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Ex vivo relaxation effect of Cuscuta chinensis extract on rabbit corpus cavernosum

Asian Journal of Andrology 2013年第1期15卷 134-137页

作者： Kai Sun Chen Zhao Xiang-Feng Chen Hye-Kyung Kim bo-ram choi Yi-Ran Huang Jong-Kwan Park Department of Urology Renji Hospital Shanghai Jiao Tong University School of Medicine and Shanghai Institute of Andrology Shanghai 200127 China Department of Urology Chonbuk National University and Research Institute of Clinical Medicine and Clinical Trial Center of Medical Device of Chonbuk National University Hospital Jeonju 561-712 South Korea

The effect of Cuscuta chinensis extract on the rabbit penile corpus cavernosum （PCC） was evaluated in the present study. Penises obtained from healthy male New Zealand white rabbits （2.5-3.0 kg） were precontracted with phenylephrine （Phe, 10 pmol I^-1） and then treated with various concentrations of Cuscuta chinensis extract （1, 2, 3, 4 and 5 mg ml^-1）. The change in penile tension was recorded, and cyclic nucleotides in the PCC were measured by radioimmunoassay （RIA）. The interaction between Cuscuta chinensis and sildenafil was also evaluated. The result indicated that the PCC relaxation induced by Cuscuta chinensis extract was concentration-dependent. Pre-treatment with an nitric oxide synthase （NOS） inhibitor （No〉 nitro-L-arginine-methyl ester, L-NAME）, a guanylyl cyclase inhibitor （1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-l-one, ODQ）, or a protein kinase A inhibitor （KT 5720） did not completely inhibit the relaxation. Incubation of penile cavernous tissue with the Cuscuta chinensis extract significantly increased cyclic guanosine monophosphate （cGMP） and cyclic adenosine monophosphate （cAMP） in the PCC. Moreover, the Cuscuta chinensis extract significantly enhanced sildenafil-induced PCC relaxation. In conclusion, the Cuscuta chinensis extract exerts a relaxing effect on penile cavernous tissue in part by activating the NO-cGMP pathway, and it may improve erectile dysfunction （ED）, which does not completely respond to sildenafil citrate.

关键词： Cuscuta chinensis erectile dysfunction (ED) NO-cGMP pathway penile corpus cavernosum (PCC) sildenafil

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Does Bicycle Riding Have an Impact on the Development of Lower Urinary Tract Symptoms and Sexual Function in Men?

Does Bicycle Riding Have an Impact on the Development of Low...

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第十七届全国泌尿外科学术会议

作者： Jong Kwan Park Dae Woong Kim bo ram choi Department of Urology Medical School Institute for Medical Sciences Jeonju561-712JeonbukKorea Department of Urology Medical SchoolJeonju561-712JeonbukKorea Department of Urology Medical SchoolJeonju561-712JeonbukKorea

Purpose This study was designed to determine whether or not subjects engaged in recreational bicycle riding are more likely to be affected by lower urinary tract symptoms(LUTS) and sexual function than those who compe...

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Nanoparticle Exsolution on Perovskite Oxides:Insights into Mechanism,Characteristics and Novel Strategies

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Nano-Micro Letters 2024年第2期16卷 312-346页

作者： Yo Han Kim Hyeongwon Jeong bo‑ram Won Hyejin Jeon Chan‑ho Park Dayoung Park Yeeun Kim Somi Lee Jae‑ha Myung Department of Materials Science and Engineering Incheon National UniversityIncheon 22012Republic of Korea

Supported nanoparticles have attracted considerable attention as a promising catalyst for achieving unique properties in numerous applications,including fuel cells,chemical conversion,and *** demonstrate high activity by expanding the number of active sites,but they also intensify deactivation issues,such as agglomeration and poisoning,*** for bottomup synthesis of supported nanoparticles has emerged as a breakthrough technique to overcome limitations associated with conventional *** are uniformly exsolved from perovskite oxide supports and socketed into the oxide support by a one-step reduction *** uniformity and stability,resulting from the socketed structure,play a crucial role in the development of novel ***,tremendous research efforts have been dedicated to further controlling exsolution *** effectively address exsolution at a more precise level,understanding the underlying mechanism is *** review presents a comprehensive overview of the exsolution mechanism,with a focus on its driving force,processes,properties,and synergetic strategies,as well as new pathways for optimizing nanocatalysts in diverse applications.

