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Integrated data mining and network pharmacology to discover a novel traditional Chinese medicine prescription against diabetic retinopathy and reveal its mechanism

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TMR Modern Herbal Medicine 2024年第2期7卷 41-55页

作者： Kai-Lun Zhang Xu Wang Xiang-Wei Chang Jun-Fei Gu bo-Yang Zhu Shi-Bing Wei bo Wu Can Peng Jiu-Sheng Nie De-Ling Wu College of Pharmacy Anhui University of Chinese MedicineHefei 230012China School of Traditional Chinese Medicine and School of Integrated Chinese and Western Medicine Nanjing University of Chinese MedicineNanjing 210023China MOE-Anhui Joint Collaborative Innovation Center for Quality Improvement of Anhui Genuine Chinese Medicinal Materials Anhui University of Chinese MedicineHefei 230012China Institute of Pharmaceutics Anhui Academy of Chinese MedicineHefei 230012China Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application Anhui University of Chinese MedicineHefei 230012China Engineering Technology Research Center of Modernized Pharmaceutics Anhui Education Department(AUCM)Hefei 230012China The First Clinical Medical College Anhui University of Chinese MedicineHefei 230012China

Background:Diabetic retinopathy(DR)is currently the leading cause of blindness in elderly individuals with *** Chinese medicine(TCM)prescriptions have shown remarkable effectiveness for treating *** study aimed to screen a novel TCM prescription against DR from patents and elucidate its medication rule and molecular mechanism using data mining,network pharmacology,molecular docking and molecular dynamics(MD)***:TCM prescriptions for treating DR was collected from patents and a novel TCM prescription was identified using data ***,the mechanism of the novel TCM prescription against DR was explored by constructing a network of core TCMs-core active ingredients-core targets-core ***,molecular docking and MD simulation were employed to validate the findings from network ***:The TCMs of the collected prescriptions primarily possessed bitter and cold properties with heat-clearing and supplementing effects,attributed to the liver,lung and kidney ***,a novel TCM prescription for treating DR was identified,composed of Lycii Fructus,Chrysanthemi Flos,Astragali Radix and Angelicae Sinensis *** core active ingredients and ten core targets of the novel TCM prescription for treating DR were ***,the novel TCM prescription played a crucial role for treating DR by inhibiting inflammatory response,oxidative stress,retinal pigment epithelium cell apoptosis and retinal neovascularization through various pathways,such as the AGE-RAGE signaling pathway in diabetic complications and the MAPK signaling ***,molecular docking and MD simulation demonstrated that almost all core active ingredients exhibited satisfactory binding energies to core ***:This study identified a novel TCM prescription and unveiled its multi-component,multi-target and multi-pathway characteristics for treating *** findings provide a scientific basis and novel insights into

关键词： TCM prescriptions diabetic retinopathy medication rule molecular mechanism data mining network pharmacology molecular docking

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可延展压电薄膜基底结构界面脱粘的预测与调控

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工程力学 2024年第4期41卷 247-256页

作者：周煜棠王博张博涵毕皓皓黄永安王烁道西北工业大学工程力学系西安710072 大连理工大学工业装备结构分析国家重点实验室大连116024 华中科技大学机械科学与工程学院武汉430074 俄克拉荷马州立大学机械与宇航工程学院美国俄克拉荷马74078

调控薄膜基底结构的表面不稳定性已被成功应用于制备可延展的新型电子设备中。然而,该类电子器件在工作中需要承受外部载荷作用,致使薄膜-基底结构界面处残余应力集中,容易诱发薄膜电子器件与基底脱粘与分层。该文将从理论分析和数值仿... 详细信息

调控薄膜基底结构的表面不稳定性已被成功应用于制备可延展的新型电子设备中。然而,该类电子器件在工作中需要承受外部载荷作用,致使薄膜-基底结构界面处残余应力集中,容易诱发薄膜电子器件与基底脱粘与分层。该文将从理论分析和数值仿真角度,研究压电薄膜在柔性基底表面上的失稳特性。由于压电薄膜变形具有大位移小应变的特点,该文基于非线性Euler-Bernoulli梁理论与能量最小化原理,建立压电薄膜基底结构无屈曲、褶皱、局部屈曲及全脱层屈曲模式的理论分析模型;从能量角度定量分析了薄膜-基底结构4种模式相互演变的临界条件;通过数值仿真,验证了该文解析结的有效性,定量、定性的讨论了薄膜基底结构的材料、几何参数对4种模式演变的影响。研究结果表明:改变基底弹性模量、预应变、物理场强度和界面粘附系数能够调控压电薄膜基底结构的屈曲模式;通过调控温度变化量和电压的方式,能够实现对压电薄膜基底结构的失稳特性精细化调控。该文的研究结果将为提升薄膜基底型的电子器件的稳定性及优化设计提供理论支持。

