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Hepatobiliary Surgery and Nutrition 2024年第1期13卷 115-118页

作者： bo Kyung Koo Dong Hyeon Lee Jeong Hwan Park Won kim Division of Endocrinology Department of Internal MedicineBoramae Medical CenterSeoulRepublic of Korea Department of Internal Medicine Seoul National University College of MedicineSeoulRepublic of Korea Division of Gastroenterology and Hepatology Department of Internal MedicineBoramae Medical CenterSeoulRepublic of Korea Department of Pathology Boramae Medical CenterSeoulRepublic of Korea

Advanced fibrosis determines the prognosis of nonalcoholic fatty liver disease(NAFLD);therefore,accurate risk-prediction for advanced fibrosis is fundamental in the management of NAFLD(1).Targeted screening for advanced fibrosis in high-risk populations,such as those with type 2 diabetes,obesity with metabolic complications,a family history of cirrhosis,or significant alcohol use is recommended for implementing early intervention to prevent future adverse hepatic outcomes of NAFLD(2,3).Non-invasive tests including fibrosis-4 index(FIB-4)and liver stiffness measurement(LSM)are recommended to identify individuals at a higher risk of liver-related events(1,2).In addition to clinical classifications,such as FIB-4;genetic information provides further stratification for liver-related outcomes(4).

关键词： Nonalcoholic fatty liver disease(NAFLD) cirrhosis PNPLA3-rs738409

Protective effects of Ecklonia cava extract on the toxicity and oxidative stress induced by hair dye in in-vitro and in-vivo models

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Journal of Oceanology and Limnology 2019年第3期37卷 909-917页

作者： OH Jae-Young RYU bo-Mi YANG Hye-Won kim Eun-A LEE Jung-Suck JEON You-Jin Department of Marine Life Science Jeju National UniversityJeju 63243Republic of Korea Jeju International Marine Science Center for Research & Education Korea Institute of Ocean Science and TechnologyJeju 63349Republic of Korea Research Center for Industrial Development of Seafood Gyeongsang National UniversityTongyeong 53064Republic of Korea

Oxidative hair dyes containingρ-phenylenediamine(PPD)are reported to induce an allergic reaction by promoting oxidative stress when absorbed through the *** the associated risk,these hair dyes remain popular owing to their convenience and sharpness of *** makes it important to minimize the cytotoxicity and oxidative stress induced by PPD-containing hair *** cava extract has been evaluated in different studies for its protective effects against external stress in fibroblasts and *** study was aimed at using in-vitro and in-vivo models to investigate the extract’s effects on cytotoxicity of and oxidative stress induced by PPD-containing hair *** of CIEL*a*b*Color space was first used to determine the range of *** extract that would not interfere with the coloring ability of the dye upon ***,the set ranges of *** extract(5% and 7%)were added to the hair dye and their toxicity assessed by evaluating the viability of fibroblasts and *** effects on developmental phenotypes and induction of oxidative stress by hair dye were evaluated and compared with those of hair dyes containing different contents of *** extract using an in-vivo zebrafish *** results showed that *** extract in hair dye could significantly decrease the cytotoxicity and levels of oxidative stress caused by hair dyes containing PPD in both in-vitro and in-vivo *** results suggest that the addition of 7% *** extract to 250μg/mL hair dye does not interfere with the coloring ability of the dye while showing significant protective eff ects against the hair *** study proposes that the use of *** extract as an adduct to hair dyes containing PPD reduces the cytotoxicity and oxidative stress induced by these hair dyes.

关键词： hair dye Ecklonia cava cytotoxicity oxidative stress in-vitro and in-vivo models

Middle Paleozoic metamorphic and sedimentary events in the central Korean Peninsula and their geological implications

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Geoscience Frontiers 2024年第5期15卷 136-161页

作者： Byung Choon Lee Sung Won kim bo Young Lee Chang Whan Oh Deung-Lyong Cho Weon-Seo Kee Department of Earth and Environmental Sciences Chonnam National University77Yongbong-roBuk-guGwangju 61186Republic of Korea Geology and Space Division Korea Institute of Geoscience and Mineral ResourcesDaejeon 34132Republic of Korea Department of Earth and Environmental Sciences Jeonbuk National UniversityJeonju 561-756Republic of Korea

