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Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： Xihang chen Zhifeng chen Menghua li Weiwei Guo Shuolong Yuan liangwei Xu Chang lin Xi Shi Wei chen Shiming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d B for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine

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Deep learning-based software engineering: progress,challenges, and opportunities

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Science China(Information Sciences) 2025年第1期68卷 57-144页

作者： Xiangping chen Xing HU Yuan HUANG He JIANG Weixing JI Yanjie JIANG Yanyan JIANG bo liU Hui liU Xiaochen li Xiaoli liAN Guozhu MENG Xin PENG Hailong SUN lin SHI bo WANG Chong WANG Jiayi WANG Tiantian WANG Jifeng XUAN Xin XIA Yibiao YANG Yixin YANG li ZHANG Yuming ZHOU Lu ZHANG School of Journalism and Communication Sun Yat-sen University School of Software Technology Zhejiang University School of Software Engineering Sun Yat-sen University School of Software Dalian University of Technology School of Computer Science and Technology Beijing Institute of Technology Key Laboratory of High Confidence Software Technologies (Peking University) Ministry of EducationSchool of Computer Science Peking University State Key Laboratory for Novel Software Technology Nanjing University School of Computer Science and Engineering Beihang University Institute of Information Engineering Chinese Academy of Sciences School of Computer Science Fudan University State Key Laboratory of Complex & Critical Software Environment (CCSE) School of Software Beihang University School of Computer and Information Technology Beijing Jiaotong University School of Computer Science and Technology Harbin Institute of Technology School of Computer Science Wuhan University Huawei Technologies

Researchers have recently achieved significant advances in deep learning techniques, which in turn has substantially advanced other research disciplines, such as natural language processing, image processing, speech recognition, and software engineering. Various deep learning techniques have been successfully employed to facilitate software engineering tasks, including code generation, software refactoring, and fault localization. Many studies have also been presented in top conferences and journals, demonstrating the applications of deep learning techniques in resolving various software engineering tasks. However,although several surveys have provided overall pictures of the application of deep learning techniques in software engineering,they focus more on learning techniques, that is, what kind of deep learning techniques are employed and how deep models are trained or fine-tuned for software engineering tasks. We still lack surveys explaining the advances of subareas in software engineering driven by deep learning techniques, as well as challenges and opportunities in each subarea. To this end, in this study, we present the first task-oriented survey on deep learning-based software engineering. It covers twelve major software engineering subareas significantly impacted by deep learning techniques. Such subareas spread out through the whole lifecycle of software development and maintenance, including requirements engineering, software development, testing, maintenance, and developer collaboration. As we believe that deep learning may provide an opportunity to revolutionize the whole discipline of software engineering, providing one survey covering as many subareas as possible in software engineering can help future research push forward the frontier of deep learning-based software engineering more systematically. For each of the selected subareas,we highlight the major advances achieved by applying deep learning techniques with pointers to the available datasets i

关键词： deep learning software engineering software benchmark software artifact representation survey

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Peripheral blood RNA biomarkers can predict lesion severity in degenerative cervical myelopathy

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Neural Regeneration Research 2025年第6期20卷 1764-1775页

作者： Zhenzhong Zheng Jialin chen Jinghong Xu Bin Jiang Lei li Yawei li Yuliang Dai Bing Wang Department of Spine Surgery The Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina

Degenerative cervical myelopathy is a common cause of spinal cord injury,with longer symptom duration and higher myelopathy severity indicating a worse *** numerous studies have investigated serological biomarkers for acute spinal cord injury,few studies have explored such biomarkers for diagnosing degenerative cervical *** study involved 30 patients with degenerative cervical myelopathy(51.3±7.3 years old,12 women and 18 men),seven healthy controls(25.7±1.7 years old,one woman and six men),and nine patients with cervical spondylotic radiculopathy(51.9±8.6 years old,three women and six men).Analysis of blood samples from the three groups showed clear differences in transcriptomic *** analysis identified 128 differentially expressed genes that were enriched in patients with neurological *** least absolute shrinkage and selection operator analysis,we constructed a five-gene model(TBCD,TPM2,PNKD,EIF4G2,and AP5Z1)to diagnose degenerative cervical myelopathy with an accuracy of 93.5%.One-gene models(TCAP and SDHA)identified mild and severe degenerative cervical myelopathy with accuracies of 83.3%and 76.7%,*** of two immune cell types(memory B cells and memory-activated CD4^(+)T cells)predicted levels of lesions in degenerative cervical myelopathy with 80%*** results suggest that peripheral blood RNA biomarkers could be used to predict lesion severity in degenerative cervical myelopathy.

