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A universal method for rapid and large‐scale growth of layered crystals

SmartMat 2020年第1期1卷 77-84页

作者： Apoorva Chaturvedi bo Chen Keke Zhang Qiyuan He Gwang‐Hyeon nam Lu You Zhuangchai Lai Chaoliang Tan Thu Ha Tran Guigao Liu Jiadong Zhou Zheng Liu Junling Wang Edwin H.T.Teo Hua Zhang Center for Programmable Materials School of Materials Science and EngineeringNanyang Technological UniversitySingaporeSingapore Department of Chemistry City University of Hong KongHong KongChina Department of Materials Science and Engineering City University of Hong KongHong KongChina Jiangsu Key Laboratory of Thin Films School of Physical Science and TechnologySoochow UniversitySuzhouChina Department of Electrical Engineering City University of Hong KongHong KongChina Department of Physics Southern University of Science and TechnologyShenzhenGuangdongChina School of Electric and Electronic Engineering Nanyang Technological UniversitySingaporeSingapore Hong Kong Branch of National Precious Metals Material Engineering Research Center(NPMM) City University of Hong KongHong KongChina

Layered van der Waals(vdW)materials,consisting of atomically thin layers,are of paramount importance in physics,chemistry,and materials science owing to their unique properties and various promising ***,their fast and large‐scale growth via a general approach is still a big challenge,severely limiting their practical ***,we report a universal method for rapid(~60 min)and large‐scale(gram scale)growth of phase‐pure,high‐crystalline layered vdW materials from their elementary powders via microwave plasma heating in sealed *** method can be used for growth of 30 compounds with different components(binary,ternary,and quaternary)and *** ferroelectric and transport properties of mechanically exfoliated flakes validate the high crystal quality of the grown *** study provides a general strategy for the fast and large‐scale growth of layered vdW materials with appealing physiochemical properties,which could be used for various promising applications.

关键词： 2D materials ferroelectric field‐effect transistors layered compounds universal method

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Multi-directionally wrinkle-able textile OLEDs for clothing-type displays

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npj Flexible Electronics 2020年第1期4卷 288-296页

作者： Seungyeop Choi Woosung Jo Yongmin Jeon Seonil Kwon Jeong Hyun Kwon Young Hyun Son Junmo Kim Jun Hong Park Hyuncheol Kim Ho Seung Lee Minwoo nam eun Gyo Jeong Jeong Bin Shin Taek-Soo Kim Kyung Cheol Choi School of Electrical Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Department of Mechanical Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea

A clothing-type wearable display can be utilized in fashion,bio-healthcare,and safety industries as well as smart textiles for the internet of things(IoTs)and wearable *** response to this trend,we demonstrate a textile display that can endure the active movements of a human *** can be applied to any kind of textile,and is durable against conditions such as rain,sweat,and *** a key technology for realizing the multi-directional wrinkle-able textile display,we fabricated a stress-lowering textile platform with an ultrathin planarization layer replicated from the flat surface of *** elastomeric strain buffer for reducing mechanical stress is also inserted into the textile ***,organic light-emitting diodes(OLEDs)with red,green and blue color,thin film transistors(TFTs)fabricated at a low temperature below 150℃,and a washable encapsulation layer blocking both gas and liquid were demonstrated on the textile platform.

关键词： OLEDs IoT directional

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IN VITRO DEVELOPMENT OF boVINE SOMATIC CELL NUCLEAR TRANSFER EMBRYOS TREATED WITH FLAVONOID

IN VITRO DEVELOPMENT OF BOVINE SOMATIC CELL NUCLEAR TRANSFER...

