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Flavonoid-Rich Extract of Oldenlandia diffusa(Willd.)*** Gastric Cancer by Activation of Caspase-Dependent Mitochondrial Apoptosis

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Chinese Journal of Integrative Medicine 2023年第3期29卷 213-223页

作者： liNG Jia-yin WANG Qiu-lan liANG Hao-nan liU Qing-bo YIN Dong-hong liN li First School of Clinical Medicine Gansu University of Chinese MedicineLanzhou(730000)China Gansu Provincial Hospital Lanzhou(730000)China College of Pharmacy Gansu University of Chinese MedicineLanzhou(730000)China Institute of Chinese(Tibetan)Medicine Resources Gansu University of Chinese MedicineLanzhou(730000)China

Objective:To evaluate the apoptosis and cycle arrest effects of Oldenlandia diffusa flavonoids on human gastric cancer cells,determine the action mechanisms in association with the mitochondrial dependent signal transduction pathway that controls production of reactive oxygen species(ROS),and evaluate the pharmacodynamics of a mouse xenotransplantation model to provide a reference for the use of flavonoids in prevention and treatment of gastric ***:Flavonoids were extracted by an enzymatic-ultrasonic assisted method and purified with D-101 *** components were characterized by high-performance liquid *** lines MKN-45,AGS,and GES-1 were treated with different concentrations of flavonoids(64,96,128,and 160μg/mL).The effect of flavonoids on cell viability was evaluated by MTT method,and cell nuclear morphology was observed by Hoechst *** apoptosis rate and cell cycle phases were measured by flow cytometry,the production of ROS was detected by laser confocal microscope,the mitochondrial membrane potential(MMP)were observed by fluorescence microscope,and the expression of apoptotic proteins related to activation of mitochondrial pathway were measured by ***-45cells were transplanted into BALB/c nude mice to establish a xenograft tumor *** and eosin staining was used to reveal the subcutaneous tumor *** tumor volume and tumor weight were measured,the expression levels of proliferation markers proliferating cell nuclear antigen(PCNA)and Ki-67were detected by immunohistochemistry,and the expression levels of CA72-4 were measured by enzyme linked immunosorbent ***:Oldenlandia diffusa flavonoids inhibited proliferation of MKN-45 and AGS human gastric cancer cells,arrested the cell cycle in G1/S phase,induced accumulation of ROS in the process of apoptosis,and altered *** addition,flavonoids increased Apaf-1,Cleaved-Caspase-3,and Bax,and decreased Cyclin A,Cdk2,Bcl-2,Pro-Caspase-9,a

关键词： Chinese medicine Oldenlandia diffusa flavonoids gastric cancer apoptosis mitochondria

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BC-PC-Share:Blockchain-Based Patient-Centric Data Sharing Scheme for PHRs in Cloud Computing

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Computer Modeling in Engineering & Sciences 2023年第9期136卷 2985-3010页

作者： Caihui lan Haifeng li School of Electronic and Information Engineering Lanzhou City UniversityLanzhou730070China School of Software Dalian University of Foreign LanguagesDalian116044China School of Software Dalian University of TechnologyDalian116024China

Sharing of personal health records(PHR)in cloud computing is an essential functionality in the healthcare ***,how to securely,efficiently and flexibly share PHRs data of the patient in a multi-receiver setting has not been well *** instance,since the trust domain of the cloud server is not identical to the data owner or data user,the semi-trust cloud service provider may intentionally destroy or tamper shared PHRs data of user or only transform partial ciphertext of the shared PHRs or even return wrong computation results to save its storage and computation resource,to pursue maximum economic interest or other malicious ***,the PHRs data storing or sharing via the cloud server should be performed with consistency and integrity ***,the emergence of blockchain technology provides new ideas and prospects for ensuring the consistency and integrity of shared PHRs *** this end,in this work,we leverage the consortiumblockchain technology to enhance the trustworthiness of each participant and propose a blockchain-based patient-centric data sharing scheme for PHRs in cloud computing(BC-PC-Share).Different from the state-of-art schemes,our proposal can achieve the following desired properties:(1)Realizing patient-centric PHRs sharing with a public verification function,i.e.,which can ensure that the returned shared data is consistent with the requested shared data and the integrity of the shared data is not compromised.(2)Supporting scalable and fine-grained access control and sharing of PHRs data with multiple domain users,such as hospitals,medical research institutes,and medical insurance companies.(3)Achieving efficient user decryption by leveraging the transformation key technique and efficient user revocation by introducing time-controlled *** security analysis and simulation experiment demonstrate that the proposed BC-PC-Share scheme is a feasible and promising solution for PHRs data sharing via consortium b

