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Pressure effects on metal/covalent-organic frameworks: structural and optical properties

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Science China Chemistry 2024年

作者： Yixuan Wang Yunfeng Yang Xinyi Yang bo zou Synergetic Extreme Condition High-Pressure Science Center College of Physics Jilin University State Key Laboratory of Superhard Materials

Metal-organic frameworks(MOFs) and covalent organic frameworks(COFs) with highly ordered porous structure, tunable bandgap, large specific surface area and structural diversity, provide an appealing platform for the development of stimulus response, sensing, imaging and optoelectronics. Among various tuning methods, pressure engineering using the diamond anvil cell is a highly powerful in-situ technique, which can efficiently modulate the structural and optical properties of MOFs/COFs.This is beyond the realization of traditional chemical methods. This review outlines the research progress in the experimentoriented discovery of new phases or unique properties under high pressure, including phase transition, abnormal compression,photoluminescence(PL) discoloration and enhancement. Notably, the improvement of PL quantum yield in MOFs could be achieved by pressure-treated engineering and hydrogen-bonding cooperativity effect. We also propose and establish the relationship between structure and optical properties under high pressure. Finally, the challenge and outlook of the current fields are summarized. We hope that this review will supply guidance for comprehending the development of high-pressure MOF/COF-related research fields, and offer novel strategies for designing more high-performance MOF/COF materials to ultimately expand their applications.

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Arbuscular mycorrhizal fungi and endophytic fungi differentially modulate polyamines or proline of peach in response to soil flooding

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Pedosphere 2024年第2期34卷 460-472页

作者： Shengmin LIANG Yingning zou bo SHU Qiangsheng WU Ministry of Education Engineering Research Center of Ecology and Agricultural Use of WetlandHubei Key Laboratory of Waterlogging Disaster and Agricultural Use of WetlandCollege of Horticulture and GardeningYangtze UniversityJingzhou 434025China

Symbiotic fungi are involved in plant flooding tolerance,while the underlying mechanism is not yet known.Since polyamines(PAs)and proline are also associated with stress tolerance,it is hypothesized that the enhancement of stress resistance by symbiotic fungi is associated with changes in PAs and/or proline.The aim of this study was to analyze the effect of inoculation with Funneliformis mosseae and Serendipita indica on plant growth,PAs,and proline and the metabolisms in peach(Prunus persica)under flooding.Two-week flooding did not affect root colonization frequence of F.mosseae,while it promoted root colonization frequence of S.indica.Under flooding,plants inoculated with F.mosseae and S.indica maintained relatively higher growth rates than uninoculated plants.Funneliformis mosseae promoted root ornithine(Orn)contentration and arginine(Arg)and Orn decarboxylase activities under flooding,which promoted putrescine(Put),cadaverine(Cad),and spermidine(Spd)contentrations.Conversely,S.indica decreased contentrations of Arg,Orn,and agmatine and Arg decarboxylase activities,thus decreasing PA contentrations under flooding.Polyamines were negatively correlated with the expression of PA uptake transporter genes,PpPUT1 and PpPUT2,in peach.Polyamine transporter genes of F.mosseae(FmTPO)and S.indica(SiTPO)were regulated by flooding,of which FmTPO1 was positively correlated with Put,Cad,and Spd,along with positive correlations of Spd with SiTPO1,SiTPO2,and SiTPO4.Under flooding,F.mosseae decreased proline concentration,while S.indica increased proline concentration and correlated with expression of a△^(1)-pyrroline-5-carboxylate synthetase gene,PpP5CS2.It was thus concluded that F.mosseae modulated polyamine accumulation,while S.indica induced proline accumulation to tolerate flooding.

关键词： △^(1)-pyrroline-5-carboxylate synthetase flooding tolerance Funneliformis mosseae ornithine aminotransferase root colonization Serendipita indica spermidine transporter

Recovery of cyanophycin granule polypeptide from activated sludge: carbon source dependence and aggregation-induced luminescence characteristics

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Frontiers of Environmental Science & Engineering 2024年第2期18卷 25-34页

作者： Kui zou Hongyuan Liu bo Feng Taiping Qing Peng Zhang College of Environment and Resources Xiangtan UniversityXiangtan 411105China

