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Repeat peroral endoscopic myotomy with simultaneous submucosal and muscle dissection as a salvage option for recurrent achalasia

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World Journal of Gastroenterology 2023年第15期29卷 2349-2358页

作者： Yun-Juan Lin Sheng-Zhen Liu Long-Song Li Ke Han bo-zong shao En-Qiang Linghu Ning-Li Chai Department of Gastroenterology and Hepatology Chinese PLA General Hospital and Chinese PLA Medical SchoolBeijing 100853China Department of Gastroenterology and Hepatology The First Medical CenterChinese PLA General HospitalBeijing 100853China

BACKGROUND For recurrent achalasia after initial peroral endoscopic myotomy(POEM)failure,repeat POEM(Re-POEM)has been reported as a treatment ***,severe esophageal interlayer adhesions caused by previous procedures impede the successful establishment of a submucosal tunnel and lead to aborted Re-POEM *** team previously described POEM with simultaneous submucosal and muscle dissection(POEM-SSMD)as a feasible solution for achalasia with severe interlayer *** To investigate the effectiveness and safety of Re-POEM with simultaneous submucosal and muscle dissection(Re-POEM-SSMD).METHODS A total of 1049 patients with achalasia who underwent successful endoscopic myotomy at the Digestive Endoscopic Center of Chinese PLA General Hospital from December 2014 to May 2022 were *** with recurrent achalasia who experienced initial POEM clinical failure were retrospectively included in this *** primary endpoint was retreatment clinical success,defined as an Eckardt score≤3 during the postretreatment follow-up and no need for additional ***-related adverse events,changes in manometric lower esophageal sphincter(LES)pressure and reflux complications,as well as procedure-related parameters,were *** Sixteen patients underwent Re-POEM(9 patients)or Re-POEM-SSMD(7 patients)successfully at a median of 45.5 mo(range,4-95 mo)after initial *** a median followup period of 31 mo(range,7-96 mo),clinical success(Eckardt score≤3)was achieved in 8(88.9%)and 6(85.7%)patients after Re-POEM and Re-POEM-SSMD,respectively(P=0.849).The median Eckardt score dropped from 4(range,3-8)at preretreatment to 1(range,0-5)at postretreatment in the Re-POEM group(P=0.025)and from 5(range,2-8)to 2(range,0-4)in the Re-POEM-SSMD group(P<0.001).The mean manometric LES pressure decreased from 23.78±9.04 mmHg to 11.45±5.37 mmHg after Re-POEM(P<0.001)and from 26.80±7.48 mmHg to 11.05±4.38 mmHg after Re-POEM-SSMD(P<0.001).No serious

关键词： Esophageal achalasia Recurrence Peroral endoscopic myotomy Simultaneous submucosal and muscle dissection Interlayer adhesion Salvage therapy

Linked color imaging vs Lugol chromoendoscopy for esophageal squamous cell cancer and precancerous lesion screening: A noninferiority study

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World Journal of Gastroenterology 2023年第12期29卷 1899-1910页

作者： Zi-Xin Wang Long-Song Li Song Su Jin-Ping Li bo Zhang Nan-Jun Wang Sheng-Zhen Liu Sha-Sha Wang Shuai Zhang Ya-Wei Bi Fei Gao Qun shao Ning Xu bo-zong shao Yi Yao Fang Liu En-Qiang Linghu Ning-Li Chai Department of Gastroenterology The First Medical Center of Chinese PLA General HospitalBeijing 100853China