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The 5th Annual Conference of the Asian Reproductive Biotechnology Society

作者： Cheol Tae JIN eun Young KIM nam Hyung KIM Se Pill PARK Cheju National University

＜正＞The success of somatic cell cloning gives promise to applications such as species preservation,cell therapy and production of somatic cell nuclear transfer（SCNT）embryonic stem *** improve the in vitro developm... 详细信息

关键词： bovine embryo Flavonoid Somatic cell nuclear transfer (SCNT)

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Hybridisation of perovskite nanocrystals with organic molecules for highly efficient liquid scintillators

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Light(Science & Applications) 2020年第1期9卷 530-538页

作者： Sangeun Cho Sungwoo Kim Jongmin Kim Yongcheol Jo Ilhwan Ryu Seongsu Hong Jae-Joon Lee Seungnam Cha eun Binam Sang Uck Lee Sam Kyu Noh Hyungsang Kim Jungwon Kwak Hyunsik Im Division of Physics and Semiconductor Science Dongguk UniversitySeoul 04620Republic of Korea Department of Radiation Oncology Asan Medical CenterSeoul 05505Republic of Korea Department of Energy and Materials Engineering Dongguk UniversitySeoul 04620Republic of Korea Department of Physics Sungkyunkwan UniversitySuwon 2066Republic of Korea Department of Bionano Technology and Department of Applied Chemistry Hanyang UniversityAnsan 15588Republic of Korea

Compared with solid scintillators,liquid scintillators have limited capability in dosimetry and radiography due to their relatively low light ***,we report a new generation of highly efficient and low-cost liquid scintillators constructed by surface hybridisation of colloidal metal halide perovskite CsPbA_(3)(A:Cl,Br,I)nanocrystals(NCs)with organic molecules(2,5-diphenyloxazole).The hybrid liquid scintillators,compared to state-of-the-art CsI and Gd_(2)O_(2)S,demonstrate markedly highly competitive radioluminescence quantum yields under X-ray irradiation typically employed in diagnosis and *** and theoretical analyses suggest that the enhanced quantum yield is associated with X-ray photon-induced charge transfer from the organic molecules to the ***-resolution X-ray imaging is demonstrated using a hybrid CsPbBr_(3) NC-based liquid *** novel X-ray scintillation mechanism in our hybrid scintillators could be extended to enhance the quantum yield of various types of scintillators,enabling low-dose radiation detection in various fields,including fundamental science and imaging.

关键词： perovskite liquid typically

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Stretchable Strain Sensors Fabricated by Screen Printing of Silver Paste on the Surface Modified Transparent Elastomeric Polyurethane Films

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Materials Sciences and Applications 2018年第13期9卷 1008-1020页

作者： Chang Gyu Lee bo Seok Kwon Hyun Min nam Duck Min Seo Jinwoo Park Hyuc Hwangbo Lee Soon Park Su Yong nam Department of Graphic Arts Information Engineering Pukyong Natioinal University Busan Korea School of Materials Science and Engineering Ulsan National Institute of Science and Technology (UNIST) Ulsan Korea Screen Finetech Solutions Co. Ltd. Kyoto Japan FP Co. Ltd. Busan Korea

Strain sensors for human-motion detection must offer high stretchability, high sensitivity, fast response, and high recovery speed. In this study, we choose silver paste as a sensing material and use a screen printing method to fabricate the strain sensor based upon an electrical-resistance mechanism. After curing elastomeric polyurethane film with a thickness of 150 μm on PET film, the polyester resin mixed with blocked isocyanate curing agent was coated as a masking layer to reduce the film’s stickiness. The effect of the polyester masking layer upon the silver paste screen printing process was examined using a rolling-ball-tack test, TGA analysis of polyester resins, and cured silver-electrode films. The cost-effective strain sensor fabricated by using silver paste and screen printing processes on the stretchable-polyurethane-substrate film showed high sensitivity and fast response in a strain range of up to 100%.

