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Induction chemotherapy with albumin-bound paclitaxel plus lobaplatin followed by concurrent radiochemotherapy for locally advanced esophageal cancer

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World Journal of Gastrointestinal Oncology 2021年第11期13卷 1781-1790页

作者： Mao-Hui Yan Fang Liu Bao-Lin Qu bo-ning cai Wei Yu Xiang-Kun Dai Department of Radiotherapy The First Medical Center of the Chinese People's Liberation Army(PLA)General HospitalBeijing 100853China

BACKGROUND Albumin-bound paclitaxel(ABP)has been used as second-and higher-line treatments for advanced esophageal cancer,and its efficacy and safety have been well ***(LBP)is a third-generation platinum antitumor agent;compared with the first two generations of platinum agents,it has lower toxicity and has been approved for the treatment of breast cancer,small cell lung cancer,and chronic granulocytic ***,its role in the treatment of esophageal cancer warrants further *** To investigate the efficacy and safety of induction chemotherapy with ABP plus LBP followed by concurrent radiochemotherapy(RCT)for locally advanced esophageal *** Patients with pathologically confirmed advanced esophageal squamous cell carcinoma(ESCC)at our hospital were enrolled in this *** patients were treated with two cycles of induction chemotherapy with ABP plus LBP followed by concurrent RCT:ABP 250 mg/m^(2),ivgtt,30 min,d1,every 3 wk;and LBP,30 mg/m^(2),ivgtt,2 h,d1,every 3 wk.A total of four cycles were *** dose of the concurrent radiotherapy was 56-60 Gy/28-30 fractions,1.8-2.0 Gy/fraction,and 5 fractions/*** A total of 29 patients were included,and 26 of them completed the treatment *** the induction chemotherapy,the objective response rate(ORR)was 61.54%,the disease control rate(DCR)was 88.46%,and the progressive disease(PD)rate was 11.54%;after the concurrent RCT,the ORR was 76.92%,the DCR was 88.46%,and the PD rate was 11.54%.The median progression-free survival was 11.1 mo and the median overall survival was 15.83 *** multivariate analysis revealed that two cycles of induction chemotherapy followed by concurrent RCT significantly reduced the risk of PD compared with two cycles of chemotherapy alone(P=0.0024).Non-hematologic toxicities were tolerable,and the only grade 3 non-hematologic toxicity was radiation-induced esophagitis(13.79%).The main hematologic toxicity was neutropenia,and no

关键词： Esophageal squamous cell carcinoma Esophagus cancer Induction chemotherapy Concurrent radiochemotherapy Radiotherapy Chemotherapy Albuminbound paclitaxel Lobaplatin

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Neoadjuvant chemoradiotherapy plus surgery in the treatment of potentially resectable thoracic esophageal squamous cell carcinoma

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World Journal of Clinical Cases 2020年第24期8卷 6315-6321页

作者： Mao-Hui Yan bo-ning cai Bao-Lin Qu Xiang-Kun Dai Fang Liu Xiao-Bin Hou Department of Radiotherapy The First Medical Center of the Chinese PLA General HospitalBeijing 100853China Department of Thoracic Surgery The First Medical Center of the Chinese PLA General HospitalBeijing 100853China