In the sewage treatment process,facilitating the conversion of pollutants into value-added resources holds great potential for reducing the amount of greenhouse gas emissions and promoting economic circulation.Cyanophycin granule polypeptide(CGP),a recently discovered high value-added biopolymer present in activated sludge,has provided new avenues for the recovery of resources.However,the mechanisms that regulate CGP synthesis and the characteristics of this biopolymer in activated sludge remain unclear thus far.This study investigated the synthesis of CGP,polyhydroxyalkanoates(PHA),and alginate-like exopolysaccharides(ALE)in various microbial aggregates under different carbon sources feeding conditions.Our results showed that the CGP yields was superior that of PHA and ALE when subjected to identical carbon source feeding conditions.Furthermore,biofilm was more conducive to CGP accumulation than floc sludge.Compared with glucose and methanol,sodium acetate significantly enriched the CGP synthetase-encoding gene(cphAabundance=~17419),resulting in the highest CGP yield(average 107.1 mg/g MLSS)in both biofilm and floc sludge.This study is the first to reported the characteristic fluorescence of CGP(Ex/Em=~360/450 nm)caused by the aggregated luminescence of arginine on the side chains.Overall,this study highlights the potential application of CGP as a fluorescent material and offers insights into CGP recovery from activated sludge in wastewater treatment plants.

关键词： Cyanophycin Polyhydroxyalkanoate Alginate-like exopolysaccharides Bioresource recovery Aggregation-induced luminescence

Biomarkers for predicting efficacy of chimeric antigen receptor T cell therapy and their detection methods

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iLABMED 2024年第1期2卷 14-26页

作者： bo zou Yanzhou Song Ning Li Zhongyi Fan Jie Li Yuanzheng Peng Wanshan Wei Yuzi Zhang Yinan Su Xianmin Meng Hongzhou Lu Xingding Zhang Xiaohua Tan Qibin Liao Department of Oncology and Bio-Therapeutic Center Shenzhen Third People's HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhenChina Molecular Cancer Research Center School of MedicineShenzhen Campus of Sun Yat-Sen UniversitySun Yat-Sen UniversityShenzhenChina Department of Hepato-Biliary Surgery Shenzhen Third People's HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhenChina Institute for Hepatology National Clinical Research Centre for Infectious DiseasesShenzhen Third People's HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhenChina Kidney Transplant Department(Liver Transplant Department) Transplant CenterNational Clinical Research Center for Infectious DiseaseShenzhen Third People's HospitalThe Second Affiliated HospitalSouthern University of Science and TechnologyShenzhenChina Institute of Translational Medicine First Affiliated Hospital of Shenzhen UniversityShenzhen Second People's HospitalShenzhenGuangdongChina BASIS International School HuizhouGuangdongChina Department of Pharmacy Shenzhen Third People's HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhenChina

Cancer immunotherapy has emerged as the fourth most prevalent approach to tumor treatment,alongside surgery,radiotherapy,and chemotherapy.After several decades of development,chimeric antigen receptor T(CAR-T)cell therapy,a promising branch of adoptive T-cell therapy,has demonstrated superior efficacy and safety in comparison to other cell therapies in the treatment of cancer.At present,CAR-T cells are predominantly used to treat hematological malignancies,although their application in solid tumors is being readily investigated.Although numerous studies have examined the biomarkers associated with the safety of CAR-T cell therapy,few have evaluated predictors of CAR-T cell therapeutic efficacy.Thus,the primary objective of this review article was to provide a comprehensive overview of the factors predicting the efficacy of CAR-T cell therapy,with a particular focus on biomarkers and their detection methods.

关键词： biomarkers cancer immunotherapy CAR-T cell detection methods therapeutic efficacy

Discovery of proqodine A derivatives with antitumor activity targeting NAD(P)H:quinone oxidoreductase 1 and nicotinamide phosphoribosyltransferase

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Chinese Journal of Natural Medicines 2024年第1期22卷 75-88页

作者： SONG Jiangzhou zou Guiqing ZHAO Zhou ZHU Ya XUE Jiayu AO Lanjia SUN Huiyong HAO Haiping ZHANG bo XU Xiaowei State Key Laboratory of Natural Medicines Key Lab of Drug Metabolism and PharmacokineticsChina Pharmaceutical UniversityNanjing 210009China State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China