关键词： Blockchain patient-centric personal health records data sharing attribute-based encryption

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Regulating crystallization and retarding oxidation in Sn-Pb perovskite via 1D cation engineering for high performance all-perovskite tandem solar cells

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Journal of Energy Chemistry 2025年第1期 646-652页

作者： Ranran liu Xin Zheng Zaiwei Wang Miaomiao Zeng Chunxiang lan Shaomin Yang Shangzhi li Awen Wang Min li Jing Guo Xuefei Weng Yaoguang Rong Xiong li Michael Gr?tzel Center for Mesoscopic Solar Cells Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Institute of Technology for Carbon Neutrality Shenzhen Institute of Advanced Technology Chinese Academy of Sciences School of Physics and Optoelectronic Engineering Hainan University Suzhou Institute of Nano-Tech and Nano-Bionics (SINANO) Chinese Academy of Sciences School of Chemistry Chemical Engineering and Life Sciences State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology

All-perovskite tandem solar cells have the potential to surpass the theoretical efficiency limit of single junction solar cells by reducing thermalization ***,the challenges encompass the oxidation of Sn2+to Sn4+and uncontrolled crystallization kinetics in Sn-Pb perovskites,leading to nonradiative recombination and compositional heterogeneity to decrease photovoltaic efficiency and operational ***,we introduced an ionic liquid additive,1-ethyl-3-methylimidazolium iodide （EMIMI） into Sn-Pb perovskite precursor to form low-dimensional Sn-rich/pure-Sn perovskites at grain boundaries,which mitigates oxidation of Sn2+to Sn4+and regulates the film-forming dynamics of Sn/Pb-based perovskite *** optimized single-junction Sn-Pb perovskite devices incorporating EMIMI achieved a high efficiency of 22.87%.Furthermore,combined with wide-bandgap perovskite sub-cells in tandem device,we demonstrate 2-terminal all-perovskite tandem solar cells with a power conversion efficiency of 28.34%,achieving improved operational stability.

关键词：

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双壁波纹钢管混凝土构件短柱轴压力学性能

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哈尔滨工业大学学报 2025年第1期57卷 56-64页

作者：路博崔燕方勇王玉银李豪哈尔滨工业大学土木工程学院哈尔滨150090 结构工程灾变与控制教育部重点实验室(哈尔滨工业大学) 哈尔滨150090 深圳市市政设计研究院有限公司广东深圳518029

为改善空心钢筋混凝土柱(HRC)的使用与受力性能,提出一种双壁波纹钢管混凝土(CFDCST)构件。本文共进行了4个大尺寸双壁波纹钢管混凝土短柱与2个空心钢筋混凝土短柱的轴压试验,关键试验参数为试件类型与波纹钢管类型。分析构件的破坏模式... 详细信息

为改善空心钢筋混凝土柱(HRC)的使用与受力性能,提出一种双壁波纹钢管混凝土(CFDCST)构件。本文共进行了4个大尺寸双壁波纹钢管混凝土短柱与2个空心钢筋混凝土短柱的轴压试验,关键试验参数为试件类型与波纹钢管类型。分析构件的破坏模式,对比不同参数下构件的承载力、峰值应变、延性系数等关键力学指标,获得荷载-波纹钢管应变关系曲线以揭示试件的约束机理并验证外波纹钢管类型的影响。试验结果表明:外波纹钢管可为夹层混凝土提供约束作用,且螺旋角越小,外波纹钢管的约束作用越强;内波纹钢管则主要为夹层混凝土内壁提供有效支撑,以保持截面的完整性。名义约束效应系数与空心率相近时,由于咬口滑移影响,大螺旋角双壁波纹钢管混凝土比小螺旋角双壁波纹钢管混凝土的峰值应力、峰值应变与延性系数分别降低15.5%、21.8%与16.7%。在总用钢量相近的情况下,小螺旋角双壁波纹钢管混凝土柱的承载力、峰值应变与延性系数分别比空心钢筋混凝土柱提高10.6%、36.2%与50.0%。基于试验结果,检验了3种典型承载力公式的适用性,并提出了相应设计建议。

关键词：组合结构空心钢筋混凝土波纹钢管双壁构件约束机理

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Implementing Entanglement Swapping and Generating Multiphoton Entanglement in Cavity QED

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Communications in Theoretical Physics 2008年第6期49卷 1483-1486页

作者： liN Gong-Wei CHEN li-bo DU Qian-Hua lan Jie-Qin liN Xiu-Min School of Physics and Optoelectronics Technology Fujian Normal University Fuzhou 350007 China

Based on the input-output relation of a one-sided cavity, we propose an experimental scheme to implement entanglement swapping with photons. In the ideal case, the successful probability of the scheme approaches unity. In addition, the protocol can be extended to establish multiphoton entanglement among distant users in a communication network.

