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Emerging role of vitamin D_(3)in alleviating intestinal structure injury caused by Aeromonas hydrophila in grass carp(Ctenopharyngodon idella)

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Animal Nutrition 2024年第1期16卷 202-217页

作者： Yao Zhang Xiao-Qiu Zhou Wei-Dan Jiang Pei Wu Yang Liu Hong-Mei Ren Lu Zhang Hai-Feng Mi Ling Tang Cheng-bo Zhong Lin Feng Animal Nutrition Institute Sichuan Agricultural UniversityChengduChina Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province Sichuan Agricultural UniversityChengduChina Key Laboratory for Animal Disease-Resistant Nutrition of China Ministry of Education Sichuan Agricultural UniversityChengduChina Healthy Aquaculture Key Laboratory of Sichuan Province Tongwei Co.Ltd.ChengduChina Sichuan Animal Science Academy Sichuan Animtech Feed Co.Ltd.ChengduChina

Bacterial pathogens destroy the structural integrity of functional organs in fish,leading to severe challenges in the aquaculture *** D_(3)(VD_(3))prevents bacterial infections and strengthens immune system function via vitamin D receptor(VDR).However,the correlation between VD_(3)/VDR and the structural integrity of functional organs remains *** study aimed to investigate the influence of VD_(3)supplementation on histological characteristics,apoptosis,and tight junction characteristics in fish intestine during pathogen infection.A total of 540 healthy grass carp(257.24±0.63 g)were fed different levels of VD_(3)(15.2,364.3,782.5,1,167.9,1,573.8,and 1,980.1 IU/kg)for 70 ***,fish were challenged with Aeromonas hydrophila,a pathogen that causes intestinal *** present study demonstrated that optimal supplementation with VD_(3)(1)alleviated intestinal structural damage,and inhibited oxidative damage by reducing levels of oxidative stress biomarkers;(2)attenuated excessive apoptosisrelated death receptor and mitochondrial pathway processes in relation to p38 mitogen-activated protein kinase signaling(P<0.05);(3)enhanced tight junction protein expression by inhibiting myosin light chain kinase signaling(P<0.05);and(4)elevated VDR isoform expression in fish intestine(P<0.05).Overall,the results demonstrated that VD_(3)alleviates oxidative injury,apoptosis,and the destruction of tight junction protein under pathogenic infection,thereby strengthening pathogen defenses in the *** finding supports the rationale for VD_(3)intervention as an essential practice in sustainable aquaculture.

关键词： Aeromonas hydrophila Antibacterial property Grass carp(Ctenopharyngodon idella) Intestinal health Vitamin D_(3)

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Semicrystalline Unfused Polymer Donors with Backbone Halogenation toward Cost-Effective Organic Solar Cells

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Chinese Journal of Chemistry 2024年第7期42卷 752-759页

作者： Yuxin Kong Shijie Ju Hongmei Qin Min Hun Jee Simeng Xia Jiaqi Ren Chao Gao Jianyu Yuan Wenyan Su Han young Woo Yuxiang Li School of Materials Science and Engineering Xi'an University of Science and TechnologyXianShaanxi 710054China Department of Chemistry Korea UniversitySeoul 02841Republic of Korea Xi'an Key Laboratory of Liquid Crystal and Organic Photovoltaic Materials State Key Laboratory of Fluorine&Nitrogen ChemicalsXi'an Modern Chemistry Research InstituteXi'anShaanxi 710065China Jiangsu Key Laboratory for Carbon-Based Functional Materials&Devices Institute of Functional Nano&Soft Materials(FUNSOM)Soochow University199 Ren'ai RoadSuzhouJiangsu 215123China