NAD(P)H:quinone oxidoreductase 1(NQO1)is a flavin protease highly expressed in various cancer cells.NQO1 catalyzes a futile redox cycle in substrates,leading to substantial reactive oxygen species(ROS)production.This ROS generation results in extensive DNA damage and elevated poly(ADP-ribose)polymerase 1(PARP1)-mediated consumption of nicotinamide adenine dinucleotide(NAD^(+)),ultimately causing cell death.Nicotinamide phosphoribosyltransferase(NAMPT),the rate-limiting enzyme in the NAD^(+)salvage synthesis pathway,emerges as a critical target in cancer therapy.The concurrent inhibition of NQO1 and NAMPT triggers hyperactivation of PARP1 and intensive NAD+depletion.In this study,we designed,synthesized,and assessed a novel series of proqodine A derivatives targeting both NQO1 and NAMPT.Among these,compound T8 demonstrated potent antitumor properties.Specifically,T8 selectively inhibited the proliferation of MCF-7 cells and induced apoptosis through mechanisms dependent on both NQO1 and NAMPT.This discovery offers a promising new molecular entity for advancing anticancer research.

关键词： NQO1 ROS NAMPT NAD^(+) T8

Electrocatalytic Performance of Carbon Layer and Spherical Carbon/Carbon Cloth Composites Towards Hydrogen Evolution from the Direct Electrolysis of Bunsen Reaction Product

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Chemical Research in Chinese Universities 2024年第1期40卷 109-118页

作者： ZHANG Wanjia GUO Tingyu LIU Yanhua ZHANG Xuewei zou bo ZHAO Chun SUO Hui WANG Hui ZHAO Xu College of Chemistry Jilin UniversityChangchun130012P.R.China State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun130012P.R.China Department of Chemical and Biological Engineering University of SaskatchewanSaskatoonSKS7N 5A9Canada

A composite material comprising a carbon layer and spherical carbon/carbon cloth(C-SC/CC)was fabricated using a hydrothermal-pyrolysis method,employing carbon cloth as the substrate and glucose as the carbon source.The C-SC/CC electrode was evaluated as an electrocatalytic electrode for hydrogen production by electrolysis of Bunsen reaction products.The electrode prepared with 4 g of glucose and annealed at 800°C showed excellent electrocatalytic activity.It requires only a potential of 185 mV(vs.SCE)to achieve a current density of 10 mA/cm2.Furthermore,the electrode demonstrated good stability with a 6%loss in current density after 1000 cycles of scanning from 0.2 V to 1.2 V.These results indicate the potential of the SC/CC electrode as an efficient and durable electrocatalyst for the electrolysis of H2SO4 and HI.

关键词： Electrolysis of Bunsen reaction product Carbon material Composite material Hydrogen production

A novel polyionic liquid with lubricity and viscosity-increasing dual functionalities as the additive in aqueous lubrication system

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Friction 2024年第4期12卷 698-710页

作者： bo YU Kun zou Rui WANG Qiang CHEN Rui DONG Xiao LIU Jiaying ZHANG Wenquan LV Qiangliang YU Meirong CAI Feng ZHOU College of Science Nanjing Forestry UniversityNanjing 210037China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China Shandong Laboratory of Advanced Materials and Green Manufacturing at Yantai Yantai 264006China Yantai Zhongke Research Institute of Advanced Materials and Green Chemical Engineering Yantai 264006China Institute of Polymer Materials Nanjing Forestry UniversityNanjing 210037China

The polyionic liquid poly-PEGMA-r-METAC(PPM)with quaternary ammonium has been synthesized and evaluated as additive in aqueous lubricating fluids.The rheological behavior of aqueous lubricating fluids with PPM has been characterized to confirm PPM’s function as a viscosity modifier.The tribological behavior of aqueous lubricating fluids with PPM has been investigated on SRV-V and MTM testing machines.It was found that PPM has excellent viscosity-increasing,lubricating,and anti-wear properties as an additive for aqueous,which can be attributed to the ability of PPM to form the protective film and boundary tribofilm generated from complex tribochemical reaction on rubbing surface.The obtained PPM with dual functions of anti-corrosion additives and viscosity index improver can play an important role in diverse lubrication regimes.