BACKGROUNDIn recent years, neoadjuvant chemoradiotherapy (NCRT) combined with surgeryhas been gradually applied in patients with locally advanced thoracic esophagealcancer, but its effectiveness and safety remains unclear. In this clinical trial, weprospectively investigated the efficacy and safety of NCRT plus surgery in thetreatment of thoracic esophageal squamous cell carcinoma (TESCC).AIMTo investigate the efficacy and safety of NCRT combined with surgery in thetreatment of potentially resectable *** patients with advanced TESCC hospitalized in our hospital from July2016 to June 2019 were prospectively studied. All patients received NCRT, whichincluded intensity modulated conformal radiotherapy (40-44 Gy/20-22f, 2 Gy/f)and chemotherapy (paclitaxel 150-175 mg/m2d1, 22 + lobaplatin 25-30 mg/m2d2,23 for two cycles). Surgery was performed after radiotherapy and *** effectiveness and safety of these treatments were *** these 30 patients, complete response was achieved in two cases (6.7%) andpartial response in 26 cases (86.7%), yielding an objective response rate of 100%.All patients underwent radical surgery successfully. The R0 resection rate was100%, and the pathologic complete response rate was 33.3%. The incidence ofgrade III- IV granulocytopenia was 10% during the NCRT, and anastomoticleakage occurred in one patient after *** patients with potentially resectable TESCC, NCRT can effectively reduce thetumor size, increase R0 resection rate, and achieve obvious pathologicaldegradation, with mild adverse reactions. Thus, it is worthy of wider clinicalapplication.

关键词： Esophageal cancer Neoadjuvant chemoradiotherapy Surgical treatment Radiotherapy Chemotherapy Toxicity

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Changes in the nutritional status of nine vitamins in patients with esophageal cancer during chemotherapy

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World Journal of Gastroenterology 2021年第19期27卷 2366-2375页

作者： Lan-Qing Liang Ling-Ling Meng bo-ning cai Ze-Ping Cui Na Ma Le-Hui Du Wei Yu Bao-Lin Qu Sheng-Qiang Feng Fang Liu Department of Radiotherapy Chinese PLA General HospitalBeijing 100853China Department of Health Service The Guard Bureau of Joint Staff Department of Chinese PLABeijing 100017China

BACKGROUND Many studies have investigated the relationships between vitamins and esophageal cancer(EC).Most of these studies focused on the roles of vitamins in the prevention and treatment of EC,and few studies have examined the changes in vitamin nutritional status and their influencing factors before and after chemotherapy for *** may have a considerable effect on EC patients’vitamin levels and hematological *** To research the nutritional status of multiple vitamins in EC patients during chemotherapy and to assess its clinical *** EC patients admitted to our center from July 2017 to September 2020 were enrolled in this *** concentrations of nine vitamins(A,D,E,B9,B12,B1,C,B2 and B6),hemoglobin,total protein,albumin,blood calcium,blood phosphorus concentrations and body mass index(BMI)were measured in all EC *** changes in nine vitamins,hematological indicators and BMI were compared before and after two cycles of *** possible influential factors were *** In total,203 EC patients receiving chemotherapy were enrolled in this *** degrees of vitamin A,D,C and B2 deficiency and weight loss were found in these patients,and the proportions of vitamin B2 and vitamin C deficiencies increased significantly after chemotherapy(both P<0.05).Serum concentrations of vitamins A,C,B2 and B6 and BMI before and after chemotherapy were statistically significant(all P<0.05).Multivariate analysis showed that vitamin A levels significantly differed between male and female EC patients,whereas vitamin D concentration significantly differed in EC patients in different stages(all P<0.05).Correlations were observed between the changes in serum concentrations of vitamin A and C before and after two cycles chemotherapy and the change in BMI(P<0.05).Hemoglobin,total protein,serum albumin and blood calcium concentrations significantly decreased in EC patients after chemotherapy(all P<0.05),while the blo

关键词： Esophageal cancer Chemotherapy Vitamins Nutritional status body mass index

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Application of the improved dung beetle optimizer,muti-head attention and hybrid deep learning algorithms to groundwater depth prediction in the ningxia area,China

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 18-23页

作者： Jiarui cai bo Sun Huijun Wang Yi Zheng Siyu Zhou Huixin Li Yanyan Huang Peishu Zong Collaborative Innovation Center on forecast and Evaluation of Meteorological Disasters/Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment ChangeNanjing University of Information Science and TechnologyNanjingChina Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) ZhuhaiChina China Meteorological Administration Key Laboratory of Transportation MeteorologyNanjingChina Jiangsu Meteorological Observatory NanjingChina

