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Progress in bioreactors of bioartificial livers

Hepatobiliary & pancreatic Diseases International 2009年第2期8卷 134-140页

作者： yu, Cheng-bo pan, Xiao-Ping Li, Lan-Juan Zhejiang Univ Sch Med Affiliated Hosp 1 State Key Lab Diag & Treatment Infect Dis Hangzhou 310003 Zhejiang Peoples R China

BACKGROUND: Bioartificial liver support systems are becoming an effective therapy for hepatic failure. Bioreactors, as key devices in these systems, can provide a favorable growth and metabolic environment, mass exchange, and immunological isolation as a platform. Currently, stagnancy in bioreactor research is the main factor restricting the development of bioartificial liver support systems. DATA SOURCES: A PubMed database search of English-language literature was performed to identify relevant articles using the keywords 'bioreactor', 'bioartificial liver', 'hepatocyte', and 'liver failure'. More than 40 articles related to the bioreactors of bioartificial livers were reviewed. RESULTS: Some progress has been made in the improvement of structures, functions, and modified macromolecular materials related to bioreactors in recent years. The current data on the improvement of bioreactor configurations for bioartificial livers or on the potential of the use of certain scaffold materials in bioreactors, combined with the clinical efficacy and safety evaluation of cultured hepatocytes in vitro, indicate that the AMC (Academic Medical Center) BAL bioreactor and MELS (modular extracorporeal liver support) BAL bioreactor system can partly replace the synthetic and metabolic functions of the liver in phase I clinical studies. In addition, it has been indicated that the microfluidic PDMS (polydimethylsiloxane) bioreactor, or SlideBioreactor, and the microfabricated grooved bioreactor are appropriate for hepatocyte culture, which is also promising for bioartificial livers. Similarly, modified scaffolds can promote the adhesion, growth, and function of hepatocytes, and provide reliable materials for bioreactors. CONCLUSIONS: Bioreactors, as key devices in bioartificial livers, play an important role in the therapy for liver failure both now and in the future. Bioreactor configurations are indispensable for the development of bioartificial livers used for liver failure, just as

关键词： bioreactor bioartificial liver hepatocyte liver failure

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Human adipose tissue-and umbilical cord-derived stem cells: which is a better alternative to treat spinal cord injury?

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Neural Regeneration Research 2020年第12期15卷 2306-2317页

作者： Ai-Mei Liu bo-Li Chen Ling-Tai yu Tao Liu Ling-Ling Shi pan-pan yu Yi-bo Qu Kwok-Fai So Li-Bing Zhou Guangdong-Hongkong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Guangzhou Regenerative Medicine and Health Guangdong Laboratory GuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

Multiple types of stem cells have been proposed for the treatment of spinal cord injury,but their comparative information remains *** this study,a rat model of T10 contusion spinal cord injury was established by the impactor *** umbilical cord-derived mesenchymal stem cells(UCMSCs)or human adipose tissue-derived mesenchymal stem cells(ADMSCs)(2.5μL/injection site,1×10^5 cells/μL)was injected on rostral and caudal of the injury segment on the ninth day after *** injected with mesenchymal stem cell culture medium were used as *** results show that although transplanted UCMSCs and ADMSCs failed to differentiate into neurons or glial cells in vivo,both significantly improved motor and sensory *** spinal cord injury,UCMSCs and ADMSCs similarly promoted spinal neuron survival and axonal regeneration,decreased glial scar and lesion cavity formation,and reduced numbers of active *** analysis of spinal samples showed a specific increase of interleukin-10 and decrease of tumor necrosis factorαin the ADMSC group,as well as a downregulation of macrophage inflammatory protein 3αin both UCMSC and ADMSC groups at 3 days after cell *** of interleukin-10 and interleukin-13 was observed in both UCMSC and ADMSC groups at 7 days after cell *** tagging for relative and absolute quantitation proteomics analyses showed that UCMSCs and ADMSCs induced changes of multiple genes related to axonal regeneration,neurotrophy,and cell apoptosis in common and specific *** conclusion,UCMSC and ADMSC transplants yielded quite similar contributions to motor and sensory recovery after spinal cord injury via anti-inflammation and improved axonal ***,there were some differences in cytokine and gene expression induced by these two types of transplanted *** experiments were approved by the Laboratory Animal Ethics Committee at Jinan University(approval No.20180228026)on Febru

