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唐山师范学院学报 2013年第5期35卷 109-110页

作者：薄建柱司福利周磊河北联合大学河北唐山063000

当今社会呼唤创新型人才,但传统教学模式、教学方法等诸多问题阻碍了创新型人才培养的质量,从创新型人才培养中存在的诸多问题出发,对其加以分析,并提出相应对策。

关键词：创新型人才培养教学模式教学方法

Palmitoylation-mediated NLRP3 inflammasome activation in teleosts highlights evolutionary divergence in immune regulation

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Zoological Research 2025年第01期 3-14页

作者： Li Nie Xiang-Yu Wu Zi-Yue Zhao Chen-Jie Fei Ting-Fang zhu jian-Zhong Shao Jiong Chen State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products School of Marine SciencesNingbo University Laboratory of Biochemistry and Molecular Biology School of Marine Sciences Ningbo University Key Laboratory of Aquaculture Biotechnology of Ministry of Education Ningbo University College of Life Sciences Key Laboratory for Cell and Gene Engineering of Zhejiang Province Zhejiang University

NLRP3 inflammasome activation is pivotal for cytokine secretion and pyroptosis in response to diverse stimuli,playing a crucial role in innate immunity. While extensively studied in mammals, the regulatory mechanisms governing NLRP3 activation in non-mammalian vertebrates remain largely unexplored. Teleosts, as basal vertebrates,represent an ideal model for exploring the evolutionary trajectory of inflammasome regulation. In this study, ABE assays, confocal microscopy, and biochemical analyses were applied to systematically characterize the mechanisms underlying NLRP3 inflammasome in teleosts,using large yellow croakers(Larimichthys crocea, Lc) and zebrafish(Danio rerio, Dr) as representative models. Our findingsrevealedapreviouslyunrecognized palmitoylation-dependent regulatory mechanism essential for teleost NLRP3 activation. Specifically, zDHHC18-mediated palmitoylation at a teleost-specific cysteine residue(C946 in Lc NLRP3, C1037 in Dr NLRP3) was required for the translocation of NLRP3 to the dispersed trans-Golgi network, facilitating its subsequent recruitment to the microtubule-organizing center. This membrane trafficking was crucial for inflammasome assembly and downstream inflammatory responses. These findings provide new insights into the distinct regulatory mechanisms of NLRP3 activation in teleosts, highlighting an evolutionary divergence that contributes to innate immunity adaptation in early vertebrates.

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Efficient gene disruption in polyploid genome by Cas9–Trex2 fusion protein

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Journal of Integrative Plant Biology 2025年第1期67卷 7-10页

作者： Wenbo Pan Chunlei Gao De Niu Jinghua Cheng Jiao Zhang Xiying Yan Qiang Long Yao Yao zhu Wenjing Sun Qi Xie Yuehui He Xing Wang Deng Huawei Zhang jian Li State Key Laboratory of Wheat Improvement Shandong Laboratory of Advanced Agricultural Sciences in WeifangPeking University Institute of Advanced Agricultural SciencesWeifang 261325China Guangdong Provincial Key Laboratory of Biotechnology for Plant Development Ministry of Education&Guangdong Provincial Key Laboratory of Laser Life ScienceSchool of Life SciencesSouth China Normal UniversityGuangzhou 510631China Shenzhen Tidy field System Biotechnology Co. LtdShenzhen 518107China State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyThe Innovative Academy of Seed DesignChinese Academy of SciencesBeijing 100101China

Despite significant advancements in the efficiency of the CRISPR/Cas9 genome editing system over the past decade,performing gene disruption in polyploid crops such as common wheat(Triticum aestivum L.)remains challeng... 详细信息

关键词： CRISPR/Cas9 crops trait

中华民族共同体理论体系的基本架构与知识生产

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中南民族大学学报(人文社会科学版) 2025年第2期45卷 28-38,182页

作者：朱碧波云南师范大学马克思主义学院云南昆明650500

中华民族共同体理论体系构建的一个关键议题就是厘定理论体系的四梁八柱。中华传统文化中“上下四方曰宇,古往今来曰宙”的宇宙认知,为中华民族共同体理论体系构建提供了思考框架的启迪:中华民族共同体理论体系构建要从古今中外的时空... 详细信息