Developing novel unfused building blocks with simple synthesis and low cost is essential to advance and enrich cost-effective poly-mer donors;however,it remains a challenge due to the lack of efficient molecular ***,a class of low-cost and fully unfused polymer donors with precisely regulated backbone planarity via halogenation was designed and synthesized,namely PDTBTBz-2H,PDTBTBz-2F,and *** polymer donors possess a four-step synthesis route with over 80%yield from cheap raw chemicals comparable to existing low-cost polymer donors,such as *** from the planar backbone via in-corporating the F…S non-covalent interactions,PDTBTBz-2F exhibits more robust J-type aggregation in solution and a long-ranged molecular stacking in film relative to PDTBTBz-2H and ***,the systematical study of PDTBTBz-based organic so-lar cells(OSCs)reveals the close relationship between optimized molecular self-assembly and charge separation/transport regarding backbone halogenation when paired with the non-fullerene acceptor(Y6-bo-4F).As a result,the photovoltaic devices based on semicrystalline PDTBTBz-2F achieved a promising power conversion efficiency(PCE)of 12.37%.Our work highlighted the influence of backbone halogenation on the molecular self-assembly properties and a potential unfused backbone motif for further developing cost-effective OSCs.

关键词： Low-cost Polymer donors Backbone halogenation Molecular self-assembly Organic solar cells

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young patient with a giant gastric bronchogenic cyst:A case report and review of literature

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World Journal of Clinical Cases 2024年第13期12卷 2254-2262页

作者： Xu-Ren Lu Xu-Guang Jiao Qi-Hang Sun bo-Wen Li Qing-Shun Zhu Guang-Xu Zhu Jian-Jun Qu School of Clinical Medicine Shandong Second Medical UniversityWeifang 261000Shandong ProvinceChina Department of Gastrointestinal Surgery Medical Center The First Affiliated HospitalShandong Second Medical UniversityWeifang 261000Shandong ProvinceChina

BACKGROUND Gastric bronchogenic cysts(BCs)are extremely rare cystic masses caused by abnormal development of the respiratory system during the embryonic *** bronchial cysts are rare lesions that were first reported in 1956;as of 2023,only 33 cases are available in the PubMed online *** usually have no clinical symptoms in the early stage,and imaging findings also lack ***,they are difficult to diagnose before histopathological *** SUMMARY A 34-year-old woman with respiratory distress presented at our *** ultrasound revealed an anechoic mass between the spleen,left kidney and gastric fundus,with hyperechogenic and soft elastography textures and with a size of approximately 6.5 cm×4.0 ***,a computed tomography scan demonstrated high density between the posterior stomach and the spleen and the left kidney,with uniform internal density and a small amount of *** maximum cross section was approximately 10.1 cm×6.1 cm,and the possibility of a cyst was *** the imaging findings did not suggest a malignancy and because the patient required complete resection,she underwent laparotomy ***,this cystic lesion was found to be located in the posterior wall of the large curvature of the fundus and was approximately 8 cm×6 cm in ***,the pathologists verified that the cyst in the fundus was a gastric *** patient recovered well,her symptoms of chest tightness disappeared,and the abdominal drain was removed on postoperative day 6,after which she was discharged on day 7 for 6 months of *** had no tumor recurrence or postoperative complications during the *** This is a valuable report as it describes an extremely rare case of gastric ***,this was a very young patient with a large BC in the stomach.

关键词： Bronchogenic cyst Stomach Endoscopic ultrasound-guided fine needle aspiration Endosonography Case report

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新时代青年美术探索——以全国青年美展为中心

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美术 2024年第1期 54-57页

作者：于波山东艺术学院

青年美术家是最富活力与创造力的群体,也是中国美术的中坚力量,每一代青年美术家都紧扣时代的脉搏,以敏锐的视角、极富探索的精神、饱满的热情奏响新时代的序曲。本文以全国青年美展为中心,纵览青年美展的发展历程,着重阐述当代青年美... 详细信息

