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Friction 2024年第4期12卷 698-710页

作者： bo YU Kun ZOU Rui WANG Qiang CHEN Rui DONG Xiao LIU Jiaying ZHANG Wenquan LV Qiangliang YU Meirong CAI Feng zhou College of Science Nanjing Forestry UniversityNanjing 210037China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China Shandong Laboratory of Advanced Materials and Green Manufacturing at Yantai Yantai 264006China Yantai Zhongke Research Institute of Advanced Materials and Green Chemical Engineering Yantai 264006China Institute of Polymer Materials Nanjing Forestry UniversityNanjing 210037China

The polyionic liquid poly-PEGMA-r-METAC(PPM)with quaternary ammonium has been synthesized and evaluated as additive in aqueous lubricating *** rheological behavior of aqueous lubricating fluids with PPM has been characterized to confirm PPM’s function as a viscosity *** tribological behavior of aqueous lubricating fluids with PPM has been investigated on SRV-V and MTM testing *** was found that PPM has excellent viscosity-increasing,lubricating,and anti-wear properties as an additive for aqueous,which can be attributed to the ability of PPM to form the protective film and boundary tribofilm generated from complex tribochemical reaction on rubbing *** obtained PPM with dual functions of anti-corrosion additives and viscosity index improver can play an important role in diverse lubrication regimes.

关键词： polyionic liquid lubricant additives viscosity modifier lubrication regime

Modification of POSS and their tribological properties and resistant to space atomic oxygen irradiation as lubricant additive of multialkylated cyclopentanes

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Friction 2024年第5期12卷 884-896页

作者： Xingwei WANG Chaoyang ZHANG Chen ZHAO Yijing LIANG Ming ZHANG Wufang YANG bo YU Qiangliang YU Meirong CAI Feng zhou Weimin LIU State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou730000China Shandong Laboratory of Yantai Advanced Materials and Green Manufacturing Yantai264000China

Developing functional additive resistant to space atomic oxygen(AO)irradiation through simple molecular design and chemical synthesis to enhance the lubricating performance of multialkylated cyclopentanes(MACs)oil is a significant ***,sulfur-containing polyhedral oligomere silsesquioxane(POSS)were synthesize via a click-chemistry reaction of octavinyl polyhedral oligomeric with alkyl *** reduce-friction(RF),anti-wear(AW)properties and anti-AO irradiation of POSS-S-R as MACs base oil additives in atmospheric and simulated space environments were systematically investigated for the first *** demonstrate that POSS-S-R not only possesses outstanding anti-AO irradiation capacity but also effectively improves the RF and AW of MACs in atmospheric or simulated space *** improvement is due to the excellent anti-AO irradiation properties of the POSS structure itself and the high load-carrying ability of silicon-containing and sulfur-containing compounds generated by tribo-chemical reactions,which effectively separates the direct contact of the friction *** believe that this synthesized POSS-S-R is a promising additive for space lubricants.

关键词： POSS additive reduce-friction anti-wear multialkylated cyclopentanes(MACs) resistant atomic irradiation

A real-time performance improvement method for composite time scale

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Chinese Physics B 2024年第9期33卷 350-357页

作者： Fangmin Wang Wenlin Li Hongfei dai Chunyi Li Jianhua zhou Shenhui Xue bo Wang State Key Laboratory of Precision Space–time Information Sensing Technology Department of Precision InstrumentTsinghua UniversityBeijing 100084China Key Laboratory of Photonic Control Technology(Tsinghua University) Ministry of EducationBeijing 100084China Beijing Satellite Navigation Center Beijing 100094China

The composite time scale(CTS)provides a stable,accurate,and reliable time scale for modern *** improvement of CTS’s real-time performance will improve its stability,which strengths related applications’*** at this goal,a method achieved by determining the optimal calculation interval and accelerating adjustment stage is proposed in this *** determinants of the CTS’s calculation interval(characteristics of the clock ensemble,the measurement noise,the time and frequency synchronization system’s noise and the auxiliary output generator noise floor)are studied and the optimal calculation interval is *** also investigate the effect of ensemble algorithm’s initial parameters on the CTS’s adjustment stage.A strategy to get the reasonable initial parameters of ensemble algorithm is *** results show that the adjustment stage can be finished rapidly or even can be shorten to zero with reasonable initial *** this basis,we experimentally generate a distributed CTS with a calculation interval of 500 s and its stability outperforms those of the member clocks when the averaging time is longer than1700 *** experimental result proves that the CTS’s real-time performance is significantly improved.