Due to the lack of accurate data and complex parameterization,the prediction of groundwater depth is a chal-lenge for numerical *** learning can effectively solve this issue and has been proven useful in the prediction of groundwater depth in many *** this study,two new models are applied to the prediction of groundwater depth in the ningxia area,*** two models combine the improved dung beetle optimizer(Dbo)algorithm with two deep learning models:The Multi-head Attention-Convolution Neural Network-Long Short Term Memory networks(MH-CNN-LSTM)and the Multi-head Attention-Convolution Neural Network-Gated Recurrent Unit(MH-CNN-GRU).The models with Dbo show better prediction performance,with larger R(correlation coefficient),RPD(residual prediction deviation),and lower RMSE(root-mean-square error).Com-pared with the models with the original Dbo,the R and RPD of models with the improved Dbo increase by over 1.5%,and the RMSE decreases by over 1.8%,indicating better prediction *** addition,compared with the multiple linear regression model,a traditional statistical model,deep learning models have better prediction performance.

关键词： Groundwater depth Multi-head attention Improved dung beetle optimizer CNN-LSTM CNN-GRU ningxia

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食管癌调强放射治疗初期疗效分析

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癌症 2009年第11期28卷 1138-1142页

作者：王军韩春李晓宁高超贾敬好蔡博宁张辛肖爱勤河北医科大学第四医院放疗科河北石家庄050011

背景与目的:食管癌调强放射治疗临床研究国内外报道较为少见,其临床疗效如何,是否会引起较为严重的大范围低剂量照射肺损伤等问题亦无成熟经验。本研究旨在评价调强放疗技术对食管癌的初期疗效及治疗不良反应。方法:2006年6月至2008年3... 详细信息

背景与目的:食管癌调强放射治疗临床研究国内外报道较为少见,其临床疗效如何,是否会引起较为严重的大范围低剂量照射肺损伤等问题亦无成熟经验。本研究旨在评价调强放疗技术对食管癌的初期疗效及治疗不良反应。方法:2006年6月至2008年3月,采用调强放疗技术治疗37例颈段、胸段食管癌,评价肿瘤反应率、肿瘤局部控制率、生存率和治疗相关不良反应。结果:全组患者100%肿瘤区(gross tumor volume,GTV)、95%临床靶区(clinical target volume,CTV)和95%计划靶区(planning target volume,PTV)接受剂量分别为(6456±172)cGy、(6293±145)cGy和(5988±53)cGy。接受≥5Gy、≥10Gy、≥20Gy、≥30Gy的肺组织占全肺体积的百分比和肺平均剂量分别为(59.6±12.8)%、(39.5±8.7)%、(22.0±5.4)%、(12.0±4.3)%和(1178±248)cGy。肿瘤总反应率为97.3%(36/37)。中位随访时间为13个月(8～29个月),3级及以上急性和晚期放射性食管损伤发生率分别为16.2%和7.2%;2级及以上急性和晚期放射性肺损伤发生率分别10.8%和8.1%。1、2年肿瘤局部控制率分别为72.9%、72.9%;1、2年总生存率分别为80.9%、67.4%;1、2年无瘤生存率分别为73.5%、51.4%。局部未控和复发占总治疗失败的69.2%。结论:食管癌调强放射治疗初期疗效较好,急性和晚期放射性肺损伤发生率较低。治疗失败的主要原因仍为肿瘤局部未控和复发。

关键词：食管肿瘤调强放射治疗预后疗效

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Moment Redistribution Effect of the Continuous Glass Fiber Reinforced Polymer-Concrete Composite Slabs Based on Static Loading Experiment

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Structural Durability & Health Monitoring 2025年第1期19卷 105-123页

作者： Zhao-Jun Zhang Wen-Wei Wang Jing-Shui Zhen bo-Cheng Li De-Cheng cai Yang-Yang Du Hui Huang Offshore Oil Engineering Co.Ltd. Tianjin300461China Department of Bridge Engineering School of TransportationSoutheast UniversityNanjing211189China