The Middle Paleozoic tectonic evolution of the central Korean Peninsula(Gyeonggi Massif,Hongseong-Imjingang,and Okcheon zone of Okcheon Belts)remains ***,the occurrence of high-grade metamorphism and sedimentation need further *** this study,we conducted zircon U-Pb-rare earth element analyses from in the ultramafic-mafic complex in the central Korean Peninsula(Cheonan and Gapyeong areas)and the Paleozoic metasedimentary rocks in the Okcheon Zone of the Okcheon Belt to constrain the timing of maximum depositional and metamorphic *** also examined the metamorphic P-T-t path from garnet-bearing amphibolite in the central Korean Peninsula by pseudosection modeling and *** results show that(i)some of the ultramafic-mafic complex and metasedimentary rocks in the central Korean Peninsula formed during the Middle Paleozoic(ca.450–374 Ma);(ii)garnet-bearing amphibolite underwent successive metamorphism from amphibolite facies condition(7.5–8.0 kbar and 540–630℃)at pre-peak stage to granulite facies condition(10.9–11.8 kbar and 740–820℃)at peak stage,and then retrograded into amphibolite facies condition(5.7–7.7 kbar and 530–670℃)along the clockwise P–T path during ca.403–362 *** and previous studies suggest that the central Korean Peninsula underwent subduction-related orogenic events during the Middle Paleozoic era,and it is well correlated to those of the orogenic events in the North Qinling belt.

关键词： Central Korean Peninsula Middle Paleozoic Orogenic event Pressure-temperature estimation Zircon U-Pb-REE analysis

Expression of apoptosis-related factors in chronic cyclosporine nephrotoxicity after cyclosporine withdrawal

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Acta Pharmacologica Sinica 2004年第4期25卷 3-13页

作者： Sun-woo LIM,bo-kyung SUN,Bum-soon CHOI,Sylvia GLOWACKA,Alison J COX,Darren J KELLY,Yong-soo kim,Jin kim,Byung-kee BANG,Chul-woo YANG Departments of Internal Medicine the Catholic University of Korea Seoul137-040 Korea Departments of Internal Medicine the Catholic University of Korea Seoul137-040 Korea Departments of Internal Medicine the Catholic University of Korea Seoul137-040 Korea Department of Medicine St Vincent’s Hospital Fitzroy University of Melbourne Australia Department of Medicine St Vincent’s Hospital Fitzroy University of Melbourne Australia Department of Medicine St Vincent’s Hospital Fitzroy University of Melbourne Australia Departments of Internal Medicine the Catholic University of Korea Seoul137-040 Korea Departments of Anatomy the Catholic University of Korea Seoul137-040 Korea Departments of Internal Medicine the Catholic University of Korea Seoul137-040 Korea Departments of Internal Medicine the Catholic University of Korea Seoul137-040 Korea MD PhD

AIM: To examine whether the reversibility of chronic cyclosporine A (CsA) nephrotoxicity is associated with apoptotic cell death and its regulatory factors. METHODS: Chronic CsA nephrotoxicity was induced in Sprague- Dawley rats by administering CsA (15 mg/kg, sc) for 5 weeks, and then withdrawing it for 5 or 10 weeks. The effect of CsA withdrawal on apoptotic cell death was evaluated by an in situ TdT-mediated deoxyuridine triphos- phate-biotin nick end-labeling (TUNEL) assay and the expression of pro-apoptotic [(transforming growth factor- beta1 (TGF-β1) and Fas] and anti-apoptotic [epidermal growth factors (EGF) and Bcl-2] factors. RESULTS: Discontinuation of CsA induced significant decreases in TUNEL-positive cells in a time-dependent manner and the reduction in TUNEL-positive cells was correlated with the tubulointerstitial fibrosis score (r=0.919, P<0.01). Upregulation of TGF-β1 and Fas expression in CsA-treated rat kidneys was decreased significantly after with- drawal of CsA. In contrast, downregulated EGF and Bcl-2 expression returned to normal or supernormal levels. CONCLUSION: CsA withdrawal is associated with a decrease in apoptotic cell death and with changes in the expression of pro-apoptotic and anti-apoptotic molecules involved in renal wound repair. This may constitute one of the mechanisms underlying the reversibility of chronic CsA nephrotoxicity.