关键词： composite time scale real-time performance calculation interval adjustment stage

LATS1 Promotes B-ALL Tumorigenesis by Regulating YAP1 Phosphorylation and Subcellular Localization

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Current Medical Science 2024年第1期44卷 81-92页

作者： Feng ZHANG Mohammed Awal Issah Hai-ying FU Hua-rong zhou Ting-bo LIU Jian-zhen SHEN Fujian Provincial Key Laboratory on Hematology Fujian Medical Center of HematologyFujian Institute of HematologyClinical Research Center for Hematological Malignancies of Fujian ProvinceFujian Medical University Union HospitalFuzhou 350001China Tamale Technical University Faculty of Allied Health and Pharmaceutical SciencesDepartment of Medical Laboratory TechnologyTamale NS-011-2000Ghana Department of Hematology The Third Affiliated People's Hospital of Fujian University of Traditional Chinese MedicineThe Third People's Hospital of Fujian ProvinceFuzhou 350122China

Objective YAP1 plays a dual role as an oncogene and tumor suppressor gene in several tumors;differentiating between these roles may depend on the YAP1 phosphorylation *** specific function of YAP1 in B cell acute lymphoblastic leukemia(B-ALL),however,is currently ***,in the present study,the role of YAP1 in B-ALL was investigated using relevant cell lines and patient *** The effects of shRNA-mediated knockdown on YAP1 and LATS1 levels in the NALM6 and MOLT-4 cell lines were examined using Western blotting,quantitative real-time polymerase chain reaction,flow cytometry,immunostaining,and nude mouse subcutaneous tumorigenesis *** expression levels of Hippo pathway-related molecules before and after verteporfin(VP)treatment were compared using RNA-Seq to identify significant Hippo pathway-related genes in NALM6 *** Patients with ALL showing high YAP1 expression and low YAP1-Ser127 phosphorylation levels had worse prognoses than those with low YAP1 protein expression and high YAP1-Ser127 phosphorylation ***1-Ser127 phosphorylation levels were lower in NALM6 cells than in MOLT-4 and control cells;YAP1 was distributed in the nuclei in NALM6 *** of YAP1 inhibited MOLT-4 and NALM6 cell proliferation and arrested the NALM6 cell cycle in the G0/G1 *** and after VP treatment,the expression of the upstream gene LATS1 was upregulated;its overexpression promoted YAP1-Ser127 ***,YAP1 was distributed in the *** LATS1 may downregulate YAP1-Ser127 phosphorylation and maintain B-ALL cell function;thus,VP,which targets this axis,may serve as a new therapeutic method for improving the outcomes for B-ALL patients.

关键词： acute lymphoblastic leukemia large tumor suppressor kinase 1 phosphorylation RNA-Seq Yesl-associated protein

An unexpected stereochemical effect of thio-substituted Asp in native chemical ligation

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Chinese Chemical Letters 2024年第8期35卷 278-281页

作者： Min Fu Pan He Sen zhou Wenqiang Liu bo Ma Shiying Shang Yaohao Li Ruihan Wang Zhongping Tan State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Center of Pharmaceutical Technology School of Pharmaceutical SciencesTsinghua UniversityBeijing 100084China Chemical Engineering College Hebei Normal University of Science and TechnologyQinhuangdao 066600China

This study presents an unexpected finding that the cis isomer of β-thio-Asp exhibits higher ligation ac-tivity than the trans *** discovery sheds light on the intricate nature of native chemical ligation and highligh... 详细信息

关键词： Native chemical ligation Stereochemistry Ligation activity β-Thio-Asp Intramolecular hydrogen bond

Design and parameters optimization of the curved sieve for an air suction jujube harvester

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International Journal of Agricultural and Biological Engineering 2024年第2期17卷 132-139页

作者： Shenghe Bai Yanwei Yuan Kang Niu Liming zhou bo Zhao Liguo Wei Lijing Liu Xuejun Zhang College of Engineering China Agricultural UniversityBeijing 100083China National Key Laboratory of Agricultural Equipment Technology Chinese Academy of Agricultural Mechanization Sciences Group Co.Ltd.Beijing 100083China College of Mechanical and Electrical Engineering Xinjiang Agricultural UniversityUrumqi 830052China

