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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 49-57页

作者： Lingxiao Li Jing Li Yanqi Song Sujuan qin Qiaoyan wen Fei Gao State Key Laboratory of Networking and Switching Technology Beijing University of Posts and Telecommunications School of Cyberspace Security Beijing University of Posts and Telecommunications

In scenarios where a large amount of data needs to be learned, incremental learning can make full use of old knowledge, significantly reduce the computational cost of the overall learning process, and maintain high performance. In this paper, taking the MaxCut problem as our example, we introduce the idea of incremental learning into quantum computing, and propose a Quantum Proactive Incremental Learning algorithm(QPIL). Instead of a one-off training of quantum circuit, QPIL contains a multi-phase training on gradually-increased subgraphs of all vertices, proactively reducing large-scale problems to smaller ones to solve in steps, providing an efficient solution for MaxCut. Specifically, some vertices and corresponding edges are randomly selected for training to obtain optimized parameters of the quantum circuit at first. Then, in each incremental phase, the remaining vertices and corresponding edges are gradually added and the parameters obtained from the previous phase are reused in the parameter initialization of the current phase. We perform experiments on 120 different small-scale graphs, and it shows that QPIL performs superior to prevalent quantum and classical baselines in terms of approximation ratio(AR), time cost, anti-forgetting, and solving stability. In particular, QPIL's AR surpasses 20% of mainstream quantum baselines, and the time cost is less than 1/5 of them. The idea of QPIL is expected to inspire efficient and high-quality solutions in large-scale Max Cut and other combinatorial optimization problems.

关键词： variational quantum algorithm incremental learning multi-phase training MaxCut quantum computing

Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao Fang Qiuxia Peng wen qin Xuebing Yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

Selective Chiral Symmetry Breaking and Luminescent Sensing of Zn(Ⅱ) Metal-Organic Framework

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Selective Chiral Symmetry Breaking and Luminescent Sensing o...

中国化学会第八届全国配位化学会议

作者： Zheng Cui Lei Zhou bo-wen qin Bao-Lei Zhou Xiao-Ying Zhang Jing-Ping Zhang Advanced Energy Materials Research Center Faculty of Chemistry Northeast Normal University

Chiral metal-organic frameworks(MOFs)have attracted increasing attention because of their fascinating structures and potential structure-related applications such as chiral recognition and separation,asymmetric catalysis and nonlinear ***,homochiral MOFs can be obtained by using enantiomerically pure molecules such as enantiopure linkers,pendant ligands,templates and asymmetric inductions(solvent or additive)[1].However,the above methods are hindered because of availability and cost-effectiveness of the enantiopure *** overcome it,achiral reagents were utilized to synthesize chiral ***,using achiral precursors via spontaneous resolution tends to form a racemic conglomerate,which is an equal mixture of left-and righthanded crystals or racemic twins[2].As a consequence,it is important and highly challenging to synthesize enantioenriched chiral MOFs without any chiral source through chiral symmetry breaking[3].The origin of chirality is still a mystery today and the study of mechanism of chiral symmetry breaking is helpful for understanding chiral ***,we successfully synthesized microporous chiral MOF[(CH)NH][Zn(ZnO)(TATAT)]·7HO(1,HTATAT=5,5’,5’’-(1,3,5-triazine-2,4,6-triyl)tris(azanediyl)triisophthalate)using achiral flexible ligand HTATAT with multiple Lewis basic sites and Zn(NO).Interestingly,we observed nonstochastic handedness excess of compound 1 through selective chiral symmetry breaking in multiple repeated experiments without any chiral *** addition,compound 1 exhibits highly selective and sensitive sensing for Fecation and nitrobenzene(NB).

关键词： metal-organic frameworks symmetry breaking sensors zinc

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高速重载滑滚摩擦副表面损伤的力学特性

交通运输工程学报 2017年第3期17卷 75-82页

作者：彭波孔文秦贾磊李永俊王黎钦中国运载火箭技术研究院研究发展中心北京100076 哈尔滨工业大学机电工程学院黑龙江哈尔滨150001

采用有限元法建立了M50钢滑滚摩擦副的弹塑性接触模型,在接触应力约为4.0GPa、线速度约为50m·s-1的高速重载工况下,分析了其等效应力、剪切应力场与表层塑性变形,研究了摩擦因数与相对滑动速度对M50钢滑滚摩擦副接触行为的影响,并对比... 详细信息

采用有限元法建立了M50钢滑滚摩擦副的弹塑性接触模型,在接触应力约为4.0GPa、线速度约为50m·s-1的高速重载工况下,分析了其等效应力、剪切应力场与表层塑性变形,研究了摩擦因数与相对滑动速度对M50钢滑滚摩擦副接触行为的影响,并对比了M50钢双滚子滑滚试验中的表层塑性变形。计算结果表明:M50钢摩擦副的最大接触应力和椭圆接触区长、短轴长度的有限元分析结果与Hertz理论计算结果的偏差分别为2.66%、0.26%、6.43%;当摩擦因数由0.1增加到0.5时,最大等效应力的位置由摩擦副次表层约0.5mm处逐渐向接触表面发展;摩擦副表面发生胶合失效时的摩擦因数大于0.3,接触表面最大等效应力大于1 700 MPa;胶合失效发生时,M50钢摩擦副的应力和塑性应变具有特定的方向性,表现在滑滚比分别为0.12、0.15条件下,接触点处线速度较高的表面最大等效应力分别达到2 847、2 689 MPa,产生较大的塑性应变,最大值分别达到0.062、0.061,而线速度较低的表面最大等效应力分别为2 269、2 101 MPa,产生的最大塑性变形相对较小,分别为0.040、0.039。