关键词： cyclosporine apoptosis bcl-2 fas epidermal growth factor transforming growth factor-beta fibrosis

A Study on the Optimal Offset Distance Between a Welding Torch and the Infrared Thermometers

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Fluid Dynamics & Materials Processing 2019年第1期15卷 1-14页

作者： Tae-Jong Yun Won-Bin Oh bo-Ram Lee Joon-Sik Son Ill-soo kim Department of Mechanical Engineering Mokpo National University1666 Yeongsan-roCheonggyemyeonMuan-gunJeollanam-do58554South Korea Research Institute of Medium&Small Shipbuilding 55Daebuljugeo 3-roSamho-eupYeongam-gunJeollanam-do58457South Korea

Detection of weld defects using real-time monitoring and controlling algorithm is of the significant task in manufacturing industries due to the increased production and liability costs that result when weld defects are not identified early in the production *** and controlling for robotic arc welding process employed should be reliable,flexible and cost-effective in non-clean,high-volume production ***,the robotic welding system has been utilized a complex jigging and mechanical devices to move the workpiece which related to the stationary welding head for getting higher efficiency and lower *** develop the fully robotic welding system,people make use of their senses of sound and/or sight to collect welding information,and take the necessary corrective measurements to ensure the weld quality after processing is ***,it is really required that the monitoring and controlling algorithm of sensors for increasing effectiveness in the robotic welding process has been *** this paper,bead-on-plate welding using an infrared thermography in the robotic GMA(Gas Metal Arc)welding process has been performed to study the effects of welding parameters on thermal profile characteristics and find the optimal offset distance which applied for monitoring and controlling of welding quality such as bead *** analysis for correlation between temperature distributions at three offset distance and bead height which based on the regression analysis such as Standard Error of Estimate(SEE),the coefficient of correlation(R)and coefficient of determination(R2)and(Predictive Ability of Model)has been *** infra-red sensor is useful for monitoring the isotherm radii that arise during the robotic welding process and identifying bead height as welding quality.

关键词： GMA welding adaptive control bead-on-plate joint infrared thermometers bead height

PD-1 blockade-unresponsive human tumor-infiltrating CD8^(+)T cells are marked by loss of CD28 expression and rescued by IL-15

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Cellular & Molecular Immunology 2021年第2期18卷 385-397页

作者： Kyung Hwan kim Hong Kwan kim Hyung-Don kim Chang Gon kim Hoyoung Lee Ji Won Han Seong Jin Choi Seongju Jeong Minwoo Jeon Hyunglae kim Jiae Koh bo Mi Ku Su-Hyung Park Myung-Ju Ahn Eui-Cheol Shin Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and TechnologyDaejeonRepublic of Korea Department of Thoracic and Cardiovascular Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea Biomedical Science and Engineering Interdisciplinary Program Korea Advanced Institute of Science and TechnologyDaejeonRepublic of Korea Research Institute for Future Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea Department of Radiation Oncology Yonsei Cancer CenterYonsei University College of MedicineSeoulRepublic of Korea Division of Hematology-Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea

Blockade of programmed death-1(PD-1)reinvigorates exhausted CD8^(+)T cells,resulting in tumor regression in cancer ***,reinvigoration of exhausted CD8^(+)T cells following PD-1 blockade was shown to be CD28-dependent in mouse ***,we examined the role of CD28 in anti-PD-1 antibody-induced human T cell reinvigoration using tumor-infiltrating CD8^(+)T cells(CD8^(+)TILs)obtained from non-small-cell lung cancer ***-cell analysis demonstrated a distinct expression pattern of CD28 between mouse and human CD8^(+)***,we found that human CD28^(+)CD8^(+)but not CD28^(–)CD8^(+)TILs responded to PD-1 blockade irrespective of B7/CD28 blockade,indicating that CD28 costimulation in human CD8^(+)TILs is dispensable for PD-1 blockade-induced reinvigoration and that loss of CD28 expression serves as a marker of anti-PD-1 antibody-unresponsive CD8^(+)*** and phenotypically,PD-1 blockade-unresponsive human CD28^(–)PD-1^(+)CD8^(+)TILs exhibited characteristics of terminally exhausted CD8^(+)T cells with low TCF1 ***,CD28^(–)PD-1^(+)CD8^(+)TILs had preserved machinery to respond to IL-15,and IL-15 treatment enhanced the proliferation of CD28^(–)PD-1^(+)CD8^(+)TILs as well as CD28^(+)PD-1^(+)CD8^(+)*** together,these results show that loss of CD28 expression is a marker of PD-1 blockade-unresponsive human CD8^(+)TILs with a TCF1–signature and provide mechanistic insights into combining IL-15 with anti-PD-1 antibodies.