关键词：压电薄膜-柔性基底结构脱粘分层表面失稳临界应变

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Eosinophilic solid and cystic renal cell carcinoma with aggressive behavior:Two case reports

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World Journal of Clinical Cases 2024年第22期12卷 5124-5130页

作者： Hui-Hui Cao Hong Li Xiao-Hong Guo Zhi-Xing Cao bo-Hui Zhang Department of Pathology Zhuhai People's Hospital(Zhuhai Clinical Medical College of Jinan University)Zhuhai 519000Guangdong ProvinceChina

BACKGROUND Eosinophilic solid and cystic(ESC)renal cell carcinoma(RCC),a unique and emerging subtype of RCC,has an indolent nature;in some rare instances,it may exhibit metastatic *** cases are inadequate to precisely predict the clinical outcome of ESC RCC and determine treatment *** SUMMARY Herein,we report two patients with ESC *** 1 was a young woman with classical pathological *** 2 was a 52-year-old man with multifocal metastases,involving the pulmonary hilar and mediastinal lymph nodes,liver,brain,mesosternum,vertebra,rib,femur,and symphysis *** of ESC RCC,along with its characteristic architecture and immunophenotype,would contribute to making a definitive diagnosis,even on core biopsy *** The discovery of ESC RCC molecular signatures may provide new therapeutic strategies in the future.

关键词： Eosinophilic solid and cystic renal cell carcinoma Solid and cystic growth pattern CK20 TSC1 mutations TSC2 mutations Case report

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Rapidly growing primordial black holes as seeds of the massive high-redshift JWST Galaxies

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Science China(Physics,Mechanics & Astronomy) 2024年

作者： Guan-Wen Yuan Lei Lei Yuan-Zhu Wang bo Wang Yi-Ying Wang Chao Chen Zhao-Qiang Shen Yi-Fu Cai Yi-Zhong Fan Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of Sciences School of Astronomy and Space Science University of Science and Technology of China Institute of High Energy Physics Chinese Academy of Sciences Deep Space Exploration Laboratory/Department of Astronomy School of Physical SciencesUniversity of Science and Technology of China Jockey Club Institute for Advanced Study The Hong Kong University of Science and Technology

A group of massive galaxies at redshifts of z 7 have been recently detected by the James Webb Space Telescope (JWST),which were unexpected to form at such an early time within the standard Big Bang *** this work,we propose that this puzzle can be explained by the presence of some primordial black holes (PBHs) with a mass of～1000M⊙.These PBHs act as seeds for early galaxy formation with masses of～108-1010M⊙at high redshift,hence accounting for the JWST *** use a hierarchical Bayesian inference framework to constrain the PBH mass distribution models,and find that the Lognormal model with the Mc～750M⊙is preferred over other *** rapidly growing BHs are expected to have strong radiation and may appear as high-redshift compact objects,similar to those recently discovered by *** we focused on PBHs in this work,the bound on the initial mass of the seed black holes remains robust even if they were formed through astrophysical channels.

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Prevention and management of adverse events following COVID-19 vaccination using traditional Korean medicine:An online survey of public health doctors

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World Journal of Clinical Cases 2022年第28期10卷 10053-10065页

作者： Byungsoo Kang Hongmin Chu bo-young Youn Jungtae Leem College of Korean Medicine Dongshin UniversityNaju-si 58245South Korea Daecheong Public Health Subcenter Ongjin Public HealthcenterIncheon 23105IncheonSouth Korea Department of Preventive Medicine College of Korean MedicineKyung Hee UniversitySeoul 02447South Korea College of Korean Medicine Wonkwang UniversityIksan 54538Jeollabuk-doSouth Korea

BACKGROUND Since February 2021,vaccination against coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2 has started in *** To perform a questionnaire survey about the prevention and management of adverse events of COVID-19 vaccination among public health doctors of Korean Medicine(PHKMDs).METHODS An online questionnaire was developed,comprising categories about adverse events of vaccination(AEVs)and perception of using Korean medicine(KM)in managing vaccine adverse events(AEs)among ***’experience of AEVs,usage of Korean medicine for AEVs,and perception and attitude in using KM for AEVs were *** survey web-link was emailed to the association of *** links were sent through Survey Monkey to all PHKMDs in *** A total of 143 participants were recruited for this study;65%of participants were vaccinated at the same of the survey(n=93).Although most participants did not take any medication for prevention of the adverse events,62%(n=58)of participants had taken herbal medicine to treat the adverse events(n=52).Approximately 35%of participants(n=33)said that they would recommend taking herbal medicine to prevent any *** various KM interventions,the participants strongly recommended taking an herbal medicine(n=69,74.19%)to treat AEs,and the second-highest was acupuncture treatment(n=19,20.43%).CONCLUSION Overall,this research demonstrated a high prevalence of KM usage by the ***,this study’s results may serve as fundamental evidence for health professionals to consider using KM treatments when treating or preventing AEVs in the near future.