关键词： Stretchable Strain Sensor Screen Printing Silver Paste

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Cyanidine-3-O-Galactoside Enriched <i>Aronia melanocarpa</i>Extract Inhibits Adipogenesis and Lipogenesis via Down-Regulation of Adipogenic Transcription Factors and Their Target Genes in 3T3-L1 Cells

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Food and Nutrition Sciences 2019年第2期10卷 128-147页

作者： Su-Min Lim Jae In Jung nam Young Kim Jung-Shik Bae Hyun Sook Lee eun Ji Kim Center for Efficacy Assessment and Development of Functional Foods and Drugs Hallym UniversityChuncheonRepublic of Korea R&D Center Wellfine Co.Ltd.ChuncheonRepublic of Korea Department of Food Science&Nutrition Dongseo UniversityBusanRepublic of Korea

Aronia melamocarpa (AM) is a rich source of anthocyanins, which are known to help prevent obesity. The cyanidine-3-O-galactoside enriched AM extract (AM-Ex) containing more cyanidine-3-O-galactoside than conventional AM extract was recently developed. The objective of this study was to examine the effect of AM-Ex on adipogenesis and its action mechanisms in vitro using 3T3-L1 adipocytes. To examine the anti-obesity effect of AM-Ex, 3T3-L1 cells were induced adipocyte differentiation and incubated with various concentration of AM-Ex. Lipid accumulation, cellular triglyceride content, mRNA expression of transcription factors and adipogenic genes were analyzed. Treatment with 100 - 400 μg/mL of AM-Ex resulted in a dose-dependent decrease in adipocyte differentiation and triglyceride accumulation. mRNA expression of adipogenic transcription factors, such as peroxisome proliferator-activated receptor gamma, CCAAT/enhancer binding protein α, sterol regulatory element-binding protein 1 were decreased. The level of gene expression of adipogenesis and lipogenesis-related genes, such as adipocyte protein 2, lipoprotein lipase, acetyl-CoA carboxylase, ATP-citrate lyase and fatty acid synthase were decreased. These results suggest that AM-Ex alleviated risk factors related to obesity by modulating multiple pathways associated with adipogenesis.

关键词： Obesity Adipocyte Adipogenesis Lipogenesis Transcription Factor Adipocyte Protein 2

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LRRK2, GBA and their interaction in the regulation of autophagy: implications on therapeutics in Parkinson’s disease

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Translational Neurodegeneration 2022年第1期11卷 869-882页

作者： Shirley Yin-Yu Pang Rachel Cheuk nam Lo Philip Wing-Lok Ho Hui-Fang Liu eunice eun Seo Chang Chi-Ting Leung Yasine Malki Zoe Yuen-Kiu Choi Wing Yan Wong Michelle Hiu-Wai Kung David boyer Ramsden Shu-Leong Ho Division of Neurology Department of MedicineQueen Mary HospitalUniversity of Hong KongHong KongChina School of Biomedical Sciences Li Ka Shing Faculty of MedicineUniversity of Hong KongHong KongChina Institute of Metabolism and Systems Research University of BirminghamBirminghamUK.

Mutations in leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GBA) represent two most common genetic causes of Parkinson’s disease (PD). both genes are important in the autophagic-lysosomal pathway (ALP), defects of which are associated with α-synuclein (α-syn) accumulation. LRRK2 regulates macroautophagy via activation of the mitogen activated protein kinase/extracellular signal regulated protein kinase (MAPK/ERK) kinase (MEK) and the calcium-dependent adenosine monophosphate (AMP)-activated protein kinase (AMPK) pathways. Phosphorylation of Rab GTPases by LRRK2 regulates lysosomal homeostasis and endosomal trafficking. Mutant LRRK2 impairs chaperone-mediated autophagy, resulting in α-syn binding and oligomerization on lysosomal membranes. Mutations in GBA reduce glucocerebrosidase (GCase) activity, leading to glucosylceramide accumulation, α-syn aggregation and broad autophagic abnormalities. LRRK2 and GBA influence each other: GCase activity is reduced in LRRK2 mutant cells, and LRRK2 kinase inhibition can alter GCase activity in GBA mutant cells. Clinically, LRRK2 G2019S mutation seems to modify the effects of GBA mutation, resulting in milder symptoms than those resulting from GBA mutation alone. However, dual mutation carriers have an increased risk of PD and earlier age of onset compared with single mutation carriers, suggesting an additive deleterious effect on the initiation of PD pathogenic processes. Crosstalk between LRRK2 and GBA in PD exists, but its exact mechanism is unclear. Drugs that inhibit LRRK2 kinase or activate GCase are showing efficacy in pre-clinical models. Since LRRK2 kinase and GCase activities are also altered in idiopathic PD (iPD), it remains to be seen if these drugs will be useful in disease modification of iPD.