关键词： anti-PD-1 T cells TCF1 CD28 IL-15

A paintable and adhesive hydrogel cardiac patch with sustained release of ANGPTL4 for infarcted heart repair

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Bioactive Materials 2024年第1期31卷 395-407页

作者： Mingyu Lee Yong Sook kim Junggeon Park Goeun Choe Sanghun Lee bo Gyeong Kang Ju Hee Jun Yoonmin Shin Minchul kim Youngkeun Ahn Jae Young Lee School of Materials Science and Engineering Gwangju Institute of Science and TechnologyGwangju61005Republic of Korea Cell Regeneration Research Center Chonnam National UniversityGwangjuRepublic of Korea Biomedical Research Institute Chonnam National University HospitalGwangjuRepublic of Korea Department of Cardiology Chonnam National University HospitalGwangjuRepublic of Korea Chonnam National University Medical School GwangjuRepublic of Korea

The infarcted heart undergoes irreversible pathological remodeling after reperfusion involving left ventricle dilation and excessive inflammatory reactions in the infarcted heart,frequently leading to fatal functional *** attempts have been made to attenuate pathological remodeling in infarcted hearts using cardiac patches and anti-inflammatory drug *** this study,we developed a paintable and adhesive hydrogel patch using dextran-aldehyde(dex-ald)and gelatin,incorporating the anti-inflammatory protein,ANGPTL4,into the hydrogel for sustained release directly to the infarcted heart to alleviate *** optimized the material composition,including polymer concentration and molecular weight,to achieve a paintable,adhesive hydrogel using 10%gelatin and 5%dex-ald,which displayed in-situ gel formation within 135 s,cardiac tissue-like modulus(40.5 kPa),suitable tissue adhesiveness(4.3 kPa),and excellent mechanical ***4 was continuously released from the gelatin/dex-ald hydrogel without substantial burst *** gelatin/dex-ald hydrogel could be conveniently painted onto the beating heart and degraded in ***,in vivo studies using animal models of acute myocardial infarction revealed that our hydrogel cardiac patch containing ANGPTL4 significantly improved heart tissue repair,evaluated by echocardiography and histological *** heart tissues treated with ANGPTL4-loaded hydrogel patches exhibited increased vascularization,reduced inflammatory macrophages,and structural maturation of cardiac *** novel hydrogel system,which allows for facile paintability,appropriate tissue adhesiveness,and sustained release of anti-inflammatory drugs,will serve as an effective platform for the repair of various tissues,including heart,muscle,and cartilage.

关键词： Cardiac patch Hydrogel Angiopoietin-like 4 Myocardial infarction

Grain flow rate sensing for a 55 kW full-feed type multi-purpose combine

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International Journal of Agricultural and Biological Engineering 2018年第5期11卷 206-210页

作者： Moon-Chan Choi Kyu-Ho Lee bo-Eun Jang Yong-Joo kim Sun-Ok Chung Jong-Soon Lee Su-Kyeong kim Department of Biosystems Machinery Engineering Chungnam National UniversityDaejeon34134Korea R&D Center Daedong Industrial Co.LtdChangyeongKorea R&D Center TongYang Co.LtdGongjuKorea

Real time sensing of crop yield is critical for a successful implementation of precision *** monitoring system is an optional component of a 55 kW multi-purpose combine harvester,developed in Korea,for both domestic and global markets,especially Asian countries where field sizes are relatively *** aim of the present study was to fabricate and evaluate the performance of a grain flow sensor suitable to the mid-sized full-feed type combine for rice,soybean,and ***,commercially available non-contact type sensing modules(optical,ultrasonic,laser,and microwave modules)were chosen for alternative candidates,to be further tested in a laboratory *** the laboratory tests,the ultrasonic module was selected as a potential approach and the performance was improved by increasing the number of modules and their ***,the improved grain flow sensor was evaluated during field harvesting *** tests with the improved grain flow sensor showed a good potential for rice(R^(2)=0.85,RMSE=126.14 g/s),soybean(R^(2)=0.78,RMSE=43.87 g/s),and barley(R^(2)=0.83,RMSE=37.39 g/s).Further research would be necessary for improvement and commercialization,through various signal processing and field tests under different field and crop conditions.

