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Efficacy and Safety of All-oral,12-week Ravidasvir Plus Ritonavir-boosted Danoprevir and Ribavirin in Treatment-naive Noncirrhotic HCV Genotype 1 Patients:Results from a Phase 2/3 Clinical Trial in China

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Journal of Clinical and Translational Hepatology 2019年第3期7卷 213-220页

作者： Xiaoyuan Xu bo Feng Yujuan Guan Sujun Zheng Jifang Sheng Xingxiang Yang Yuanji Ma Yan Huang Yi Kang Xiaofeng Wen Jun Li Youwen Tan Qing He Qing Xie Maorong Wang Ping An Guozhong Gong Huimin Liu Qin ning Rui Hua bo ning Wen Xie Jiming Zhang Wenxiang Huang Yongfeng Yang Minghua Lin Yingren Zhao Yanhong Yu Jidong Jia Dongliang Yang Liang Chen Yinong Ye Yuemin Nan Zuojiong Gong Quan Zhang Peng Hu Fusheng Wang Yongguo Li Dongliang Li Zhansheng Jia Jinlin Hou Chengwei Chen Jinzi JWu Lai Wei Peking University First Hospital BeijingChina Peking University People's Hospital BeijingChina Guangzhou Eighth People's Hospital GuangzhouChina Beijing YouAn Hospital Capital Medical UniversityBeijingChina The First Affiliated Hospital of Medical School of Zhejiang University HangzhouChina Sichuan Provincial People's Hospital ChengduChina West China Hospital Sichuan UniversityChengduChina Xiangya Hospital Central South UniversityChangshaChina Henan Provincial People's Hospital ZhengzhouChina Liuzhou People's Hospital LiuzhouChina Jiangsu Province Hospital NanjingChina Zhenjiang No.3 People's Hospital ZhenjiangChina The Third People's Hospital of Shenzhen ShenzhenChina Ruijin Hospital Shanghai Jiaotong University School of MedicineShanghaiChina People's Liberation Army Bayi Hospital NanjingChina Shenyang Sixth People's Hospital ShenyangChina The 2nd Xiangya Hospital of Central South University ChangshaChina Xixi Hospital of Hangzhou HangzhouChina Tongji Medical College of Huazhong University of Science&Technology WuhanChina The First Hospital of Jilin University ChangchunChina Baoji Center Hospital BaojiChina Beijing Ditan Hospital BeijingChina Huashan Hospital Affiliated to Fudan University ShanghaiChina Chongqing Medical University No.1 Affiliated Hospital ChongqingChina The Second Hospital of Nanjing NanjingChina Fujian Fuzhou Municipal Infectious Disease Hospital FuzhouChina No.1 Affiliated Hospital of Xi'an Jiaotong University Xi'anChina The First Affiliated Hospital of Guangxi Medical University NanningChina Beijing Friendship Hospital Capital Medical UniversityBeijingChina Wuhan Union Hospital WuhanChina Shanghai Public Health Clinical Center ShanghaiChina Foshan No.1 People's Hospital FoshanChina The Third Hospital of Hebei Medical University ShijiazhuangChina Wuhan University Renmin Hospital WuhanChina The Affiliated Hospital of Guizhou Medical University GuiyangChina The Second Affiliated Hospital of Chongqing Medical University ChongqingChina PLA 302 Hospital Be