In order to improve the screening performance and cleaning effect of the jujube harvesting machinery cleaning device,a vibrating curved screen device was designed in this *** analyzing the structure mechanism of the curved sieve body,it was obtained that the arc-shaped mesh hole spacing S was 15-25 mm and the curved mesh hole curvature U was 90°-150°.By exploring the movement state and stress of jujube and impurities on the curved sieve body,it was determined that the horizontal spacing L of the curved layer sieve was 30 mm and the vertical spacing H was 45-65 *** the vertical spacing H of the curved layer sieve,the curvature U of the curved mesh hole,and the spacing S of the curved mesh hole as the experimental factors,considering the screening efficiencyαand the impurity contentβof the jujube as the response values,the three-factor three-level quadratic regression orthogonal experiment was designed,establishing the regression mathematical model of each factor and response value,and the multiple target optimization algorithm of Design-expert software was used to optimize various *** results showed that the influence factors on the screening efficiency were in the descending order as:the arc screen spacing,the vertical spacing of the curved layer screen,and the curved screen hole curvature;The significant factors affecting the impurity content of jujube were in the descending order as:the arc screen spacing,the curved screen hole curvature,and the vertical spacing of the curved layer *** experimental results were verified by the optimized combination of parameters:when the vertical spacing H of the curved layer screen was 65 mm,the curved screen hole curvature U was 110°,and the arc screen spacing S was 23 mm,the average screening efficiencyαin the test was 91.09%.The relative error between the experimental verification value and the theoretical optimization value was 1.36%,which was less than 5%.The impurity content of jujubeβin the test w

关键词： jujube harvesting cleaning device curved sieve sieve structure conveying pipe mathematical model

RsaL is a self-regulatory switch that controls alternative biosynthesis of two AHL-type quorum sensing signals in Pseudomonas aeruginosa PA1201

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mLife 2024年第1期3卷 74-86页

作者： Ya-Wen He Zi-Jing Jin Ying Cui Kai Song bo Chen Lian zhou State Key Laboratory of Microbial Metabolism Joint International Research Laboratory of Metabolic and Developmental SciencesSJTU-NLBP Joint R&D Centre for Biopesticides and BiofertilizersSchool of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghaiChina Zhiyuan Innovative Research Centre Student Innovation CentreZhiyuan CollegeShanghai Jiao Tong UniversityShanghaiChina

Pseudomonas aeruginosa is a ubiquitous and metabolically versatile microorganism naturally found in soil and *** is also an opportunistic pathogen in plants,insects,animals,and *** response to increasing cell density,*** uses two acylhomoserine lactone(AHL)quorum-sensing(QS)signals(i.e.,N-3-oxo-dodecanoyl homoserine lactone[3-oxo-C12-HSL]and Nbutanoyl-homoserine lactone[C4-HsL]),which regulate the expression of hundreds of ***,how the biosynthesis of these two QS signals is coordinated remains *** studied the regulation of these two QS signals in the rhizosphere strain ***1201 sequentially produced 3-oxo-C12-HSL and C4-HSL at the early and late growth stages,*** highest 3-oxo-C12-HSL-dependent elastase activity was observed at the early stage,while the highest C4-HSL-dependent rhamnolipid production was observed at the late *** atypical regulator RsaL played a pivotal role in coordinating 3-oxo-C12-HSL and C4-HSL biosynthesis and QS-associated *** repressed las/transcription by binding the-10 and-35 boxes of the lasl *** contrast,RsaL activated rhll transcription by binding the region encoding the 5'-untranslated region of the rhll ***,RsaL repressed its own expression by binding a nucleotide motif located in the-35 box of the rsaL ***,RsaL acts as a molecular switch that coordinates the sequential biosynthesis of AHL QS signals and differential virulence in ***,C4-HSL activation by RsaL was independent of the Las and Pseudomonas quinolone signal(PQS)QS signaling ***,we propose a new model of the QS regulatory network in PA1201,in which RsaL represents a superior player acting at the top of the hierarchy.

关键词： N-3-oxo-dodecanoyl homoserine lactone N-butanoyl-homoserine lactone Pseudomonas aeruginosa quorum sensing RsaL

Discovery of proqodine A derivatives with antitumor activity targeting NAD(P)H:quinone oxidoreductase 1 and nicotinamide phosphoribosyltransferase

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Chinese Journal of Natural Medicines 2024年第1期22卷 75-88页

作者： SONG Jiangzhou ZOU Guiqing ZHAO zhou ZHU Ya XUE Jiayu AO Lanjia SUN Huiyong HAO Haiping ZHANG bo XU Xiaowei State Key Laboratory of Natural Medicines Key Lab of Drug Metabolism and PharmacokineticsChina Pharmaceutical UniversityNanjing 210009China State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China

NAD(P)H:quinone oxidoreductase 1(NQO1)is a flavin protease highly expressed in various cancer ***1 catalyzes a futile redox cycle in substrates,leading to substantial reactive oxygen species(ROS)*** ROS generation results in extensive DNA damage and elevated poly(ADP-ribose)polymerase 1(PARP1)-mediated consumption of nicotinamide adenine dinucleotide(NAD^(+)),ultimately causing cell *** phosphoribosyltransferase(NAMPT),the rate-limiting enzyme in the NAD^(+)salvage synthesis pathway,emerges as a critical target in cancer *** concurrent inhibition of NQO1 and NAMPT triggers hyperactivation of PARP1 and intensive NAD+*** this study,we designed,synthesized,and assessed a novel series of proqodine A derivatives targeting both NQO1 and *** these,compound T8 demonstrated potent antitumor ***,T8 selectively inhibited the proliferation of MCF-7 cells and induced apoptosis through mechanisms dependent on both NQO1 and *** discovery offers a promising new molecular entity for advancing anticancer research.

