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Molecular dynamics of de novo telomere heterochromatin formation in budding yeast

Journal of Genetics and Genomics 2016年第7期43卷 451-465页

作者： Yi-Min Duan bo-o.zhou Jing Peng Xia-Jing Tong Qiong-Di Zhang Jin-Qiu zhou The State Key Laboratory of Molecular Biology Shanghai Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences University of Chinese Academy of Sciences 320 Yue Yang Road Shanghai 200031 China School of Life Science and Technology Shanghai Tech University 100 Haike Road Shanghai 200031 China

In the budding yeast Saccharomyces cerevisiae, heterochromatin structure is found at three chromosome regions, which are homothallic mating-type loci, rDNA regions and telomeres. To address how telomere heterochromatin is assembled under physiological conditions, we employed a de novo telomere addition system, and analyzed the dynamic chromatin changes of the TRPI reporter gene during telomere elongation. We found that integrating a 255-bp, but not an 81-bp telomeric sequence near the TRP1 promoter could trigger Sir2 recruitment, active chromatin mark（s）＇ removal, chromatin compaction and TRP1 gene silencing, indicating that the length of the telomeric sequence inserted in the internal region of a chromosome is critical for determining the chromatin state at the proximal region. Interestingly, Rill but not Rif2 or yKu is indispensable for the formation of intra-chromosomal silent chromatin initiated by telomeric sequence. When an internal short telomeric sequence （e.g., 81 bp） gets exposed to become a de novo telomere, the herterochromatin features, such as Sir recruitment, active chromatin mark（s）＇ removal and chromatin compaction, are detected within a few hours before the de novo telomere reaches a stable length. our results recapitulate the molecular dynamics and reveal a coherent picture of telomere het- erochromatin formation.

关键词： Telomere Heterochromatin Nucleosome positioning Siry Ku

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Identifying the niche for spermatogenesis

Identifying the niche for spermatogenesis

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2019中国生理学会学术年会暨张锡钧基金第十五届全国青...

作者：彭义 bo o.zhou Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences

＜正＞Mammalian spermatogenesis is a complex developmental process based on a robust stem cell system, which is controlled by a special microenvironment in the *** multiple cell types have been proposed as potential niche（s） for spermatogenesis, direct in vivo evidence is lacking among these ***/c-kit pathway have been implied in the regulation of spermatogenesis and

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Exercise-induced miR-17-3p prevents pathological myocardial dysfunction

Exercise-induced miR-17-3p prevents pathological myocardial ...

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2019中国生理学会学术年会暨张锡钧基金第十五届全国青...

作者：周秋莲 bo o.zhou Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences

＜正＞Background:Exercise is beneficial for pathological myocardial dysfunction and heart *** previously reported that miR-17-3p contributed to exercise-induced cardiac growth and protected against cardiac ischemia/reperfusion ***, if exercise-induced miR-17-3p can prevent pathological myocardial dysfunction is undetermined.

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Seasonal increase in nest defense,but not egg rejection,in a cuckoo host

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Avian Research 2024年第1期15卷 50-54页

作者： Bo.zhou Wei Liang Ministry of Education Key Laboratory for Ecology of Tropical Islands Key Laboratory of Tropical Animal and Plant Ecology of Hainan ProvinceCollege of Life SciencesHainan Normal UniversityHaikou 571158China Institute of Biological Resources Jiangxi Academy of ScienceNanchang 330096China

The interactions between avian brood parasites and their hosts provide an informative and easy-to-handle system for studying *** brood parasitism reduces the reproductive success of hosts,and thus,hosts have evolved anti-parasitic strategies,such as rejecting parasitic eggs and adopting aggressive nest defense strategies,to avoid the cost brought on by brood *** test whether host anti-parasitic strategies are adjusted with the risk of being parasitized when the breeding seasons of brood parasites and hosts are not synchronous,we conducted a field experiment assessing nest defense and egg recognition behaviors of the Isabelline Shrike(Lanius isabellinus),a host of the Common Cuckoo(Cuculus canorus).In the local area,the host Isabelline Shrike begins to breed in April,whereas the summer migratory Common Cuckoo migrates to the local area in May and begins to lay parasitic *** showed that nest defense behaviors of the Isabelline Shrike increases significantly after cuckoo arrival,showing higher aggressiveness to cuckoo dummies,with no significant difference in attack rates among cuckoo,sparrowhawk and dove dummies,but their egg rejection did not change *** results imply that Isabelline Shrikes may adjust their nest defense behavior,but not egg rejection behavior,with seasonality.