Background and Aims:Ravidasvir(RDV)is a new generation pangenotypic hepatitis C virus(HCV)NS5A inhibitor,with high barrier to baseline resistance-associated species.This is the first phase 2/3 study conducted in China's Mainland confirming the efficacy and safety of RDV+ritonavir-boosted danoprevir+ribavirin for 12 weeks in treatment-naive noncirrhotic patients with genotype 1 infection in a large population.Methods:In this multicenter,randomized,doubleblinded,placebo-controlled phase 2/3 trial(NCT03362814),we enrolled 424 treatment-nafve,noncirrhotic adult HCV genotype 1 patients.All patients were randomized at 3∶1 ratio to receive a combination of RDV 200mg once daily plus ritonavir-boosted danoprevir 100mg/100mg twice daily and oral ribavirin 1000/1200mg/day(body weightbo(n=106)for 12 weeks.The primary end-point was the rate of sustained virologic response 12 weeks after the end of treatment,and the safety was evaluated and compared between treatment and placebo groups.Results:The overall rate of sustained virological response at 12 weeks after treatment is 99%(306/309,95%,CI:97%-100%)under per protocol set analysis.All patients harboring baseline NS5A resistance-associated species in the treatment group(76/76,per protocol set)achieved sustained virological response at 12 weeks after treatment.No treatment-related serious adverse events were reported.Laboratory abnormalities showed mild or moderate severity(grade 1 and grade 2)in liver function tests.Conclusions:In treatment-na(i)ve,noncirrhotic HCV Chinese patients infected with HCV genotype 1,all-oral regimen of RDV+ritonavir-boosted danoprevir+ribavirin for 12 weeks was highly efficacious,safe,and well tolerated.

关键词： Ravidasvir Danoprevir HCV SVR Treatment-naive Noncirrhotic GT1

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叶面喷施硒肥对香榧幼苗叶片代谢组的影响

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林业科学研究 2024年第3期37卷 203-212页

作者：陈振生李爱华杜拾平黄培耕许秀环宁博林李文广西国有博白林场广西博白537617 湖北省林业科学研究院湖北武汉430075

[目的]分析亚硒酸钠叶面喷施后对香榧(Torreya grandis)幼苗叶片代谢组的影响,探究亚硒酸钠喷施后香榧叶片次生代谢物的累积情况及其对果实品质的影响。[方法]以苗龄2年的香榧幼苗为供试材料,叶面喷施亚硒酸钠(浓度为100μg·L^(-1))2次... 详细信息

[目的]分析亚硒酸钠叶面喷施后对香榧(Torreya grandis)幼苗叶片代谢组的影响,探究亚硒酸钠喷施后香榧叶片次生代谢物的累积情况及其对果实品质的影响。[方法]以苗龄2年的香榧幼苗为供试材料,叶面喷施亚硒酸钠(浓度为100μg·L^(-1))2次,间隔15 d。第二次喷施后15 d,采取1年生叶片进行代谢组分析,以色谱-质谱研究香榧幼苗叶片代谢物差异。[结果]在正离子模式下,处理组和对照组之间有909种差异代谢物,其中69种显著变化(27种显著上调,42种显著下调)。在负离子模式下,出现433种差异代谢物,其中43种显著变化(11种显著上调,32种显著下调)。对人体有益的一些次生代谢物显著增加,如车前苷(2.827倍)、川芎内酯(2.524倍)、6-唾液乳糖(2.021倍)、阿齐沙坦(1.931倍)。[结论]香榧叶片喷施亚硒酸钠有利于促进对人体有益的次生代谢物的生物合成及其在叶片中的累积。

关键词：香榧硒肥代谢组生物强化

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大型袋式除尘器边界轮廓法数值模拟及结构优化设计

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水泥技术 2024年第4期 55-61页

作者：宁波喻宏祥韩德夫马玉震孙海全天津水泥工业设计研究院有限公司天津300400

以某万吨水泥生产线窑尾大型袋式除尘器为例,采用基于CFD数值模拟技术的边界轮廓法进行数值模拟分析,提出除尘设备内部结构优化方案,改善设备运行状态。首先,介绍了边界轮廓法的计算步骤;其次,通过对除尘设备的整机和单袋室进行数值模拟... 详细信息

以某万吨水泥生产线窑尾大型袋式除尘器为例,采用基于CFD数值模拟技术的边界轮廓法进行数值模拟分析,提出除尘设备内部结构优化方案,改善设备运行状态。首先,介绍了边界轮廓法的计算步骤;其次,通过对除尘设备的整机和单袋室进行数值模拟,分析对比了各袋室烟气量的分配情况,利用对应袋室入口的边界数据计算分析单袋室的流场状态,提出优化内部结构的合理方案。模拟分析发现,在灰斗处布置高效导流板、在滤袋侧部合理布置格栅板,为该袋式除尘器的最优结构优化方案。应用实践表明,采用基于CFD数值模拟技术的边界轮廓法,对于结构复杂、零部件较多的设备,能够精确模拟其内部气流状态,确保设备运行状态良好。