中华民族共同体理论体系构建的一个关键议题就是厘定理论体系的四梁八柱。中华传统文化中“上下四方曰宇,古往今来曰宙”的宇宙认知,为中华民族共同体理论体系构建提供了思考框架的启迪:中华民族共同体理论体系构建要从古今中外的时空之维展开思考,即“爬梳历史、聚焦现实;立足中国、放眼全球”。爬梳历史,就是爬梳各民族交往交流交融的史实,揭示中华民族形成发展的历史规律。聚焦现实,就是锚定中华民族伟大复兴战略全局,展开各民族共建共治和共富共享的知识生产。立足中国,就是立足我国统一多民族国家的基本国情,着眼中华文明的源远流长和中国式现代化伟大实践,推进中华民族共同体理论自主建构。放眼全球,就是吸收人类创造的一切优秀文明成果,既要回应国外学界涉华民族事务研究的讹误,又要提炼中国民族事务治理的本土智慧,彰显中华民族共同体建设的全球价值,为破解全球民族事务治理的难题提供可资借鉴的中国经验。

关键词：中华民族共同体理论民族交往交流交融中国式现代化文化主体性

Highly selective synthesis and near-infrared photothermal response of heterometallic double trefoil knot and D-type[2]catenanes

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Science China Chemistry 2025年

作者： Ying Zhao jian-Xin Yang Yin-Hang Chai Yao He Peng Wang Francisco Aznarez bo Li Li-Long Dang Lu-Fang Ma College of Chemistry and Chemical Engineering Luoyang Normal University College of Chemical and Pharmaceutical Engineering Nanyang Normal University

The selective construction of sophisticated supramolecular topologies has always attracted the remarkable attention of ***,various molecular knots and catenanes have recently been reported and were obtained either accidentally or by following a previously planned synthetic ***,we introduce a series of supramolecular topologies including double trefoil knot (1),trefoil knot (2) and[2]catenanes (4,5),which were prepared via an elaborated self-assembly strategy by using half-sandwich units based on a flexible pyridyl linker *** formation of all the structures has been confirmed by single crystal X-ray diffraction analysis and NMR spectroscopy,and ***,the central potassium ion of 1 coordinates six oxygen atoms belonging to six amide groups from two trefoil *** double trefoil knot 1 and[2]catenanes 4,5 are stabilized by parallel-displacedπ···πstacking interactions (of interlayer distance 3.34–3.82?) between the pyridyl fraction and phenyl moieties of three ligands L1,and by edge-to-face-type CH···πinteractions (2.64–2.83?) between BiBzIm conjugated planes and phenyl hydrocarbon ***,the addition/removal of potassium ions resulted in topological transformation between the double trefoil knot 1 and the trefoil knot *** addition,the addition of DMF-d7to a methanolic solution of the double trefoil knot 1 induced its structural conversion into the metallamacrocycle *** photothermal studies of 1,4,and 5 showed different photothermal responses in solid and solution ***,the photothermal conversion efficiencies of 4,and 5 were within the limit of 16.8%–45.1%based on different power areas,the number and the fashion ofπ···πstacking interactions can directly affect the photothermal conversion efficiency,and EPR experiments confirmed the recorded results.

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医学影像储存介质特点浅析

中国医学影像技术 2005年第9期21卷 1469-1469页

作者：王云珊薄建柱山东省曹县邵庄中心医院内科山东菏泽274408 华北煤炭医学院临床医学系河北唐山063000

医学影像在临床诊断和治疗中占有重要位置,以各种媒介承载的原始真实的影像在医、教、研、防中有着重要意义.随着超声、X线、磁共振、数字血管造影、X线断层摄影等技术的发展,医学影像的种类越来越多且存储方式日趋多元化,了解保存医学... 详细信息

医学影像在临床诊断和治疗中占有重要位置,以各种媒介承载的原始真实的影像在医、教、研、防中有着重要意义.随着超声、X线、磁共振、数字血管造影、X线断层摄影等技术的发展,医学影像的种类越来越多且存储方式日趋多元化,了解保存医学影像的各种存贮介质的特点以及利用方法具有重要意义.