关键词： COVID-19 Vaccination Adverse events Herbal medicine Korean medicine

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Development of in situ characterization techniques in molecular beam epitaxy

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Journal of Semiconductors 2024年第3期45卷 9-32页

作者： Chao Shen Wenkang Zhan Manyang Li Zhenyu Sun Jian Tang Zhaofeng Wu Chi Xu bo Xu Chao Zhao Zhanguo Wang Laboratory of Solid State Optoelectronics Information Technology Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China College of Materials Science and Opto-Electronic Technology University of Chinese Academy of SciencesBeijing 101804China School of Physics Science and Technology Xinjiang UniversityUrumqi 830046China School of New Energy and Electronics Yancheng Teachers UniversityYancheng 224002China Key Laboratory of Optoelectronic Materials and Devices Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China

Ex situ characterization techniques in molecular beam epitaxy(MBE)have inherent limitations,such as being prone to sample contamination and unstable surfaces during sample transfer from the MBE *** recent years,the need for improved accuracy and reliability in measurement has driven the increasing adoption of in situ characterization *** techniques,such as reflection high-energy electron diffraction,scanning tunneling microscopy,and X-ray photoelectron spectroscopy,allow direct observation of film growth processes in real time without exposing the sample to air,hence offering insights into the growth mechanisms of epitaxial films with controlled *** combining multiple in situ characterization techniques with MBE,researchers can better understand film growth processes,realizing novel materials with customized properties and extensive *** review aims to overview the benefits and achievements of in situ characterization techniques in MBE and their applications for material science *** addition,through further analysis of these techniques regarding their challenges and potential solutions,particularly highlighting the assistance of machine learning to correlate in situ characterization with other material information,we hope to provide a guideline for future efforts in the development of novel monitoring and control schemes for MBE growth processes with improved material properties.

关键词： epitaxial growth thin film in situ characterization molecular beam epitaxy(MBE)

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考虑个体偏好异质性的定制公交选择行为

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中国公路学报 2024年第6期37卷 279-287页

作者：刘锴王静王江波冯涛侯悦大连理工大学经济管理学院辽宁大连116024 大连理工大学交通运输学院辽宁大连116024 广岛大学城市与数据科学实验室广岛东广岛739-8511 广岛大学先进理工系科学研究科广岛东广岛739-8511

定制公交需求响应策略往往把出行者看成均一特征群体,忽视了出行者选择偏好异质性。为探究多样化需求下的定制公交选择行为机理,并充分挖掘不可观测变量影响,结合定制公交运营特性,构建了反映便捷性、舒适性和可靠性的心理潜变量,并将... 详细信息

定制公交需求响应策略往往把出行者看成均一特征群体,忽视了出行者选择偏好异质性。为探究多样化需求下的定制公交选择行为机理,并充分挖掘不可观测变量影响,结合定制公交运营特性,构建了反映便捷性、舒适性和可靠性的心理潜变量,并将其作为解释变量加入Mixed Logit模型形成混合选择模型。在大连市运营的30条定制公交线路开展跟车问卷调查,采用实证数据研究定制公交运营特征,量化分析多类型属性对定制公交选择行为的影响。结果表明:定制公交对中高收入的中青年女性群体更有吸引力;可靠性与行程时间等传统服务水平变量对出行选择具有同等重要的影响,基于大连市数据得到出行者平均认知可靠性的效用与减少6.15 min行程时间的效用等同,出行者感知可靠性评价每提升一个等级,定制公交选择概率将增长为原来的1.09倍。混合选择模型比传统Logit模型对实证数据有更高拟合度,预测结果也更为稳健,出行者对行程时间、等待时间、常规公交是否有座位、定制公交票价折扣和绕行比率都具有偏好异质性;考虑异质性,为保障较稳定的满座率,需至少提供12%的票价折扣才能抵消约90%出行者对绕行10%路径的认知负效用。因此运营商在提供多车型、多模式出行服务的基础上,需要寻找定制公交需求响应式站点和线路调整与车费之间的平衡点。

关键词：交通工程出行方式选择混合选择模型定制公交潜变量

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OBE理念下高职化工装备技术专业人才培养路径研究

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湖北开放职业学院学报 2024年第6期37卷 78-79,82页

作者：安博河北化工医药职业技术学院河北石家庄050026

科教兴国是我国自二十一世纪以来始终坚持贯彻落实的强国战略,科技的发展离不开人才的培育。长期以来,高职教育对于培养专业对口的技术型人才是尤为重要的,大国工匠的精神也始终激励着青年学生的发展进步。归根结底,科技竞争的核心是人... 详细信息