关键词： Supported nanoparticle Exsolution In situ growth Mechanism Perovskite oxide Catalyst

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Optimal Design of Splitters Attached to Turbo Blower Impeller by RSM

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Journal of Thermal Science 2012年第3期21卷 215-222页

作者： Choon-Man Jang Ka-ram choi Environmental Engineering Research Division Korea Institute of Construction Technology

This paper describes the optimization of the impeller having splitters for a turbo *** design variables,chord of splitter and pitch of splitter,are introduced to enhance the blower *** pressure and ef-ficiency are selected as an object function,and the optimization of the blower impeller is performed by a response surface method (RSM).Three-dimensional Navier-Stokes equations are introduced to analyze the internal flow of the blower and to find the value of the object function for each *** the shape optimization of the splitters attached to the impeller in the turbo blower,pressure and efficiency at the design flow condition are suc-cessively increased by 5.9 percent and 17.9 percent respectively based on the reference *** higher blower efficiency obtained by optimization of impeller having splitters is mainly caused by reducing the number of im-peller blades and optimal design of splitters in the blade passage while pressure increase keeps almost the same with the reference *** the object function of pressure,pressure increase is obtained at the design and off-design conditions while efficiency keeps higher compared to the reference *** enhancement of blow-er performance is due to the reduction of reverse and circulation flows in the blade passage.

关键词： Turbo Blower Splitter Numerical Simulation Optimal Design Pressure Response Surface Method

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Controlling the contact levels of details for fast and precise haptic collision detection

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Frontiers of Information Technology & Electronic Engineering 2017年第8期18卷 1117-1130页

作者： A ram choi Sung Min KIM Mee Young SUNG Department of Computer Science and Engineering lncheon National University lncheon Korea

For accurate and stable haptic rendering, collision detection for interactive haptic applications has to be done by filling in or covering target objects as tightly as possible with bounding volumes （spheres, axis-aligned bounding boxes, oriented bounding boxes, or polytopes）. In this paper, we propose a method for creating bounding spheres with respect to the contact levels of details （CLOD）, which can fit objects while maintaining the balance between high speed and precision of collision detection. Our method is composed mainly of two parts： bounding sphere formation and two-level collision detection. To specify further, bounding sphere formation can be divided into two steps： creating spheres and clustering spheres. Two-level collision detection has two stages as well： fast detection of spheres and precise detection in spheres. First, bounding spheres are created for initial fast probing to detect collisions of spheres. Once a collision is probed, a more precise detection is executed by examining the distance between a haptie pointer and each mesh inside the colliding boundaries. To achieve this refmed level of detection, a special data structure of a bounding volume needs to be defined to include all mesh information in the sphere. After performing a number of experiments to examine the usefulness and performance of our method, we have concluded that our algorithm is fast and precise enough for haptic simulations. The high speed detection is achieved through the clustering of spheres, while detection precision is realized by voxel-based direct collision detection. Our method retains its originality through the CLOD by distance-based clustering.