关键词： behavior central nervous system factor inflammation model spinal cord stem cells transplantation

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Difference of sintering performance of different types of limonitic nickel laterite

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Journal of Iron and Steel Research International 2023年第1期30卷 21-30页

作者： yu-xiao Xue Jian pan De-qing Zhu Xin Wang bo-hua Li Wei Liu School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083HunanChina

To achieve the more extensive utilization of limonitic nickel laterite,the difference of sintering performance of different types of limonitic nickel laterite including high-gangue and low-gangue nickel ores was investigated by sinter pot tests and relevant mechanism analyses such as thermodynamic analysis and the chemistry and mineralogy of product *** the type of limonitic nickel laterite transformed from high-gangue to low-gangue nickel ore,tumble index and productivity are improved from 45.87%and 0.97 t m^(-2) h^(-1) to 50.16%and 1.05 t m^(-2) h^(-1),respectively,and solid fuel rate is reduced from 140.52 to 131.13 kg/t,indicating that the low-gangue nickel ore possesses relatively better sintering *** is mainly due to the fact that the much lower contents of MgO and Al2O3 improve the formation ability and fluidity of liquid phase,which eventually contributes to the formation of relatively tighter sinter microstructure with the lower sinter porosity,more silico-ferrite of calcium and alumina amount and better bonding of hercynite by liquid *** addition,the metallurgical performance and nickel content of product sinter would not be reduced as different types of limonitic nickel laterite are blended for *** this basis,it is entirely feasible to more widely utilize limonitic nickel laterite and simultaneously obtain much better-quality Ni-containing product sinter via effective sintering strengthening technologies.

关键词： Limonitic nickel laterite Sintering Stainless steel High-melting component Extensive utilization

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Degradation of chlorpyrifos alone and in combination with chlorothalonil and their effects on soil microbial populations

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Journal of Environmental Sciences 2008年第4期20卷 464-469页

作者： CHU Xiaoqiang FANG Hua pan Xuedong WANG Xiao SHAN Min FENG bo yu yunlong Department of Plant Protection College of Agriculture and Biotechnology Zhejiang University Hangzhou 310029 China

In practice, pesticides are usually applied simultaneously or one after another for crop protection, and this type of pesticide application often leads to a combined contamination of pesticide residues in the soil environment. A laboratory study was conducted to investigate the influence of chlorothalonil on chlorpyrifos degradation and its effects on soil bacterial, fungal, and actinomycete populations. Under the experimental conditions here, the half-lives of chlorpyrifos alone, and in combination with chlorothalonil, at the recommended and double dosages, were measured to be 3.24, 2.77, and 2.63 d, respectively. Chlorpyrifos degradation was not significantly altered by its combination with chlorothalonil. However, the inhibitory effect of chlorpyrifos on soil microorganisms was increased by its combination with chlorothalonil, and the increase was related to the levels of chlorothalonil added. Compared to those in the controls, the populations of bacteria, fungi, and actinomycetes were significantly reduced by 44.1%, 61.1%, and 72.8%, respectively, on the first day after treatment （DAT） by chlorpyrifos alone. With the addition of chlorothalonil, the inhibition was increased to 55.2%, 79.3%, and 85,8% at the recommended dosage, and 86.0%, 94.1%, and 90.8% at the double dosage, at one DAT, respectively. The results suggested that combined effects should be taken into account to assess the actual impacts of pesticide applications.