关键词： Aggression Anti-parasite strategy Egg rejection Mismatch cuckoo parasitism Nest defense

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Demonstration of high-dimensional controlled quantum teleportation for the first time

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Science China(Physics,Mechanics & Astronomy) 2024年第3期67卷 163-164页

作者： Yu-bo Sheng Lan zhou College of Electronic and optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023China College of Science Nanjing University of Posts and TelecommunicationsNanjing 210023China

Controlled quantum teleportation(CQT) [1] is the tripartite version of quantum teleportation and it allows the teleportation of an unknown quantum state under the control of a third party. Compared with low-dimensional counterparts,high-dimensional CQT can exhibit larger information transmission capacity and a higher control power [2,3].

关键词： quantum dimensional high

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Reversibly sensitizing-storing-releasing ^(1)o_(2) within a single platinum(Ⅱ)-acetylide-based metallacycle molecule via laser power modulation

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Science China Chemistry 2024年第2期67卷 604-611页

作者： Ruyi zhou Wen Lv bo Li bo Yu Sudi Zhang Yucheng zhou Shujuan Liu Qiang Zhao State Key Laboratory of organic Electronics and Information Displays&Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)&Institute of Flexible Electronics(Future Technology)Nanjing University of Posts and Telecommunications(NUPT)Nanjing210023China College of Electronic and optical Engineering&College of Flexible Electronics(Future Technology) Jiangsu Province Engineering Research Center for Fabrication and Application of Special Optical Fiber Materials and DevicesNanjing University of Posts and Telecommunications(NUPT)Nanjing210023China

Tumor hypoxia severely limits the therapeutic efficacy of photodynamic therapy(PDT) for solid tumors,which is highly dependent on tissue oxygen *** this study,we developed a platinum(Ⅱ)-acetylide-based metallacycle compound bearing six 1,4-dimethylnaphthalenes(DMN) groups,and controlled the photodynamic and photothermal effects of the compound by adjusting the power of 730 nm laser to achieve reversible sensitization,storage and release of 1~o_(2) within a single *** compound formed nanoparticles by self-assembly and exhibited good water solubility and *** laser irradiation,the strong spin-orbit coupling of platinum atoms in the metallacycle facilitated 1~o_(2) *** produced 1~o_(2) was captured by the DMN carriers and transported into the hypoxic tumor,where 1~o_(2) release was triggered owing to the good photothermal effect of the extended conjugation of the *** therapy,the metallacycle serving as a photosensitizer,1~o_(2) carrier,and photothermal reagent,achieved the synergistic therapy of PDT/PTT,demonstrating the versatility of the *** study proposes a new strategy to develop phototherapy agents that are suitable for hypoxic tumors.

关键词： metallacycles singlet oxygen endoperoxides near-infrared absorption synergistic treatment

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Identifying the niche for spermatogenesis

Identifying the niche for spermatogenesis

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中国生理学会张锡钧基金第十五届全国青年优秀生理学学术论文交流及评奖会议;中国生理学会第十三届全国青年生理学工作者学术会议

作者： Yi Jacky Peng bo o.zhou Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences

Mammalian spermatogenesis is a complex developmental process based on a robust stem cell system,which is controlled by a special microenvironment in the *** multiple cell types have been proposed as potential niche(s) for spermatogenesis,direct in vivo evidence is lacking among these ***/c-kit pathway have been implied in the regulation of spermatogenesis and is essential for maintaining normal sperm *** this purpose,we employed different cell

关键词： Identifying the niche for spermatogenesis SCF niche

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Realizing high initial Coulombic efficiency in manganese-based layered oxide cathodes for sodium-ion batteries via P2/o'3 biphasic structure optimization

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Rare Metals 2024年第5期43卷 2093-2102页

作者： bo Peng Zi-Hao.zhou Ping Xuan Jie Xu Lian-bo Ma School of Materials Science and Engineering Anhui University ofTechnologyMa'anshan 243002China Anhui Product Quality Supervision&Inspection Research Institute Hefei 230051China