关键词：袋式除尘器 CFD技术数值模拟内部气流优化设计

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西安市植被碳汇时空演变特征及影响因素解析

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地理空间信息 2024年第2期22卷 30-33页

作者：赵月帅张秀红范田禾王锐宁博陕西华地勘察设计咨询有限公司陕西西安710018

基于2001-2015年MOD17A3 NPP数据,运用土壤呼吸模型,计算出植被NEP值,以植被NEP值作为估算碳汇的重要指标,借助GIS空间分析、相关性分析,研究了2001-2015年西安市碳汇时空格局及演变特征,分析了气温、降水、高程、坡度对植被碳汇变化的... 详细信息

基于2001-2015年MOD17A3 NPP数据,运用土壤呼吸模型,计算出植被NEP值,以植被NEP值作为估算碳汇的重要指标,借助GIS空间分析、相关性分析,研究了2001-2015年西安市碳汇时空格局及演变特征,分析了气温、降水、高程、坡度对植被碳汇变化的影响,为西安市生态环境调控提供了一定参考。研究结果表明:如果不考虑人为干扰条件影响,西安市除建设用地之外均属于碳汇用地。2001-2015年西安市植被碳汇整体呈上升趋势,显著增加区域面积占比达44.49%;植被NEP与高程、坡度间存在阶段性变化特征,且高程影响幅度较大;植被碳汇与降水呈正相关,与气温呈负相关关系,但局部存在较大差异。

关键词： NPP NEP 植被碳汇时空演变西安市

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农用地时空变化及其对农业布局影响——以西安市鄠邑区为例

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国土与自然资源研究 2024年第3期 1-5页

作者：马存霞宁博王锐范田禾刘晗李兰陕西华地勘察设计咨询有限公司西安710000 玉溪师范学院地理与国土工程学院云南玉溪653100

本文以西安市鄠邑区为研究区,运用农用地动态变化度,并结合空间自相关方法,分析了农用地时空动态变化特征,并在此基础上探究其对农业布局的影响。本研究利用农用地空间时空变化特征和规律,以鄠邑区乡镇为单位,划分出粮食种植区、现代观... 详细信息

本文以西安市鄠邑区为研究区,运用农用地动态变化度,并结合空间自相关方法,分析了农用地时空动态变化特征,并在此基础上探究其对农业布局的影响。本研究利用农用地空间时空变化特征和规律,以鄠邑区乡镇为单位,划分出粮食种植区、现代观光农业区、果园休闲区和生态林业区四大农业产业区块,对优化调整鄠邑区农业空间布局具有重要意义。

关键词：农用地变化动态度空间自相关鄠邑区

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Steriod for Autoimmune pancreatitis complicating by gastric varices: A case report

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World Journal of Clinical Cases 2022年第12期10卷 3930-3935页

作者： ning-bo Hao Xue Li Wen-Wei Hu Dan Zhang Jing Xie Xiao-Lin Wang Chang-Zheng Li Department of Gastroenterology PLA Rocket Force Characteristics Medical CenterBeijing 100088China

BACKGROUND both autoimmune pancreatitis(AIP)and gastric varices are related to various diseases.However,AIP complicated by gastric varices is extremely rare,and has only been reported in a few studies.Here,we report a case of AIP complicated by gastric varices in a female Chinese patient.CASE SUMMARY A 59-year-old Chinese woman was admitted to our hospital with mild abdominal pain.Computed tomography and magnetic resonance cholangiopancreatography revealed a diffusely enlarged pancreas,an obstructed splenic vein and slight splenomegaly.Esophagogastroduodenoscopy showed gastric varices in the partial gastric fundus and the red-color sign was positive.Blood chemistry showed that IgG4 was notablely elevated.The patient was diagnosed with AIP complicated by gastric varices.Steroid therapy was administered to this patient with the risk of gastrointestinal bleeding.After one year of therapy,the pancreas,spleen and splenic vein recovered to the normal states,and the gastric varices had disappeared.CONCLUSION We present this case together with evidence from the literature to demonstrate the effectiveness of steroid therapy in the treatment of AIP complicated by gastric varices.