关键词： biomarkers candidate genes degenerative cervical myelopathy gene expression analysis immune cell types neurological disabilities peripheral blood RNA profiles spinal cord injury

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18岁以下青少年肝病患者肝脏切除23例

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世界华人消化杂志 2007年第26期15卷 2852-2855页

作者：陈立波王国斌华中科技大学协和医院肝胆外科中心湖北省武汉市430022

目的:分析18岁以下青少年肝病患者肝脏切除的相关因素.方法:对2004-06/2007-03在我中心接受手术的23例18岁以下青少年肝脏疾病患者的病因学,手术方式,相关情况进行分析,以明确该年龄组肝脏切除的相关规律.结果:23例中,原发性肝癌6例,肝... 详细信息

目的:分析18岁以下青少年肝病患者肝脏切除的相关因素.方法:对2004-06/2007-03在我中心接受手术的23例18岁以下青少年肝脏疾病患者的病因学,手术方式,相关情况进行分析,以明确该年龄组肝脏切除的相关规律.结果:23例中,原发性肝癌6例,肝母细胞瘤7例,肝淋巴瘤3例,肝肉瘤2例,肝海绵状血管瘤3例,局灶性结节性增生2例;行右半肝切除5例,左半肝切除4例,右三叶肝切除1例,肝左叶加尾叶切除2例,单独尾叶切除1例,肝段切除10例.手术后平均住院时间8.3±2.4 d;手术后7 d肝功能指标恢复至手术前水平21例,无肝功能衰竭、围手术期死亡病例.结论:18岁以下青少年肝脏疾病患者肝脏原发病较为分散,肝脏储备与代偿功能好,可以接受极限性肝切除,手术后并发症少,手术后恢复快.

关键词：肝切除青少年并发症

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Advances in Graphene‑Based Electrode for Triboelectric Nanogenerator

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Nano-Micro Letters 2025年第1期17卷 378-403页

作者： Bin Xie Yuanhui Guo Yun chen Hao Zhang Jiawei Xiao Maoxiang Hou Huilong liu li Ma Xin chen Chingping Wong State Key Laboratory of Precision Electronic Manufacturing Technology and Equipment Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

With the continuous development of wearable electronics,wireless sensor networks and other micro-electronic devices,there is an increasingly urgent need for miniature,flexible and efficient nanopower generation *** nanogenerator(TENG)technology can convert small mechanical energy into electricity,which is expected to address this *** the core component of TENG,the choice of electrode materials significantly affects its *** metal electrode materials often suffer from problems such as durability,which limits the further application of ***,as a novel electrode material,shows excellent prospects for application in TENG owing to its unique structure and excellent electrical *** review systematically summarizes the recent research progress and application prospects of TENGs based on graphene *** precision processing methods of graphene electrodes are introduced,and the applications of graphene electrode-based TENGs in various scenarios as well as the enhancement of graphene electrodes for TENG performance are *** addition,the future development of graphene electrode-based TENGs is also prospectively discussed,aiming to promote the continuous advancement of graphene electrode-based TENGs.

关键词： Triboelectric nanogenerator Precision processing Graphene electrode Self-powered sensor

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应用于生物医疗领域的碳纳米点及其复合物

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中国光学 2018年第3期11卷 401-419页

作者：王晓筠李波陈力李迪曲松楠李志民吉林大学口腔医院吉林长春130021 吉林大学第二医院吉林长春130000 中国科学院长春光学精密机械与物理研究所吉林长春130033

碳纳米点作为新兴的碳纳米材料,具备制备成本低、尺寸小、低毒、生物相容性高、水溶性好、易修饰、光物理性质独特等诸多优点,在生物医疗领域展现了独有的优势和应用前景。由于具有丰富的表面官能团,碳纳米点可以与靶向配体、医学影像... 详细信息

碳纳米点作为新兴的碳纳米材料,具备制备成本低、尺寸小、低毒、生物相容性高、水溶性好、易修饰、光物理性质独特等诸多优点,在生物医疗领域展现了独有的优势和应用前景。由于具有丰富的表面官能团,碳纳米点可以与靶向配体、医学影像造影剂、核酸、化学药物、光敏剂、光热转换试剂等功能性诊断治疗试剂相互作用形成复合物。目前,碳纳米点及其复合物在医学影像、基因治疗、化学药物治疗、光热、光动力治疗等生物医学诊断治疗领域的应用正在被广泛的开发和报道。这些工作对开发基于碳纳米点的医学诊断治疗试剂及其临床推进具有重要意义,为推进人类重大疾病的个体化、可视化、非入侵式、小损伤的诊断治疗提供一种新的药物体系。本文将关注应用于诊断治疗领域的碳纳米点及其复合物的设计、构建及性能研究,对已报道的基于碳纳米点的诊断治疗试剂在生物医疗领域的研究进展进行总结和讨论。