关键词： Collision detection Haptic rendering bounding sphere Clustering Contact levels of details (CLOD)

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Electrodeposited Ni-W-TiC Composite Coatings:Effect of TiC Reinforcement on Microstructural and Tribological Properties

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Acta Metallurgica Sinica(English Letters) 2020年第4期33卷 573-582页

作者： Jin Hyuk choi Gobinda Gyawali Dhani ram Dhakal Bhupendra Joshi Soo Wohn Lee Department of Materials Metal Engineering Sun Moon University31460 AsanSouth Korea Department of Fusion Science and Technology Sun Moon UniversityTangjeong Myeon31460 AsanChungnamSouth Korea Department of Environmental and Bio-Chemical Engineering Sun Moon University31460 AsanSouth Korea

Ni-W-TiC composite coatings were prepared via electrodeposition technique by dispersing the different amount of TiC particles into the plating *** Ni-W and Ni-W-TiC composite coatings containing different concentrations of TiC particles were characterized by using the scanning electron microscope,X-ray diffraction technique,Vickers microhardness test,surface roughness test,and tribology *** results show that the Ni-W coatings containing reinforced TiC particles have shown a typical FCC Ni-W crystal structure with significantly higher Vickers *** amount of dispersed TiC particles into the plating bath considerably affected codeposition weight percent of TiC into the Ni-W matrix,as revealed by the EDS ***-W-TiC samples demonstrated the decreased abrasive wear as compared to Ni-W coating and no characteristic features observed for the adhesive ***,an improvement in coefficient of friction was observed in Ni-W-TiC composite coating as compared to Ni-W coating.

关键词： Ni-W alloy Composite coating Microhardness Wear Coefficient of friction

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Effect of Pulse and Direct Current Electrodeposition on Microstructure,Surface,and Scratch Resistance Properties of Ni-W Alloy and Ni-W-SiC Composite Coatings

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Acta Metallurgica Sinica(English Letters) 2020年第10期33卷 1321-1330页

作者： Sami Bin Humam Gobinda Gyawali Dhani ram Dhakal Jin-Hyuk choi Soo Wohn Lee Department of Environmental and Bio-Chemical Engineering Sun Moon UniversityAsan 31460Korea Department of Fusion Science and Technology Sun Moon UniversityAsan 31460Korea

The present work aims to study the influence of direct current and pulse current techniques as well as embedded SiC nanoparticles on the mechanical properties of the electrodeposited Ni-W *** electrodeposited coatings were studied for morphological,microstructural,mechanical,and scratch resistance properties using the surface roughness tester,scanning electron microscopy,energy-dispersive X-ray spectroscopy,X-ray diffraction,Vickers microhardness,and scratch *** of pulse current exhibited relatively homogeneous and smooth surface of the coatings.A remarkable increment of microhardness was observed in both Ni-W and Ni-W-SiC coatings prepared under pulse current as compared to the direct current ***,the scratch test revealed a considerable improvement in the scratch resistance behavior of the Ni-W alloy and the composite coatings from the pulsed current ***,the application of pulse current not only improved the surface-and microstructure-related properties but also enhanced the Vickers microhardness and scratch resistance properties of the *** addition,the reduction in micro-cracks revealed the improvement in scratch resistance properties of the coatings due to the incorporated SiC nanoparticles into the Ni-W alloy matrix.

关键词： Ni-W-SiC composite Surface Microstructure Microhardness Scratch resistance

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Validity and reliability of Korean version Competency Assessment Tool-Mental Health

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Frontiers of Nursing 2020年第2期7卷 143-152页

作者： Hyun Mee Cho Jeong Won Han Eun Joung choi Hyo Eun Jeong bo ram Hong Eun Yong Kim Department of Nursing Science Kaya UniversityGimhae 50830Republic of Korea College of Nursing Science Kyung Hee UniversitySeoul 02447Republic of Korea

Objective:To establish basic data for identifying the level of mental health care competency of general nurses through verification of the reliability and validity of Competency Assessment Tool-Mental Health in the development of a measurement tool for mental health care competency in ***:This study was conducted on nurses working at general wards,excluding those working at the Department of Psychiatry,in five hospitals with 200 beds or more located in ***,construct,concurrent validity,and internal consistency of the measurement were ***:As a result of the construct validity,the section on importance of skills and knowledge for mental health care had 21 items,whereas the section on benefits of additional education had 22 *** internal consistency of measurement was confirmed as follows:Cronbach’s α=0.96 for the section on importance and 0.96 for the section on benefits ***:This study verified the high validity and reliability of the tool in assessing the mental health care competency of nurses,and it is believed to be significant as basic data for enhancing such competency.