BACKGROUND Lugol chromoendoscopy(LCE)has served as a standard screening technique in high-risk patients with esophageal ***,LCE is not suitable for general population screening given its side *** color imaging(LCI)is a novel image-enhanced endoscopic technique that can distinguish subtle differences in mucosal *** To compare the diagnostic performance of LCI with LCE in detecting esophageal squamous cell cancer and precancerous lesions and to evaluate whether LCE can be replaced by LCI in detecting esophageal neoplastic *** In this prospective study,we enrolled 543 patients who underwent white light imaging(WLI),LCI and LCE *** compared the sensitivity and specificity of LCI and LCE in the detection of esophageal neoplastic *** features and color analysis of lesions were *** In total,43 patients(45 neoplastic lesions)were *** them,36 patients(38 neoplastic lesions)were diagnosed with LCI,and 39 patients(41 neoplastic lesions)were diagnosed with *** sensitivity of LCI was similar to that of LCE(83.7%vs 90.7%,P=0.520),whereas the specificity of LCI was greater than that of LCE(92.4%vs 87.0%,P=0.007).The LCI procedure time in the esophageal examination was significantly shorter than that of LCE[42(34,50)s vs 160(130,189)s,P<0.001].The color difference between the lesion and surrounding mucosa in LCI was significantly greater than that observed with ***,the color difference in LCI was similar in different pathological types of esophageal squamous cell *** LCI offers greater specificity than LCE in the detection of esophageal squamous cell cancer and precancerous lesions,and LCI represents a promising screening strategy for general populations.

关键词： Linked color imaging Lugol chromoendoscopy Esophageal squamous cell cancer Precancerous lesions Color difference

Impact of Paneth Cell Autophagy on Inflammatory bowel Disease

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Impact of Paneth Cell Autophagy on Inflammatory Bowel Diseas...

Application of the improved dung beetle optimizer,muti-head attention and hybrid deep learning algorithms to groundwater depth prediction in the Ningxia area,China

首届东方药理论坛暨2018年全国心脑血管药理学术会议、上海市药理学会第十九届学术年会

作者： Shu-Ling Wang bo-zong shao Chao-Yu Miao Department of Gastroenterology Changhai HospitalSecond Military Medical University/Naval Medical University Department of Pharmocology Second Military Medical University/Naval Medical University

Intestinal mucosal barrier,mainly consisting of the mucus layer and epithelium,functions in absorbing nutrition as well as prevention of the invasion of pathogenic *** cell,an important component of mucosal barrier,plays a vital role in maintaining the intestinal homeostasis by producing antimicrobial materials and controlling the host-commensal *** evidence shows that the dysfunction of intestinal mucosal barrier,especially Paneth cell,participates in the onset and progression of inflammatory bowel disease(IBD).Autophagy,a cellular stress response,involves various physiological processes,such as secretion of proteins,production of antimicrobial peptides and degradation of aberrant organelles or *** the recent years,the roles of autophagy in the pathogenesis of IBD have been increasingly *** in this review,we mainly focus on describing the roles of Paneth cell autophagy in IBD as well as several popular autophagy-related genetic variants in Penath cell and the related therapeutic strategies against IBD.

关键词： autophagy Paneth cell inflammatory bowel disease unfolded protein response endoplasmic reticulum stress

来源： cnki会议评论

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 18-23页

作者： Jiarui Cai bo Sun Huijun Wang Yi Zheng Siyu Zhou Huixin Li Yanyan Huang Peishu zong Collaborative Innovation Center on forecast and Evaluation of Meteorological Disasters/Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment ChangeNanjing University of Information Science and TechnologyNanjingChina Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) ZhuhaiChina China Meteorological Administration Key Laboratory of Transportation MeteorologyNanjingChina Jiangsu Meteorological Observatory NanjingChina

Due to the lack of accurate data and complex parameterization,the prediction of groundwater depth is a chal-lenge for numerical *** learning can effectively solve this issue and has been proven useful in the prediction of groundwater depth in many *** this study,two new models are applied to the prediction of groundwater depth in the Ningxia area,*** two models combine the improved dung beetle optimizer(Dbo)algorithm with two deep learning models:The Multi-head Attention-Convolution Neural Network-Long Short Term Memory networks(MH-CNN-LSTM)and the Multi-head Attention-Convolution Neural Network-Gated Recurrent Unit(MH-CNN-GRU).The models with Dbo show better prediction performance,with larger R(correlation coefficient),RPD(residual prediction deviation),and lower RMSE(root-mean-square error).Com-pared with the models with the original Dbo,the R and RPD of models with the improved Dbo increase by over 1.5%,and the RMSE decreases by over 1.8%,indicating better prediction *** addition,compared with the multiple linear regression model,a traditional statistical model,deep learning models have better prediction performance.