Mn-based layered oxides are among the most promising cathode materials for sodium-ion batteries owing to the advantages of abundance,environmenta friendliness,low cost and high specific capacity.P2 and o'3 are two representative structures of Mn-based layered ***,the P2 structure containing insufficien Na generally exhibits low initial charge capacity,while o'3structure with sufficient Na delivers high initial charge capacity but poor cycle *** study prepared a multitude of Na_(x)Mno_(2)(x=0.7,0.8,0.9)cathode materials with varying P2/o'3 ratios and further investigated their electrochemical *** optimized Na_(0.8)Mno_(2) comprising 69.9 wt%o'3 and 30.1 wt%P2 phase,exhibited relatively balanced specific capacity,Coulombic efficiency and cycle ***,it achieved a high specific capacity of 128.9 mAh·g^(-1) with an initia Coulombic efficiency of 98.2%in half-cell configuration The Na_(0.8)Mno_(2)//hard carbon full cell also achieved a high specific capacity of 126.7 mAh·g^(-1) with an initia Coulombic efficiency of 98.9%.Moreover,the capacity fading mechanism was revealed by combining in-situ and ex-situ X-ray *** findings of this study provide theoretical guidance for further modification design of Mnbased layered cathodes.

关键词： Sodium-ion batteries Cathode materials Mn-based layered oxides P2/0'3 composites

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Plasmon coupling-driven enhanced high-order multiphoton excited fluorescent performance of metal-organic frameworks

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Nano Research 2024年第7期17卷 6502-6508页

作者： Tong Meng bo Li Linlin Zeng Xianshun Sun Yupeng Tian Hongping zhou Meng zhou Dandan Li Institutes of Physical Science and Information Technology Key Laboratory of Structure and Functional Regulation of Hybrid MaterialsMinistry of EducationAnhui UniversityHefei 230601China School of Chemistry and Chemical Engineering Anhui UniversityHefei 230601China Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China

Accessing high-order multiphoton excited fluorescence(H-MPEF)materials is challenging yet and needs complicated synthesis *** this study,we successfully assembled plasmonic Au nanorods(Au NRs)with multiphoton responsive metalorganic frameworks(MoFs),resulting in a significant several-fold enhancement of *** extent of multiphoton enhancement was found to be strongly dependent on the degree of overlap between the multiphoton excitation wavelength of MoFs and the localized surface plasmon resonance absorbance of Au NRs,indicating the importance of plasmon-induced resonance energy ***,plasmon-induced hot electron transfer played a vital role in enhanced multiphoton activity as ***,the optimum H-MPEF enhancement occurs at the second near-infrared(NIR-II)region,which provides a promising platform for fluorescent *** findings provide a feasible and practical method to fabricate optimized H-MPEF materials for biological imaging using tissue-penetrating NIR-II light.

关键词： metal-organic framework(MoF) plasmon resonance multiphoton activity fluorescence imaging

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Improved catalytic performance of Co_(2) electrochemical reduction reaction towards ethanol on chlorine-modified Cu-based electrocatalyst

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Nano Research 2024年第5期17卷 3761-3768页

作者： Yifan Liu Hehua Tang Yitian zhou bo-Lin Lin School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China

Effective electrochemical conversion of Co_(2) to value-added liquid multi-carbon products driven by renewable energy is a promising approach to alleviate excessive Co_(2) emission and achieve large-scale renewable energy ***,the selectivity and catalytic activity towards liquid multi-carbon products of Co_(2) electroreduction reaction are still unsatisfactory due to the sluggish C-C coupling process and the formation of complex oxygen-containing ***,designing and fabricating highly effective electrocatalysts is crucial for practical applications in this ***,we developed Cl-modified Cu catalyst(Cu-Cl)for efficient electrochemical reduction of Co_(2) to *** optimal Faradaic efficiency and partial current density of ethanol on the Cu-Cl sample reached 26.2%and 343.2 mA·cm^(-2) at-0.74 V(*** hydrogen electrode(RHE)),which were 1.66 and 1.76 times higher than those of the catalyst without Cl decoration,outperforming those in most previously reported *** functional theory(DFT)calculations revealed that the Cl-modified Cu surface suppressed the parasitic hydrogen evolution reaction(HER)and reduced the energy barrier for the C-C coupling process,making the formation of key intermediates favorable for ethanol ***,the decoration of Cl on the Cu surface facilitated ethanol formation.

关键词： Co_(2)electrochemical reduction halogen chlorine Cu-based catalysts ethanol multi-carbon products

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