关键词：碳纳米点碳纳米点复合物诊断治疗试剂纳米医疗

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Integrating landscape ecological principles and land evaluation for sustainable land use

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Journal of Environmental Sciences 1999年第2期11卷 9-13页

作者： Fu bo jie, chen li ding Research Centre for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China He Chan sheng Department of Geography, Western Michigan University, Kalamazoo, MI 49008, USA

Many existing methods for appraisal of agricultural areas and farming systems are short of dynamics and spatial analysis. The main objective of this paper is to merge approaches in classical land evaluation, largely based on soil science, and newer approaches in landscape ecology, which are rather based on the relationships between spatial patterns (physiography, land use and farming system design, vegetation etc.) and processes (farming activities, scale changes, geomorphological processes, bio ecological processes). Rapid changes in rural areas have an impact on both processes and patterns. Planning for sustainable use of these areas should include the assessment of the interrelations between these patterns and processes.

关键词： landscape pattern ecological process land evaluation land sustainable use.

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The potential mechanism and clinical application value of remote ischemic conditioning in stroke

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Neural Regeneration Research 2025年第6期20卷 1613-1627页

作者： Yajun Zhu Xiaoguo li Xingwei Lei liuyang Tang Daochen Wen bo Zeng Xiaofeng Zhang Zichao Huang Zongduo Guo The First Affiliated Hospital of Chongqing Medical University ChongqingChina

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity, non-invasiveness, safety, and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not yet been achieved.

关键词： Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke neuroinflammation neuroprotection Notch1 PI3K remote ischemic conditioning stroke

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Microstructural evolution during the progressive transformation-induced plasticity effect in a Fe-0.1C-5Mnmedium manganese steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 369-379页

作者： Mei Zhang Wenhao li Yangfei chen Yang Jiang Xiaofei Guo Han Dong School of Materials Science and Engineering Shanghai UniversityShanghai 200444China State Key Laboratory of Advanced Special Steel Shanghai UniversityShanghai 200444China

The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10C-5Mn)was investigated during uniaxial tensile ***-situ observations under scanning electron microscopy,transmission electron microscopy,and X-ray diffraction analysis were conducted to characterize the progressive transformation-induced plasticity process and associated fracture initiation *** findings were discussed with the local strain measurements via digital image *** results indicated that Lüders band formation in the steel was limited to 1.5%strain,which was mainly due to the early-stage martensitic phase transformation of a very small amount of the less stable large-sized retained austenite(RA),which led to localized stress concentrations and strain hardening and further retardation of *** small-sized RA exhibited high stability and progressively transformed into martensite and contributed to a stably extended Portevin-Le Chatelier *** volume fraction of RA gradually decreased from 26.8%to 8.2%prior to *** the late deformation stage,fracture initiation primarily occurred at the austenite/martensite and ferrite/martensite interfaces and the ferrite phase.

关键词： medium-Mn steel retained austenite progressive transformation-induced plasticity effect local strain fracture initiation

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Achieving ultralow leakage current in Schottky-MIS cascode anode lateral field-effect diode based on AlGaN/GaN HEMT

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Science China(Information Sciences) 2025年第1期68卷 379-385页

作者： Fangzhou WANG Changhong GAO Guojian DING cheng YU Zhuocheng WANG Xiaohui WANG Qi FENG Ping YU Peng ZUO Wanjun chen Yang WANG Haiqiang JIA Hong chen bo ZHANG Zeheng WANG Songshan Lake Materials Laboratory School of Microelectronics Southern University of Science and Technology State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of China Manufacturing Commonwealth Scientific and Industrial Research Organisation

In this paper,we design and fabricate a Schottky-metal-insulator-semiconductor（MIS） cascode anode GaN lateral field-effect diode（CA-LFED） to achieve ultralow reverse leakage current(ILEAK).The device based on AlGaN/GaN highelectron-mobility-transistor（HEMT） includes a normally-off MIS-controlled channel that is cascoded with a high barrier height Schottky *** reverse bias,the high electric-field is effectively prevented by the normally-off MIS-controlled channel *** with the high barrier height Schottky contact,this feature significantly suppresses the *** by the device fabrication,the CA-LFED with high breakdown voltage（BV）>600 V shows an ultralow ILEAKof 3.6×10-9A/mm as well as a low forward voltage drop（VF） of 2.2 *** performance suggests that the CA-LFED can be a promising candidate for ultralow ILEAKand better VF-ILEAKtrade-off GaN power diode applications.

关键词： Schottky-MIS cascode anode lateral field-effect diode (LFED) ultralow reverse leakage current ($I_{\rm{LEAK}}$) forward drop and reverse leakage trade-off AlGaN/GaN HEMTs

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