青年美术家是最富活力与创造力的群体,也是中国美术的中坚力量,每一代青年美术家都紧扣时代的脉搏,以敏锐的视角、极富探索的精神、饱满的热情奏响新时代的序曲。本文以全国青年美展为中心,纵览青年美展的发展历程,着重阐述当代青年美术家在主题内容、生存体验、语言表达、图像与媒介转换等方面的有益探索,挖掘这一群体守正创新的内在动因。

关键词：青年美术新时代全国青年美展

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A post-modification strategy to precisely construct dual-atom sites for oxygen reduction electrocatalysis

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Journal of Energy Chemistry 2024年第3期90卷 511-517,I0012页

作者： Juan Wang Xinyan Liu Chang-Xin Zhao Yun-Wei Song Jia-Ning Liu Xi-Yao Li Chen-Xi Bi Xin Wan Jianglan Shui Hong-Jie Peng bo-Quan Li Jia-Qi Huang School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 611731SichuanChina School of Materials Science and Engineering Beihang UniversityBeijing 100191China

Dual-atom catalysts(DACs) afford promising potential for oxygen reduction electrocatalysis due to their high atomic efficiency and high intrinsic ***,precise construction of dual-atom sites remains a *** this work,a post-modification strategy is proposed to precisely fabricate DACs for oxygen reduction ***,a secondary metal precursor is introduced to the primary single-atom sites to introduce direct metal-metal interaction,which ensures the formation of desired atom pair structure during the subsequent pyrolysis process and allows for successful construction of *** as-prepared FeCo-NC DAC exhibits superior oxygen reduction electrocatalytic activity with a half-wave potential of 0,91 V *** hydrogen ***-air batteries equipped with the FeCo-NC DAC demonstrate higher peak power density than those with the Pt/C *** importantly,this post-modification strategy is demonstrated universal to achieve a variety of dual-atom *** work presents an effective synthesis methodology for precise construction of catalytic materials and propels their applications in energy-related devices.

关键词： Dual-atom catalysts Electrocatalysis Oxygen reduction reaction Post-modification Zinc–air batteries

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Impact of gonadotropin-releasing hormone agonist and hormone replacement therapy on pregnancy outcomes in single euploid frozen-thawed embryo transfer for patients with endometrial polyps

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生殖与发育医学(英文) 2024年第1期08卷 1-7页

作者： Zhao Qing Li Jie Wang Wei-Lin Liu Ying-bo Li Jing Ni Tian-Xiang Zhou Wei Zhang Qian Yan Jun-Hao Center for Reproductive Medicine Shandong University 3. Jinan 250012 4. China

Objective: Although consensus on the optimal endometrial preparation protocol for frozen-thawed embryo transfer (FET) is lacking, this is particularly true for patients with infertility and a history of endometrial polyps (EPs). In this study, we aimed to investigate whether a gonadotropin-releasing hormone agonist combined with hormone replacement therapy (GnRHa-HRT) could improve pregnancy outcomes in single euploid FET for patients with a history of ***: In this retrospective cohort study, 395 women who underwent their first single euploid FET cycle were divided into groups according to endometrial preparation protocols as follows: natural cycle (NC) (n = 220), hormone replacement therapy (HRT) (n = 122), and GnRHa-HRT groups (n = 53). Subsequently, the FET cycles in the three groups were subdivided according to maternal age. All patients underwent hysteroscopic polypectomy before FET, and their EPs were confirmed by ***: No statistically significant differences were observed in live birth rates among the three groups (58.64%vs. 58.20%vs. 56.60%,P = 0.964). Furthermore, the rates of miscarriage, ectopic pregnancy, premature live birth, and pregnancy complications were comparable among the three groups (P >0.05). After adjusting for potential confounding factors, no significant differences in pregnancy outcomes were reported between the groups (adjusted odds ratios [OR] and 95% credible intervals [CI] for live birth rate, HRTvs. NC: 1.119, 0.660–1.896,P = 0.677; GnRHa-HRTvs. NC: 1.165, 0.610–2.226,P = 0.643). Additionally, the pregnancy outcomes of the FET cycle were not influenced by the endometrial preparation protocols in the subgroups when stratified by maternal age (P >0.05).Conclusion: GnRHa-HRT did not improve the pregnancy outcomes of the single euploid FET in patients with a history of EPs.