关键词： entanglement swapping multiphoton entanglement

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Antibacterial Property of Cu Modified Stainless Steel by Plasma Surface Alloying

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Journal of Iron and Steel Research International 2012年第4期19卷 75-79页

作者： ZHANG Xiang-yu HUANG Xiao-bo JIANG li MA Yong FAN Ai-lan TANG Bin Research Institute of Surface Engineering Taiyuan University of Technology Taiyuan 030024 Shanxi China

Stainless steel（SS） is not recommended to be used in hospital environments for work surfaces and door furniture due to the lack of antibacterial *** this end,a novel SS surface modified layer with both a quick bacterial killing rate and relatively thick has been obtained by plasma surface alloying with *** microstructure,elements distribution and phase identification were analyzed by SEM,GDS,XRD and XPS.A spread plate method was adopted for evaluation of antibacterial property of specimens against Escherichia coli（***） and Staphylococcus aureus（***）.The experimental results demonstrate that the surface modified layer with the thickness of about 26 μm is uniform and *** layer is mainly composed of a mixture of pure Cu,expanded austenite phase and a few Fe3O4 *** Cu modified layer exhibits excellent antibacterial effects against *** and *** within 1 *** viable *** and *** was found after 3 h（100% killed）.The modified layer is relatively thick,hence it is expected that the Cu modified SS will have a durable antibacterial function

关键词： plasma alloying Cu antimicrobial AISI 304 stainless steel

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boosting charge extraction and efficiency of inverted perovskite solar cells through coordinating group modification at the buffer layer/cathode interface

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Nano Research 2025年第1期18卷 415-423页

作者： Zhiqing liang Ziqiu Ren Ziyu Wang Nan Yan ling li bo Zhang Yanlin Song College of Chemistry Zhengzhou UniversityZhengzhou 450052China Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education Shaanxi Key Laboratory for Advanced Energy DevicesShaanxi Engineering Lab for Advanced Energy Technology School of Materials Science and EngineeringShaanxi Normal UniversityXi’an 710119China Key Laboratory of Green Printing Institute of ChemistryChinese Academy of Sciences(ICCAS)Beijing Engineering Research Center of Nanomaterials for Green Printing TechnologyNational Laboratory for Molecular Sciences(BNLMS)Beijing 100190China

In inverted perovskite solar cells (PSCs),effective modification of the interface between the metalcathode and electron transport layer (ETL) is crucial forachieving high performance and stability. Herein, sulfonatedbathocuproine, commonly known as disodium bathocuproinedisulfonate (BCDS), was employed as a cathode buffer layerto address the interfacial issues at the [6,6]-phenyl-C61-butyricacid methyl ester (PCBM)/Ag interface. BCDS possesses theability to form coordinate bonds with Ag electrodes. Theutilization of the BCDS buffer layer enhanced the chargeextraction capability at the cathode interface whilesimultaneously achieving interfacial defect passivation,improving interfacial contact and increasing the built-in electricfield. Consequently, a power conversion efficiency (PCE) of25.06% was achieved. Furthermore, owing to the excellent filmforminguniformity of BCDS on PCBM, the stability of thedevice was also improved. After storage in dry air for morethan 2000 h, the device maintained 96% of its initial efficiency. This work underscores the remarkable potential of tailoringcoordination groups to enhance charge extraction efficiency at the ETL-cathode interface, unveiling a promising newfrontier in buffer layer development and performance optimization strategies for PSCs.

关键词： perovskite solar cells buffer layer bathocuproine disulfonate coordination group modification electron transport layer(ETL)-cathode interface

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A novelα-ketoamide reactivity-based two-photon fluorogenic probe for visualizing peroxynitrite in Parkinson's disease models

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Journal of Innovative Optical Health Sciences 2023年第4期16卷 79-89页

作者： Tao Shao Xianning Xu lan Wang Yu Shen Jun Zhao Huizi li Duoteng Zhang Wei Du Hua Bai bo Peng lin li Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics(IFE)and Xi'an Institute of Biomedical Materials&Engineering Northwestern Polytechnical University Xi'an 710072P.R.China Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM)Nanjing Tech University(NanjingTech) Nanjing 211816P.R.China Department of Outpatient PLA Rocket Force Characteristic Medical Center Beijing 100088 P.R.China The Institute of Flexible Electronics(IFE Future Technologies)Xiamen UniversityXiamen 361005FujianP.R.China