关键词：图像档案诊断显像

英美体育志愿者的培养体系对我国大学生志愿者服务的启示

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华北理工大学学报（社会科学版） 2018年第4期18卷 45-48页

作者：张文杰郑建辉薄建柱华北理工大学河北唐山063210

英国和美国体育志愿服务传统历史悠久,体育志愿服务事业蓬勃发展得益于两国对体育志愿服务事业的高度重视。两国丰富多样的体育志愿服务项目在运作上已具备比较健全的法律法规、规章制度、显著的激励措施、规范的组织管理。借鉴英美体... 详细信息

英国和美国体育志愿服务传统历史悠久,体育志愿服务事业蓬勃发展得益于两国对体育志愿服务事业的高度重视。两国丰富多样的体育志愿服务项目在运作上已具备比较健全的法律法规、规章制度、显著的激励措施、规范的组织管理。借鉴英美体育志愿服务发展经验,结合我国国情,应从政府重视、健全法制、营造良好社会基础、丰富运动项目、健全激励机制等方面不断加强我国的体育志愿服务建设。

关键词：英国美国体育志愿服务

由“双线并行”到“闭环联动”:政府救助与慈善帮扶有效衔接

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苏州大学学报(哲学社会科学版) 2025年第1期46卷 56-67页

作者：祝建华浙江工业大学公共管理学院浙江杭州310023

在传统救助帮扶模式中,政府救助与慈善帮扶往往“双线并行”,彼此之间没有形成互补与合力,无法发挥最大效能。研究基于资源依赖理论,提出政府救助与慈善帮扶将在彼此借力获取各自资源的同时实现组织效能的最大化,形成有效衔接的“闭环... 详细信息

在传统救助帮扶模式中,政府救助与慈善帮扶往往“双线并行”,彼此之间没有形成互补与合力,无法发挥最大效能。研究基于资源依赖理论,提出政府救助与慈善帮扶将在彼此借力获取各自资源的同时实现组织效能的最大化,形成有效衔接的“闭环联动”综合救助帮扶模式。从制度环境、共同载体、主体协同、服务类救助的内容供给、数字赋能过程衔接等维度分析了政府救助与慈善帮扶有效衔接的现实需求;基于浙江省杭州市的“双循环”救助帮扶体系,从制度环境、衔接载体、衔接主体、衔接内容、衔接过程等方面分析了政府救助与慈善帮扶有效衔接的典型经验,由此提出了相应的五个层面的优化策略。最后基于政府救助与慈善帮扶有效衔接的“闭环联动”综合救助帮扶体系,从理念、体系、功能、主体、内容和方法等方面推进了社会救助体系的迭代升级。

关键词：政府救助慈善帮扶衔接闭环联动

An Improved LZO Compression Algorithm for FPGA Configuration Bitstream Files

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Computers, Materials & Continua 2025年第2期82卷 3091-3109页

作者： Xiaoling Lai jian Zhang Yangming Guo Ting Ju Qi zhu Guochang Zhou School of Computer Science Northwestern Polytechnic UniversityXi’an710072China Xi’an Branch of China Academy of Space Technology Xi’an710100China

With the increase in the quantity and scale of Static Random-Access Memory Field Programmable Gate Arrays (SRAM-based FPGAs) for aerospace application, the volume of FPGA configuration bit files that must be stored has increased dramatically. The use of compression techniques for these bitstream files is emerging as a key strategy to alleviate the burden on storage resources. Due to the severe resource constraints of space-based electronics and the unique application environment, the simplicity, efficiency and robustness of the decompression circuitry is also a key design consideration. Through comparative analysis current bitstream file compression technologies, this research suggests that the Lempel Ziv Oberhumer (LZO) compression algorithm is more suitable for satellite applications. This paper also delves into the compression process and format of the LZO compression algorithm, as well as the inherent characteristics of configuration bitstream files. We propose an improved algorithm based on LZO for bitstream file compression, which optimises the compression process by refining the format and reducing the offset. Furthermore, a low-cost, robust decompression hardware architecture is proposed based on this method. Experimental results show that the compression speed of the improved LZO algorithm is increased by 3%, the decompression hardware cost is reduced by approximately 60%, and the compression ratio is slightly reduced by 0.47%.

关键词： FPGA configuration bitstream file LZO compression decompression

单味中药中多糖类有效成分对糖尿病的治疗作用

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时珍国医国药 2010年第2期21卷 432-433页

作者：田春雨薄建柱薄海美李继安喇万英华北煤炭医学院河北唐山063000

回顾了近年来单味中药中多糖类有效成分对糖尿病的治疗作用,为治疗糖尿病新药的研究与开发奠定基础。

关键词：多糖糖尿病中药