关键词： Parkinson’s disease Interaction LRRK2 GBA GCase Mutation Autophagy α-Synuclein

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Serum 25-hydroxyvitamin deficiency in middle-aged a cross-sectional study D levels and testosterone Korean men：

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Asian Journal of Andrology 2015年第2期17卷 324-328,I0012页

作者： Young Jin Tak Jeong Gyu Lee Yun Jin Kim nam Cheol Park Sang Soo Kim Sangyeoup Lee Byung Mann Cho eun Hee Kong Dong Wook Jung Yu Hyeon Yi Department of Family Medicine Pusan National University School of Medicine Busan Korea Biomedical Research Institute Pusan National University Hospital Busan Korea Department of Urology Pusan National University School of Medicine Busan Korea Department of Internal Medicine Pusan National University School of Medicine Busan Korea Medical Education Unit Pusan National University School of Medicine Yangsan Korea Department of Preventive Medicine and Occupational Medicine Pusan National University School of Medicine Yangsan Korea Department of Family Medicine College of Medicine Kosin University Busan Korea.

Previous studies have demonstrated that male hypogonadism is associated with a low level of vitamin D. However, no reports have investigated the effects of vitamin D on testosterone levels in Korean men. Our aim was to investigate whether testosterone levels are associated with serum vitamin D levels and whether seasonal variation exists. This cross-sectional study analyzed serum 25-hydroxyvitamin D [25（OH）D], total testosterone （TT）, and free testosterone （FT） in 652 Korean men over 40 years of age who had undergone a comprehensive medical examination. The average age of the subjects was 56.7± 7.9 years, and the mean serum 25（OH）D, TT and FT levels were 21.23 ± 7.9 ng m1-1, 4.70 ±1.6 ng m1-1, and 8.12± 3.3 pg m1-1, respectively. In the multiple linear regression model, 25（OH）D showed positive association with TT （β =0.137, P〈 0.001） and FT （p =0.103, P= 0.008）. 25（OH） D and FT showed similar seasonal or monthly variation after adjustment for age. A vitamin D deficiency [25（OH）D 〈 20 ng m1-1] was associated with an increased risk of deficiencies of TT （〈2.30 ng ml-1）（odds ratio [OR]： 2.65; 95% confidence interval [CI]. 1.21-5.78, P = 0.014） and FT （〈6.50 pg ml-1）（OR： 1.44; 95% Ch 1.01-2.06 P = 0.048） after adjusting for age, season, body mass index, body composition, chronic disease, smoking, and alcohol use. In conclusion, we demonstrated a positive correlation between 25（OH）D and testosterone, which showed similar seasonal variation in Korean men.

关键词： 25-hydroxyvitamin D hypogonadism seasons testosterone vitamin D

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Assessing the impact of meteorological factors on malaria patients in demilitarized zones in Republic of Korea

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Infectious Diseases of Poverty 2016年第1期5卷 180-191页

