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Bioactive biodegradable polycitrate nanoclusters enhances the myoblast differentiation and in vivo skeletal muscle regeneration via p38 MAPK signaling pathway

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Bioactive Materials 2020年第3期5卷 486-495页

作者： Yi guo min Wang Juan Ge Wen Niu Mi Chen Wei Cheng bo Lei Frontier Institute of Science and Technology Xi'an Jiaotong UniversityXi'an710054China Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi'an Jiaotong UniversityXi'an710054China National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an710000China Instrument Analysis Center Xi'an Jiaotong UniversityXi'an710054China Department of Biomedical Engineering University of MichiganAnn ArborMI48109United States

Complete skeletal muscle repair and regeneration due to severe large injury or disease is still a *** cues are critical to control myoblast cell function and can be utilized to develop smart biomaterials for skeletal muscle *** acid-based biodegradable polymers have received much attention on tissue engineering,however,their regulation on myoblast cell differentiation and mechanism was few ***,we find that citrate-based polycitrate-polyethylene glycol-polyethylenimine(POCG-PEI600)nanoclusters can significantly enhance the in vitro myoblast proliferation by probably reinforcing the mitochondrial number,promote the myotube formation and full-thickness skeletal muscle regeneration in vivo by activating the myogenic biomarker genes expression of Myod and ***-PEI600 nanoclusters could also promote the phosphorylation of p38 in MAP kinases(MAPK)signaling pathway,which led to the promotion of the myoblast *** in vivo skeletal muscle loss rat model also confirmed that POCG-PEI600 nanoclusters could significantly improve the angiogenesis,myofibers formation and complete skeletal muscle ***-PEI600 nanocluster could be also biodegraded into small molecules and eliminated in vivo,suggesting their high biocompatibility and *** study could provide a bioactive biomaterial-based strategy to repair and regenerate skeletal muscle tissue.

关键词： Bioactive biomaterials Citrate nanopolymer Myoblast differentiation Skeletal muscle regeneration

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Moving scanning emitter tracking by a single observer using time of interception:Observability analysis and algorithm

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Chinese Journal of Aeronautics 2017年第3期30卷 1174-1183页

作者： Yifei ZHANG min ZHANG Fucheng guo Information Engineering Department Rocket Force University of Engineering College of Electronic Science and Engineering National University of Defense Technology

The target motion analysis（TMA） for a moving scanning emitter with known fixed scan rate by a single observer using the time of interception（TOI） measurements only is investigated in this *** transforming the TOI of multiple scan cycles into the direction difference of arrival（DDOA） model,the observability analysis for the TMA problem is *** necessary conditions for uniquely identifying the scanning emitter trajectory are *** paper also proposes a weighted instrumental variable（WIV） estimator for the scanning emitter TMA,which does not require any initial solution guess and is closed-form and computationally *** importantly,simulations show that the proposed algorithm can provide estimation mean square error close to the Cramer-Rao lower bound（CRLB） at moderate noise levels with significantly lower estimation bias than the conventional pseudo-linear least square（PLS） estimator.

关键词： Cramer-Rao lower bound Least squares Observability Scanning emitter Target motion analysis Time of interception

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Soundscape of the West Lake Scenic Area with profound cultural background—a case study of Evening Bell Ringing in Jingci Temple,China

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第3期14卷 219-229页

作者： Jian GE min guo Miao YUE Deptartment of Architecture Zhejiang University State Key Lab of Subtropical Building Science South China University of Technology Deptartment of Architecture and Art Zhejiang College of Construction

From the case study of Evening Bell Ringing at Nanping Hill,one of the West Lake Cultural Landscapes in Hangzhou,China,we investigated the soundscape of a scenic area with a profound cultural ***,we conducted the soundscape physical index of the area in both winter and spring seasons to analyze its objective graphical ***,we focused on people's reactions to the soundscape in order to obtain a subjective evaluation of each component in the soundscape and integrated ***,the relationship between the objective data and the subjective evaluation was ***,the impacts of the natural environment,history,and cultural factors on the evaluation of the Jingci Temple soundscape were *** was found that natural sounds,cultural sounds,and historic sounds were widely acclaimed in people's subjective feelings,which indicated the close relationships among historical and cultural background,soundscape,and natural ***,the conclusion was made that soundscape should be consistent with the local natural environment and the historical and cultural background.