关键词： NQO1 ROS NAMPT NAD^(+) T8

A review of reservoir damage during hydraulic fracturing of deep and ultra-deep reservoirs

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Petroleum Science 2024年第1期21卷 384-409页

作者： Kun Zhang Xiong-Fei Liu dao-Bing Wang bo Zheng Tun-Hao Chen Qing Wang Hao Bai Er-Dong Yao Fu-Jian zhou National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum-BeijingBeijing102249China School of Mechanical Engineering Beijing Institute of Petrochemical TechnologyBeijing102617China Tuha Downhole Operation Company CNPC Xibu Drilling Engineering Company LimitedShanshan838200XinjiangChina

Deep and ultra-deep reservoirs have gradually become the primary focus of hydrocarbon exploration as a result of a series of significant discoveries in deep hydrocarbon exploration *** reservoirs present unique challenges due to their deep burial depth(4500-8882 m),low matrix permeability,complex crustal stress conditions,high temperature and pressure(HTHP,150-200℃,105-155 MPa),coupled with high salinity of formation ***,the costs associated with their exploitation and development are exceptionally *** deep and ultra-deep reservoirs,hydraulic fracturing is commonly used to achieve high and stable *** hydraulic fracturing,a substantial volume of fluid is injected into the ***,statistical analysis reveals that the flowback rate is typically less than 30%,leaving the majority of the fluid trapped within the ***,hydraulic fracturing in deep reservoirs not only enhances the reservoir permeability by creating artificial fractures but also damages reservoirs due to the fracturing fluids *** challenging“three-high”environment of a deep reservoir,characterized by high temperature,high pressure,and high salinity,exacerbates conventional forms of damage,including water sensitivity,retention of fracturing fluids,rock creep,and proppant *** addition,specific damage mechanisms come into play,such as fracturing fluid decomposition at elevated temperatures and proppant diagenetic reactions at HTHP ***,the foremost concern in deep oil and gas development lies in effectively assessing the damage inflicted on these reservoirs by hydraulic fracturing,comprehending the underlying mechanisms,and selecting appropriate ***'s noteworthy that the majority of existing studies on reservoir damage primarily focus on conventional reservoirs,with limited attention given to deep reservoirs and a lack of systematic *** light of this,our approach entails initially summarizin

关键词： Artificial fracture Deep and ultra-deep reservoir Fracture conductivity Fracturing fluid Hydraulic fracturing Reservoir damage

Coherent beam combining of two all‑PM thulium‑doped fiber chirped pulse amplifiers

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Frontiers of Optoelectronics 2024年第2期17卷 33-42页

作者： bo Ren Hongxiang Chang Can Li Tao Wang Kaikai Jin Jiayi Zhang Kun Guo Rongtao Su Jinyong Leng Pu zhou College of Advanced Interdisciplinary Studies National University of Defense TechnologyChangsha 410073China Nanhu Laser Laboratory National University of Defense TechnologyChangsha 410073China Hunan Provincial Key Laboratory of High Energy Laser Technology National University of Defense TechnologyChangsha 410073China

In this paper,we report a coherent beam combining(CBC)system that involves two thulium-doped all-polarization maintaining(PM)fiber chirped pulse *** phase-locking the two channels via a fiber stretcher by using the stochastic parallel gradient descent(SPGD)algorithm,a maximum average power of 265 W is obtained,with a CBC efficiency of 81%and a residual phase error of λ/*** de-chirping by a pair of diffraction gratings,the duration of the combined laser pulse is compressed to 690 *** into account the compression efficiency of 90%and the main peak energy proportion of 91%,the corresponding peak power is calculated to be 4 *** laser noise characteristics before and after CBC are examined,and the results indicate that the CBC would degrade the low frequency relative intensity noise(RIN),of which the integration is 1.74%in[100 Hz,2 MHz]at the maximum combined output *** addition,the effects of the nonlinear spectrum broadening during chirped pulse amplification on the CBC efficiency are also investigated,showing that a higher extent of pulse stretching is effective in alleviating the spectrum broadening and realizing a higher output power with decent combining efficiency.

关键词： Coherent beam combining Thulium-doped fiber laser High-average power Chirped pulse amplifier