关键词： pesticide soil microorganism chlorpyrifos chlorothalonil combination

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Enhanced electrochemical CO_(2)reduction coupled with urea oxidation using bifunctional atomically dispersed CuNi catalysts

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Nano Research 2025年第1期18卷 208-216页

作者： Wenjie Wu Haoyang Zhou Ying Liu Yifei pan Qingqing Chen yu Zhang Junjie Mao Wenjie Ma Ping yu Beijing National Laboratory for Molecular Sciences Key Laboratory of Analytical Chemistry for Living BiosystemsInstitute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China College of Chemistry and Materials Science Anhui Normal UniversityWuhu 241002China University of Chinese Academy of Sciences Beijing 100049China

The electrochemical conversion of carbon dioxide(CO_(2))into chemical fuels represents a promising approach for addressing global carbon balance ***,this process is hindered by the kinetic limitations of anodic reactions,usually the oxygen evolution reaction,resulting in less efficient production of high value-added ***,we report an integrated electrocatalytic system that couples CO_(2)reduction reaction(CO_(2)RR)with urea oxidation reaction(UOR)using a bifunctional electrocatalyst with atomically dispersed dual-metal CuNi sites anchored on bamboo-like nitrogen-doped carbon nanotubes(CuNi-CNT),which were synthesized through a one-step pyrolysis *** bifunctional CuNi-CNT catalyst exhibits a near 100%CO Faraday efficiency for CO_(2)RR over a wide potential range and outstanding UOR performance with a negatively shifted potential of 210 mV at 10 mA·cm^(-2).In addition,we assemble a two-electrode electrolyzer using bifunctional CuNi-CNT-modified carbon fiber paper electrodes as both cathode and anode,capable of operating at a remarkably low cell voltage of 1.81 V at 10 mA·cm-2,significantly lower than conventional *** study provides a novel avenue to achieving an efficient carbon cycle with reduced electric power consumption.

关键词： electrochemical conversion bimetallic site catalyst bifunctional electrocatalyst carbon dioxide reduction urea oxidation

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Volcanic Hazard Mapping for Changbaishan-Tianchi Region,China

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Journal of Earth Science 2024年第6期35卷 2030-2044页

作者： yuan Wan Jiandong Xu bo pan Jingwei Zhang Hongmei yu bo Zhao Feixiang Wei Jilin Changbaishan Volcano National Observation and Research Station Institute of GeologyChina Earthquake AdministrationBeijing100029China

Volcanic hazard zoning is an effective way to reduce and mitigate volcanic *** to its frequent magmatic unrest and potential for catastrophic eruption,the Changbaishan-Tianchi Volcano is currently the focus of attention for volcanic disaster prevention in *** study uses past eruption data obtained from geological surveys and geochronological studies,to construct simulations of tephra fall,pyroclastic flows,lava flows,and *** widely accepted numerical models were adopted to simulate each hazard at different eruption *** zoning was then conducted,producing a comprehensive hazards map of the Changbaishan-Tianchi *** map identifies areas of high,medium,and low hazard,mostly at 0-15,15-60,60-100 km from the *** work serves as the scientific basis for the authorities and general public in the areas around the Changbaishan-Tianchi Volcano in planning for future response,as well as provides a reference for hazard zoning in other areas potentially affected by volcanic hazards.

关键词： Changbaishan-Tianchi Volcano active volcano numerical models hazards mapping

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Initial Descent Phase Guidance for Hypersonic Glide vehicle 36

Initial Descent Phase Guidance for Hypersonic Glide vehicle

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第36届中国控制会议

作者： Sun Jian-bo pan Xing-hua Zhao yu-shan School of Astronautics Beihang University Beijing Electro-mechanical Engineering Institute

ISBN: (纸本)9781538629185

A novel initial descent guidance law based on the transition function is proposed for the hypersonic glide vehicle without offline nominal angle of attack（AOA） design and online iteration *** the variation of the gravitational acceleration,a new transition condition between the initial descent phase and the quasi-equilibrium glide phase is ***,the initial descent phase is divided into two sub-phases noted as the open-loop guidance phase and the transition scheme *** guidance command during the transition scheme phase is generated by transition functions firstly proposed in this paper,which can smoothly adjust the AOA to satisfy the transition *** simulation results show that the proposed guidance law can satisfy the transition condition and the path constraints.