关键词： Autoimmune pancreatitis Gastric varices Steroid Case report

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Enhancement of heavy metals desorption from the soil by eddy deep leaching in hydrocyclone

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Journal of Environmental Sciences 2024年第1期135卷 242-251页

作者： ning Wang Hao Lu bo Liu Tai Xiong Jianping Li Hualin Wang Qiang Yang School of Mechanical and Power Engineering East China University of Science and TechnologyShanghai 200237China National Engineering Laboratory for High Concentration Refractory Organic Wastewater Treatment Technology East China University of Science and TechnologyShanghai 200237China

An eddy deep leaching technology was developed in this paper to address the challenge of treating heavy metal contaminants in industrial mining areas.The desorption effect of As,Cd,Sb and Pb was investigated utilizing chemical leaching and physical eddy techniques.It was found that the heavy metals concentration increased with decreasing particle size.The highest proportion of Cd in the form distribution of soil was in the bound to iron and manganese oxides,while the maximum proportion of As,Sb and Pb were in the residual.The optimal solid-liquid ratio of the hydrocyclone was 1:20,and the corresponding separation efficiency and flow rate were 84.7%and 1.76 m^(3)/hr,respectively.The grade efficiency of soil particle separation increases with particle size and exceeds 99%for particles above 1,000μm.Leaching experiments have revealed that oxalic acid(OA)and a combination of oxalic acid and EDTA(OAPE)were more efficient than citric acid(CA)and a combination of citric acid and EDTA(CAPE)for the desorption of heavy metals,respectively.The comparison of OAPE and eddy leaching found that the latter improved the desorption efficiency by 9.4%,7.5%,7.2%and 7.8%for As,Cd,Sb and Pb compared to the former,respectively.The results demonstrated that the eddy leaching technique could further enhance the desorption efficiency of heavy metals.It is expected to provide technical support for soil remediation with reduced usage of leaching agents.

关键词： Heavy metals Soil remediation Oxalic acid Eddy leaching Hydrocyclone

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The state of the art of fetal magnetic resonance imaging

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Chinese Medical Journal 2006年第15期119卷 1294-1299页

作者： GUO Yuan LUO bo-ning Department of Radiology First Affiliated Hospital of Sun Yat-sen University Guangzhou 510080 China

Objective To assess the state of the art of fetal magnetic resonance imaging （MRI） in China. Data sources both Chinese and English language literatures were searched in the databases of PUBMED （1998-2005） and CNKI （1998-2005）, 41 published articles about fetal MRI were selected. Results Fetal MRI can serve as an adjunct tool for ultrasonography because of its excellent soft tissue contrast, high spatial resolution, multiplanar capabilities, large field of view and simultaneous visualization of fetal and maternal structures. Since the development of ultrafast MRI sequences provides faster scan time and avoids motion artifacts, it is widely applied in detecting normal or abnormal fetal development, including the central nervous system, thoracic region, abdomen and others. In China, experience in fetal MRI has been scanty, but the technique will be extensively used in the near future because of its multi-faceted advantages. Conclusions Compared with ultrasonography, MRI as a complementary imaging for fetal screening is prospective in China or other parts of the world because of its multiple superiorities.