关键词： Soundscape Culture Evaluation West Lake Evening Bell Ringing at Nanping Hill

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Double minimum creep processing and mechanism forγ'strengthened cobalt-based superalloy

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Journal of Materials Science & Technology 2022年第17期112卷 123-129页

作者： Jia Chen min guo min Yang Lin Liu Jun Zhang State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China

The double minimum creep,characterized by two creep rate minima,in Co-based superalloy is investigated using a phase-field model coupled with a crystal plasticity *** constitutive modeling,based on the dislocation slip theory considering dislocation interaction,is applied to simulate microstructural evolution and deformation *** process commences at the beginning of creep until the global minimum of creep rate is reached,demonstrating a strengthening effect from N-type rafts under compressive *** high shear strain rate of(111)[011]slip system in the intersections of horizontal and verticalγchannels leads to a slight increase of creep rate after the first local *** evolution of stress field shows that the softening effect is the combined effect of the increase of resolved shear stress and the decrease of hardening stress in the ***,these changes in stress are primarily caused by the dislocation annihilation and the inhomogeneous plastic *** study indicates that the intermediate local softening stage during creep may be eliminated if the initial inter-distance betweenγ’precipitates is decreased.

关键词： Cobalt-based superalloy Phase-field simulation Creep γ’precipitates Slip system

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Decomposing Composite Changes for Code Review and Regression Test Selection in Evolving Software

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Journal of Computer Science & Technology 2019年第2期34卷 416-436页

作者： bo guo Young-Woo Kwon Myoungkyu Song Department of Global Operations PayPal Omaha Nebraska 68128 U.S.A. School of Computer Science and Engineering Kyungpook National University Daegu 702-701 South Korea Department of Computer Science University of Nebraska at Omaha Omaha 68128 U.S.A.

Inspecting and testing code changes typically require a significant amount of developer *** a system evolves,developers often create composite changes by mixing multiple development issues,as opposed to addressing one independent issue—an atomic *** composite changes often becomes time-consuming and *** test unrelated edits on composite changes,rerunning all regression tests may require excessive *** address the problem,we present an interactive technique for change decomposition to support code reviews and regression test selection,called *** a developer specifies code change within a diff patch,ChgCutter partitions composite changes into a set of related atomic changes,which is more cohesive and self-contained regarding the issue being *** composite change inspection,it generates an intermediate program version that only includes a related change subset using program dependence *** cost reduction during regression testing,it safely selects only affected tests responsible for changes to an intermediate *** the evaluation,we apply ChgCutter to 28 composite changes in four open source *** partitions these changes with 95.7% accuracy,while selecting affected tests with 89.0% *** conduct a user study with professional software engineers at PayPal and find that ChgCutter is helpful in understanding and validating composite changes,scaling to industry projects.

关键词： software maintenance and evolution code review test selection program slicing

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Pressure characteristics of landslide-generated impulse waves

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Journal of Mountain Science 2019年第8期16卷 1774-1787页

作者： TAN Jian-min HUANG bo-lin ZHAO Yong-bo Wuhan Center of China Geological Survey WuhanChina433002 Hubei Key laboratory of Disaster Prevention and Mitigation China Three Gorges UniversityYichangChina443000

The destructiveness of impulse waves generated by landslides(IWL) originates from the wave’s movement and load, wherein the impulse wave’s load is the major cause of sub-aerial building damage and casualties. In this study, an experiment involving 16 groups of physical tests for the wave pressure generated by a landslide was designed, consisting of 4 sets of IWL and 4 opposite bank slope angles. A high-frequency strain system was used to measure the total pressure of the impulse wave in a water tank. The tests showed that the dynamic pressure caused by the IWL can be divided into two types: impact pressure generated by the jetflow and the pulsating pressure caused by the wave. Under the same impulse wave conditions, the maximum run-up becomes smaller as the opposite bank’s slope angle increases, and the jetflow maximum impact pressure experienced by the opposite bank increases, while the maximum pulsating pressure caused by the impulse wave is slightly decreased. Different from previous studies, the spatial maximum pressure distributions of the wave generated by landslide were concluded that the position of the maximum pulsating pressure appears adjacent to the still water surface, and the overall spatial distribution pattern of maximum wave pressure is presented as an inclined 'M' ***, this study is the first to quantitatively analyzed that impact pressure has a very short action time, is even 7 times of the pulse pressure value, and there is a simple mathematical linear relationship between the two. Currently, some wave-load formulas for wind waves and tides are not applicable to calculating the loads of IWL. Research on the load of IWL will explain the hazard of impulse wave very clearly, and will greatly contribute to hazard prevention, mitigation and risk assessment work associated with IWL.

关键词： Landslide Impulse wave Wave pressure Impact pressure Pulsating pressure Pressure distribution

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DNA mismatch repair in trinucleotide repeat instability

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Science China(Life Sciences) 2017年第10期60卷 1087-1092页

作者： Jinzhen guo Luping Chen guo-min Li Department of Radiation Oncology University of Texas Southwestern Medical Center Department of Biochemistry and Molecular Medicine Norris Comprehensive Cancer Center University of Southern California Keck School of Medicine

Trinucleotide repeat expansions cause over 30 severe neuromuscular and neurodegenerative disorders, including Huntington's disease, myotonic dystrophy type 1, and fragile X syndrome. Although previous studies have substantially advanced the understanding of the disease biology, many key features remain unknown. DNA mismatch repair(MMR) plays a critical role in genome maintenance by removing DNA mismatches generated during DNA replication. However, MMR components,particularly mismatch recognition protein MutSβ and its interacting factors MutLα and MutLγ, have been implicated in trinucleotide repeat instability. In this review, we will discuss the roles of these key MMR proteins in promoting trinucleotide repeat instability.

