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Chinese Medical Journal 2020年第12期133卷 1495-1496页

作者： Yue-Ting Li Han-Ze Du Chun-Yao Wang Tie-Nan Zhu bo-ju pan Lu Zhang Department of Rheumatology and Clinical Immunology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Department of Endocrinology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Department of Medical Intensive Care Unit Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Department of Hematology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Department of Pathology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China

To the Editor:Thrombotic thrombocytopenic purpura(TTP)is a type of life-threatening thrombotic microangiopathy(TMA)clinically characterized by severe thrombocytopenia,microangiopathic hemolytic anemia,and symptoms of ... 详细信息

关键词： thrombotic insufficiency anemia

TAFRO Syndrome - A Specific Subtype of Castleman＇s Disease in China

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Chinese Medical Journal 2018年第15期131卷 1868-1870页

作者： Wan-Lu Ma Lu Zhang Tie-Nan Zhu Dao-Bin Zhou Jian Liz Jian Sun bo-ju pan Wei-Xing Xu Department of Endocrinology Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing 100730 China Department of Hematology Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing 100730 China Department of Pathology Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing 100730 China Department of Hematology Cangzhou Central Hospital Cangzhou Hebei 061001 China

To the Editor： Castleman＇s disease （CD） describes a group of lymphoproliferative disorders with heterogeneous clinical manifestations.[1] CD comprises at least two distinct diseases （unicentric CD [UCD] and multicentric CD [MCD]） with respective clinical features and prognoses： UCD often involves one lymph node area with favorable outcome： MCD is a systemic disease with relatively poor prognosis which involves multiple lymph node areas with constitutional symptoms （e.g. fever, night sweats, and weakness） and organ dysfunction. According to pathogenesis, MCD can be further divided into different subtypes based on the status of human herpes virus-8 （HHV-8） infection. Of the HHV-8 negative MCD （also named as idiopathic MCD [iMCD]）, there is a peculiar subtype named TAFRO syndrome which constitutes a constellation of unique clinical manifestations （T： Thrombocytopenia, A： Anasarca, F： myelofibrosis, R： Renal dysfunction, and O： Organomegaly）. This syndrome, first reported in Japan[2] has been reported mostly in the Japanese population and occasionally in Caucasians. There is no such case reported in China. We herein report the first patient with TAFRO syndrome in China with confirmed myelofibrosis.

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Sky location of massive black hole binaries in the foreground of Galactic white dwarf binaries

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 97-108页

作者： pan Guo Hong-bo Jin Cong-Feng Qiao Yue-Liang Wu The International Centre for Theoretical Physics Asia-Pacific University of Chinese Academy of Sciences The School of Physical Sciences University of Chinese Academy of Sciences Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University National Astronomical Observatories Chinese Academy of Sciences Institute of Theoretical Physics Chinese Academy of Sciences

For space-based gravitational wave （GW） detection,the main noise source for massive black hole binaries （MBHBs） is attributed to approximately 10～7double white dwarf binaries in the *** a GW source,the amplitude of the detector response,recorded by a space-based gravitational wave detector,exhibits a modulation effect with a year period when observing the source from various orbital *** the adverse conditions mentioned above,where there is a strong foreground noise and annual modulation in the signals,we employed the wavelet transform and the strong-amplitude relevant orbital position search methods,which allows the weak MBHB sources to achieve higher locating *** detail,for two MBHB sources of lower intensity,the precision of luminosity distance,represented by the ratio ?DL/DLat the 95%confidence level,is enhanced by factors of ～*** angular resolutions,denoted by??s,are enhanced by a factor of ～*** improvements increase the number of detectable GW sources,facilitate multi-messenger follow-up observations and provide constraints on the cosmological constant.