This study aimed to investigate the moment redistribution in continuous glass fiber reinforced polymer(GFRP)-concrete composite slabs caused by concrete cracking and steel bar yielding in the negative bending moment *** experimental bending moment redistribution test was conducted on continuous GFRP-concrete composite slabs,and a calculation method based on the conjugate beam method was *** composite slabs were formed by combining GFRP profiles with a concrete layer and supported on steel beams to create two-span continuous composite slab *** methods,epoxy resin bonding,and stud connection,were used to connect the composite slabs with the steel *** experimental findings showed that the specimen connected with epoxy resin exhibited two moments redistribution phenomena during the loading process:concrete cracking and steel bar yielding at the internal *** contrast,the composite slab connected with steel beams by studs exhibited only one-moment redistribution phenomenon throughout the loading *** the concrete at the internal support cracked,the bending moment decreased in the internal support section and increased in the midspan *** the steel bars yielded,the bending moment further decreased in the internal support section and increased in the mid-span *** GFRP profiles do not experience cracking,there was no significant decrease in the bending moment of the mid-span *** test specimens experienced compressive failure of concrete at the mid-span *** results showed good agreement between the calculated and experimental values of bending moments in the mid-span section and internal support *** proposed model can effectively predict the moment redistribution behavior of continuous GFRP-concrete composite slabs.

关键词： Moment redistribution GFRP-concrete composite slabs bending moment experimental study analysis model

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Effect of Triisopropanolamine on the Compressive Strength and Early Hydration of Cement at Low Temperature

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Journal of Wuhan University of Technology(Materials Science) 2020年第3期35卷 611-619页

作者： ZHANG Feng BAI Yin cai Yuebo CHEN bo ning Fengwei State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Nanjing Hydraulic Research InstituteNanjing 210029China

Triisopropanolamine (TIPA) was used as an early strength component to study its effects on mortar strength, cement paste setting time and early hydration characteristic of cement. And the early strength mechanism of TIPA at low temperature of 5 ℃ was also discussed. The results showed that, at 5 ℃, the incorporation of TIPA promoted the condensation of cement paste, shortened the initial and final setting time, and accelerated the strength development of specimens at all ages, among which the strength after 3 d increased significantly. The 1, 3, 7, and 28 d compressive strength ratios of the mortars mixed with 1% TIPA could reach 196%, 179%, 160% and 110% respectively, and the mortar strength after 3 d exceeded that of the contrast sample cured at 20 ℃. Under low temperature condition, TIPA could promote the hydration reaction of cement, shorten the induction period and advance the acceleration period. Furthermore, the maximum heat release rate and cumulative heat release quantity would be all increased, and the cumulative heat release of the cement mixed with TIPA hydrated for 12 h and 7 d increased 73% and 38% respectively. TIPA could shorten the nucleation and crystal growth (NG) stage and increase its hydration degree significantly, so it promoted cement hydration reaction. Additionally, the hydration reaction rates in phase boundary reaction (I) phase and diffusion reaction (D) phase were increased, and the duration of I process was prolonged, thereby the development of specimen strength would be accelerated. TIPA did not obviously change the types of hydration products, but increased the content of Ca(OH)2 in the samples and the degree of cement hydration. After hydration to 7 d, large amounts of hydration products, whose surface was smooth, were formed and bonded into sheets, and the structural density of samples improved significantly.

关键词： low temperature triisopropanolamine compressive strength hydration mechanism

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Correlation between the rock mass properties and maximum horizontal stress:A case study of overcoring stress measurements

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 39-48页

作者： Peng Li Meifeng cai Shengjun Miao Yuan Li Yu Wang Key Laboratory of Ministry of Education for Efficient Mining and Safety of Metal Mines University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Coal Resources and Safe Mining China University of Mining and TechnologyXuzhou 221116China