关键词： Hypersonic glide vehicle quasi-equilibrium glide initial descent guidance transition function

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基于谐振网络控制策略的无线电能传输系统

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现代电子技术 2025年第2期48卷 109-114页

作者：潘星星李光平陈宇广东工业大学信息工程学院广东广州510006 深圳市磁迹科技有限公司广东深圳518054

为了提高无线电能传输系统的工作距离范围和效率,提出一种基于谐振网络控制策略的无线电能传输系统方案。该方案采用谐振电容控制电路和谐振电感控制电路来实现系统谐振频率的自适应匹配,进一步,通过对线圈的结构进行重构,优化线圈结构... 详细信息

为了提高无线电能传输系统的工作距离范围和效率,提出一种基于谐振网络控制策略的无线电能传输系统方案。该方案采用谐振电容控制电路和谐振电感控制电路来实现系统谐振频率的自适应匹配,进一步,通过对线圈的结构进行重构,优化线圈结构设计,调节不同距离下的互感和耦合系数,提高工作距离范围及功率传输性能。为了验证系统方案的可行性,首先通过磁场仿真和电路仿真进行验证,然后搭建无线电能传输样机进行性能测试。测试结果表明,相比于通用的无线电能传输系统,所提方案工作距离范围增加了50%,全距离范围内效率显著提升。

关键词：无线电能传输谐振网络谐振电容控制谐振电感控制传输效率串联拓扑线圈设计

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Magnetic and microwave absorbing properties of Ce-Co-based alloy powders driven with lanthanum content

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Journal of Rare Earths 2020年第7期38卷 749-754,I0003页

作者： yu He Shunkang pan Jingjing yu School of Material Science and Engineering Guilin University of Electronic TechnologyGuilin 541004China

The composites of Ce-Co-based alloys doped with La content were fabricated via a vacuum arc melting *** influences of La addition on microstructure,electromagnetic parameters,magnetic property and microwave absorbing property were measured by the corresponding *** morphology characteristics manifest that all samples display sheet structure,and the average particle size of alloy powders increases with increasing La content The saturation magnetization(MS) decreases with increasing La addition as a *** minimum reflection loss(RL) of La0.4Ce1.6Co17 alloy powder about-42.29 dB can be obtained about-42.29 dB at 7.84 GHz with the matching thickness of 1.8 mm,and the corresponding effective bandwidth can achieve about 2.24 *** addition,the minimum RL frequency moves towards a lower frequency region as the La content *** minimum RL of La0.3Ce1.7Co17alloy powder is less than-20 dB ranging from 1.2 to 2.4 mm in the whole 4-16 *** maximum bandwidth can reach about 4.88 GHz at the given thickness of 1.2 *** general,these all indicate that the La addition is beneficial to improving the microwave absorbing performance in both effective bandwidth and absorption intensity.

关键词： Ce-Co-Based alloys Magnetic property Microwave absorbing property Reflection loss Rare earths

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THE EXTENDED JACOBIAN ELLIPTIC FUNCTION EXpanSION METHOD AND ITS APPLICATIONS IN WEAKLY NONLINEAR WAVE EQUATIONS

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Journal of Hydrodynamics 2006年第3期18卷 352-361页

作者： HUANG Wen-hua LIU yu-lu LU Zhi-ming pan bo-ying LIU Mao-sheng Shanghai Institute of Applied Mathematics and Mechanics Shanghai University Shanghai 200072 China Department of Physics College of Science Huzhou University Huzhou 313000 China Shanghai Institute of Applied Mathematics and Mechanics Shanghai University Shanghai 200072 China PAN Bo-ying Basic Department YiChun Vocational Technical College Yichun 336000 China

The extended Jacobian elliptic function expansion method is introduced and applied to solve the coupled ZK equations and the coupled KP equations describing two weakly long nonlinear wave models in fluid system. Many types of doubly periodic traveling wave solutions are obtained. Under limiting conditions these solutions are reduced into solitary wave solutions.

关键词： Jacobian elliptic function expansion method,the coupled ZK equation the coupled KP equation

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