关键词： precision agriculture combine harvester yield monitoring system sensor grain flow rate

Pancreatic pseudocystocolonic fistula treated without surgical or endoscopic intervention

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World Journal of Gastroenterology 2014年第7期20卷 1882-1886页

作者： Jae Choon Kwon bo Yean kim Ah Lim kim Tae Hoon kim Myung Il Park Ho Jin Jung Jang Hwan Lim Jae Kwon Jung Hyun Soo kim Dong Wook Lee Division of Gastroenterology and Hepatology Department of Internal MedicineDaegu Fatima HospitalDong-gu Daegu701-600South Korea

We report here a case of pancreatic pseudocystocolic fistula that was treated without surgical or endoscopic intervention.A 76-year-old woman,presenting with a fever and epigastric pain,was referred to our *** months prior to this admission,the patient had been admitted to the hospital for acute *** computerized tomography(CT)revealed a 9 cm pseudocyst containing air,and a fistular opening was observed via *** colonoscopy,the abdominal pain was slightly improved,the fever subsided and laboratory results showed decreased C-reactive protein *** observed improvement was likely due to the cleansing of the bowel,which induced spontaneous drainage from the pseudocyst into the *** therapy was administered and daily bowel cleansing was performed using a polyethylene glycol *** three weeks,a follow-up CT revealed that the size of the pseudocyst had decreased significantly from 9 to 5.3 *** addition,laboratory tests were *** patient was able to resume a normal diet and was discharged in good overall health from the hospital,without aggravation of the symptoms.A colonoscopy performed 3 mo later and a follow-up CT performed 6 mo later confirmed that both the fistula and pseudocyst had completely disappeared.

关键词： Acute pancreatitis Pseudocyst Pseudocystocolic fistula

Field-effect transistor with a chemically synthesized MoS2 sensing channel for label-free and highly sensitive electrical detection of DNA hybridization

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Nano Research 2015年第7期8卷 2340-2350页

作者： Doo-Won Lee Jinhwan Lee II Yung Sohn bo-Yeong kim Young Min Son Hunyoung Bark JaehyuckJung Minseok Choi Tae Hyeong kim Changgu Lee Nae-Eung Lee Department of Advanced Materials Science & Engineering Sungkyunkwan University Suwon Gyunggi-do 440-746 Republic of Korea Department of Mechanical Engineering Sungkyunkwan University Suwon Gyunggi-do 440-746 Republic of Korea SKKU Advanced Institute of Nanotechnology (SAINT) Sungkyunkwan University Suwon Gyunggi-do 440-746 Republic of Korea Samsung Advanced Institute for Health Sciences & Technology (SAIHST) Sungkyunkwan University Suwon Gyeonggi-do 440-746 Republic of Korea New Materials Team Future Device R&D Department LG Electronics Advanced Research Institute Seou1137-724 Republic of Korea These authors contributed equally to this work.

A field-effect transistor （FET） with two-dimensional （2D） few-layer MoS2 as a sensing-channel material was investigated for label-free electrical detection of the hybridization of deoxyribonucleic acid （DNA） molecules. The high-quality MoS2-channel pattern was selectively formedthrough the chemical reaction of the Mo layer with H2S gas. The MoS2 FET was very stable in an electrolyte and inert to pH changes due to the lack of oxygen-containing functionalities on the MoS2 surface. Hybridization of single-stranded target DNA molecules with single-stranded probe DNA molecules physically adsorbed on the MoS2 channel resulted in a shift of the threshold voltage （Vt,） in the negative direction and an increase in the drain current. The negative shift in Vth is attributed to electrostatic gating effects induced by the detachment of negatively charged probe DNA molecules from the channel surface after hybridization. A detection limit of 10 fM, high sensitivity of 17 mWdec, and high dynamic range of 106 were achieved. The results showed that a bio-FET with an ultrathin 2D MoS2 channel can be used to detect very small concentrations of target DNA molecules specifically hybridized with the probe DNA molecules.

关键词： two-dimensional(2D)materials, MoS2,field-effect transistor, biosensor,deoxyribonucleic acid (DNA) hybridization