作者： Se-Min Hwang Seok-Joon Yoon Yoo-Mi Jung Geun-Yong Kwon Soo-nam Jo eun-Jeong Jang Myoung-Ok Kwon Korea Human Resource Development Institute for Health&Welfare OsongRepublic of Korea Department of Preventive Medicine College of MedicineKorea UniversitySeoulRepublic of Korea Department of Preventive Medicine Armed Forces Medical CommandSeongnamRepublic of Korea Department of Health Policy and Hospital Management Graduate School of Public HealthKorea University73 Inchon-ro.Seongbuk-GuSeoul 136-705Republic of Korea Korea Armed Forces Nursing Academy 90 Jaun-roYuseong-guDaejeon 305-153Republic of Korea Korean Centers for Disease Control and Prevention OsongRepublic of Korea

Background:The trend of military patients becoming infected with vivax malaria reemerged in the Republic of Korea(ROK)in *** common explanation has been that infective Anopheles mosquitoes from the Democratic People’s Republic of Korea have invaded Republic of Korea’s demilitarized zone(DMZ).The aim of this study was to verify the relationship between meteorological factors and the number of malaria patients in the military in this ***:The authors estimated the effects of meteorological factors on vivax malaria patients from the military based on the monthly number of malaria cases between 2006 and ***,precipitation,snow depth,wind velocity,relative humidity,duration of sunshine,and cloud cover were selected as the meteorological factors to be studied.A systematic pattern in the spatial distribution of malaria cases was assessed using the Moran’s *** causality tests and cross-correlation coefficients were used to evaluate the relationship between meteorological factors and malaria patients in the ***:Spatial analysis revealed significant clusters of malaria patients in the military in Republic of Korea in 2011(Moran’s I=0.136,p-value=0.026).In the six years investigated,the number of malaria patients in the military in Paju decreased,but the number of malaria patients in the military in Hwacheon and Chuncheon *** average,maximum and minimum temperatures;wind velocity;and relative humidity were found to be predicting factors of malaria in patients in the military in *** contrast,wind velocity alone was not able to predict malaria in Hwacheon and Chuncheon,however,precipitation and cloud cover were able to predict malaria in Hwacheon and ***:This study demonstrated that the number of malaria patients in the military is correlated with meteorological *** variation in occurrence of malaria cases was principally attributed to differences in meteorological factors by regions of

关键词： Malaria Plasmodium vivax Meteorological factors

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The Apoptotic Effect of the Methanol Extract of <i>Polygonum cuspidatum</i>through Up-Regulation Death Receptor 5 and CHOP in HSC-2 Human Oral Cancer Cells

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Journal of Cancer Therapy 2012年第1期3卷 1-6页

作者： Hyun-Ju Yu Ji-Ae Shin eun-Sun Choi Jae-Gyu Jeon nam-Pyo Cho Sung-Dae Cho Department of Oral Pathology School of Dentistry Institute of Oral Bioscience Chonbuk National University Jeonju South Korea

Polygonum cuspidatum is used as a traditional medicinal herb for the therapy of various diseases including several types of cancers. In the present study, we focused on addressing the anti-cancer activity and molecular mechanism of methanol extract of Polygonum cuspidatum (MEPC) in HSC-2 human oral cancer cells. The effect of MEPC on oral cancer cells was estimated by 3-(4,5-dimethylthiazol-20yl)-(3-carboxymethoxyphenyl)-2-(4-sulphophenyl)-2H-tetrazolium (MTS) assay, 4’-6-diamidino-2-phenylindole (DAPI) staining and Western blot analysis. MEPC inhibited the cell viability and induced apoptosis through the induction of death receptor (DR) 5. MEPC also increased the expression of C/EBP homologous protein/growth arrest and the DNA damage-inducible gene 153 (CHOP), a transcription factor induced by ER stress. Thus, we concluded that the induction of CHOP leading to DR5 up-regulation is required for the anti-cancer activity of MEPC in HSC-2 cells and MEPC may be a promising drug candidate for oral cancer.

关键词： Polygonum cuspidatum Endoplasmic Reticulum Stress C/EBP Homologous Protein/Growth Arrest and the DNA Damage-Inducible Gene 153 (CHOP) Death Receptor 5 (DR5) Apoptosis Human Oral Cancer Cell

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