Understanding the mechanical properties of the lithologies is crucial to accurately determine the horizontal stress *** investigate the correlation between the rock mass properties and maximum horizontal stress,the three-dimensional(3D)stress tensors at 89 measuring points determined using an improved overcoring technique in nine mines in China were adopted,a newly defined characteristic parameter C_(ERP)was proposed as an indicator for evaluating the structural properties of rock masses,and a fuzzy relation matrix was established using the information distribution *** results indicate that both the vertical stress and horizontal stress exhibit a good linear growth relationship with *** is no remarkable correlation between the elastic modulus,Poisson's ratio and depth,and the distribution of data points is scattered and ***,there is no obvious relationship between the rock quality designation(RQD)and *** maximum horizontal stress σ_(H) is a function of rock properties,showing a certain linear relationship with the C_(ERP)at the same *** addition,the overall change trend of σ_(H) determined by the established fuzzy identification method is to increase with the increase of C_(ERP).The fuzzy identification method also demonstrates a relatively detailed local relationship betweenσ_H and C_(ERP),and the predicted curve rises in a fluctuating way,which is in accord well with the measured stress data.

关键词： overcoring stress measurements elastic modulus Poisson's ratio rock quality designation maximum horizontal stress fuzzy identification

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SensFL:Privacy-Preserving Vertical Federated Learning with Sensitive Regularization

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 385-404页

作者： Chongzhen Zhang Zhichen Liu Xiangrui Xu Fuqiang Hu Jiao Dai Baigen cai Wei Wang School of Automation and Intelligence Beijing Jiaotong UniversityBeijing100044China Shuohuang Railway Development Co. Ltd.National Energy GroupCangzhou062350China Beijing Key Laboratory of Security and Privacy in Intelligent Transportation School of Computer Science and TechnologyBeijing Jiaotong UniversityBeijing100044China

In the realm of Intelligent Railway Transportation Systems,effective multi-party collaboration is crucial due to concerns over privacy and data *** Federated Learning(VFL)has emerged as a promising approach to facilitate such collaboration,allowing diverse entities to collectively enhance machine learning models without the need to share sensitive training ***,existing works have highlighted VFL’s susceptibility to privacy inference attacks,where an honest but curious server could potentially reconstruct a client’s raw data from embeddings uploaded by the *** vulnerability poses a significant threat to VFL-based intelligent railway transportation *** this paper,we introduce SensFL,a novel privacy-enhancing method to against privacy inference attacks in ***,SensFL integrates regularization of the sensitivity of embeddings to the original data into the model training process,effectively limiting the information contained in shared *** reducing the sensitivity of embeddings to the original data,SensFL can effectively resist reverse privacy attacks and prevent the reconstruction of the original data from the *** experiments were conducted on four distinct datasets and three different models to demonstrate the efficacy of *** results show that SensFL can effectively mitigate privacy inference attacks while maintaining the accuracy of the primary learning *** results underscore SensFL’s potential to advance privacy protection technologies within VFL-based intelligent railway systems,addressing critical security concerns in collaborative learning environments.

关键词： Vertical federated learning privacy defenses

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Multi-objective strategy to optimize dithering technique for high-quality three-dimensional shape measurement

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Chinese Physics B 2019年第10期28卷 381-386页

作者： ning cai Zhe-bo Chen Xiang-Qun Cao Bin Lin State Key Laboratory of Modern Optical Instrumentation CNERC for Optical InstrumentsZhejiang UniversityHangzhou 310027China Research Institute of Zhejiang University-Taizhou Taizhou 318000China

Dithering optimization techniques can be divided into the phase-optimized technique and the intensity-optimized technique. The problem with the former is the poor sensitivity to various defocusing amounts, and the problem with the latter is that it cannot enhance phase quality directly nor efficiently. In this paper, we present a multi-objective optimization framework for three-dimensional(3D) measurement by utilizing binary defocusing technique. Moreover, a binary patch optimization technique is used to solve the time-consuming issue of genetic algorithm. It is demonstrated that the presented technique consistently obtains significant phase performance improvement under various defocusing amounts.

关键词： three-dimensional(3D) shape measurement multi-objective dithering genetic algorithm

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