关键词： Groundwater depth Multi-head attention Improved dung beetle optimizer CNN-LSTM CNN-GRU Ningxia

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B7-H1基因修饰的调节性DC对小鼠甲状腺相关性眼病的治疗作用

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国际眼科杂志 2014年第10期14卷 1765-1769页

作者：陈华新邵伯棕陈宣辰周维明张意广州军区武汉总医院眼科中国湖北省武汉市430070 第二军医大学研究生管理大队临床十队中国上海市200433 第二军医大学免疫学教研室中国上海市200433

目的:构建表达小鼠B7-H1基因的腺病毒载体,转染修饰树突状细胞,并研究该细胞对小鼠甲状腺相关性眼病(thyroid-associated ophthalmopathy,TAO)的治疗效应。方法:设计并构建小鼠B7-H1的腺病毒表达载体,转染小鼠骨髓来源的树突状细胞,检... 详细信息

目的:构建表达小鼠B7-H1基因的腺病毒载体,转染修饰树突状细胞,并研究该细胞对小鼠甲状腺相关性眼病(thyroid-associated ophthalmopathy,TAO)的治疗效应。方法:设计并构建小鼠B7-H1的腺病毒表达载体,转染小鼠骨髓来源的树突状细胞,检测该树突状细胞的表型和功能,鉴定其对免疫应答的负向调控能力,采用实验动物模型观察B7-H1基因修饰的树突状细胞在体内治疗TAO的效果。结果:成功构建出具有良好B7-H1表达效力的腺病毒载体,病毒滴度为1.8×109PFU/mL,转染腺病毒的小鼠骨髓来源的树突状细胞表现出调节性树突状细胞性能,能够负向抑制免疫应答;在动物模型中使用该型树突状细胞可以有效控制甲状腺眼病的发生发展。结论:成功构建了表达小鼠B7-H1基因的腺病毒表达载体,转染了该载体的树突状细胞具有调节性树突状细胞的性能,抑制正向免疫应答,能够有效抑制甲状腺眼病的发生发展,揭示基因修饰的树突状细胞可能成为治疗甲状腺眼病的潜在生物制剂。

关键词： B7-H1 树突状细胞腺病毒甲状腺相关性眼病负向免疫调控

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Primary parenchymal squamous cell carcinoma of the kidney:A case report

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World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： Zhi-Hui Zheng bo shao Chao-Min Xu Ke Wang Jia-Zhu Wen Li-Kang Luo Jia-Cheng Guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report

Performance variability of Ba0.5Sr0.5Co0.8Fe0.2O3-δ cathode on proton-conducting electrolyte SOFCs with Ag and Au current collectors

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Rare Metals 2018年第8期37卷 633-641页

作者： Ting-Ting Wan An-Kang Zhu Hai-bo Li Chun-Chang Wang You-Min Guo zong-Ping shao Oumarou Savadogo School of Physics and Materials Science Anhui UniversityHefei 230601China State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemistry and Chemical EngineeringNanjing University of TechnologyNanjing 210009China Department of Chemical Engineering Curtin UniversityPerth W A 6845.Australia Laboratory of New Materials for Electrochemistry and Energy Polytechnique MontrealC.P.6079Succursale Centre-VilleMontr6alQC H3C 3A7Canada

Ba0.5Sr0.5Co0.8Fe0.2O3-δ （BSCF） is one of the most active cathode materials and shows significant hydration effect suggesting possible proton conductivity. In this study, the performance of BSCF cathode on a protonconducting BaZr0.1Ce0.7Y0.2O3-δ（BZCY） electrolyte with silver and gold current collectors was determined. The electrochemical characteristics of the symmetrical and anode-supported cell with diluted silver electrode, silver current collector or gold current collector on BSCF electrode were compared. The significant result is that, although the diluted silver electrode itself shows poor operation stability, the silver current collector has strong electrocatalytic contribution to the BSCF cathode performance on the proton-conducting electrolyte, leading to higher cell performance than that with the gold current collector.