关键词：滑滚摩擦副表面损伤有限元分析力学特性塑性应变

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遮荫条件下光伏发电仿真实验设计

实验室研究与探索 2016年第9期35卷 105-107页

作者：肖文波王庆颜超南昌航空大学国家级大学物理实验教学示范中心江西南昌330063

将Matlab/Simulink仿真软件平台引入光伏发电实验,可解决目前相关课程缺乏丰富实验条件的问题。结合遮荫条件下光伏发电的具体仿真教学实例,探索与总结出了该类实验的注意事项。结果证明该实验教学效果良好,为光伏发电技术等相关课程的... 详细信息

将Matlab/Simulink仿真软件平台引入光伏发电实验,可解决目前相关课程缺乏丰富实验条件的问题。结合遮荫条件下光伏发电的具体仿真教学实例,探索与总结出了该类实验的注意事项。结果证明该实验教学效果良好,为光伏发电技术等相关课程的实验教学提供了一种新的途径及方法。

关键词：实验教学遮荫条件下光伏发电仿真实验 Matlab/Simulink

The potential mechanism and clinical application value of remote ischemic conditioning in stroke

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Neural Regeneration Research 2025年第6期20卷 1613-1627页

作者： Yajun Zhu Xiaoguo Li Xingwei Lei Liuyang Tang Daochen wen bo Zeng Xiaofeng Zhang Zichao Huang Zongduo Guo The First Affiliated Hospital of Chongqing Medical University ChongqingChina

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity, non-invasiveness, safety, and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not yet been achieved.

关键词： Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke neuroinflammation neuroprotection Notch1 PI3K remote ischemic conditioning stroke

Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min qin Zhongliang Li wen‑Xia Su Jia‑Min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

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微波法制备焦糖色素的研究

中国调味品 2006年第12期31卷 44-47页

作者：房健陈洪兴闻伯芹盐城工学院食品科学与工程系江苏盐城224003

以葡萄糖和尿素为原料,利用微波独特的加热机制制备焦糖色素。探讨了工艺条件对焦糖色素色率的影响,结果显示:调节体系含水量15%、pH8.0,在中火条件下辐射14min,制得色率为93132EBC单位的焦糖色素,产品带正电荷;同时,观察了NaCl、KCl、F... 详细信息

以葡萄糖和尿素为原料,利用微波独特的加热机制制备焦糖色素。探讨了工艺条件对焦糖色素色率的影响,结果显示:调节体系含水量15%、pH8.0,在中火条件下辐射14min,制得色率为93132EBC单位的焦糖色素,产品带正电荷;同时,观察了NaCl、KCl、FeCl3、CaCl2等盐的存在对焦糖色素色率的影响,研究表明:这些金属氯化物均能增加焦糖色素的色率,其中FeCl3的影响最显著,其次为NaCl;稳定性试验显示:不加盐和加入NaCl制备得到的焦糖色素耐酸性和耐盐性均良好,而加入FeCl3制备得到的焦糖色素耐酸性和耐盐性差。

关键词：焦糖色素微波辐射色率

Moment Redistribution Effect of the Continuous Glass Fiber Reinforced Polymer-Concrete Composite Slabs Based on Static Loading Experiment

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Structural Durability & Health Monitoring 2025年第1期19卷 105-123页

作者： Zhao-Jun Zhang wen-Wei Wang Jing-Shui Zhen bo-Cheng Li De-Cheng Cai Yang-Yang Du Hui Huang Offshore Oil Engineering Co.Ltd. Tianjin300461China Department of Bridge Engineering School of TransportationSoutheast UniversityNanjing211189China

This study aimed to investigate the moment redistribution in continuous glass fiber reinforced polymer(GFRP)-concrete composite slabs caused by concrete cracking and steel bar yielding in the negative bending moment *** experimental bending moment redistribution test was conducted on continuous GFRP-concrete composite slabs,and a calculation method based on the conjugate beam method was *** composite slabs were formed by combining GFRP profiles with a concrete layer and supported on steel beams to create two-span continuous composite slab *** methods,epoxy resin bonding,and stud connection,were used to connect the composite slabs with the steel *** experimental findings showed that the specimen connected with epoxy resin exhibited two moments redistribution phenomena during the loading process:concrete cracking and steel bar yielding at the internal *** contrast,the composite slab connected with steel beams by studs exhibited only one-moment redistribution phenomenon throughout the loading *** the concrete at the internal support cracked,the bending moment decreased in the internal support section and increased in the midspan *** the steel bars yielded,the bending moment further decreased in the internal support section and increased in the mid-span *** GFRP profiles do not experience cracking,there was no significant decrease in the bending moment of the mid-span *** test specimens experienced compressive failure of concrete at the mid-span *** results showed good agreement between the calculated and experimental values of bending moments in the mid-span section and internal support *** proposed model can effectively predict the moment redistribution behavior of continuous GFRP-concrete composite slabs.

关键词： Moment redistribution GFRP-concrete composite slabs bending moment experimental study analysis model