科教兴国是我国自二十一世纪以来始终坚持贯彻落实的强国战略,科技的发展离不开人才的培育。长期以来,高职教育对于培养专业对口的技术型人才是尤为重要的,大国工匠的精神也始终激励着青年学生的发展进步。归根结底,科技竞争的核心是人才,人才培育的核心是创新型人才。化工装备技术专业作为具有高度实践操作性的专业,与我国化工行业的发展前景和人才培养息息相关。为满足创新型人才的培养需求,本文另辟蹊径,围绕OBE教育理念来探索高职化工装备技术专业创新工匠型人才培养路径。

关键词： OBE教育理念高职化工装备技术专业创新工匠型人才人才培养路径

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第一性原理计算研究γ'-Co3(V,M)(M=Ti,Ta)相的结构稳定性、力学和热力学性质

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物理学报 2024年第8期73卷 261-272页

作者：袁文翎姚碧霞李喜胡顺波任伟上海大学材料基因组工程研究院上海200444 上海大学高品质特殊钢冶金与制备国家实验室上海200444 上海交通大学上海市先进高温材料及精密成形重点实验室上海200240 上海大学文化遗产保护基础科学研究院上海200444 上海大学物理系量子与分子结构国际中心上海200444

本文采用基于密度泛函理论的第一性原理计算方法并结合准谐德拜模型,对Co基高温合金中γ'-Co_(3)(V,M)(M=Ti,Ta)相的结构稳定性、热力学性质以及有限温度下的力学性质进行了系统的研究和讨论.结果表明,γ'-Co_(3)(V,M)相能以L12结构稳... 详细信息

本文采用基于密度泛函理论的第一性原理计算方法并结合准谐德拜模型,对Co基高温合金中γ'-Co_(3)(V,M)(M=Ti,Ta)相的结构稳定性、热力学性质以及有限温度下的力学性质进行了系统的研究和讨论.结果表明,γ'-Co_(3)(V,M)相能以L12结构稳定存在,其具有良好的抵抗变形的能力.γ'-Co_(3)(V,Ti)相的热力学性能对温度的敏感性要大于γ'-Co_(3)(V,Ta)相,且γ'-Co_(3)(V,M)相具有高温稳定性.在有限温度下,随着温度的升高,γ'-Co_(3)(V,M)相由塑性材料向脆性材料过渡转变,而且,除了硬度性能有所提升外,γ'-Co_(3)(V,MM=Ti,Ta)相的力学性能均呈下降趋势.

关键词：高温合金第一性原理结构稳定性热力学性质

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Hatching and development of maize cyst nematode Heterodera zeae infecting different plant hosts

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Journal of Integrative Agriculture 2024年第5期23卷 1593-1603页

作者： Jiangkuan Cui Haohao Ren boWang Fujie Chang Xuehai Zhang Haoguang Meng Shijun Jiang Jihua Tang College of Plant Protection National Key Laboratory of Wheat and Maize Crop ScienceHenan Agricultural UniversityZhengzhou 450002China

The occurrence, distribution, and rapid molecular detection technology of Heterodera zeae Koshy et al. 1971, have been reported in China. We explored the biological characteristics of H. zeae sampled in Henan Province, China to understand its interaction with plants. Cysts and second-stage juveniles(J2s) were identified under an optical and scanning electron microscope, internal transcribed spacer(ITS) phylogenetic tree, and sequence characterized amplified region(SCAR)-PCR analyses. The optimum hatching temperatures of H. zeae were 30°C and 28°C, with cumulative hatching rates of 16.5 and 16.1%, respectively, at 30 days post-hatching(dph). The hatching rate of H. zeae eggs was improved by 20-and 50-time maize soil leachate and root juice, and 10-time root exudates. The hatching rate in 10-time root exudates was the highest(25.9%). The 10-time root exudates of maize and millet produced the highest hatching rate at 30 dph(25.9 and 22.9%, respectively), followed by wheat(19.9%), barley(18.3%), and rice(17.6%). Heterodera zeae developed faster in maize than in other crops. Fourth-stage juveniles(J4s) were detected in maize roots 8 days post-inoculation(dpi) at 28°C but not in other crops. Combined with hatching tests, the Huang–Huai–Hai summer maize region and the south and central-southwest mountainous maize areas are highly suitable for H. zeae in China. This is the first systematically study of the hatching and infection characteristics on different plant hosts of corn cyst nematode H. zeae in temperate regions. This study laid a theoretical foundation for the rapid spread and high environmental adaptability of corn cyst nematode.

关键词： crop host resistance Heterodera zeae incubation fluid maize cyst nematode nematode development nematodehatching

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