关键词： space-based gravitational wave detection gravitational waves massive black hole binaries

Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli Han bo Yan pan Liao Zhenyu Yin Xintong Ge Dai Li Rongrong Zhong Qiang Liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

Gut-brain axis as a bridge in obesity and depression:Mechanistic exploration and therapeutic prospects

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World Journal of Psychiatry 2025年第1期15卷 12-20页

作者： Rui-Ying Fang Xiao-Rui pan Xin-Xing Zeng Zheng-Zheng Li bo-Fan Chen Hai-Min Zeng Jie Peng The Second Clinical Medical College The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina

A recent study by Wang et al,published in the World Journal of Psychiatry,provided preventative and therapeutic strategies for the comorbidity of obesity and *** gut-brain axis,which acts as a two-way communication system between the gastrointestinal tract and the central nervous system,plays a pivotal role in the pathogenesis of these *** suggests that metabolic byproducts,such as short-chain fatty acids,lipopolysaccharide and bile acids,which are generated by the gut microbiota,along with neurotransmitters and inflammatory mediators within the gut-brain axis,modulate the host's metabolic processes,neuronal regulation,and immune responses through diverse *** interaction between obesity and depression via the gut-brain axis involves disruptions in the gut microbiota balance,inflammatory immune responses,and alterations in the neuroendocrine *** the gut-brain axis,for example,through a ketogenic diet,the use of probiotics,and the supplementation of antioxidants,offers new remedial approaches for obesity and *** research that explores the mechanisms of the gut-brain axis is needed to provide more evidence for clinical treatment.

关键词： Gut-brain axis Obesity Depression Gut microbiota Mechanism

Molecular mechanism and research progress of traditional Chinese medicine in the treatment of prostate cancer

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Traditional Medicine Research 2025年第1期10卷 62-72页

作者： Hai-Luo Wang Ruo-Ran Zhang Hao Wang Peng Xu Jing-Kai Wang bo Chen Hao Xu Deng pan Yu-Yang Ma Kun pang Department of Urology Xuzhou Central HospitalXuzhou Clinical School of Xuzhou Medical CollegeXuzhou 221009China Graduate School Jiangsu UniversityZhenjiang 212013China Graduate School Bengbu Medical UniversityBengbu 233040China Department of Urology The Peixian People’s HospitalXuzhou 221699China.

Prostate cancer(PCa)is one of the most common malignant tumors in the male genitourinary system,ranking second in incidence *** Chinese medicine(TCM),as an important component of complementary and alternative medicine,shows unique advantages in cancer *** herbal medicine is usually composed of multiple ingredients and involves multiple signaling pathways,which showed function of inducing apoptosis of cancer cells,arresting the cell cycle,inhibiting invasion and metastasis,reducing drug resistance,and regulating immune *** therapy is also an important treatment of ***,Physical therapy such as acupuncture or Tai Chi and Qigong are gaining increased recognition in the management of PCa,particularly in addressing issues like urinary incontinence and bone metastasis-related *** article reviews the TCM treatment and therapy of PCa,in order to provide new research avenues and treatment options for the treatment of PCa with TCM and improve the quality of life of patients.

关键词： traditional Chinese medicine prostate cancer Chinese herbal medicine physical therapy

Viscoelastic Property Evolution of Thermoplastic Polyurethane during Annealing Treatment and Its Correlation with Segmental Crystallization

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Chinese Journal of Polymer Science 2024年第12期42卷 1976-1985,I0010页

作者： Jian-Wen Shan Yan-bo Zhu Ling-Ling Ni Peng-ju pan State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou310058China Department of Polymer Science and Engineering Zhejiang UniversityHangzhou310058China

Viscoelastic properties of thermoplastic polyurethane(TPU)is of fundamental importance for its *** this work,we prepared different TPUs from polycaprolactone(PCL)diol,diphenylmethane-4,4′-diisocyanate(MDI),and 1,4-butanediol(BDO),and investigated the viscoelastic behavior of three TPUs with different hard segment content during thermal annealing *** storage modulus(G′)of TPU increases over time in a medium annealing temperature(T_(a))region,but remains unchanged at both high and low temperature *** growth of loss modulus(G″)over time is slower than that of G′.At medium T_(a),both G′and G″increase during the repeating frequency(ω)sweep,due to the gradual crystallization of hard *** indicates that the crystallites primarily restrain the relaxation of unit with large *** increments of G′and G″are weakened when the content of hard segment in TPU is *** TPU with high content of hard segments,a complete high elastic platform with a width of 3 orders of magnitude was observed only through one frequency scan test at medium T_(a).In addition,the crystallites of hard segments grow up continuously during frequency scan test(isothermal annealing treatment)and cause the extreme increase in G′and G″withωin lowωregion.