Peroxynitrite(ONOO^(-))contributes to oxidative stress and neurodegeneration in Parkinson's disease(PD).Developing a peroxynitrite probe would enable in situ visualization of the overwhelming ONOO^(-)flux and understanding of the ONOO^(-)stress-induced neuropathology of ***,a novelα-ketoamide-based fluorogenic probe(DFlu)was designed for ONOO^(-)monitoring in multiple PD *** results demonstrated that DFlu exhibits a fluorescence turn-on response to ONOO^(-)with high specificity and *** efficacy of DFlu for intracellular ONOO^(-)imaging was demonstrated *** results showed that DFlu can successfully visualize endogenous and exogenous ONOO^(-)in cells derived from chemical and biochemical *** importantly,the two-photon excitation ability of DFlu has been well demonstrated by monitoring exogenous/endogenous ONOO^(-)production and scavenging in live zebraflsh PD *** work provides a reliable and promisingα-ketoamide-based optical tool for identifying variations of ONOO^(-)in PD models.

关键词： α-Ketoamide two-photon fluorogenic probe bioimaging peroxynitrite Parkinson's disease.

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肠道菌群在肿瘤免疫治疗耐药中的作用机制研究进展

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中国药理学通报 2025年第1期41卷 1-6页

作者：李慧玲李晓曦冯英楠胡欣张兰董宪喆首都医科大学宣武医院药学部北京100053 遵义医科大学药学院贵州遵义563000

肠道菌群多样性和组成与肿瘤免疫治疗效果相关,但是肠道菌群影响肿瘤免疫治疗耐药的机制鲜少总结和归纳。该文不仅阐述了目前肿瘤免疫治疗耐药的临床现状,还概括分析了肠道菌群的组成和稳态与不同类型肿瘤免疫治疗耐药的相关性及调控机... 详细信息

肠道菌群多样性和组成与肿瘤免疫治疗效果相关,但是肠道菌群影响肿瘤免疫治疗耐药的机制鲜少总结和归纳。该文不仅阐述了目前肿瘤免疫治疗耐药的临床现状,还概括分析了肠道菌群的组成和稳态与不同类型肿瘤免疫治疗耐药的相关性及调控机制,为肠道菌群改善肿瘤免疫治疗耐药的潜在靶点研究提供参考。

关键词：肠道菌群肿瘤免疫治疗耐药性临床现状研究进展调控策略

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The relation between the Mindanao Current and Mindanao Undercurrent on seasonal scale

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Acta Oceanologica Sinica 2016年第5期35卷 1-8页

作者： WANG Yan lan Jian li li College of Oceanic and Atmospheric Sciences Ocean University of China Physical Oceanography Laboratory Ocean University of China

The ocean general circulation model for the earth simulator（OFES） products is applied to estimate the transports of the Mindanao Current（MC） and the Mindanao undercurrent（MUC） and explore the relation between them on seasonal scale. In general, the MUC is composed of the lower part of the Southern Pacific Tropical Water（SPTW）and Antarctic Intermediate Water（AAIW）. While the deep northward core below 1 500 m is regarded as a portion of MUC. both salinity and potential density restrictions become more reasonable to estimate the transports of MC/MUC as the properties of water mass having been taken into consideration. The climatological annual mean transport of MC is（37.4±5.81）×10~6 m^3/s while that of MUC is（23.92±6.47）×10~6 m^3/s integrated between 26.5 σ_θ and 27.7 σ_θ, and（17.53±5.45）×10~6 m^3/s integrated between 26.5 σ_θ and 27.5 σ_θ in the OFES. The variations of MC and MUC have good positive correlation with each other on the seasonal scale： The MC is stronger in spring and weaker in fall, which corresponds well with the MUC, and the correlation coefficient of them is 0.67 in the *** same variations are also appeared in hybrid coordinate ocean model（HYCOM） results. Two sensitive experiments based on HYCOM are conducted to explore the relation between MC and MUC. The MUC（26.5〈σ_θ〈27.7） is strengthening as the MC increases with the enhancement of zonal wind field. It is shown,however, that the main part of the increasement is the deeper northward high potential density water（HPDW）,while the AAIW almost remains stable, SPTW decreases, and vice versa.

关键词： Mindanao Current Mindanao Undercurrent potential density transport seasonal variability

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