关键词： polyionic liquid lubricant additives viscosity modifier lubrication regime

Griseofulvin enantiomers and bromine-containing griseofulvin derivatives with antifungal activity produced by the mangrove endophytic fungus Nigrospora sp.QQYB1

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Marine Life Science & Technology 2024年第1期6卷 102-114页

作者： Ge zou Wencong Yang Tao Chen Zhaoming Liu Yan Chen Taobo Li Gulab Said Bing Sun bo Wang Zhigang She School of Chemistry Sun Yat-sen UniversityGuangzhou 510275China State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and ApplicationInstitute of MicrobiologyGuangdong Academy of SciencesGuangzhou 510070China School of Pharmacy Anhui Medical UniversityHefei 230032China Department of Chemistry Women University SwabiSwabi 23430Pakistan

Marine microorganisms have long been recognized as potential sources for drug discovery.Griseofulvin was one of the first antifungal natural products and has been used as an antifungal agent for decades.In this study,12 new griseofulvin derivatives[(±)-1-2,(+)-3,(±)-4,10-12,and 14-15]and two new griseofulvin natural products(9 and 16)together with six known analogues[(-)-3,5-8,and 13]were isolated from the mangrove-derived fungus Nigrospora sp.QQYB1 treated with 0.3%NaCl or 2%NaBr in rice solid medium.Their 2D structures and absolute configurations were established by extensive spectroscopic analysis(1D and 2D NMR,HRESIMS),ECD spectra,computational calculation,DP4+analysis,and X-ray single-crystal diffraction.Compounds 1-4 represent the first griseofulvin enantiomers with four absolute configurations(2S,6'S;2R,6'R;2S,6'R;2R,6'S),and compounds 9-12 represent the first successful production of brominated griseofulvin derivatives from fungi via the addition of NaBr to the culture medium.In the antifungal assays,compounds 6 and 9 demonstrated significant inhibitory activities against the fungi Colletotrichum truncatum,Microsporum gypseum,and Trichophyton mentagrophyte with inhibition zones varying between 28 and 41 mm(10μg/disc).The structure-activity relationship(SAR)was analyzed,which showed that substituents at C-6,C-7,C-6'and the positions of the carbonyl and double bond of griseofulvin derivatives significantly affected the antifungal activity.

关键词： Mangrove endophytic fungus Nigrospora sp. Griseofulvin Antifungal activity

Computed tomography radiogenomics:A potential tool for prediction of molecular subtypes in gastric stromal tumor

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1296-1308页

作者： Xiao-Nan Yin Zi-Hao Wang Li zou Cai-Wei Yang Chao-Yong Shen Bai-Ke Liu Yuan Yin Xi-Jiao Liu bo Zhang Gastric Cancer Research Center West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Paediatric Surgery West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Radiology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Gastrointestinal Surgery Sichuan University West China HospitalChengdu 610041Sichuan ProvinceChina

BACKGROUND Preoperative knowledge of mutational status of gastrointestinal stromal tumors(GISTs)is essential to guide the individualized precision therapy.AIM To develop a combined model that integrates clinical and contrast-enhanced computed tomography(CE-CT)features to predict gastric GISTs with specific genetic mutations,namely KIT exon 11 mutations or KIT exon 11 codons 557-558 deletions.METHODS A total of 231 GIST patients with definitive genetic phenotypes were divided into a training dataset and a validation dataset in a 7:3 ratio.The models were constructed using selected clinical features,conventional CT features,and radiomics features extracted from abdominal CE-CT images.Three models were developed:ModelCT sign,modelCT sign+rad,and model CTsign+rad+clinic.The diagnostic performance of these models was evaluated using receiver operating characteristic(ROC)curve analysis and the Delong test.RESULTS The ROC analyses revealed that in the training cohort,the area under the curve(AUC)values for model_(CT sign),model_(CT sign+rad),and modelCT_(sign+rad+clinic)for predicting KIT exon 11 mutation were 0.743,0.818,and 0.915,respectively.In the validation cohort,the AUC values for the same models were 0.670,0.781,and 0.811,respectively.For predicting KIT exon 11 codons 557-558 deletions,the AUC values in the training cohort were 0.667,0.842,and 0.720 for model_(CT sign),model_(CT sign+rad),and modelCT_(sign+rad+clinic),respectively.In the validation cohort,the AUC values for the same models were 0.610,0.782,and 0.795,respectively.Based on the decision curve analysis,it was determined that the model_(CT sign+rad+clinic)had clinical significance and utility.CONCLUSION Our findings demonstrate that the combined modelCT_(sign+rad+clinic)effectively distinguishes GISTs with KIT exon 11 mutation and KIT exon 11 codons 557-558 deletions.This combined model has the potential to be valuable in assessing the genotype of GISTs.

关键词： Gastrointestinal stromal tumor Radiomics Gene mutation Computed tomography Model