关键词： Thermoplastic polyurethane Viscoelastic properties Annealing Crystalization

Deciphering the role of mtH2O2 in hepatic ischemia-reperfusion injury mechanisms with low-background super-resolution fluorogenic probe

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Science China Chemistry 2025年第1期 297-307页

作者： Bin Fang Limin Wang Haoqin Li Jiaxin Zhang Yang Ding pan pan Li bo Peng Hua Bai Lin Li Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials &Engineering Northwestern Polytechnical University Institute of Flexible Electronics (IFE Future Technologies) Xiamen University

Hepatic ischemia-reperfusion injury（HIRI） is characterized by mitochondrial dysfunction and oxidative stress. Monitoring mitochondrial hydrogen peroxide（mtH2O2） levels in real-time through super-resolution imaging is crucial for elucidating its distribution in live cells and its mechanism of action during HIRI. However, low-background fluorogenic probes have been overlooked in the context of super-resolution imaging. In this study, we developed a low-background fluorogenic probe（MitoWG） with the potential for super-resolution morphology-correlated mitochondrial identification to track the fluctuates of mtH2O2in HIRI. Activation of the desirable fluorescence properties of the probe by mtH2O2was confirmed using structural illumination microscopy（SIM）, enabling high-quality mitochondrial imaging with exceptional specificity and *** in mtH2O2levels were successfully observed in both cellular and rat models of HIRI. Furthermore, we associated the decline in mitochondrial redox homeostasis with accelerated mtH2O2production during HIRI, which triggered mitophagy deficiency and led to cell death. In conclusion, Mito-WG possesses excellent photophysical and low-background properties for SIM imaging, making it a promising tool for mtH2O2tracking in HIRI research and clinical diagnosis.

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On Conway's Potential Function for Colored Links

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Acta Mathematica Sinica,English Series 2016年第1期32卷 25-39页

作者： bo ju JIANG Department of Mathematics Peking University

The Conway potential function （CPF） for colored links is a convenient version of the multi- variable Alexander-Conway polynomial. We give a skein characterization of CPF, much simpler than the one by Murakami. In particular, Conway＇s ＂smoothing of crossings＂ is not in the axioms. The proof uses a reduction scheme in a twisted group-algebra PnBn, where Bn is a braid group and Pn is a domain of multi-variable rational fractions. The proof does not use computer algebra tools. An interesting by-product is a characterization of the Alexander-Conway polynomial of knots.

关键词： Colored links Conway potential function Alexander polynomial skein relations

A framework for identifying the onset of landslide acceleration based on the exponential moving average(EMA)

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Journal of Mountain Science 2023年第6期20卷 1639-1649页

作者： WANG Jia-zhu ju Neng-pan TIE Yong-bo BAI Yong-jian GE Hua State Key Laboratory of Geohazard Prevention and Geoenvironment Protection(SKLGP) Chengdu University of TechnologyChengdu 610059China Chengdu Center of China Geological Survey Chengdu 610081China

Predicting the failure time of a landslide is considered as challenging work in the field of landslide research,and inverse velocity is proved to be an effective and convenient *** onset of acceleration(OOA)has a crucial effect on the prediction failure time from the inverse velocity ***,a simple method to identify OOA points is lacked,and most of the identifications rely on expert ***,this study presents an application of a simple framework developed to identify the OOA by analyzing monitoring velocity data in three steps,including selection of the absolute value of velocity,reliable area identification and OOA identification.A new parameter based on exponential moving average(EMA)is developed to identify the landslide *** framework is applied to three historical case studies to test its practicability and *** forecasting results show a good correspondence between the accuracy rate and the coefficient of determination(R2).The predicted failure time according to the linear extrapolation starting from the identified OOA points is acceptable with a high R2 and high accuracy.

关键词： Landslides failure time Acceleration Inverse velocity method Monitoring Tertiary creep phase