关键词： DNA mismatch repair trinucleotide repeat instability neurodegenerative diseases MutSβ

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A closed-form solution for moving source localization using LBI changing rate of phase difference only

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Chinese Journal of Aeronautics 2014年第2期27卷 365-374页

作者： Zhang min guo Fucheng Zhou Yiyu College of Electronic Science and Engineering National University of Defense Technology

Due to the deficiencies in the conventional multiple-receiver localization syste,.ns based on direction of arrival （DOA） such as system complexity of interferometer or array and ampli- tude/phase unbalance between multiple receiving channels and constraint on antenna configuration, a new radiated source localization method using the changing rate of phase difference （CRPD） measured by a long baseline interferometer （LBI） only is studied. To solve the strictly nonlinear problem, a two-stage closed-form solution is proposed. In the first stage, the DOA and its changing rate are estimated from the CRPD of each observer by the pseudolinear least square （PLS） method, and then in the second stage, the source position and velocity are found by another PLS minimiza- tion. The bias of the algorithm caused by the correlation between the measurement matrix and the noise in the second stage is analyzed. To reduce this bias, an instrumental variable （IV） method is derived. A weighted IV estimator is given in order to reduce the estimation variance. The proposed method does not need any initial guess and the computation is small. The Cramer-Rao lower bound （CRLB） and mean square error （MSE） are also analyzed. Simulation results show that the proposed method can be close to the CRLB with moderate Gaussian measurement noise.

关键词： Changing rate of phase dif-ference Cramer-Rao lower bound Estimation bias Instrumental variable Least square Long baseline interferome-ter Radiated source localization

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Nitrogen-doped cobalt nanoparticles/nitrogen-doped plate-like ordered mesoporous carbons composites as noble-metal free electrocatalysts for oxygen reduction reaction

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Journal of Energy Chemistry 2017年第1期26卷 63-71页

作者： Vincent Mirai Bau Xiangjie bo Liping guo Faculty of Chemistry Northeast Normal UniversityChangchun 130024JilinChina

In this work, nitrogen-doped cobalt nanoparticlesinitrogen-doped plate-like ordered mesoporous carbons (N/Co/OMCs) were used as noble-metal free electrocatalysts with high catalytic efficiency. Compared with OMCs with long channel length, due to more entrances for catalytic target accessibility and a short pathway for rapid diffusion, the utilization efficiency of cobalt nanoparticles inside the plate-like OMCs with short pore length is well improved, which can take full advantage of porous structure in electrocatalysis and increase the utilization of catalysts. The active sites in N/Co/OMCs for oxygen reduction reaction (ORR) are highly exposed to oxygen molecule, which results in a high activity for ORR. By combination of the catalytic properties of nitrogen dopant, incorporation of Co nanoparticles, and structural properties of OMCs, the N/Co/plate-like OMCs are highly active noble-metal free catalysts for ORR in alkaline solution. (C) 2016 Science Press and Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Published by Elsevier B.V. and Science Press. All rights reserved.

关键词： Ordered mesoporous carbons Nitrogen doping Cobalt nanoparticles Oxygen reduction reaction

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Blowing up of Solutions to the Cauchy Problem for the Generalized Zakharov System with Combined Power-Type Nonlinearities

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Acta Mathematica Sinica,English Series 2012年第9期28卷 1917-1936页

作者： Zai Hui GAN bo Ling guo Chun Xiao guo College of Mathematics and Software Science Sichuan Normal University Institute of Applied Physics and Computational Mathematics Department of Mathematics China University of Mining and Technology Beijing

This paper deals with blowing up of solutions to the Cauchy problem for a class of general- ized Zakharov system with combined power-type nonlinearities in two and three space dimensions. On the one hand, for co = ＋oo we obtain two finite time blow-up results of solutions to the aforementioned 4 ≤ p 〈 N＋2/N-2 4 system. One is obtained under the condition a ≥ 0 and 1 ＋ 4/N or a 〈 0 and 1 〈 p 〈 1 ＋（N = 2,3）; the other is established under the condition N = 3, 1 〈 p 〈 N=2/N-2 and α（p - 3）〉 0. On the other hand, for co 〈＋∞ and α（p - 3）〉 0, we prove a blow-up result for solutions with negative energy to the Zakharov system under study.

关键词： Generalized Zakharov system blowing up combined power-type nonlinearities Lyapunov function in time

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