关键词： Endometrial polyps Frozen-thawed embryo transfer GnRHa Hormone replacement therapy Preimplantation genetic testing

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Rapid development of double-hit mRNA antibody cocktail against orthopoxviruses

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1768-1776页

作者： Hang Chi Suo-Qun Zhao Ru-Yi Chen Xing-Xing Suo Rong-Rong Zhang Wen-Hui Yang Dong-Sheng Zhou Min Fang bo Ying Yong-Qiang Deng Cheng-Feng Qin State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyAMMS100071BeijingChina College of Life Sciences Inner Mongolia Agricultural UniversityHohhot010018Inner MongoliaChina School of Life Sciences Henan UniversityKaifeng475004HenanChina Suzhou Abogen Biosciences Co. LtdSuzhou215123JiangsuChina Research Unit of Discovery and Tracing of Natural Focus Diseases Chinese Academy of Medical Sciences100071BeijingChina

The Orthopoxvirus genus,especially variola virus(VARV),monkeypox virus(MPXV),remains a significant public health threat *** development of therapeutic antibodies against orthopoxviruses is largely hampered by the high cost of antibody engineering and manufacturing ***-encoded antibodies have emerged as a powerful and universal platform for rapid antibody ***,by using the established lipid nanoparticle(LNP)-encapsulated mRNA platform,we constructed four mRNA combinations that encode monoclonal antibodies with broad neutralization activities against *** vivo characterization demonstrated that a single intravenous injection of each LNP-encapsulated mRNA antibody in mice resulted in the rapid production of neutralizing *** importantly,mRNA antibody treatments showed significant protection from weight loss and mortality in the vaccinia virus(VACV)lethal challenge mouse model,and a unique mRNA antibody cocktail,Mix2a,exhibited superior in vivo protection by targeting both intracellular mature virus(IMV)-form and extracellular enveloped virus(EEV)-form *** summary,our results demonstrate the proof-of-concept production of orthopoxvirus antibodies via the LNP-mRNA platform,highlighting the great potential of tailored mRNA antibody combinations as a universal strategy to combat orthopoxvirus as well as otheremerging viruses.

关键词： proof universal neutral

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NLRP3 activation in macrophages promotes acute intestinal injury in neonatal necrotizing enterocolitis

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World Journal of Pediatrics 2024年第2期20卷 153-164页

作者： bo Shi Cheng-Jie Lyu Zhen-Kai Le Hao-Sen Ji Yi Xiao Yuan-Yuan Zhang Shou-Jiang Huang Lin-Jun Yu Qiang Shu Jin-Fa Tou Deng-Ming Lai Department of Neonatal Surgery Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Pulmonology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Thoracic and Cardiovascular Surgery Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China

Background Macrophages are involved in various immune inflammatory disease *** study aimed to investigate the role and mechanism of macrophages in regulating acute intestinal injury in neonatal necrotizing enterocolitis(NEC).Methods CD68,nucleotide-binding oligomerization domain,leucine-rich repeat,and pyrin domain-containing 3(NLRP3),cysteine aspartate-specific protease-1(caspase-1),and interleukin-1β(IL-1β)in paraffin sections of intestinal tissues from NEC and control patients were detected with immunohistochemistry,immunofluorescence,and western *** pet milk,hypoxia and cold stimulation were used to establish a mouse(wild type and Nlrp3^(-/-))model of *** mouse macrophage(RAW 264.7)and rat intestinal epithelial cell-6 lines were also cultured followed by various ***,intestinal epithelial cell injuries,and IL-1β release were *** Compared to the gut“healthy”patients,the intestinal lamina propria of NEC patients had high macrophage infiltration and high NLRP3,caspase-1,and IL-1β ***,in vivo,the survival rate of Nlrp3^(-/-)NEC mice was dramatically improved,the proportion of intestinal macrophages was reduced,and intestinal injury was decreased compared to those of wild-type NEC ***3,caspase-1,and IL-1β derived from macrophages or supernatant from cocultures of macrophages and intestinal epithelial cells also caused intestinal epithelial cell *** Macrophage activation may be essential for NEC ***3/caspase-1/IL-1β cellular signals derived from macrophages may be the underlying mechanism of NEC development,and all these may be therapeutic targets for developing treatments for NEC.