关键词： competency mental health nurse reliability validity

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Atomic level deposition to extend Moore’s law and beyond

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International Journal of Extreme Manufacturing 2020年第2期2卷 29-52页

作者： Rong Chen Yi-Cheng Li Jia-Ming Cai Kun Cao Han-bo-ram Lee State Key Laboratory of Digital Manufacturing Equipment and Technology School of Mechanical Science and EngineeringHuazhong University of Science and Technology1037 Luoyu RoadWuhanHubeiPeople’s Republic of China Department of Materials Science and Engineering Incheon National UniversityIncheon 22012Republic of Korea

In the past decades,Moore’s law drives the semiconductor industry to continuously shrink the critical size of transistors down to 7 *** transistors further downscaling to smaller sizes,the law reaches its limitation,and the increase of transistors density on the chip *** to now,extreme ultraviolet lithography has been used in some key steps,and it is facing alignment precision and high costs for high-volume ***,the introduction of new materials and 3D complex structures brings serious challenges for top-down ***,bottom-up schemes are believed to be necessary methods combined with the top-down *** this article,atomic level deposition methods are reviewed and categorized to extend Moore’s law and ***,the deposition brings lateral angstrom resolution to the vertical direction as well as top-down etching,such as double patterning,transfer of nanowires,deposition of nanotubes,and so ***,various template-assisted selective deposition methods including dielectric templates,inhibitors and correction steps have been utilized for the alignment of 3D complex *** resolution can be achieved by inherently selective deposition,and the underlying selective mechanism is ***,the requirements for higher precision and efficiency manufacturing are also discussed,including the equipment,integration processes,scale-up issues,*** article reviews low dimensional manufacturing and integration of 3D complex structures for the extension of Moore’s law in semiconductor fields,and emerging fields including but not limited to energy,catalysis,sensor and biomedicals.

关键词： Moore’s law atomic level deposition high resolution selective deposition alignment

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Exploratory Data Analysis Applied in Mapping Multi-element Soil Geochemical Anomalies for Drill Target Definition:A Case Study from the Unpha Layered Non-magmatic Hydrothermal Pb-Zn Deposit,DPR Korea

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Acta Geologica Sinica(English Edition) 2021年第4期95卷 1357-1365页

作者： JANG Gwang-Hyok WON Hyon-Chol HWANG bo-Hyon choi Chol-Man Faculty of Geology Kim Il Sung UniversityPyongyangDemocratic People's Republic of Korea

A factor analysis was applied to soil geochemical data to define anomalies related to buried Pb-Zn mineralization.A favorable main factor with a strong association of the elements Zn,Cu and Pb,related to mineralization,was selected for *** median+2 MAD(median absolute deviation)method of exploratory data analysis(EDA)and C-A(concentration-area)fractal modeling were then applied to the Mahalanobis distance,as defined by Zn,Cu and Pb from the factor analysis to set the thresholds for defining multi-element *** a result,the median+2 MAD method more successfully identified the Pb-Zn mineralization than the C-A fractal *** soil anomaly identified by the median+2 MAD method on the Mahalanobis distances defined by three principal elements(Zn,Cu and Pb)rather than thirteen elements(Co,Zn,Cu,V,Mo,Ni,Cr,Mn,Pb,Ba,Sr,Zr and Ti)was the more favorable reflection of the ore *** identified soil geochemical anomalies were compared with the in situ economic Pb-Zn ore bodies for *** results showed that the median+2 MAD approach is capable of mapping both strong and weak geochemical anomalies related to buried Pb-Zn mineralization,which is therefore useful at the reconnaissance drilling stage.

关键词： factor analysis exploratory data analysis Mahalanobis distance multi-element Unpha

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