关键词： Solid oxide fuel cell Proton conductor Agcurrent collector Operation stability

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Experimental and numerical investigation on the gas leakage regime for ventilated tail cavity of an underwater vehicle

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Journal of Hydrodynamics 2023年第1期35卷 46-60页

作者： Xiao-bo Quan shao-hua Cheng College of Shipbuilding Engineering Harbin Engineering UniversityHarbin150001China China Academy of Launch Vehicle Technology Beijing100076China Beijing Institute of Astronautical Systems Engineering Beijing100076China

The objective of this paper is mainly to investigate the ventilated tail cavity flow of an underwater vehicle with focus on the gas leakage regime by experimental and numerical methods.A high-speed camera and pressure measurement system are used to record the cavity flow patterns and pressure behavior,*** numerical simulation is carried out with volume of fluid(VOF)model and Filter-based turbulence model(FBM).Good agreement can be obtained between the experimental and numerical *** are three gas leakage types in the evolution of the intact tail cavity,i.e.,twin-vortex tube entrainment(TVTE),toroidal vortex shedding(TVS)and hybrid twin-vortex tube entrainment and toroidal vortex shedding(TVTE-TVS).With the increase of Fr,the unsteady behavior of the cavity with different gas leakage types becomes more *** internal flow characteristics revealed three distinct regions including the ventilation influence region,the reverse flow region and the high shear flow region and have an important effect on the transition of gas leakage regime.

关键词： Ventilated tail cavity gas leakage regime unsteady behavior internal flow characteristics

采用骨料架构-固化技术对开挖淤泥加固试验研究

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土木与环境工程学报（中英文） 2025年第1期47卷 100-109页

作者：邵吉成袁波白银银骆嘉成浙江华坤地质发展有限公司浙江温州325006 温州市地质资源与生态环境重点实验室浙江温州325006 浙江省第十一地质大队浙江温州325006 温州市渣土利用开发股份有限公司浙江温州325700

为了对淤泥和建筑垃圾进行处置,实现二者的共同资源化利用,在室内和现场分别对淤泥进行固化试验。将建筑垃圾作为骨料按淤泥质量比的15%添加到淤泥中,再向淤泥中加入淤泥固化剂,通过机械搅拌的方式将淤泥与建筑垃圾、固化剂混合均匀,然... 详细信息

为了对淤泥和建筑垃圾进行处置,实现二者的共同资源化利用,在室内和现场分别对淤泥进行固化试验。将建筑垃圾作为骨料按淤泥质量比的15%添加到淤泥中,再向淤泥中加入淤泥固化剂,通过机械搅拌的方式将淤泥与建筑垃圾、固化剂混合均匀,然后对固化土进行养护。室内试验结果表明,当固化剂掺量为8%时,固化淤泥土强度较高,养护28 d后,室内无侧限抗压强度可达320 kPa;在现场试验中,静力触探试验和平板荷载试验表明,固化剂对淤泥的固化效果明显。将低剂量固化剂添加到淤泥中,固化淤泥土强度较低,骨料的架构作用不明显;当固化剂掺量为8%时,固化土的强度较高,骨料的架构作用有利于提升固化淤泥土的承载力,土体的承载力特征值可达325kPa,架构作用对固化淤泥土强度的提升率为71.05%,可实现淤泥和建筑垃圾的同步资源化利用。

关键词：淤泥固化骨料资源化利用架构作用承载力

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