关键词： Caspase-1 Interleukin-1β Macrophage Necrotizing enterocolitis NLRP3

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Efficacy and safety of bilastine *** for the treatment of chronic idiopathic urticaria:A multicenter,double-blind,double-dummy,phase III,non-inferiority,randomized clinical trial

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Chinese Medical Journal 2024年第12期137卷 1480-1482页

作者： Xue Chen Xiuping Han bo Cheng Hui Li Lingling Liu Songmei Geng Linfeng Li Jie Li Qing Guo Guoyi Zhang Hong Fang Jianzhong Zhang Department of Dermatology Peking University People’s HospitalBeijing 100044China Department of Dermatology Shengjing Hospital of China Medical UniversityShenyangLiaoning 110055China Department of Dermatology The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian 350004China Department of Dermatology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Dermatology Peking University First HospitalBeijing 100034China Department of Dermatology The Second Affiliated Hospital of Xi’an Jiaotong University(Xibei Hospital)Xi’anShaanxi 710006China Department of Dermatology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Dermatology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Dermatology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdong 510120China Department of Dermatology Hospital for Skin DiseasesChinese Academy of Medical SciencesNanjingJiangsu 210042China Department of Dermatology The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiang 310003China

To the Editor:Chronic urticaria,prevalent globally and increasing in China,predominantly affects young and middle-aged women,impacting their quality of life(QoL).[1]Standard treatment involves second-generation H1 antihistamines,with bilastine showing promise due to its selective action and minimal side ***,direct comparative studies are scarce,particularly in the Chinese *** aimed to evaluate the efcacy and safety of bilastine compared to levocetirizine in Chinese patients.

关键词： treatment double globally

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高阶网络统计指标综述

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物理学报 2024年第12期73卷 60-77页

作者：刘波曾钰洁杨荣湄吕琳媛电子科技大学基础与前沿研究院成都 610054 电子科技大学长三角研究院(湖州) 湖州 313001 电子科技大学基础与前沿研究院成都 610054 中国科学技术大学网络空间安全学院合肥 230026 电子科技大学基础与前沿研究院成都 610054 电子科技大学长三角研究院(湖州) 湖州 313001

复杂网络是描述和理解现实世界中复杂系统的有力工具.近年来,为了更准确地描述复杂网络中的交互关系,或者从高阶视角分析成对交互作用网络,许多学者开始使用高阶网络进行建模,并在研究其动力学过程中发现了与成对交互作用网络不同的新现... 详细信息

复杂网络是描述和理解现实世界中复杂系统的有力工具.近年来,为了更准确地描述复杂网络中的交互关系,或者从高阶视角分析成对交互作用网络,许多学者开始使用高阶网络进行建模,并在研究其动力学过程中发现了与成对交互作用网络不同的新现象.然而,与成对交互作用网络相比,高阶网络的研究相对较少;而且,高阶网络结构相对复杂,基于结构的统计指标定义较为分散且形式不统一,这些都给描述高阶网络的拓扑结构特征带来了困难.鉴于此,本文综述了两种最常见的高阶网络——超图和单纯形网络——常用的统计指标及其物理意义.本文有助于加深对高阶网络的理解,促进对高阶网络结构特征的定量化研究,也有助于研究者在此基础上开发更多适用于高阶网络的统计指标.

关键词：高阶网络超图单纯形网络统计指标

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