folds at 10 and 30 mL/kg of HW, in comparison with a negligible effect of PW. As a mechanism study,only HW significantly inhibited lipid peroxidation in vitro Fenton reaction-mediated ·OH-generating ***, the results indicate that HW not only effectively eliminated PM from the lungs and blood by enhancing phagocytic activity, but also attenuated the lung injuries by inhibiting lipid peroxidation.

关键词： particulate matter pneumoconiosis hydrogen-enriched water particle clearance antioxidation

Effects of a soybean milk product on feto-neonatal development in rats

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The Journal of Biomedical Research 2018年第1期32卷 51-57页

作者： Eun Suk An Dongsun Park Young-Hwan Ban Jieun Choi Da Woom seo Yoon bok Lee Mi Yae Shon Ehn-Kyoung Choi Yun-bae Kim College of Veterinary Medicine and Veterinary Medical Center Chungbuk National University Cheongiu 28644 Republic of Korea Central Research Institute Dr. Chung's Food Co. Ltd. Cheongju 28446 Republic of Korea International Ginseng and Herb Research Institute Geumsan 312804 Republic of Korea

Since estrogenic pollutants and phytoestrogens can cause the disorder of the reproductive system, the effects of a soybean milk product（Vegemil^（？） containing 162 ppm isoflavones） on the feto-neonatal development, including male reproductive function, were investigated. Pregnant rats were fed the soybean milk（5% or 100% in drinking water）from gestational day（GD） 6 to parturition or to post-natal day（PND） 56. Specifically, the rats were divided into 4 groups： the control group（drinking water）, the GD5% group（5% soybean milk during only the GD period）, the GDPND5% group（5% soybean milk during the GD and PND periods）, and the GD-PND100% group（100% soybean milk instead of water during the GD and PND periods）. During the gestational, lactational, and developmental periods, the reproductive and developmental parameters of dams and offspring were observed. Feeding soybean milk did not affect the birth and physical development of both male and female offspring. At PND57, the weights of the testes and epididymides of F1 males significantly increased by feeding a high concentration of the soybean milk（GDPND100%）. In addition, feeding of the soybean milk during both the GD and PND periods（GD-PND5% and GDPND100%） enhanced the sperm counts and motility. The results indicate that soybean milk is safe for embryos,fetuses, and offspring, and improves the post-generational development of male reproductive function.

关键词： soybean milk feto-neonatal development reproductive function sperm quality

Transverse myelitis caused by herpes zoster following COVID-19 vaccination:A case report

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World Journal of Clinical Cases 2023年第6期11卷 1419-1425页

作者： Su-Yeon Cho bo-Hyun Jang Jun-Won seo Suk-Whee Kim Kyung-Joon Lim Hyun-Young Lee Dong-Joon Kim Department of Anesthesiology and Pain Medicine Chosun University HospitalGwangju 61453South Korea Department of Internal Medicine Chosun UniversityCollege of MedicineGwangju 61453South Korea Department of Anesthesiology and Pain Medicine Chosun UniversityCollege of MedicineGwangju 61453South Korea

BACKGROUND Transverse myelitis(TM)is characterized by sudden lower extremity progressive weakness and sensory impairment,and most patients have a history of advanced viral infection symptoms.A variety of disorders can cause TM in association with viral or nonviral infection,vascular,neoplasia,collagen vascular,and iatrogenic,such as *** has become common through the global implementation against coronavirus disease 2019(COVID-19)and reported complications like herpes zoster(HZ)activation has *** SUMMARY This is a 68-year-old woman who developed multiple pustules and scabs at the T6-T9 dermatome site 1 wk after vaccination with the COVID-19 vaccine(Oxford/AstraZeneca([ChAdOx1S{recombinant}]).The patient had a paraplegia aggravation 3 wk after HZ symptoms *** magnetic resonance imaging(MRI)showed transverse myelitis at the T6–T9 *** was acyclovir with steroids combined with physical *** neurological function was slowly restored by Day *** HZ developed after COVID-19 vaccination,which may lead to more severe ***,HZ treatment itself should not be *** neurological complications worsen after appropriate management,an immediate diagnostic procedure,such as magnetic resonance imaging and laboratory tests,will start and should treat the neurological complications.

关键词： Herpes zoster Transverse myelitis Paraplegia COVID-19 Vaccination Case report