关键词： fetal magnetic resonance imaging appfication

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愈创紫草油对头颈部恶性肿瘤患者放疗所致放射性皮肤黏膜损伤的改善作用研究

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现代生物医学进展 2024年第10期24卷 1873-1877页

作者：苗庆红吴宁波陈静慈书俊梁惠安徽中医药大学附属六安医院肿瘤放疗科安徽六安237000

目的:探讨愈创紫草油改善头颈部恶性肿瘤放疗患者所致放射性皮肤黏膜损伤的临床疗效,以期为头颈部恶性肿瘤放疗患者所致放射性皮肤黏膜损伤提供新的治疗方法。方法:选取安徽中医药大学附属六安医院2021年3月-2023年3月头颈部恶性肿瘤放... 详细信息

目的:探讨愈创紫草油改善头颈部恶性肿瘤放疗患者所致放射性皮肤黏膜损伤的临床疗效,以期为头颈部恶性肿瘤放疗患者所致放射性皮肤黏膜损伤提供新的治疗方法。方法:选取安徽中医药大学附属六安医院2021年3月-2023年3月头颈部恶性肿瘤放疗患者100例作为研究对象,随机数字表随机分为观察组和对照组,各50例。两组均采用适形调强放射治疗,对照组给予常规放疗皮肤管理与宣教,观察组在对照组基础上给予涂抹愈创紫草油治疗。比较两组皮肤黏膜损伤程度、临床疗效、放疗完成率、皮损愈合时间,放疗2、4、6周时数字评分法(NRS)评分、Karnofsky功能状态(KPS)评分、皮肤病生活质量量表(DLQI)评分;放疗前、放疗6周时炎性细胞因子[白介素-6(IL-6)、降钙素原(PCT)、超敏C反应蛋白(hs-CRP)]水平及皮肤不良反应。结果:观察组皮肤黏膜损伤程度分级低于对照组(P<0.05);观察组总有效率94.00%较对照组80.00%高(P<0.05);放疗4、6周时观察组NRS评分、DLQI评分低于对照组,KPS评分高于对照组(P<0.05);两组放疗完成率均为100%,观察组皮损愈合时间较对照组短(P<0.05);放疗6周时观察组血清IL-6、PCT、hs-CRP水平低于对照组(P<0.05);两组患者均未出现过敏所致皮疹、红肿、瘙痒等皮肤不良反应。结论:愈创紫草油可有效减轻头颈部恶性肿瘤放疗所致放射性皮肤黏膜损伤,降低血清炎性细胞因子水平,促进患者皮损愈合,提高生活质量,疗效显著,且安全性高。

关键词：愈创紫草油头颈部肿瘤放疗放射性皮肤黏膜损伤临床疗效

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Signaling pathways and intervention therapies in sepsis

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Signal Transduction and Targeted Therapy 2021年第12期6卷 3567-3602页

作者： Yun-yu Zhang bo-tao ning Department of Pediatric Intensive Care Unit Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong University200127 ShanghaiChina

Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host systemic inflammatory and immune response to infection.Over decades,advanced understanding of host–microorganism interaction has gradually unmasked the genuine nature of sepsis,guiding toward new definition and novel therapeutic approaches.Diverse clinical manifestations and outcomes among infectious patients have suggested the heterogeneity of immunopathology,while systemic inflammatory responses and deteriorating organ function observed in critically ill patients imply the extensively hyperactivated cascades by the host defense system.From focusing on microorganism pathogenicity,research interests have turned toward the molecular basis of host responses.Though progress has been made regarding recognition and management of clinical sepsis,incidence and mortality rate remain high.Furthermore,clinical trials of therapeutics have failed to obtain promising results.As far as we know,there was no systematic review addressing sepsis-related molecular signaling pathways and intervention therapy in literature.Increasing studies have succeeded to confirm novel functions of involved signaling pathways and comment on efficacy of intervention therapies amid sepsis.However,few of these studies attempt to elucidate the underlining mechanism in progression of sepsis,while other failed to integrate preliminary findings and describe in a broader view.This review focuses on the important signaling pathways,potential molecular mechanism,and pathway-associated therapy in sepsis.Host-derived molecules interacting with activated cells possess pivotal role for sepsis pathogenesis by dynamic regulation of signaling pathways.Cross-talk and functions of these molecules are also discussed in detail.Lastly,potential novel therapeutic strategies precisely targeting on signaling pathways and molecules are mentioned.

关键词： sepsis mentioned finding

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